keyword
MENU ▼
Read by QxMD icon Read
search

Mode of transport

keyword
https://www.readbyqxmd.com/read/28537748/pesticide-interactions-mechanisms-benefits-and-risks
#1
John E Casida
Interactions between pesticides at common molecular targets and detoxification systems often determine their effectiveness and safety. Compounds with the same mode of action or target are candidates for cross resistance and restrictions in their recommended uses. Discovery research is therefore focused on new mechanisms and modes of action. Interactions in detoxification systems also provide cross resistance and synergist and safener mechanisms illustrated with serine hydrolases and inhibitors, cytochrome P450s and insecticide synergists, and glutathione S-transferases and herbicide safeners...
May 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28534004/integrating-health-and-transportation-in-nashville-tennessee-usa-from-policy-to-projects
#2
Leslie A Meehan, Geoffrey P Whitfield
The Nashville Area Metropolitan Planning Organization (MPO) is among the first MPOs in the United States to recognize the interplay of transportation and public health, particularly regarding physical activity, air pollution, and traffic crashes. The Nashville MPO has taken a multifaceted approach to simultaneously improve the transportation system, quality of life, and health status of the region's population. The purpose of this paper is to describe the multiple programs and projects that the MPO has undertaken to this end, so that other cities might learn from Nashville's example...
March 2017: Journal of Transport & Health
https://www.readbyqxmd.com/read/28530798/heterogeneous-molecular-catalysis-of-electrochemical-reactions-volcano-plots-and-catalytic-tafel-plots
#3
Cyrille Costentin, Jean-Michel Savéant
We analyze here, in the framework of heterogeneous mo-lecular catalysis the reasons of occurrence or non-occurrence of volcanoes upon plotting the kinetics of the catalytic reaction versus the stabilization free energy of the primary intermediate of the catalytic process. As in the case of homogeneous molecular catalysis or catalysis by surface active metallic sites, a strong motivation of such studies relates to modern energy challenges, particularly those involving small molecules such as water, hydrogen, oxygen, proton and carbon dioxide...
May 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28527312/low-energy-electron-potentiometry
#4
Johannes Jobst, Jaap Kautz, Maria Mytiliniou, Rudolf M Tromp, Sense Jan van der Molen
In a lot of systems, charge transport is governed by local features rather than being a global property as suggested by extracting a single resistance value. Consequently, techniques that resolve local structure in the electronic potential are crucial for a detailed understanding of electronic transport in realistic devices. Recently, we have introduced a new potentiometry method based on low-energy electron microscopy (LEEM) that utilizes characteristic features in the reflectivity spectra of layered materials [1]...
May 13, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28524820/chemical-structure-guided-design-of-dynapyrazoles-potent-cell-permeable-dynein-inhibitors-with-a-unique-mode-of-action
#5
Jonathan Baruch Steinman, Cristina C Santarossa, Rand M Miller, Lola S Yu, Anna S Serpinskaya, Hideki Furukawa, Sachie Morimoto, Yuta Tanaka, Mitsuyoshi Nishitani, Moriteru Asano, Ruta Zalyte, Alison E Ondrus, Alex G Johnson, Fan Ye, Maxence V Nachury, Yoshiyuki Fukase, Kazuyoshi Aso, Michael A Foley, Vladimir I Gelfand, James K Chen, Andrew P Carter, Tarun M Kapoor
Cytoplasmic dyneins are motor proteins in the AAA+ superfamily that power transport of cellular cargos towards microtubule minus-ends. Recently, ciliobrevins were reported as selective cell-permeable inhibitors of cytoplasmic dyneins. As is often true for first-in-class inhibitors, the use of ciliobrevins has been limited by low potency. Moreover, suboptimal chemical properties, such as the potential to isomerize, have hindered efforts to improve ciliobrevins. Here, we characterized the structure of ciliobrevins and designed conformationally-constrained isosteres...
May 19, 2017: ELife
https://www.readbyqxmd.com/read/28522872/integrated-multi-port-circulators-for-unidirectional-optical-information-transport
#6
Parinaz Aleahmad, Mercedeh Khajavikhan, Demetrios Christodoulides, Patrick LiKamWa
On-chip photonic networks hold great promise for enabling next-generation high speed computation and communication systems. It is currently envisioned that future integrated photonic networks will be capable of processing dense digital information on a single monolithic platform by involving a multitude of optical components ranging from lasers to modulators, to routers, interconnects and detectors. Among the possible functionalities to be incorporated in such arrangements is the ability to route information in a unidirectional way among N-ports - a capability typically afforded through the use of optical circulators...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28517939/breakdown-of-optical-phonons-splitting-in-two-dimensional-materials
#7
Thibault Sohier, Marco Gibertini, Matteo Calandra, Francesco Mauri, Nicola Marzari
We investigate the long-wavelength dispersion of longitudinal and transverse optical phonon modes in polar two-dimensional materials, multilayers, and their heterostructures. Using analytical models and density-functional perturbation theory in a two-dimensional framework, we show that at variance with the three-dimensional case these modes are degenerate at the zone center but the macroscopic electric field associated with the longitudinal-optical modes gives rise to a finite slope at the zone center in their corresponding phonon dispersions...
May 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28513151/acoustophoretic-mobility-and-its-role-in-optimizing-acoustofluidic-separations
#8
Philip Stephen Williams, Michel Martin, Mauricio Hoyos
In the separation sciences, sample species are separated according to their physicochemical properties, the nature of the selective field, and, if present, the properties of the medium in which they are dissolved or suspended. Separations may be carried out on a continuous basis in microfluidic devices or split-flow thin channel (SPLITT) devices by selectively transporting species in a direction transverse to the direction of flow of the suspending fluid. Separation is achieved in the so-called transport mode according to relative differences in mobility of the species under the influence of the applied field...
May 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28510130/the-penetration-of-5-oxo-pro-arg-pro-into-the-brain-and-the-major-metabolic-pathways-of-this-peptide-in-the-rat-brain-and-blood-at-the-intranasal-and-intravenous-administration
#9
K V Shevchenko, I Yu Nagaev, V P Shevchenko, L A Andreeva, S I Shram, N F Myasoedov
It was shown that the neuroactive peptide 5-oxo-Pro-Arg-Pro (5-oxo-PRP) is detected in the brain in the time interval of 5-120 min after it was intravenously or intranasally administered to rats; the maximum concentration of labeled tripeptide in these modes of administration was observed after 30 and 10 min, respectively. A significant difference in the concentrations of 5-oxo-PRP in the blood and brain (the latter was 50 times lower) during intravenous administration indicates a relatively low permeability of the peptide across the blood-brain barrier...
March 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28504644/direct-reconstruction-of-parametric-images-for-brain-pet-with-event-by-event-motion-correction-evaluation-in-two-tracers-across-count-levels
#10
Mary Germino, Jean-Dominique Gallezot, Jianhua Yan, Richard Carson
Parametric images for dynamic positron emission tomography (PET) are typically generated by an indirect method, i.e., reconstructing a time series of emission images, then fitting a kinetic model to each voxel time activity curve. Alternatively, "direct reconstruction," incorporates the kinetic model into the reconstruction algorithm itself, directly producing parametric images from projection data. Direct reconstruction has been shown to achieve parametric images with lower standard error than the indirect method...
May 15, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28504271/probing-nanofriction-and-aubry-type-signatures-in-a-finite-self-organized-system
#11
J Kiethe, R Nigmatullin, D Kalincev, T Schmirander, T E Mehlstäubler
Friction in ordered atomistic layers plays a central role in various nanoscale systems ranging from nanomachines to biological systems. It governs transport properties, wear and dissipation. Defects and incommensurate lattice constants markedly change these properties. Recently, experimental systems have become accessible to probe the dynamics of nanofriction. Here, we present a model system consisting of laser-cooled ions in which nanofriction and transport processes in self-organized systems with back action can be studied with atomic resolution...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28499459/dispatch-and-prehospital-transport-for-acute-septic-patients-an-observational-study
#12
Peter Bank Pedersen, Daniel Pilsgaard Henriksen, Søren Mikkelsen, Annmarie Touborg Lassen
BACKGROUND: In order to dispatch ambulances with the correct level of urgency, the dispatch center has to balance the perceived urgency and traffic safety considerations with the available resources. As urgency is not clear in all clinical situations, some high urgency patients may end up with a suboptimal mode of transport. Patients with severe sepsis or septic shock suffer from highly time dependent conditions but they present with a wide range of symptoms, which might be difficult to identify in the dispatch system...
May 12, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28499269/identification-of-novel-serotonin-reuptake-inhibitors-targeting-central-and-allosteric-binding-sites-a-virtual-screening-and-molecular-dynamics-simulations-study
#13
Ismail Erol, Busecan Aksoydan, Isik Kantarcioglu, Ramin E Salmas, Serdar Durdagi
The serotonin (5-hydroxytryptamine, 5HT) transporter (SERT) is a member of neurotransmitter sodium symporter (NSS) family, which maintains neurotransmitter by reuptaking 5HT into synapses. Decrease in serotonin concentrations in synaptic clefts have been reported to cause psychological and neurological disorders. Therefore, inhibition of SERT is a potent strategy for the treatment of related diseases such as depression. In this study, approximately 260,000 small molecules from an available chemical database have been virtually screened both at central and allosteric binding sites of SERT to identify potent novel candidate SERT inhibitors...
March 22, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28498701/fast-low-to-high-confinement-mode-bifurcation-dynamics-in-a-tokamak-edge-plasma-gyrokinetic-simulation
#14
C S Chang, S Ku, G R Tynan, R Hager, R M Churchill, I Cziegler, M Greenwald, A E Hubbard, J W Hughes
Transport barrier formation and its relation to sheared flows in fluids and plasmas are of fundamental interest in various natural and laboratory observations and of critical importance in achieving an economical energy production in a magnetic fusion device. Here we report the first observation of an edge transport barrier formation event in an electrostatic gyrokinetic simulation carried out in a realistic diverted tokamak edge geometry under strong forcing by a high rate of heat deposition. The results show that turbulent Reynolds-stress-driven sheared E×B flows act in concert with neoclassical orbit loss to quench turbulent transport and form a transport barrier just inside the last closed magnetic flux surface...
April 28, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28497275/na-ca-2-exchangers-and-orai-channels-jointly-refill-endoplasmic-reticulum-er-ca-2-via-er-nanojunctions-in-vascular-endothelial-cells
#15
Cristiana M L Di Giuro, Niroj Shrestha, Roland Malli, Klaus Groschner, Cornelis van Breemen, Nicola Fameli
We investigated the role of Na(+)/ Ca(2+) exchange (NCX) in the refilling of endoplasmic reticulum (ER) Ca(2+) in vascular endothelial cells under various conditions of cell stimulation and plasma membrane (PM) polarization. Better understanding of the mechanisms behind basic ER Ca(2+) content regulation is important, since current hypotheses on the possible ultimate causes of ER stress point to deterioration of the Ca(2+) transport mechanism to/from ER itself. We measured [Ca(2+)]i temporal changes by Fura-2 fluorescence under experimental protocols that inhibit a host of transporters (NCX, Orai, non-selective transient receptor potential canonical (TRPC) channels, sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA), Na(+)/ K(+) ATPase (NKA)) involved in the Ca(2+) communication between the extracellular space and the ER...
May 11, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28496556/epidemiological-profile-of-hispanics-admitted-with-acute-myocardial-infarction-in-puerto-rico-the-experience-of-2007-2009-and-2011
#16
Dagmar F Hernandez-Suarez, Anthony D Osterman-Pla, Onelys Carrasquillo, Juan Aranda, Stella Baez, Mariel Lopez, Enid J Garcia-Rivera
BACKGROUND: A limited number of studies have been published about coronary artery disease in Hispanics, particularly among the Puerto Rican population. The aim of this study was to present a clinical epidemiological profile and management practices in patients hospitalized in Puerto Rico with acute myocardial infarction (AMI). METHODS: This secondary data analysis from the Puerto Rico Cardiovascular Surveillance Study included 6,162 patients at 19 hospitals in Puerto Rico, during years 2007, 2009 and 2011...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28489933/a-practical-model-for-the-train-set-utilization-the-case-of-beijing-tianjin-passenger-dedicated-line-in-china
#17
Yu Zhou, Leishan Zhou, Yun Wang, Xiaomeng Li, Zhuo Yang
As a sustainable transportation mode, high-speed railway (HSR) has become an efficient way to meet the huge travel demand. However, due to the high acquisition and maintenance cost, it is impossible to build enough infrastructure and purchase enough train-sets. Great efforts are required to improve the transport capability of HSR. The utilization efficiency of train-sets (carrying tools of HSR) is one of the most important factors of the transport capacity of HSR. In order to enhance the utilization efficiency of the train-sets, this paper proposed a train-set circulation optimization model to minimize the total connection time...
2017: PloS One
https://www.readbyqxmd.com/read/28487425/a-variant-pfcrt-isoform-can-contribute-to-plasmodium-falciparum-resistance-to-the-first-line-partner-drug-piperaquine
#18
Satish K Dhingra, Devasha Redhi, Jill M Combrinck, Tomas Yeo, John Okombo, Philipp P Henrich, Annie N Cowell, Purva Gupta, Matthew L Stegman, Jonathan M Hoke, Roland A Cooper, Elizabeth Winzeler, Sachel Mok, Timothy J Egan, David A Fidock
Current efforts to reduce the global burden of malaria are threatened by the rapid spread throughout Asia of Plasmodium falciparum resistance to artemisinin-based combination therapies, which includes increasing rates of clinical failure with dihydroartemisinin plus piperaquine (PPQ) in Cambodia. Using zinc finger nuclease-based gene editing, we report that addition of the C101F mutation to the chloroquine (CQ) resistance-conferring PfCRT Dd2 isoform common to Asia can confer PPQ resistance to cultured parasites...
May 9, 2017: MBio
https://www.readbyqxmd.com/read/28486215/phonon-thermal-transport-in-silicene-germanene-superlattice-a-molecular-dynamics-study
#19
Xinyu Wang, Yang Hong, Paddy K L Chan, Jingchao Zhang
Two-dimensional (2D) hybrid materials have drawn enormous attentions in thermoelectric applications. In this work, we apply molecular dynamics (MD) simulation to investigate the phonon thermal transport in silicene-germanene superlattice. A non-monotonic thermal conductivity of silicene-germanene superlattice with period length is revealed, which is due to the coherent-incoherent phonon conversion and phonon confinement mechanisms. We also calculate the thermal conductivity of Si-Ge random mixing monolayer, showing a U-shaped trend...
May 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28485883/cell-survival-and-protein-secretion-associated-with-golgi-integrity-in-response-to-golgi-stress-inducing-agents
#20
Tatiana I Ignashkova, Mathieu Gendarme, Katrin Peschk, Hans-Michael Eggenweiler, Ralph K Lindemann, Jan H Reiling
The Golgi apparatus is part of the secretory pathway and of central importance for modification, transport and sorting of proteins and lipids. ADP-ribosylation factors, whose activation can be blocked by brefeldin A, play a major role in functioning of the Golgi network and regulation of membrane traffic and are also involved in proliferation and migration of cancer cells. Due to high cytotoxicity and poor bioavailability brefeldin A has not passed the pre-clinical stage of drug development. Recently, AMF-26 and golgicide A have been described as novel inhibitors of the Golgi system with anti-tumor or bactericidal properties...
May 9, 2017: Traffic
keyword
keyword
113670
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"