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Mariano Tomás Flórez, Raquel Almodóvar, Fernando García Pérez, Ana Belén Rodríguez Cambrón, Loreto Carmona, María Ángeles Pérez Manzanero, Juan Aboitiz Cantalapiedra, Ana Urruticoechea-Arana, Carlos J Rodríguez Lozano, Carmen Castro, Cristina Fernández-Carballido, Eugenio de Miguel, Eva Galíndez, José Luis Álvarez Vega, Juan Carlos Torre Alonso, Luis F Linares, Mireia Moreno, Victoria Navarro-Compán, Xavier Juanola, Pedro Zarco
To develop and evaluate a web application based on multimedia animations, combined with a training program, to improve the prescription of exercises in spondyloarthritis (SpA). After a review of exercises included in the main clinical trials and recommendations of international societies, a multidisciplinary team-rehabilitators, rheumatologists, physiotherapists, computer scientists and graphic designers-developed a web application for the prescription of exercises (EJES-3D). Once completed, this was presented to 12 pairs of rehabilitators-rheumatologists from the same hospital in a workshop...
May 21, 2018: Rheumatology International
Hana Uhlirova, Peifang Tian, Kıvılcım Kılıç, Martin Thunemann, Vishnu B Sridhar, Radim Chmelik, Hauke Bartsch, Anders M Dale, Anna Devor, Payam A Saisan
The importance of sharing experimental data in neuroscience grows with the amount and complexity of data acquired and various techniques used to obtain and process these data. However, the majority of experimental data, especially from individual studies of regular-sized laboratories never reach wider research community. A graphical user interface (GUI) engine called Neurovascular Network Explorer 2.0 (NNE 2.0) has been created as a tool for simple and low-cost sharing and exploring of vascular imaging data...
May 4, 2018: Journal of Visualized Experiments: JoVE
Priscille de Dumast, Clément Mirabel, Lucia Cevidanes, Antonio Ruellas, Marilia Yatabe, Marcos Ioshida, Nina Tubau Ribera, Loic Michoud, Liliane Gomes, Chao Huang, Hongtu Zhu, Luciana Muniz, Brandon Shoukri, Beatriz Paniagua, Martin Styner, Steve Pieper, Francois Budin, Jean-Baptiste Vimort, Laura Pascal, Juan Carlos Prieto
OBJECTIVE: The purpose of this study is to describe the methodological innovations of a web-based system for storage, integration and computation of biomedical data, using a training imaging dataset to remotely compute a deep neural network classifier of temporomandibular joint osteoarthritis (TMJOA). METHODS: This study imaging dataset consisted of three-dimensional (3D) surface meshes of mandibular condyles constructed from cone beam computed tomography (CBCT) scans...
May 1, 2018: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
Sung-Min Kim, Yosoon Choi
Cessation of dewatering following underground mine closure typically results in groundwater rebound, because mine voids and surrounding strata undergo flooding up to the levels of the decant points, such as shafts and drifts. SIMPL (Simplified groundwater program In Mine workings using the Pipe equation and Lumped parameter model), a simplified lumped parameter model-based program for predicting groundwater levels in abandoned mines, is presented herein. The program comprises a simulation engine module, 3D visualization module, and graphical user interface, which aids data processing, analysis, and visualization of results...
May 10, 2018: International Journal of Environmental Research and Public Health
Seungkuk Ahn, Herdeline Ann M Ardoña, Johan U Lind, Feyisayo Eweje, Sean L Kim, Grant M Gonzalez, Qihan Liu, John F Zimmerman, Georgios Pyrgiotakis, Zhenyuan Zhang, Juan Beltran-Huarac, Paul Carpinone, Brij M Moudgil, Philip Demokritou, Kevin Kit Parker
Due to the unique physicochemical properties exhibited by materials with nanoscale dimensions, there is currently a continuous increase in the number of engineered nanomaterials (ENMs) used in consumer goods. However, several reports associate ENM exposure to negative health outcomes such as cardiovascular diseases. Therefore, understanding the pathological consequences of ENM exposure represents an important challenge, requiring model systems that can provide mechanistic insights across different levels of ENM-based toxicity...
May 10, 2018: Analytical and Bioanalytical Chemistry
Nadeem Baig, Tawfik A Saleh
Three-dimensional (3D) porous networks of planar 2D graphene have attractive features with respect to sensing. These include a large electroactive surface area, good inner and outer surface contact with the analyte, ease of loading with (bio)catalysts, and good electrochemical sensitivity. 3D free-standing graphene can even be used directly as an electrode. This review (with 140 refs.) covers the progress made in the past years. Following an introduction into the field (including definitions), a large section is presented that covers methods for the synthesis of 3D graphene (3DG) (including chemical vapor deposition, hydrothermal methods, lithography, support assisted synthesis and chemical deposition, and direct electrochemical methods)...
May 7, 2018: Mikrochimica Acta
So Fujimoto, Keisuke Takai, Hirofumi Nakatomi, Taichi Kin, Nobuhito Saito
Digital subtraction angiography (DSA) is the gold standard for diagnosing vascular malformations; however, difficulties are associated with visualizing the angioarchitecture of arteriovenous fistulas at the craniocervical junction (CCJ AVFs) using DSA because of their complex regional neurovascular anatomy. The present study evaluated the application of 3-dimensional computer graphics (3D CG) to the surgical planning of CCJ AVFs. Six patients with CCJ AVFs who underwent microsurgery and/or endovascular treatment were included...
May 3, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Francesco Ortuso, Donatella Bagetta, Annalisa Maruca, Carmine Talarico, Maria L Bolognesi, Norbert Haider, Fernanda Borges, Sharon Bryant, Thierry Langer, Hanoch Senderowitz, Stefano Alcaro
For every lead compound developed in medicinal chemistry research, numerous other inactive or less active candidates are synthetized/isolated and tested. The majority of these compounds will not be selected for further development due to a sub-optimal pharmacological profile. However, some poorly active or even inactive compounds could live a second life if tested against other targets. Thus, new therapeutic opportunities could emerge and synergistic activities could be identified and exploited for existing compounds by sharing information between researchers who are working on different targets...
2018: Frontiers in Chemistry
Boaz Jessie Jackin, Shinpei Watanabe, Kanemitsu Ootsu, Takeshi Ohkawa, Takashi Yokota, Yoshio Hayasaki, Toyohiko Yatagai, Takanobu Baba
A parallel computation method for large-size Fresnel computer-generated hologram (CGH) is reported. The method was introduced by us in an earlier report as a technique for calculating Fourier CGH from 2D object data. In this paper we extend the method to compute Fresnel CGH from 3D object data. The scale of the computation problem is also expanded to 2 gigapixels, making it closer to real application requirements. The significant feature of the reported method is its ability to avoid communication overhead and thereby fully utilize the computing power of parallel devices...
April 20, 2018: Applied Optics
Guillaume Pagès, Elvira Kinzina, Sergei Grudinin
Symmetry in protein, and, more generally, in macromolecular assemblies is a key point to understand their structure, stability and function. Many symmetrical assemblies are currently present in the Protein Data Bank (PDB) and some of them are among the largest solved structures, thus an efficient computational method is needed for the exhaustive analysis of these. The cyclic symmetry groups represent the most common assemblies in the PDB. These are also the building blocks for higher-order symmetries. This paper presents a mathematical formulation to find the position and the orientation of the symmetry axis in a cyclic symmetrical protein assembly, and also to assess the quality of this symmetry...
April 26, 2018: Journal of Structural Biology
George Wang, A K Fazlur Rahman, Bin Wang
Ionic hydrocarbon compounds that contain hypercarbon atoms, which bond to five or more atoms, are important intermediates in chemical synthesis and may also find applications in hydrogen storage. Extensive investigations have identified hydrocarbon compounds that contain a five- or six-coordinated hypercarbon atom, such as the pentagonal-pyramidal hexamethylbenzene, C6 (CH3 )6 2+ , in which a hexacoordinate carbon atom is involved. It remains challenging to search for further higher-coordinated carbon in ionic hydrocarbon compounds, such as seven- and eight-coordinated carbon...
April 25, 2018: Journal of Molecular Modeling
Cheng-Kuan Su, Wei-Cheng Chen
To extend the applicability of solid phase extraction devices manufactured using 3D printing technologies, a stereolithographic 3D printer and resins incorporating titanium dioxide nanoparticles (TiO2 NPs) were employed to fabricate a demountable minicolumn with TiO2 NP-incorporated packing as a sample pretreatment device for the selective extraction of inorganic As and Se species from high-salt-content samples, and to facilitate their analyses when coupled to an inductively coupled plasma mass spectrometer...
April 25, 2018: Mikrochimica Acta
Carol S Bruggers, Sabrina Baranowski, Mathew Beseris, Rachel Leonard, Derek Long, Elizabeth Schulte, Ashton Shorter, Rowan Stigner, Clinton C Mason, Alisa Bedrov, Ian Pascual, Grzegorz Bulaj
Background: Medical advances continue to improve morbidity and mortality of serious pediatric diseases, including cancer, driving research addressing diminished physical and psychological quality of life in children with these chronic conditions. Empowerment enhances resilience and positively influences health, disease, and therapy understanding. We describe the development and usability assessment of a prototype Empower Stars! mobile video game grounded in behavioral and exercise theories with the purpose of coupling physical exercise with empowerment over disease in children with cancer...
2018: Frontiers in Pediatrics
Shigehito Yamada, Shiori Nakano, Haruyuki Makishima, Tamaki Motoki
Advances in imaging technology and development have recently enabled high-resolution three-dimensional (3D) imaging of embryos and fetuses. Embryos and fetuses stored at the Congenital Anomaly Research Center (Kyoto Collection of Human Embryos, Kyoto, Japan) were imaged using multiple modalities including magnetic resonance imaging, episcopic fluorescence image capture, and X-ray computed tomography, both in absorption and phase-contrasted configurations. Using the acquired images, 3D computer graphics were generated and a movie was created to gain further insight into understanding the developmental process...
April 23, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Sarajit Biswas
Electronic, magnetic, and structural properties of pure and V-doped CrO2 were extensively investigated utilizing density functional theory. Usually, pure CrO2 is a half-metallic ferromagnet with conductive spin majority species and insulating spin minority species. This system remains in its half-metallic ferromagnetic phase even at 50% V-substitution for Cr within the crystal. The V-substituted compound Cr0.5 V0.5 O2 encounters metal-insulator transition upon the application of on-site Coulomb repulsion U = 7 eV preserving its ferromagnetism in the insulating phase...
April 17, 2018: Journal of Molecular Modeling
Rubén Martos, Andrea Valsecchi, Oscar Ibáñez, Inmaculada Alemán
Photo-anthropometry is a metric-based facial image comparison technique where measurements of the face are taken from an image using predetermined facial landmarks. In particular, dimensions and proportionality indices (DPIs) are compared to DPIs from another facial image. Different studies concluded that photo-anthropometric facial comparison, as it is currently practiced, is unsuitable for elimination purposes. The major limitation is the need for images acquired under very restrictive, controlled conditions...
April 3, 2018: Forensic Science International
Ding-Ping Sun, Ling-Hsien Lee, Yu-Feng Tian, Hong-Xiang Zheng, Jinn-Rung Kuo, Che-Chuan Wang
PURPOSE: Dealing with the empty space after organ removal for transplantation has not been investigated. MATERIALS AND METHODS: From January 28, 2005, to November 21, 2017, 111 organ donors were enrolled in this study. They were divided into three groups: no replacement, replaced with paper printed with organ graphics, or replaced with 3D-printed simulated organs after the organs were removed at different periods. The donor's age, gender, etiology of admission, characteristic and clinical pictures, time interval between admission and the date of donation, and time interval between donor coordinator consultations were evaluated...
April 13, 2018: World Neurosurgery
J Pérez-Mota, F Solorio-Ordaz, J Cervantes-de Gortari
Air conditioning for the human respiratory system is the most important function of the nose. When obstruction occurs in the nasal airway, turbinectomy is used to correct such pathology. However, mucosal atrophy may occur sometime after this surgery when it is overdone. There is not enough information about long-term recovery of nasal air conditioning performance after partial or total surgery. The purpose of this research was to assess if, based on the flow and temperature/humidity characteristics of the air intake to the choana, partial resection of turbinates is better than total resection...
April 16, 2018: Medical & Biological Engineering & Computing
Danfeng Zhang, Lei Zhang, Tong Liu
3D magnetic hollow porous CdFe2 O4 microspheres (3D MHPS-CdFe2O4) were prepared by a one-step and template-free hydrothermal method. The material was applied for magnetic solid phase extraction of three azo colorants (Acid Red, Congo Red, Sunset Yellow). Compared to conventional CdFe2 O4 nanoparticles, the new 3D material exhibits superior extraction capability because of its unique hollow porous structure, high specific surface area, and the strong interaction between 3D microspheres and the colorants. A magnetic solid phase extraction (MPSE) combined with HPLC was established for simultaneous detection of the three azo colorants in food samples...
April 5, 2018: Mikrochimica Acta
Nadine Besse, Samuel Rosset, Juan Jose Zarate, Elisabetta Ferrari, Luca Brayda, Herbert Shea
We present a fully latching and scalable 4 × 4 haptic display with 4 mm pitch, 5 s refresh time, 400 mN holding force, and 650 μm displacement per taxel. The display serves to convey dynamic graphical information to blind and visually impaired users. Combining significant holding force with high taxel density and large amplitude motion in a very compact overall form factor was made possible by exploiting the reversible, fast, hundred-fold change in the stiffness of a thin shape memory polymer (SMP) membrane when heated above its glass transition temperature...
January 2018: IEEE Transactions on Haptics
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