Claire Molony, Damien King, Mariana Di Luca, Michael Kitching, Abidemi Olayinka, Roya Hakimjavadi, Lourdes A N Julius, Emma Fitzpatrick, Yusof Gusti, Denise Burtenshaw, Killian Healy, Emma K Finlay, David Kernan, Andreu Llobera, Weimin Liu, David Morrow, Eileen M Redmond, Jens Ducrée, Paul A Cahill
A hallmark of subclinical atherosclerosis is the accumulation of vascular smooth muscle cell (SMC)-like cells leading to intimal thickening and lesion formation. While medial SMCs contribute to vascular lesions, the involvement of resident vascular stem cells (vSCs) remains unclear. We evaluated single cell photonics as a discriminator of cell phenotype in vitro before the presence of vSC within vascular lesions was assessed ex vivo using supervised machine learning and further validated using lineage tracing analysis...
October 2021: Stem cell reviews and reports