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https://www.readbyqxmd.com/read/29138892/-partial-and-complete-joint-transplantation-with-fresh-osteochondral-allografts-the-flocsat-concept
#1
REVIEW
C Krettek, J-D Clausen, N Bruns, C Neunaber
Cartilage defects in adult patients do not heal well. Fresh osteochondral allograft (OCA) transplantation is based on mature, living, mechanically sound hyaline cartilage attached to a bone interface, which is brought into an osteochondral defect, where it becomes osseointegrated. According to current knowledge, intact hyaline cartilage tissue is immune privileged and does not, in contrast to bone, meniscus or ligaments, cause an immune reaction. The technique has the unique advantage of transplanting viable, mature and mechanically stable hyaline cartilage into the affected area...
November 14, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29121651/a-modeling-study-of-budding-yeast-colony-formation-and-its-relationship-to-budding-pattern-and-aging
#2
Yanli Wang, Wing-Cheong Lo, Ching-Shan Chou
Budding yeast, which undergoes polarized growth during budding and mating, has been a useful model system to study cell polarization. Bud sites are selected differently in haploid and diploid yeast cells: haploid cells bud in an axial manner, while diploid cells bud in a bipolar manner. While previous studies have been focused on the molecular details of the bud site selection and polarity establishment, not much is known about how different budding patterns give rise to different functions at the population level...
November 9, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29116664/unraveling-the-biology-of-bipolar-disorder-using-induced-pluripotent-stem-derived-neurons
#3
REVIEW
Nathaniel D Miller, John R Kelsoe
OBJECTIVES: Bipolar disorder has been studied from numerous angles, from pathological studies to large-scale genomic studies, overall making moderate gains toward an understanding of the disorder. With the advancement of induced pluripotent stem (iPS) cell technology, in vitro models based on patient samples are now available that inherently incorporate the complex genetic variants that largely are the basis for this disorder. A number of groups are starting to apply iPS technology to the study of bipolar disorder...
November 8, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/29116126/development-of-multivariable-models-to-predict-change-in-body-mass-index-within-a-clinical-trial-population-of-psychotic-individuals
#4
Rebecca N S Harrison, Fiona Gaughran, Robin M Murray, Sang Hyuck Lee, Jose Paya Cano, David Dempster, Charles J Curtis, Danai Dima, Hamel Patel, Simone de Jong, Gerome Breen
Many antipsychotics promote weight gain, which can lead to non-compliance and relapse of psychosis. By developing models that accurately identify individuals at greater risk of weight gain, clinicians can make informed treatment decisions and target intervention measures. We examined clinical, genetic and expression data for 284 individuals with psychosis derived from a previously published randomised controlled trial (IMPACT). These data were used to develop regression and classification models predicting change in Body Mass Index (BMI) over one year...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114335/imaging-of-the-unstable-shoulder
#5
Paolo Baudi, Manuela Rebuzzi, Giovanni Matino, Fabio Catani
Background: Unstable shoulder can occur in different clinical scenarios with a broad spectrum of symptoms and presentations: first-time (or recurrent) traumatic acute shoulder anterior dislocation or chronic anterior instability after repeated dislocations.Imaging in unstable shoulder is fundamental for choosing the right treatment preventing recurrence.The goal of imaging depends on clinical scenario and patient characteristics. Method: Careful selection and evaluation of the imaging procedures is therefore essential to identify, characterize and quantify the lesions...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29096909/-assessment-of-mood-disorders-by-passive-data-gathering-the-concept-of-digital-phenotype-versus-psychiatrist-s-professional-culture
#6
A Bourla, F Ferreri, L Ogorzelec, C Guinchard, S Mouchabac
OBJECTIVES: The search for objective clinical signs is a constant practitioners' and researchers' concern in psychiatry. New technologies (embedded sensors, artificial intelligence) give an easier access to untapped information such as passive data (i.e. that do not require patient intervention). The concept of "digital phenotype" is emerging in psychiatry: a psychomotor alteration translated by accelerometer's modifications contrasting with the usual functioning of the subject, or the graphorrhea of patients presenting a manic episode which is replaced by an increase of SMS sent...
October 30, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29093600/chemical-segregation-in-the-young-protostars-barnard-1b-n-and-s-evidence-of-pseudo-disk-rotation-in-barnard-1b-s
#7
A Fuente, M Gerin, J Pety, B Commerçon, M Agúndez, J Cernicharo, N Marcelino, E Roueff, D C Lis, H A Wootten
The extremely young Class 0 object B1b-S and the first hydrostatic core (FSHC) candidate, B1b-N, provide a unique opportunity to study the chemical changes produced in the elusive transition from the prestellar core to the protostellar phase. We present 40"×70" images of Barnard 1b in the (13)CO 1→0, C(18)O 1→0, NH2D 11,1a→10,1s, and SO 32→21 lines obtained with the NOEMA interferometer. The observed chemical segregation allows us to unveil the physical structure of this young protostellar system down to scales of ∼500 au...
October 2017: Astronomy and Astrophysics
https://www.readbyqxmd.com/read/29083536/bipolar-disorder-in-pregnancy-a-review-of-pregnancy-outcomes
#8
REVIEW
Debra A Scrandis
INTRODUCTION: Women with bipolar disorder may benefit from continuation of their medications during pregnancy, but there may be risks to the fetus associated with some of these medications. This article examines the evidence relating to the effect of bipolar disorder and pharmacologic treatments for bipolar disorder on pregnancy outcomes. METHODS: MEDLINE, CINAHL, ProQuest Dissertation & Theses, and the Cochrane Database of Systematic Reviews were searched for English-language studies published between 2000 and 2017, excluding case reports and integrative reviews...
October 30, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29081354/the-eversible-tentacle-organs-of-polyommatus-caterpillars-lepidoptera-lycaenidae-morphology-fine-structure-sensory-supply-and-functional-aspects
#9
W Gnatzy, M Jatho, T Kleinteich, S N Gorb, R Hustert
In their late (3(th) and 4th) larval stages, caterpillars of the myrmecophilous lycaenid (Lepidoptera) species Polyommatus coridon and P.icarus respectively, possess on their 8th abdominal segment two eversible so called tentacle organs (TOs). Previous histological and behavioural results have proposed that the TOs may release a volatile substance that elicits "excited runs" in attendant ants. In our study we investigated for the first time the temporal in- and eversion pattern of TOs. Using nerve tracing, Micro-CT, light- and electron microscopy techniques we studied (i) the histology of the 8th abdominal segment, (ii) the fine structure of the cuticular and cellular apparatus of the TOs, (iii) the attachment sites of the retractor muscle of each TO and (iv) the fine structure of the long slender tentacle hairs which are exposed to the outside, when the TOs are everted and fold back into the TO-sac during inversion...
October 25, 2017: Arthropod Structure & Development
https://www.readbyqxmd.com/read/29069113/renal-concerns-relative-to-the-use-of-lithium-in-geriatric-bipolar-disorder-patients
#10
Jakub Szpunar, Hitoshi Maeshima, George T Grossberg
BACKGROUND: Lithium is a first-line treatment for bipolar disorder in geriatric patients; however, it has long been associated with potentially significant renal consequences, including chronic kidney disease (CKD). METHODS: We reviewed the available evidence to characterize the effects of lithium on renal function, provide a consensus on periodic monitoring, and propose criteria for transitioning an older patient with bipolar disorder and renal issues to an alternate medication...
November 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/29065864/do-some-anxiety-disorders-belong-to-the-prodrome-of-bipolar-disorder-a-clinical-study-combining-retrospective-and-prospective-methods-to-analyse-the-relationship-between-anxiety-disorder-and-bipolar-disorder-from-the-perspective-of-biorhythms
#11
Na Du, Ya-Ling Zhou, Xu Zhang, Jing Guo, Xue-Li Sun
BACKGROUND: In clinical practice, some patients diagnosed with anxiety disorder (AD) may develop bipolar disorder (BD) many years later, and some cases of AD may be cured by the use of mood stabilizers. However, the relationship between AD and BD should be explored further. METHOD: To track how many cases of AD turned to BD and to discover the differences between them, we recruited 48 patients diagnosed with BD, who were assigned to the BD group for the retrospective analysis, and we also recruited 186 patients diagnosed with AD at enrolment; this latter group was asked to complete follow-up surveys conducted 3 months, 6 months, 12 months and 18 months after the primary stage of the study...
October 24, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29037595/cellular-characterization-of-optical-coherence-tomography-and-outer-retinal-bands-using-specific-immunohistochemistry-markers-and-clinical-implications
#12
Nicolás Cuenca, Isabel Ortuño-Lizarán, Isabel Pinilla
PURPOSE: Optical coherence tomography has been a technological breakthrough in the diagnosis, treatment, and follow-up of many ocular diseases, especially retinal and neuro-ophthalmologic pathologic conditions. Until now, several controversies have arisen over the specific cell types that the bands observed in the OCT represent, especially over the 4 outer retinal bands. DESIGN: To correlate the 4 outer hyperreflective bands observed in the OCT with the histologic structures using human retinal sections and immunocytochemistry at the fovea level...
October 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29037192/retroperitoneal-ectopic-pregnancy-a-case-report-and-review-of-the-literature
#13
Man Yang, Lamu Cidan, Dan Zhang
BACKGROUND: Retroperitoneal ectopic pregnancy (REP) is an extremely rare type of ectopic pregnancy, with a total of less than 20 cases reported in the English literature. However, failure to recognize REP may result in severe consequences. CASE PRESENTATION: We report a case of 32-year-old woman with REP. She had amenorrhea, left lower abdominal pain, but no vaginal bleeding. Her urine human chorionic gonadotropin (HCG) test was positive and blood HCG level was 1880 m-international units per milliliter (mIU/mL)...
October 16, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28973935/cytoplasmic-mtocs-control-spindle-orientation-for-asymmetric-cell-division-in-plants
#14
Ken Kosetsu, Takashi Murata, Moé Yamada, Momoko Nishina, Joanna Boruc, Mitsuyasu Hasebe, Daniël Van Damme, Gohta Goshima
Proper orientation of the cell division axis is critical for asymmetric cell divisions that underpin cell differentiation. In animals, centrosomes are the dominant microtubule organizing centers (MTOC) and play a pivotal role in axis determination by orienting the mitotic spindle. In land plants that lack centrosomes, a critical role of a microtubular ring structure, the preprophase band (PPB), has been observed in this process; the PPB is required for orienting (before prophase) and guiding (in telophase) the mitotic apparatus...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28953761/a-review-of-the-efficacy-and-role-of-the-card-sort-exercise-in-the-treatment-of-bipolar-disorder
#15
Paul Jie Wen Tern, Ali Abdaal, Jake Tobin, Katherine Macfarland, Molly Hunt, Mark Agius
The current card sort exercise described by Agius et al. in 2006 provides a tool for patients and their families to characterise the temporal pattern of occurrence of both stereotyped and idiosyncratic prodromal symptoms that serve as early warning signs predicting a relapse. This 'individual relapse signature' is highly specific for bipolar relapse, and aids identification of a relapse such that patients can be channeled into appropriate early intervention pathways. This review examines the role of the card sort exercise in the treatment of bipolar disorder, and evaluates the evidence for its efficacy...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28950781/blockade-of-dopamine-d1-family-receptors-attenuates-the-mania-like-hyperactive-risk-preferring-and-high-motivation-behavioral-profile-of-mice-with-low-dopamine-transporter-levels
#16
Morgane Milienne-Petiot, Lucianne Groenink, Arpi Minassian, Jared W Young
BACKGROUND: Patients with bipolar disorder mania exhibit poor cognition, impulsivity, risk-taking, and goal-directed activity that negatively impact their quality of life. To date, existing treatments for bipolar disorder do not adequately remediate cognitive dysfunction. Reducing dopamine transporter expression recreates many bipolar disorder mania-relevant behaviors (i.e. hyperactivity and risk-taking). The current study investigated whether dopamine D1-family receptor blockade would attenuate the risk-taking, hypermotivation, and hyperactivity of dopamine transporter knockdown mice...
October 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28950198/gametogenesis-and-auxospore-development-in-the-bipolar-centric-diatom-brockmanniella-brockmannii-family-cymatosiraceae
#17
Brajogopal Samanta, Michael E Kinney, Quentin Heffell, James M Ehrman, Irena Kaczmarska
We examined gametogenesis and auxospore development in the cymatosiroid diatom Brockmanniella brockmannii. Our mating experiments demonstrated that the clones were homothallic, self-compatible, produced two eggs per oogonium and four hologenous uniflagellate male gametes per spermatogonium. Auxospores grew free in the culture medium and the most external layer of the auxospore wall was made up of spinescent scaly elements in their early globular stage of development. The anisodiametric expansion of the globular auxospore was rather limited, at best proceeding only to a sub-globular stage...
July 20, 2017: Protist
https://www.readbyqxmd.com/read/28943889/-if-there-s-no-stability-around-them-experienced-therapists-view-on-the-role-of-patients-social-world-in-recovery-in-bipolar-disorder
#18
Marius Veseth, Per-Einar Binder, Signe Hjelen Stige
BACKGROUND: Recovery in severe mental illness has traditionally been described as a deeply personal process. At the same time, researchers are increasingly attending to the social nature of such processes. In this article, we aim to supplement the growing knowledge base regarding these social aspects by exploring the perspectives of experienced therapists: how do they view the role of the social world in processes of healing and growth for people with bipolar disorder? And in what ways can the social world impede recovery? METHODS: We conducted 12 semi-structured individual interviews and analyzed the resulting transcripts using a team-based thematic analysis method...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28942748/nutritional-psychiatry-the-present-state-of-the-evidence
#19
Wolfgang Marx, Genevieve Moseley, Michael Berk, Felice Jacka
Mental illness, including depression, anxiety and bipolar disorder, accounts for a significant proportion of global disability and poses a substantial social, economic and heath burden. Treatment is presently dominated by pharmacotherapy, such as antidepressants, and psychotherapy, such as cognitive behavioural therapy; however, such treatments avert less than half of the disease burden, suggesting that additional strategies are needed to prevent and treat mental disorders. There are now consistent mechanistic, observational and interventional data to suggest diet quality may be a modifiable risk factor for mental illness...
November 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28938233/no-apparent-association-between-bipolar-disorder-and-cancer-in-a-large-epidemiological-study-of-outpatients-in-a-managed-care-population
#20
Natan R Kahan, Barbara Silverman, Irena Liphshitz, Dan-Andrei Waitman, Itzhak Ben-Zion, Alexander M Ponizovsky, Abraham Weizman, Alexander Grinshpoon
An association between bipolar disorder (BD) and cancer risk has been reported. The purpose of this study was to investigate this association through linkage analysis of a national HMO database and a national cancer registry. All members of the Leumit Health Services (LHS) HMO of Israel from 2000 to 2012 were included. Members with a recorded diagnosis of BD and a record of at least one written or dispensed prescription for pharmacotherapy for treatment of BD were classified as patients with BD. We linked the LHS population with the Israel National Cancer Registry database to capture all cases of cancer reported...
September 21, 2017: International Clinical Psychopharmacology
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