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limb arteriosclerosis (ASO)

Xue-Mei He, Ying-Qiang Zheng, Sheng-Zhi Liu, Yong Liu, Yan-Zheng He, Xiang-Yu Zhou
AIM: Arteriosclerosis obliterans (ASO) of the lower extremities is a major cause of adult limb loss worldwide. A timely diagnosis in the early stages of the disease determines the clinical outcomes, however lacking of palpable symptoms remains the biggest obstacle. This study aimed to screen a cluster of microRNAs (miRNAs) that can be used as biomarker for the ASO in the earlier stages. METHODS: Plasma from 3 patients with ASO and 3 healthy controls were profiled to screen altered miRNAs by microarray, then Real time PCR was further used to confirm the changes in 55 ASO patients and 54 controls...
2016: Journal of Atherosclerosis and Thrombosis
Akiyoshi Shimatani, Fumiaki Inori, Taku Yoshida, Masahiko Tohyama, Sadahiko Konishi, Hirotsugu Ohashi
We present a case of osteonecrosis of femoral head (ONFH) that occurred after stent angiography of femoral artery for the treatment of arteriosclerosis obliterans (ASO) of left inferior limb in a 76-year-old woman. No case of late collapse of femoral head as a complication of endovascular procedure such as stent placement has been previously documented. We considered that ONFH occurred after detaining stent at a junction of left deep femoral artery for the treatment of the ischemia of left lateral and medial femoral circumflex artery...
2014: Case Reports in Orthopedics
Run-Sheng Li, Da-Yong Li, Wen-Na Chen, Xian-De Ma, Yang Zhang, Xue-Jing Li
OBJECTIVE: To discuss the effect of Taohong Siwu Decoction (TSD) in regulating functions of endothelial cells and treating arteriosclerosis obliterans (ASO). METHODS: The ASO model was prepared by using high-fat diet plus intimal injury. They were randomly divided into the model group (n = 10), the normal control group (n = 9), the low dose TSD group (group A, n = 12), the middle dose TSD group (group B, n = 10), and the high dose TSD group (group C, n = 9). Eight weeks after modeling, the limb blood perfusion was observed using laser Doppler flowmetry...
February 2014: Chinese Journal of Integrated Traditional and Western Medicine
Gen Takagi, Masaaki Miyamoto, Shuhei Tara, Sonoko Kirinoki-Ichikawa, Yoshiaki Kubota, Tomohito Hada, Ikuyo Takagi, Kyoichi Mizuno
OBJECTIVE: SSc causes intractable ischaemic ulcers. To avoid major amputation, we examined the safety and efficacy of therapeutic vascular angiogenesis for digital ulcers due to SSc. METHODS: A single-centre, open-label pilot study was conducted in patients with an ischaemic digital ulcer [n = 40, mean age 65 years (s.d. 8), Rutherford class III-5 or III-6) due to lcSSc (n = 11) or arteriosclerosis obliterans (ASO; n = 29). Bone marrow mononuclear cells (0.4-5.1 × 10(10) cells in total) were administered into the ischaemic limbs...
May 2014: Rheumatology
Yiping Dang, Yin Xia, Yiqing Li, Danny C W Yu
OBJECTIVE: Peripheral arterial disease (PAD) is a chronic occlusive disease mainly occurred in elderly adults. Arteriosclerosis obliterans (ASO) mainly occurring from small or medium sized arteries of the lower extremities is one of the most common causes of PAD. The gender-related differences of circulating risk factors in diabetic patients with ASO in China remain unknown. The aim of this study is to investigate the gender-related differences in the pattern of several potential risk factors between male and female patients with ASO and type 2 diabetes mellitus (T2D)...
November 2013: Clinical Biochemistry
Tadashi Arai
INTRODUCTION: Arteriosclerosis obliterans (ASO) causes ischemic symptoms of the lower limbs, reducing quality of life (QOL), and has a poor prognosis. Early diagnosis and treatment are necessary. In this study, the effects of long-term administration of beraprost sodium (beraprost) to treat ASO were investigated. METHODS: One hundred and eighty eight patients treated with beraprost for ≥1 year were retrospectively identified. Outcomes were lower limb ischemic symptoms, carotid intima/media thickness (IMT), and cardiovascular events...
May 2013: Advances in Therapy
Hisao Masaki, Atushi Tabuchi, Yasuhiro Yunoki, Hiroshi Kubo, Kosaku Nishikawa, Hiroki Yakiuchi, Kazuo Tanemoto
OBJECTIVE: To determine a treatment strategy based on the outcomes of various previous interventions for critical limb ischemia in arteriosclerosis obliterans (ASO). MATERIAL AND METHODS: We examined outcomes of 292 ASO patients who had had critical limb ischemia between May 1995 and July 2009. Patients underwent the following procedures in 167 cases: aortofemoral bypass (n = 14), femorofemoral crossover bypass (n = 29), femoropopliteal bypass (n = 104) and femorotibial bypass (n = 40)...
2013: Annals of Vascular Diseases
Koji Kido, Hiroyuki Ito, Koshi Makita
Most patients with arteriosclerosis obliterans (ASO) have severe complications such as coronary artery disease, congestive heart failure and chronic kidney disease. They receive long-term antithrombotic therapy which is a contraindication to neuraxial anesthesia. In this retrospective study, we reviewed nine high-risk patients with ASO (revised cardiac risk index more than three) who underwent an urgent lower limb surgery under ultrasound-guided peripheral nerve block (PNB). In all cases, intraoperative hemodynamic changes remained minimized...
October 2012: Masui. the Japanese Journal of Anesthesiology
Fumitaka Nakajima, Satoshi Morimoto, Takatomi Yurugi, Yoshihumi Amari, Yuko Kasuno, Masayoshi Fukui, Yoshiyuki Furumatsu, Tetsuya Kitamura
OBJECTIVE: The prevalence of thrombotic cerebral infarction is higher in dialysis than in general patients. Changes in cerebral blood flow (CBF) during low-density lipoprotein cholesterol-apheresis (LDL-A) in dialysis patients with arteriosclerosis obliterans (ASO) were evaluated employing xenon-CT (Xe-CT) to investigate the possibility of CBF improvement. SUBJECTS AND METHODS: Xe-CT was performed before LDL-A in 4 dialysis patients with ASO (3 males and 1 female)...
November 2012: International Journal of Artificial Organs
D Saito, N Yashiki, S Tomita, G Watanabe
With the overall increase in ischemic heart disease (IHD), cases combining arteriosclerosis obliterans (ASO) of the lower extremities and IHD are on the rise. Therefore, it is necessary to consider methods and timing of operation. These cases have occasionally large collateral pathways from the internal thoracic artery (ITA) to the femoral artery via the epigastric artery. To prevent irreversible ischemia of the lower limbs after harvesting of ITA, we planned to perform a one-stage operation for ASO-combined IHD...
May 2011: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Masato Oda, Ken Toba, Kiminori Kato, Takuya Ozawa, Takao Yanagawa, Noboru Ikarashi, Tsugumi Takayama, Tomoyasu Suzuki, Haruo Hanawa, Masayoshi Masuko, Hironori Kobayashi, Yoshifusa Aizawa
The aim of this study was to identify the clinical parameters of absolutely poor-prognosis patients with chronic critical limb ischemia (AP-CLI). Sixteen no-option CLI patients with arteriosclerosis obliterans: ASO (nine) and non-ASO patients (seven) treated with bone marrow-mononuclear cell implantation (BMI) were analyzed. There were three AP-CLI patients (all ASO). The mRNA expression of several angiogenic factors in the implanted cells was analyzed in comparison with normal donor bone marrow. To observe the response of bone marrow components to hypoxia, normal bone marrow cells were cultured for 24 h in 2...
January 2012: Heart and Vessels
Yong Gao, Shiyuan Chen, Chaowen Yu, Zhonglin Nie
OBJECTIVE: To evaluate the clinical effect of percutaneous transluminal angioplasty (PTA) and PTA and stenting (PTAS) in treating multilevel arteriosclerosis obliterans (ASO) of lower extremities. METHODS: Between January 2007 and October 2009, 29 cases of multilevel ASO of lower extremities were treated with PTA or PTAS. There were 17 males and 12 females with an average age of 71 years (range, 56-83 years). The clinical manifestations were limbs numb with cold sensation, intermittent claudication (< 100 m), and 19 patients had rest pain...
September 2010: Chinese Journal of Reparative and Reconstructive Surgery
R Onodera, S Teramukai, S Tanaka, S Kojima, T Horie, S Matoba, T Murohara, H Matsubara, M Fukushima, et al.
In this study, we report the comparative result of long-term clinical prognoses for patients with no-option critical limb ischemia (CLI) caused by arteriosclerosis obliterans, who are implanted with autologous bone marrow mononuclear cells (BMMNC; n=74) or G-CSF-mobilized (M)-PBMNC (n=111), as no information is available on how the two treatments compare in terms of long-term prognosis, such as survival or amputation. We performed pooled analysis using data from two previous cohort studies. All patients had disease of Fontaine classification III or IV...
February 2011: Bone Marrow Transplantation
Megumi Koshikawa, Uichi Ikeda
The goal of treatment in arteriosclerosis obliterans (ASO) is to aggressively treat atherosclerotic risk factors to reduce future cardiovascular events as well as to improve symptoms of claudication and prevent limb amputation. Patients with ASO have an increased risk of cardiovascular events such as myocardial infarction and stroke in addition to significant impairment in their quality of life and physical function. Strategies for management of ASO include conservative treatment with risk factor modification, smoking cessation, exercise, pharmacologic therapy, balloon angioplasty and stenting of vessels, or bypass surgery, and therapeutic angiogenesis...
May 2010: Nihon Rinsho. Japanese Journal of Clinical Medicine
Junji Moriya, Tohru Minamino, Kaoru Tateno, Naomi Shimizu, Yoichi Kuwabara, Yasunori Sato, Yasushi Saito, Issei Komuro
BACKGROUND: Injection of bone marrow mononuclear cells has been reported to promote neovascularization of ischemic tissues effectively. We found that peripheral blood mononuclear cells were as efficient as bone marrow mononuclear cells for the treatment of limb ischemia in animals and showed that this treatment was feasible and safe in no-option patients with limb ischemia. However, the long-term outcome of such therapy has not been investigated. METHODS AND RESULTS: We retrospectively analyzed the data for 42 patients who were treated between July 2002 and December 2005 by using the log-rank test, the Kaplan-Meier method, and the Cox proportional hazard model...
June 2009: Circulation. Cardiovascular Interventions
Takashi Horie, Rie Onodera, Makoto Akamastu, Yukio Ichikawa, Junichi Hoshino, Eiji Kaneko, Chikara Iwashita, Akaru Ishida, Tatsuo Tsukamoto, Satoshi Teramukai, Masanori Fukushima, Akio Kawamura et al.
BACKGROUND: Many studies have described the clinical effects of treating critical limb ischemia with granulocyte colony-stimulating factor-mobilized autologous peripheral blood mononuclear cells (M-PBMNC); however, there are no long-term data available on survival, limb salvage, or prognostic factors. METHODS: To investigate the long-term clinical outcomes of M-PBMNC implantation, we reviewed data for 162 consecutive patients with limb ischemia who were treated with M-PBMNC implantation at 6 hospitals between 2001 and 2006...
February 2010: Atherosclerosis
Pramook Mutirangura, Chanean Ruangsetakit, Chumpol Wongwanit, Nuttawut Sermsathanasawadi, Khamin Chinsakchai
The aim of this study was to identify the influence of diabetes mellitus on patients with atherosclerosis obliterans (ASO) of the lower extremities. A prospective study was designed to compare differences between ASO patients with and without diabetes mellitus in regard to clinical characteristics and outcomes of management. Two hundred fifty-three consecutive (61.1%) diabetic and 161 (38.9%) nondiabetic patients were included in this study. Crural artery occlusion occurred more frequently in diabetic patients (tibioperoneal segment 26...
November 2008: Vascular
Masato Oda, Kiminori Kato, Ken Toba, Keita Otaki, Toshiki Kitajima, Noboru Ikarashi, Takao Yanagawa, Masutaka Higashimura, Fuyuki Asami, Manabu Isoda, Takuya Ozawa, Masato Moriyama, Satoru Hirono, Yuji Okura, Haruo Hanawa, Makoto Kodama, Yoshifusa Aizawa
OBJECTIVES: Autologous bone marrow implantation (BMI) is effective to treat critical limb ischemia, but the long-term prognosis is not clear. The outcome of BMI treatment for ischemic legs was investigated related to the clinical background of the patient, and short-term effects of BMI. The end event was defined as unexpected lower limb amputation. METHODS AND RESULTS: This study included 21 consecutive patients (mean age 60.0 +/- 13.6 years) with peripheral arterial disease who underwent BMI between December 2001 and March 2005...
October 2007: Journal of Cardiology
Cheng-Ren Lin, Xue-Ying Ma, Min Wang, Bai-Xi Zhuang, Jian-Xun Liu
OBJECTIVE: To explore the effects of Tongxinluo capsule (TXL) on the atherosclerosis obliterans (ASO) in iliofemoral artery of rabbits. METHOD: Rabbits were randomly divided into 7 groups: sham, model, TXL (0.8, 0.4, 0.2 g x kg(-1)), Tongsaimai tablet (0.8 g x kg(-1)) and Laishike (0.002 g x kg(-1)). The animal model of ASO was established with a combined method of mechanical trauma, immunologic injury and high fat fodder feeding. Rabbits were administrated the drugs 8 weeks after surgery...
March 2007: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Bai-xi Zhuang, Lu-bo Ma, Chun-li Yu
OBJECTIVE: To observe the effects of refined Xuefu Capsule (RXC) in patients with arteriosclerosis obliterans (ASO) after femoral-popliteal bypass (FPB). METHODS: Thirty-eight ASO patients with 41 limbs underwent FPB were randomly assigned to two groups: the control group (18 cases with 20 operated limbs) and the RXC group (20 cases with 21 operated limbs). All patients received long-term anticoagulant treatment with Warfarin, and RXC was given to the RXC group additionally for 3 months...
January 2007: Chinese Journal of Integrated Traditional and Western Medicine
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