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https://www.readbyqxmd.com/read/27792243/prediction-of-progression-to-severe-disease-in-women-with-late-preterm-hypertensive-disorders-of-pregnancy
#1
Eva F Zwertbroek, Kim Broekhuijsen, Josje Langenveld, Gert-Jan van Baaren, Paul P van den Berg, Henk A Bremer, Wessel Ganzevoort, Aren J van Loon, Ben W J Mol, Maria G van Pampus, Denise A M Perquin, Robbert J P Rijnders, Hubertina Cj Scheepers, Marko J Sikkema, Mallory D Woiski, Henk Groen, Maureen T M Franssen
If hypertensive disorders of pregnancy (HDP) are diagnosed before term, the benefits of immediate delivery need to be weighed against the neonatal consequences of preterm delivery. If we are able to predict which women are at high risk of progression to severe disease, they could be targeted for delivery and maternal complications may be reduced. In addition, this may prevent unnecessary preterm births in women at low risk MATERIAL AND METHODS: We developed a prediction model using data from the HYPITAT-II trail, which evaluated immediate delivery versus expectant monitoring in women with non-severe HDP between 34 and 37 weeks of gestation...
October 28, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27396975/management-of-pregnancies-complicated-by-hypertensive-disorders-of-pregnancy-could-we-do-better
#2
Amyna Helou, Susan Walker, Kay Stewart, Johnson George
BACKGROUND: Hypertensive disorders are among the most common medical problems in pregnancy. Compliance with clinical practice guidelines has potential to translate to significant maternal and perinatal health benefits. AIMS: To evaluate compliance with Society of Obstetric Medicine of Australia and New Zealand (SOMANZ) clinical guidelines for management of hypertension during pregnancy. METHODS: Inclusion criteria: women with hypertension in pregnancy who gave birth at a tertiary obstetric centre in 2010...
July 11, 2016: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27173131/caesarean-section-rates-and-adverse-neonatal-outcomes-after-induction-of-labour-versus-expectant-management-in-women-with-an-unripe-cervix-a-secondary-analysis-of-the-hypitat-and-digitat-trials
#3
T P Bernardes, K Broekhuijsen, C M Koopmans, K E Boers, L van Wyk, P Tajik, M G van Pampus, S A Scherjon, B W Mol, M T Franssen, P P van den Berg, H Groen
OBJECTIVE: To evaluate caesarean section and adverse neonatal outcome rates after induction of labour or expectant management in women with an unripe cervix at or near term. DESIGN: Secondary analysis of data from two randomised clinical trials. SETTING: Data were collected in two nationwide Dutch trials. POPULATION: Women with hypertensive disease (HYPITAT trial) or suspected fetal growth restriction (DIGITAT trial) and a Bishop score ≤6...
August 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26969198/an-economic-analysis-of-immediate-delivery-and-expectant-monitoring-in-women-with-hypertensive-disorders-of-pregnancy-between-34-and-37%C3%A2-weeks-of-gestation-hypitat-ii
#4
G-J van Baaren, K Broekhuijsen, M G van Pampus, W Ganzevoort, J M Sikkema, M D Woiski, M A Oudijk, Kwm Bloemenkamp, Hcj Scheepers, H A Bremer, Rjp Rijnders, A J van Loon, Dam Perquin, Jmj Sporken, Dnm Papatsonis, M E van Huizen, C B Vredevoogd, Jtj Brons, M Kaplan, A H van Kaam, H Groen, M Porath, P P van den Berg, Bwj Mol, Mtm Franssen, J Langenveld
OBJECTIVE: To assess the economic consequences of immediate delivery compared with expectant monitoring in women with preterm non-severe hypertensive disorders of pregnancy. DESIGN: A cost-effectiveness analysis alongside a randomised controlled trial (HYPITAT-II). SETTING: Obstetric departments of seven academic hospitals and 44 non-academic hospitals in the Netherlands. POPULATION: Women diagnosed with non-severe hypertensive disorders of pregnancy between 34(0/7) and 37(0/7)  weeks of gestation, randomly allocated to either immediate delivery or expectant monitoring...
March 10, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/26103803/high-blood-pressure-six-weeks-postpartum-after-hypertensive-pregnancy-disorders-at-term-is-associated-with-chronic-hypertension
#5
V S Visser, W Hermes, A Franx, C M Koopmans, M G van Pampus, B W Mol, C J M de Groot
OBJECTIVES: Hypertension in pregnancy is associated with cardiovascular disease (CVD) later in life. Blood pressure monitoring in women who experienced hypertension in pregnancy after puerperium has been suggested to be important for early detection and prevention of CVD. The aim of this study is to evaluate if hypertension six weeks postpartum is associated with chronic hypertension in women with a history of term hypertensive pregnancy disorders. STUDY DESIGN: Women with a history of term gestational hypertension or preeclampsia were included in a follow up study of the HYPITAT trial...
October 2013: Pregnancy Hypertension
https://www.readbyqxmd.com/read/26070123/prediction-of-cesarean-section-risk-in-women-with-gestational-hypertension-or-mild-preeclampsia-at-term
#6
RANDOMIZED CONTROLLED TRIAL
Karin van der Tuuk, Maria G van Pampus, Corine M Koopmans, Jan G Aarnoudse, Paul P van den Berg, Johannes J van Beek, Frans J A Copraij, Gunilla Kleiverda, Martina Porath, Robbert J P Rijnders, Paulien C M van der Salm, Leonard P Morssink, Rob H Stigter, Ben W J Mol, Henk Groen
OBJECTIVE: In a recent randomized controlled trial we found that induction of labor in women with gestational hypertension (GH) or mild (preeclampsia) PE at term prevented high risk situations without increasing the cesarean section (CS) rate. We aimed to assess the predictability of the risk of CS. STUDY DESIGN: We used multivariable logistic regression analysis to identify predictive factors. Two models were created, one including antepartum and one including antepartum and intrapartum variables...
August 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26070038/homocysteinemia-after-hypertensive-pregnancy-disorders-at-term
#7
Sanne Visser, Wietske Hermes, Henk J Blom, Annemieke C Heijboer, Arie Franx, Maria G Van Pampus, Kitty W M Bloemenkamp, Corine Koopmans, Ben Willem J Mol, Christianne J M De Groot
BACKGROUND: Results from a number of long-term follow-up studies have suggested that hypertensive disorders in pregnancy are associated with increased risk of cardiovascular disease later in life. More recently, this putative relationship has been substantiated with findings of elevated cardiovascular risk factors, such as lipid profiles and glucose, in women with a history of hypertensive pregnancy disorders. Homocysteine is a sensitive indicator of increased risk but data on homocysteine levels in women with a history of hypertensive pregnancy disorders are inconsistent...
June 2015: Journal of Women's Health
https://www.readbyqxmd.com/read/25817374/immediate-delivery-versus-expectant-monitoring-for-hypertensive-disorders-of-pregnancy-between-34-and-37-weeks-of-gestation-hypitat-ii-an-open-label-randomised-controlled-trial
#8
RANDOMIZED CONTROLLED TRIAL
Kim Broekhuijsen, Gert-Jan van Baaren, Maria G van Pampus, Wessel Ganzevoort, J Marko Sikkema, Mallory D Woiski, Martijn A Oudijk, Kitty W M Bloemenkamp, Hubertina C J Scheepers, Henk A Bremer, Robbert J P Rijnders, Aren J van Loon, Denise A M Perquin, Jan M J Sporken, Dimitri N M Papatsonis, Marloes E van Huizen, Corla B Vredevoogd, Jozien T J Brons, Mesrure Kaplan, Anton H van Kaam, Henk Groen, Martina M Porath, Paul P van den Berg, Ben W J Mol, Maureen T M Franssen, Josje Langenveld
BACKGROUND: There is little evidence to guide the management of women with hypertensive disorders in late preterm pregnancy. We investigated the effect of immediate delivery versus expectant monitoring on maternal and neonatal outcomes in such women. METHODS: We did an open-label, randomised controlled trial, in seven academic hospitals and 44 non-academic hospitals in the Netherlands. Women with non-severe hypertensive disorders of pregnancy between 34 and 37 weeks of gestation were randomly allocated to either induction of labour or caesarean section within 24 h (immediate delivery) or a strategy aimed at prolonging pregnancy until 37 weeks of gestation (expectant monitoring)...
June 20, 2015: Lancet
https://www.readbyqxmd.com/read/25541530/determinants-of-health-related-quality-of-life-in-the-postpartum-period-after-obstetric-complications
#9
RANDOMIZED CONTROLLED TRIAL
Babette W Prick, Denise Bijlenga, A J Gerard Jansen, Kim E Boers, Sicco A Scherjon, Corine M Koopmans, Marielle G van Pampus, Marie-Louise Essink-Bot, Dick J van Rhenen, Ben W Mol, Johannes J Duvekot
OBJECTIVE: To determine the influence of socio-demographic, clinical parameters and obstetric complications on postpartum health-related quality of life (HRQoL). STUDY DESIGN: We used data of three randomized controlled trials to investigate HRQoL determinants in women after an obstetric complication. The DIGITAT and HYPITAT trials compared induction of labor and expectant management in women with intra-uterine growth restriction (IUGR) and hypertensive disorders...
February 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/24949930/prediction-of-neonatal-outcome-in-women-with-gestational-hypertension-or-mild-preeclampsia-after-36-weeks-of-gestation
#10
K van der Tuuk, M A G Holswilder-Olde Scholtenhuis, C M Koopmans, E S A van den Akker, P J M Pernet, L S M Ribbert, C A van Meir, K Boers, A P Drogtrop, A J van Loon, M J C P Hanssen, J M J Sporken, B W J Mol, P P van den Berg, H Groen, M G van Pampus
BACKGROUND: There is little knowledge about neonatal complications in GH and PE and induction at term, we aim to assess whether they can be predicted from clinical data. METHODS: We used data of the HYPITAT trial and evaluated whether adverse neonatal outcome (Apgar score < 7, pH < 7.05, NICU admission) could be predicted from clinical data. Logistic regression, ROC analysis and calibration were used to identify predictors and evaluate the predictive capacity in an antepartum and intrapartum model...
May 2015: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/24575790/prediction-of-postpartum-hemorrhage-in-women-with-gestational-hypertension-or-mild-preeclampsia-at-term
#11
Corine M Koopmans, Karin van der Tuuk, Henk Groen, Johannes P R Doornbos, Irene M de Graaf, Pauline C M van der Salm, Martina M Porath, Simone M I Kuppens, Ella J Wijnen, Robert Aardenburg, Aren J van Loon, Bettina M C Akerboom, Peggy J A van der Lans, Ben W J Mol, Maria G van Pampus
OBJECTIVE: To assess whether postpartum hemorrhage can be predicted in women with gestational hypertension or mild preeclampsia at term. DESIGN: A cohort study in which we used data from our multicentre randomized controlled trial (HYPITAT trial). SETTING: The study was conducted in 38 hospitals in the Netherlands between 2005 and 2008. POPULATION: Women with gestational hypertension or mild preeclampsia at term (n = 1132)...
April 2014: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/24011382/induction-of-labour-or-expectant-monitoring-in-hypertensive-pregnancy-disorders-at-term-do-women-s-postpartum-cardiovascular-risk-factors-differ-between-the-two-strategies
#12
RANDOMIZED CONTROLLED TRIAL
Wietske Hermes, Corine M Koopmans, Maria G van Pampus, Arie Franx, Kitty W M Bloemenkamp, Joris van der Post, Martina Porath, Jouke T Tamsma, Ben W Mol, Christianne J M de Groot
OBJECTIVE: Cardiovascular disease (CVD) is the leading cause of death in women in the western world. Several studies have described the association between hypertensive pregnancy disorders and CVD in later life. Our aim was to compare postpartum cardiovascular risk factors in women who had a shorter and women who had a longer exposure to endothelial activation during their term hypertensive pregnancy. STUDY DESIGN: We studied a subsample of women with pregnancy-induced hypertension or mild preeclampsia at term, who had participated in the randomized HYPITAT trial comparing induction of labour (IOL cohort) (n=110) or expectant monitoring (EM cohort) (n = 91)...
November 2013: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/23399585/management-of-gestational-hypertension-the-impact-of-hypitata
#13
Jaimey M Pauli, Julianne R Lauring, Christy M Stetter, John T Repke, John J Botti, Serdar H Ural, Anthony Ambrose
AIMS: The objective of this study was to examine the impact of one trial (the HYPITAT trial) on management of gestational hypertension. STUDY DESIGN: This is a retrospective cohort study of 5077 patients delivered at our institution from 7/1/2008 to 6/15/2011. "Pre-HYPITAT" was defined as 7/1/2008-9/30/2009 and "Post-HYPITAT" as 10/1/2009-6/15/2011. The primary outcome is the rate of delivery intervention for gestational hypertension. Secondary maternal and neonatal outcomes were analyzed in patients with gestational hypertension only...
July 2013: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/22703475/should-cervical-favourability-play-a-role-in-the-decision-for-labour-induction-in-gestational-hypertension-or-mild-pre-eclampsia-at-term-an-exploratory-analysis-of-the-hypitat-trial
#14
RANDOMIZED CONTROLLED TRIAL
P Tajik, K van der Tuuk, C M Koopmans, H Groen, M G van Pampus, P P van der Berg, J A van der Post, A J van Loon, C J M de Groot, A Kwee, A J M Huisjes, E van Beek, D N M Papatsonis, K W Bloemenkamp, G A van Unnik, M Porath, R J Rijnders, R H Stigter, K de Boer, H C Scheepers, A H Zwinderman, P M Bossuyt, B W Mol
OBJECTIVE: To examine whether cervical favourability (measured by cervical length and the Bishop score) should inform obstetricians' decision regarding labour induction for women with gestational hypertension or mild pre-eclampsia at term. DESIGN: A post hoc analysis of the Hypertension and Pre-eclampsia Intervention Trial At Term (HYPITAT). SETTING: Obstetric departments of six university and 32 teaching and district hospitals in the Netherlands...
August 2012: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/21985398/impact-of-the-hypitat-trial-on-doctors-behaviour-and-prevalence-of-eclampsia-in-the-netherlands
#15
K van der Tuuk, C M Koopmans, H Groen, B W Mol, M G van Pampus
We questioned if participation in the HYPITAT trial (induction of labour versus expectant monitoring in women with gestational hypertension or pre-eclampsia at term) impacted implementation of its results and subsequently maternal health. We identified women with hypertensive disease from the Perinatal Registry, and distinguished the period before, during and after the trial. We included 43 641 women. Induction of labour increased from 58.3 to 67.1% (P < 0.001) and prevalence of eclampsia decreased from 0...
December 2011: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/21962629/management-of-late-preterm-and-early-term-pregnancies-complicated-by-mild-gestational-hypertension-pre-eclampsia
#16
REVIEW
Baha M Sibai
Gestational hypertension/pre-eclampsia is the most frequent obstetrical complication, complicating 26%-29% of all gestations in nulliparous women. In general, the diagnosis of mild gestational hypertension/pre-eclampsia is made at 38 weeks or more in approximately 80% of cases. For many years, the optimal timing of delivery for patients with mild gestational hypertension/pre-eclampsia at 37-0/7 to 39-6/7 weeks was unclear. Recently, investigators of the HYPITAT (Pregnancy-induced hypertension and pre-eclampsia after 36 weeks: induction of labor versus expectant monitoring: A comparison of maternal and neonatal outcome, maternal quality of life and costs) randomized trial evaluated maternal and neonatal complications in patients at 36-40 weeks' gestation who were randomized to either induction of labor or expectant monitoring...
October 2011: Seminars in Perinatology
https://www.readbyqxmd.com/read/21806572/prediction-of-progression-to-a-high-risk-situation-in-women-with-gestational-hypertension-or-mild-pre-eclampsia-at-term
#17
RANDOMIZED CONTROLLED TRIAL
Karin van der Tuuk, Corine M Koopmans, Henk Groen, Jan G Aarnoudse, Paul P van den Berg, Johannes J van Beek, Frans J A Copraij, Gunilla Kleiverda, Martina Porath, Robbert J P Rijnders, Paulien C M van der Salm, Job G Santema, Robert H Stigter, Ben W J Mol, Maria G van Pampus
OBJECTIVE: To evaluate whether progression to a high-risk situation is predictable in women with gestational hypertension (GH) or mild pre-eclampsia (PE) at term. METHODS: Women with a singleton pregnancy, a fetus in cephalic position, between 36 and 41 weeks of gestation, complicated by GH or mild PE that were managed expectantly, were selected from the HYPITAT trial. We evaluated the predictability of progression to a high-risk situation. Logistic regression was used to determine the predictive value of clinical characteristics or laboratory findings and to generate a prediction model for progression to a high-risk situation...
August 2011: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/21736705/induction-of-labour-versus-expectant-monitoring-for-gestational-hypertension-or-mild-pre-eclampsia-between-34-and-37-weeks-gestation-hypitat-ii-a-multicentre-open-label-randomised-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Josje Langenveld, Kim Broekhuijsen, Gert-Jan van Baaren, Maria G van Pampus, Anton H van Kaam, Henk Groen, Martina Porath, Martijn A Oudijk, Kitty W Bloemenkamp, Christianne J de Groot, Erik van Beek, Marloes E van Huizen, Herman P Oosterbaan, Christine Willekes, Ella J Wijnen-Duvekot, Maureen T M Franssen, Denise A M Perquin, Jan M J Sporken, Mallory D Woiski, Henk A Bremer, Dimitri N M Papatsonis, Jozien T J Brons, Mesruwe Kaplan, Bas W A Nij Bijvanck, Ben-Willen J Mol
BACKGROUND: Gestational hypertension (GH) and pre-eclampsia (PE) can result in severe complications such as eclampsia, placental abruption, syndrome of Hemolysis, Elevated Liver enzymes and Low Platelets (HELLP) and ultimately even neonatal or maternal death. We recently showed that in women with GH or mild PE at term induction of labour reduces both high risk situations for mothers as well as the caesarean section rate. In view of this knowledge, one can raise the question whether women with severe hypertension, pre-eclampsia or deterioration chronic hypertension between 34 and 37 weeks of gestation should be delivered or monitored expectantly...
July 7, 2011: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/21125706/an-economic-analysis-of-induction-of-labour-and-expectant-monitoring-in-women-with-gestational-hypertension-or-pre-eclampsia-at-term-hypitat-trial
#19
COMMENT
A Shennan, N Hezelgrave
No abstract text is available yet for this article.
December 2010: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/20840526/an-economic-analysis-of-induction-of-labour-and-expectant-monitoring-in-women-with-gestational-hypertension-or-pre-eclampsia-at-term-hypitat-trial
#20
RANDOMIZED CONTROLLED TRIAL
S M C Vijgen, C M Koopmans, B C Opmeer, H Groen, D Bijlenga, J G Aarnoudse, D J Bekedam, P P van den Berg, K de Boer, J M Burggraaff, K W M Bloemenkamp, A P Drogtrop, A Franx, C J M de Groot, A J M Huisjes, A Kwee, A J van Loon, A Lub, D N M Papatsonis, J A M van der Post, F J M E Roumen, H C J Scheepers, R H Stigter, C Willekes, B W J Mol, M G Van Pampus
OBJECTIVE: To assess the economic consequences of labour induction compared with expectant monitoring in women with gestational hypertension or pre-eclampsia at term. DESIGN: An economic analysis alongside the Hypertension and Pre-eclampsia Intervention Trial At Term (HYPITAT). SETTING: Obstetric departments of six university and 32 teaching and district hospitals in the Netherlands. POPULATION: Women diagnosed with gestational hypertension or pre-eclampsia between 36(+0) and 41(+0) weeks of gestation, randomly allocated to either induction of labour or expectant monitoring...
December 2010: BJOG: An International Journal of Obstetrics and Gynaecology
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