keyword
MENU ▼
Read by QxMD icon Read
search

Bipolar DO

keyword
https://www.readbyqxmd.com/read/28721494/a-comprehensive-characterization-of-parameters-affecting-high-frequency-irreversible-electroporation-lesions
#1
Tyler Miklovic, Eduardo L Latouche, Matthew R DeWitt, Rafael V Davalos, Michael B Sano
Several focal therapies are being investigated clinically to treat tumors in which surgery is contraindicated. Many of these ablation techniques, such as radiofrequency ablation and microwave ablation, rely on thermal damage mechanisms which can put critical nerves or vasculature at risk. Irreversible electroporation (IRE) is a minimally invasive, non-thermal technique to destroy tumors. A series of short electric pulses create nanoscale defects in the cell membrane, eventually leading to cell death. Typical IRE protocols deliver a series of 50-100 µs monopolar pulses...
July 18, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28720617/protocol-for-an-online-randomised-controlled-trial-to-evaluate-the-clinical-and-cost-effectiveness-of-a-peer-supported-self-management-intervention-for-relatives-of-people-with-psychosis-or-bipolar-disorder-relatives-education-and-coping-toolkit-react
#2
Fiona Lobban, Heather Robinson, Duncan Appelbe, Johanna Barraclough, Emma Bedson, Lizzie Collinge, Susanna Dodd, Sue Flowers, Mahsa Honary, Sonia Johnson, Ceu Mateus, Barbara Mezes, Valerie Minns, Elizabeth Murray, Andrew Walker, Paula Williamson, Catherine Wintermeyer, Steven Jones
INTRODUCTION: Despite clinical guidelines recommendations, many relatives of people with psychosis or bipolar disorder do not currently receive the support they need. Online information and support may offer a solution. METHODS AND ANALYSIS: This single-blind, parallel, online randomised controlled trial will determine clinical and cost-effectiveness of the Relatives Education And Coping Toolkit (REACT) (including an online resource directory (RD)), compared with RD only, for relatives of people with psychosis or bipolar disorder...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28714555/evidence-that-eye-movement-profiles-do-not-explain-slow-binocular-rivalry-rate-in-bipolar-disorder-support-for-a-perceptual-endophenotype
#3
Phillip Cf Law, Caroline T Gurvich, Trung T Ngo, Steven M Miller
OBJECTIVES: Presenting conflicting images simultaneously, one to each eye, produces perceptual alternations known as binocular rivalry (BR). Slow BR rate has been proposed as an endophenotype for bipolar disorder (BD) for use in large-scale genome-wide association studies. However, the trait could conceivably reflect eye movement (EM) dysfunction in BD rather than anomalous perceptual processing per se. To address this question, we examined the relationship between EM profiles and BR rate for various stimulus types in BD and healthy subjects...
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28672735/safety-concerns-associated-with-second-generation-antipsychotic-long-acting-injection-treatment-a-systematic-update
#4
Salvatore Gentile
Background It has been recently suggested that second-generation antipsychotic long-acting injection (SGA-LAIs) are underutilized in clinical practice, despite that their costs significantly impact on national health system budgets. Hence, an updated analysis of safety data shown by SGA-LAIs may contribute to clarify their role in clinical practice. Materials and methods English-language, peer-reviewed articles reporting updated, primary findings on the SGA-LAI safety were identified (updated through an electronic search of five databases - PubMed, EMBASE, PsycInfo, DARE and the Cochrane Library)...
June 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28667890/subcortical-structural-volumes-in-recently-remitted-first-episode-mania
#5
Shyam Sundar Arumugham, Ivan J Torres, Donna J Lang, Wayne Su, Raymond W Lam, William G Honer, Lakshmi N Yatham
BACKGROUND: Magnetic resonance imaging (MRI) studies have yielded inconsistent findings with regard to subcortical volumetric abnormalities in patients with bipolar I disorder. Duration of illness and long term medication intake could have confounded the findings. METHOD: Volumes of nine subcortical structures were compared between 63 patients who recently remitted from their first manic episode and 77 healthy volunteers. The volumetric segmentation was performed with the automated segmentation algorithm Freesurfer version 5...
June 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28666638/a-study-on-the-bioequivalence-of-lithium-and-valproate-salivary-and-blood-levels-in-the-treatment-of-bipolar-disorder
#6
A Murru, M Torra, A Callari, I Pacchiarotti, S Romero, B Gonzalez de la Presa, C Varo, J M Goikolea, V Pérez-Sola, E Vieta, F Colom
Lithium (Li) and valproate (VPA) are used in the treatment of bipolar disorder (BD), with narrow therapeutic window requiring periodic control of serum levels. This prevents intoxication, lack of efficacy due to low serum concentrations, and allows monitoring adherence. We aimed at evaluating the bioequivalence of salivary and blood levels of LI or VPA in a sample of adult BD patients. Secondarily, lithium bioequivalence was evaluated across different patients' lifespans. BD patients treated with either Li or VPA underwent contemporary standard serum and salivary measurements...
June 27, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28657634/multiscale-modeling-of-a-rectifying-bipolar-nanopore-explicit-water-versus-implicit-water-simulations
#7
Zoltán Ható, Mónika Valiskó, Tamás Kristóf, Dirk Gillespie, Dezsö Boda
In a multiscale modeling approach, we present computer simulation results for a rectifying bipolar nanopore at two modeling levels. In an all-atom model, we use explicit water to simulate ion transport directly with the molecular dynamics technique. In a reduced model, we use implicit water and apply the Local Equilibrium Monte Carlo method together with the Nernst-Planck transport equation. This hybrid method makes the fast calculation of ion transport possible at the price of lost details. We show that the implicit-water model is an appropriate representation of the explicit-water model when we look at the system at the device (i...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28649145/do-ssris-and-snris-reduce-the-frequency-and-or-severity-of-hot-flashes-in-menopausal-women
#8
Chris Stubbs, Lisa Mattingly, Steven A Crawford, Elizabeth A Wickersham, Jessica L Brockhaus, Laine H McCarthy
CLINICAL QUESTION: In menopausal women who experience regular hot flashes, does treatment with selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs) reduce the frequency and/or severity of hot flashes? ANSWER: Yes. Review of the literature suggests that treatment with SSRIs or SNRIs reduces the frequency and severity of hot flashes in menopausal and post-menopausal women. Studies demonstrated that paroxetine (Paxil), citalopram (Celexa) and escitolapram (Lexapro) were the most effective SSRIs, and venlafaxine (Effexor) was the most effective first line SNRI, with desvenlafaxine as a second option...
May 2017: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/28607613/complex-fractionated-atrial-electrograms-high-dominant-frequency-regions-and-left-atrial-voltages-during-sinus-rhythm-and-atrial-fibrillation
#9
Naoko Sasaki, Ichiro Watanabe, Yasuo Okumura, Koichi Nagashima, Rikitake Kogawa, Kazumasa Sonoda, Kazuki Iso, Keiko Takahashi, Masaru Arai, Ryuta Watanabe, Sayaka Kurokawa, Kimie Ohkubo, Toshiko Nakai, Atsushi Hirayama, Mizuki Nikaido
BACKGROUND: Ablation targeting complex fractionated atrial electrograms (CFAEs) or high dominant frequency (DF) sites is generally effective for persistent atrial fibrillation (AF). CFAEs and/or high DF sites may exist in low-voltage regions, which theoretically represent abnormal substrates. However, whether CFAEs or high DF sites reflect low voltage substrates during sinus rhythm (SR) is unknown. METHODS: Sixteen patients with AF (8 with paroxysmal AF; 8, persistent AF) underwent high-density mapping of the left atrium (LA) with a 3-dimensional electroanatomic mapping system before ablation...
June 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28585513/meta-analysis-of-longitudinal-studies-of-cognition-in-bipolar-disorder-comparison-with-healthy-controls-and-schizophrenia
#10
E Bora, A Özerdem
BACKGROUND: Bipolar disorder (BP) is associated with significant cognitive impairment. Recent evidence suggests that cognitive deficits are already evident after first-episode mania. However, it is not clear whether BP is associated with further decline in cognitive functions in individuals with established illness. Aim of this meta-analytic review was to examine longitudinal neurocognitive changes in BP and to compare trajectory of cognitive deficits in BP with schizophrenia and healthy controls...
June 6, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28585221/vagal-nerve-stimulation-for-treatment-resistant-depression
#11
REVIEW
Flavia R Carreno, Alan Frazer
Major depressive disorder (MDD) is prevalent. Although standards antidepressants are more effective than placebo, up to 35% of patients do not respond to 4 or more conventional treatments and are considered to have treatment-resistant depression (TRD). Considerable effort has been devoted to trying to find effective treatments for TRD. This review focuses on vagus nerve stimulation (VNS), approved for TRD in 2005 by the Food and Drugs Administration. Stimulation is carried by bipolar electrodes on the left cervical vagus nerve, which are attached to an implanted stimulator generator...
July 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28583708/prefrontal-fatty-acid-composition-in-schizophrenia-and-bipolar-disorder-association-with-reelin-expression
#12
Clare L Beasley, William G Honer, Alfredo Ramos-Miguel, Fidel Vila-Rodriguez, Alasdair M Barr
OBJECTIVE: The extracellular matrix protein reelin regulates early brain development and synaptic plasticity in adulthood. Reelin is decreased in the postmortem brain in schizophrenia patients. Reelin's two receptors, ApoER2 and VLDLR, are also substrates for ApoE - a key lipoprotein that regulates phospholipid homeostasis in the brain. The goal of the present study was therefore to examine phospholipids and their constituent fatty acids, and determine whether there is an association between reelin, its receptors and phospholipids in the brain...
June 2, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28581442/photopharmacological-control-of-bipolar-cells-restores-visual-function-in-blind-mice
#13
Laura Laprell, Ivan Tochitsky, Kuldeep Kaur, Michael B Manookin, Marco Stein, David M Barber, Christian Schön, Stylianos Michalakis, Martin Biel, Richard H Kramer, Martin P Sumser, Dirk Trauner, Russell N Van Gelder
Photopharmacological control of neuronal activity using synthetic photochromic ligands, or photoswitches, is a promising approach for restoring visual function in patients suffering from degenerative retinal diseases. Azobenzene photoswitches, such as AAQ and DENAQ, have been shown to restore the responses of retinal ganglion cells to light in mouse models of retinal degeneration but do not recapitulate native retinal signal processing. Here, we describe diethylamino-azo-diethylamino (DAD), a third-generation photoswitch that is capable of restoring retinal ganglion cell light responses to blue or white light...
June 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28576914/do-not-treat-the-numbers-lithium-toxicity
#14
Peter Foulser, Yasmin Abbasi, Anand Mathilakath, Ramin Nilforooshan
We describe the case of a 62-year-old man with a history of bipolar disorder, previously stable on lithium for over 20 years, who presented with a manic relapse and signs of lithium toxicity in the form of a coarse tremor. Serum lithium levels were in the normal range, and the patient had stage 3 chronic kidney disease. He was admitted for treatment under Section 2 of the Mental Health Act, and after stopping lithium was started on olanzapine. Signs of lithium toxicity improved after withdrawal of lithium. This case highlights the need to treat normal serum lithium levels with caution in patients showing signs of clinical lithium toxicity...
June 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28574009/potential-biomarkers-for-bipolar-disorder-where-do-we-stand
#15
REVIEW
Rajesh Sagar, Raman Deep Pattanayak
Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the diagnosis of BD is made by history taking, interview and behavioural observations, thereby lacking an objective, biological validation. This approach may result in underdiagnosis, misdiagnosis and eventually poorer outcomes...
January 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28558363/lifetime-anxiety-disorder-and-current-anxiety-symptoms-associated-with-hastened-depressive-recurrence-in-bipolar-disorder
#16
Saloni Shah, Jane P Kim, Dong Yeon Park, Hyun Kim, Laura D Yuen, Dennis Do, Bernardo Dell'Osso, Farnaz Hooshmand, Shefali Miller, Po W Wang, Terence A Ketter
AIMS: To assess differential relationships between lifetime anxiety disorder/current anxiety symptoms and longitudinal depressive severity in bipolar disorder (BD). METHODS: Stanford BD Clinic outpatients enrolled during 2000-2011 were assessed with the Systematic Treatment Enhancement Program for BD (STEP-BD) Affective Disorders Evaluation and followed with the STEP-BD Clinical Monitoring Form while receiving naturalistic treatment for up to two years. Baseline unfavorable illness characteristics/current mood symptoms and times to depressive recurrence/recovery were compared in patients with versus without lifetime anxiety disorder/current anxiety symptoms...
May 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28554324/multi-target-directed-ligands-affecting-serotonergic-neurotransmission-for-alzheimer-s-disease-therapy-advances-in-chemical-and-biological-research
#17
Agnieszka Jankowska, Anna Wesołowska, Maciej Pawłowski, Grażyna Chłoń-Rzepa
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive cognitive impairments and chronic inflammation that affects over 30 million people all over the world. Most of Alzheimer's patients also suffer from psychosis, aggression, agitation, depression, anxiety, and many other behavioral and psychological symptoms of dementia. Unfortunately, currently available anti-AD drugs provide modest symptomatic relief, and do not reverse the neurodegeneration. Consequently, the average life expectancy after diagnosis is between six to ten years...
May 29, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28544944/mood-and-anxiety-disorders-in-australia-and-new-zealand-s-indigenous-populations-a-systematic-review-and-meta-analysis
#18
REVIEW
Emma Black, Steve Kisely, Karolina Alichniewicz, Maree Toombs
The Indigenous populations of Australia and New Zealand are considered at higher risk of mood and anxiety disorders but many studies do not include direct comparisons with similar non-Indigenous controls. We conducted a systematic search of relevant electronic databases, as well as snowballing and targeted searches of the grey literature. Studies were included for meta-analysis if they compared rates of mood and anxiety disorders between Indigenous and non-Indigenous Australians or Maori. Seven Australian and 10 NZ studies were included...
May 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28520834/effect-of-electrode-montage-and-head-position-on-air-conducted-ocular-vestibular-evoked-myogenic-potential
#19
Kathryn Makowiec, Devin L McCaslin, Gary P Jacobson, Kelsey Hatton, John Lee
Purpose: The purpose of this investigation was to identify the optimal recording parameters for evoking the ocular vestibular evoked myogenic potential (oVEMP) using air-conduction stimuli. Method: Subjects were 17 otologically and neurologically intact adults (age: M = 24.18 years, SD = 1.91 years). The oVEMP responses were elicited using a 500-Hz tone burst air-conduction stimulus presented at an intensity of 95 dB nHL. The setting was a balance function laboratory that was part of a large tertiary care otology clinic...
June 13, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28506666/prevalence-and-factors-associated-with-body-mass-index-in-children-aged-9-11-years
#20
Gerson Luis de Moraes Ferrari, Victor Matsudo, Peter T Katzmarzyk, Mauro Fisberg
OBJECTIVE: This study aimed to identify the prevalence and factors associated with body mass index (BMI) in children aged 9-11 years. METHODS: The study is part of the International Study of Childhood Obesity Lifestyle and the Environment (ISCOLE). Body composition was determined using the bipolar bioimpedance technique. The mean BMI value was categorized as recommended by the World Health Organization. For seven consecutive days, participants used an accelerometer to objectively monitor sedentary behavior (SB) and moderate to vigorous physical activity...
May 12, 2017: Jornal de Pediatria
keyword
keyword
113656
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"