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Dan MacDougall, Joshua Farrell, Jeremy Brown, Manohar Bance, Robert Adamson
We present the design, implementation and validation of a swept-source optical coherence tomography (OCT) system for real-time imaging of the human middle ear in live patients. Our system consists of a highly phase-stable Vernier-tuned distributed Bragg-reflector laser along with a real-time processing engine implemented on a graphics processing unit. We use the system to demonstrate, for the first time in live subjects, real-time Doppler measurements of middle ear vibration in response to sound, video rate 2D B-mode imaging of the middle ear and 3D volumetric B-mode imaging...
November 1, 2016: Biomedical Optics Express
Mikoláš Jurda, Petra Urbanová
The present paper aims to test performances of semi-automatic tools for mesh-to-mesh processing while assessing sex and ancestry in documented human crania. The studied sample of 80 human crania, which originated in two documented Brazilian collections (São Paulo, Brazil) was digitized using photogrammetry and laser scanning. 3D cranial morphology was quantified by computing inter-mesh dissimilarity measures using in-house freeware FIDENTIS Analyst ( Numerical outputs were further processed using Discriminant Function Analysis and Canonical Variant Analysis in order to classify models into sex and ancestry groups...
November 2016: Legal Medicine
Deborah Jarvis, Rahim Akram, Laura Mandefield, Michael Paddock, Paul Armitage, Paul D Griffiths
OBJECTIVE: Interpretation of MR imaging of the fetal brain in utero is primarily undertaken using 2D images to provide anatomical information about structural abnormalities. It is now possible to obtain 3D image acquisitions that allow measurement of fetal brain volumes that are potentially useful clinically. The aim of our current work is to provide reference values of total brain volumes obtained from a cohort of low risk fetuses with no abnormalities on ante-natal ultrasonography and in utero MR imaging...
November 13, 2016: Prenatal Diagnosis
Luca Cevenini, Maria Maddalena Calabretta, Antonia Lopreside, Giuseppe Tarantino, Annalisa Tassoni, Maura Ferri, Aldo Roda, Elisa Michelini
The availability of smartphones with high-performance digital image sensors and processing power has completely reshaped the landscape of point-of-need analysis. Thanks to the high maturity level of reporter gene technology and the availability of several bioluminescent proteins with improved features, we were able to develop a bioluminescence smartphone-based biosensing platform exploiting the highly sensitive NanoLuc luciferase as reporter. A 3D-printed smartphone-integrated cell biosensor based on genetically engineered Hek293T cells was developed...
December 2016: Analytical and Bioanalytical Chemistry
Varun Arora, Richard Hannan, Richard Beaver, Timothy Fletcher, Paul Harvie
OBJECTIVE: The aim was to develop a CT-based protocol to accurately measure post-operative acetabular cup inclination and anteversion establishing which bony reference points facilitate the most accurate estimation of these variables. MATERIALS AND METHODS: An all-polyethylene acetabular liner was implanted into a cadaveric acetabulum. A conventional pelvic CT scan was performed and reformatted images created in both functional and anterior pelvic planes. CT images were transferred to a Freedom-Plus Graphics software package enabling an identical, virtual 3D model of the cadaveric pelvis to be created and definitive acetabular cup orientation established...
November 8, 2016: Skeletal Radiology
Tian Shi, Ping Wang
In this manuscript, we will introduce a recently developed program GPView, which can be used for wave function analysis and visualization. The wave function analysis module can calculate and generate 3D cubes for various types of molecular orbitals and electron density of electronic excited states, such as natural orbitals, natural transition orbitals, natural difference orbitals, hole-particle density, detachment-attachment density and transition density. The visualization module of GPView can display molecular and electronic (iso-surfaces) structures...
October 24, 2016: Journal of Molecular Graphics & Modelling
Refaat E Gabr, Getaneh B Tefera, William J Allen, Amol S Pednekar, Ponnada A Narayana
PURPOSE: We present a platform, GRAphical Pipeline Environment (GRAPE), to facilitate the development of patient-adaptive magnetic resonance imaging (MRI) protocols. METHODS: GRAPE is an open-source project implemented in the Qt C++ framework to enable graphical creation, execution, and debugging of real-time image analysis algorithms integrated with the MRI scanner. The platform provides the tools and infrastructure to design new algorithms, and build and execute an array of image analysis routines, and provides a mechanism to include existing analysis libraries, all within a graphical environment...
October 28, 2016: International Journal of Computer Assisted Radiology and Surgery
Chao Lai, Fangzhao Li, Shiyao Jin
Realistic 3D human model reconstruction is an important component in computer graphics and computer vision. In particular, texturing on the surface of models is a key stage of reconstruction. In this paper, we dispose the texture mapping on the model's surface as an optimization of image stitching, and present an effective method to generate a seamless, integrated and smooth texture on the surface of 3D human model. First, we build a corresponding Markov Random Field model with respect to color images and triangular meshes of the surface...
2016: SpringerPlus
Alessandro Esposito, Taxiarchis Sakellaris, Patrícia Limede, Filipa Costa, Luis T Cunha, Anabela Gregório Dias, Joana Lencart, Sandra Sarmento, Carla Carmelo Rosa
PURPOSE: To study the impact of shielding elements in the proximity of Intra-Operative Radiation Therapy (IORT) irradiation fields, and to generate graphical and quantitative information to assist radiation oncologists in the design of optimal shielding during pelvic and abdominal IORT. METHOD: An IORT system was modeled with BEAMnrc and EGS++ Monte Carlo codes. The model was validated in reference conditions by gamma index analysis against an experimental data set of different beam energies, applicator diameters, and bevel angles...
November 2016: Physica Medica: PM
Alexey Chistyakov, Maria Teresa Soto, Enric Martí, Jordi Carrabina
The benefits of stereoscopic vision in medical applications were appreciated and have been thoroughly studied for more than a century. The usage of the stereoscopic displays has a proven positive impact on performance in various medical tasks. At the same time the market of 3D-enabled technologies is blooming. New high resolution stereo cameras, TVs, projectors, monitors, and head mounted displays become available. This equipment, completed with a corresponding application program interface (API), could be relatively easy implemented in a system...
December 2016: Journal of Medical Systems
Jee Hoon Kim, Joon Woo Lee, Tae In Ahn, Jong Hwa Shin, Kyung Sub Park, Jung Eek Son
Canopy photosynthesis has typically been estimated using mathematical models that have the following assumptions: the light interception inside the canopy exponentially declines with the canopy depth, and the photosynthetic capacity is affected by light interception as a result of acclimation. However, in actual situations, light interception in the canopy is quite heterogenous depending on environmental factors such as the location, microclimate, leaf area index, and canopy architecture. It is important to apply these factors in an analysis...
2016: Frontiers in Plant Science
Simone L Vernez, Zhamshid Okhunov, Jamie Wikenheiser, Cyrus Khoyilar, Rahul Dutta, Kathryn Osann, Kamaljot Kaler, Thomas K Lee, Ralph V Clayman, Jaime Landman
PURPOSE: We sought to characterize and 3-dimensionally reconstruct the distribution of the autonomic innervation of the human ureter. MATERIALS AND METHODS: Three male and 3 female pairs of ureters were evaluated at 2 mm serial transverse sections along the entire length of the ureter. The location of nerve tissue was immunohistochemically identified using the neuronal marker, S100 protein. ImageJ software was used to calculate nerve count and density in the adventitia and smooth muscle...
September 14, 2016: Journal of Urology
Luis D Lledó, Jorge A Díez, Arturo Bertomeu-Motos, Santiago Ezquerro, Francisco J Badesa, José M Sabater-Navarro, Nicolás García-Aracil
Post-stroke neurorehabilitation based on virtual therapies are performed completing repetitive exercises shown in visual electronic devices, whose content represents imaginary or daily life tasks. Currently, there are two ways of visualization of these task. 3D virtual environments are used to get a three dimensional space that represents the real world with a high level of detail, whose realism is determinated by the resolucion and fidelity of the objects of the task. Furthermore, 2D virtual environments are used to represent the tasks with a low degree of realism using techniques of bidimensional graphics...
2016: Frontiers in Aging Neuroscience
Yusu Ni, Kaishi Wang, Yi Jiang, Ren Zhou, Yan Sha, Huawei Li
OBJECTIVE: To explore and quantify the surgically relevant anatomic relationships and three-dimensional (3D) morphology of the supralabyrinthine space, and enable a deeper, clearer understanding of its regional anatomy. MATERIALS AND METHODS: 3D-DOCTOR software was used to create a 3D reconstruction of the axial CT images and multiplanar reformatting of 55 slices of temporal bone in 29 patients (17 males and 12 females), whose average age was 38.69 ± 17.81 years...
September 10, 2016: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Nathalie Lagarde, Solenne Delahaye, Jean-François Zagury, Matthieu Montes
Nuclear receptors (NRs) constitute an important class of therapeutic targets. We evaluated the performance of 3D structure-based and ligand-based pharmacophore models in predicting the pharmacological profile of NRs ligands using the NRLiSt BDB database. We could generate selective pharmacophores for agonist and antagonist ligands and we found that the best performances were obtained by combining the structure-based and the ligand-based approaches. The combination of pharmacophores that were generated allowed to cover most of the chemical space of the NRLiSt BDB datasets...
2016: Journal of Cheminformatics
R Beveridge, S Wilson, D Coyle
A brain-computer interface (BCI) offers movement-free control of a computer application and is achieved by reading and translating the cortical activity of the brain into semantic control signals. Motion-onset visual evoked potentials (mVEP) are neural potentials employed in BCIs and occur when motion-related stimuli are attended visually. mVEP dynamics are correlated with the position and timing of the moving stimuli. To investigate the feasibility of utilizing the mVEP paradigm with video games of various graphical complexities including those of commercial quality, we conducted three studies over four separate sessions comparing the performance of classifying five mVEP responses with variations in graphical complexity and style, in-game distractions, and display parameters surrounding mVEP stimuli...
2016: Progress in Brain Research
T Hoang Nguyen Vo, Ngan Tran, Dat Nguyen, Ly Le
Herbal medicines have become strongly preferred treatment to reduce the negative impacts of diabetes mellitus (DM) and its severe complications due to lesser side effects and low cost. Recently, strong anti-hyperglycemic effect of Euphorbia thymifolia Linn. (E. thymifolia) on mice models has reported but the action mechanism of its bioactive compounds has remained unknown. This study aimed to evaluate molecular interactions existing between various bioactive compounds in E. thymifolia and targeted proteins related to Type 2 DM...
2016: SpringerPlus
V K Rana, S Rudin, D R Bednarek
PURPOSE: Neurovascular interventional procedures using biplane fluoroscopic imaging systems can lead to increased risk of radiation-induced skin injuries. The authors developed a biplane dose tracking system (Biplane-DTS) to calculate the cumulative skin dose distribution from the frontal and lateral x-ray tubes and display it in real-time as a color-coded map on a 3D graphic of the patient for immediate feedback to the physician. The agreement of the calculated values with the dose measured on phantoms was evaluated...
September 2016: Medical Physics
Quentin P Vanbellingen, Anthony Castellanos, Monica Rodriguez-Silva, Iru Paudel, Jeremy W Chambers, Francisco A Fernandez-Lima
In this work, we show the advantages of label-free, tridimensional mass spectrometry imaging using dual beam analysis (25 keV Bi3(+)) and depth profiling (20 keV with a distribution centered at Ar1500(+)) coupled to time of flight secondary ion mass spectrometry (3D-MSI-TOF-SIMS) for the study of A-172 human glioblastoma cell line treated with B-cell lymphoma 2 (Bcl-2) inhibitor ABT-737. The high spatial (~250 nm) and high mass resolution (m/Δm ~10,000) of TOF-SIMS permitted the localization and identification of the intact, unlabeled drug molecular ion (m/z 811...
December 2016: Journal of the American Society for Mass Spectrometry
G W Griffiths, Ł Płociniczak, W E Schiesser
In part I we discussed the solution of corneal curvature using a 2D meshless method based on radial basis functions (RBFs). In Part II we use these methods to fit a full nonlinear thin membrane model to a measured data-set in order to generate a topological mathematical description of the cornea. In addition, we show how these results can lead to estimations for corneal radius of curvature and certain physical properties of the cornea; namely, tension and elasticity coefficient. Again all calculations and graphics generation were performed using the R language programming environment...
October 1, 2016: Computers in Biology and Medicine
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