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https://www.readbyqxmd.com/read/28057878/pseudoautosomal-abnormalities-in-terminal-azfb-c-deletions-are-associated-with-isochromosomes-yp-and-may-lead-to-abnormal-growth-and-neuropsychiatric-function
#1
A Castro, F Rodríguez, M Flórez, P López, B Curotto, D Martínez, A Maturana, M C Lardone, C Palma, V Mericq, M Ebensperger, F Cassorla
STUDY QUESTION: Are copy number variations (CNVs) in the pseudoautosomal regions (PARs) frequent in subjects with Y-chromosome microdeletions and can they lead to abnormal stature and/or neuropsychiatric disorders? SUMMARY ANSWER: Only subjects diagnosed with azoospermia factor (AZF)b+c deletions spanning to the end of the Y chromosome (i.e. terminal deletions) harbor Y isochromosomes and/or cells 45,X that lead to pseudoautosomal gene CNVs, which were associated with abnormal stature and/or neuropsychiatric disorders...
January 5, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28049620/how-do-people-experiencing-schizophrenia-spectrum-disorders-or-other-psychotic-disorders-use-the-internet-to-get-information-on-their-mental-health-literature-review-and-recommendations
#2
Murielle Villani, Viviane Kovess-Masfety
BACKGROUND: Studies show that the Internet has become an influential source of information for people experiencing serious psychiatric conditions such as schizophrenia spectrum disorders or other psychotic disorders, among which the rate of Internet users is growing, with rates ranging from 33.3% to 79.5% given the country. Between 20.5% and 56.4% of these Internet users seek mental health information. OBJECTIVE: Focusing on this population's Web searches about their mental health, this paper examines what type of content they look for and what could be the benefits and disadvantages of this navigation...
January 3, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28038458/chromosome-nondisjunction-during-bipolar-mitoses-of-binucleated-intermediates-promote-aneuploidy-formation-along-with-multipolar-mitoses-rather-than-chromosome-loss-in-micronuclei-induced-by-asbestos
#3
Tianwei Zhang, Lei Lv, Yun Huang, Xiaohui Ren, Qinghua Shi
Asbestos is a well-known occupational carcinogen that can cause aneuploidy during the early stages of neoplastic development. To explore the origins of asbestos-induced aneuploidy, we performed long-term live-cell imaging followed by fluorescence in situ hybridization of chromosomes 8 and 12 in human bronchial epithelial (HBEC) and mesothelial (MeT5A) cells. We demonstrate that asbestos induces aneuploidy via binucleated intermediates resulting from cytokinesis failure. On the one hand, asbestos increases chromosome nondisjunction during bipolar divisions of binucleated intermediates and produces near-tetraploidy...
December 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/28002662/association-between-lithium-use-and-risk-of-alzheimer-s-disease
#4
Chin Cheng, Peter Zandi, Elizabeth Stuart, Ching-Heng Lin, Pei-Yu Su, G Caleb Alexander, Tsuo-Hung Lan
OBJECTIVE: Current evidence for the association between use of lithium and risk of dementia is mixed. The objective of this study was to assess the risk of Alzheimer's disease associated with use of lithium. METHODS: A population-based, nested case-control study was conducted using data from the National Health Insurance Research Database in 2002 covering 24.5 million beneficiaries of the Taiwan National Health Insurance Program from January 1, 1997, to December 31, 2009...
December 20, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27987053/protection-against-hormone-mediated-mood-symptoms
#5
Leah C Susser, Alison D Hermann
We present the case of a woman with bipolar I disorder with severe premenstrual mood instability, confusion, and psychosis resembling the clinical features of postpartum psychosis when estrogen levels are expected to be low, and hypomania when estrogen levels are expected to be elevated. While depressive symptoms across the menstrual cycle have been extensively documented in the literature, there is little information regarding manic and hypomanic symptoms. In addition, we describe the successful treatment of her menstrual-cycle related symptoms...
December 16, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27984169/a-novel-splice-variant-of-the-excitatory-amino-acid-transporter-5-cloning-immunolocalization-and-functional-characterization-of-heaat5v-in-human-retina
#6
A Lee, M G Stevens, A R Anderson, A Kwan, V J Balcar, D V Pow
Excitatory Amino Acid Transporter 5 (EAAT5) is abundantly expressed by retinal photoreceptors and bipolar cells, where it acts as a slow glutamate transporter and a glutamate-gated chloride channel. The chloride conductance is large enough for EAAT5 to serve as an "inhibitory" glutamate receptor. Our recent work in rodents has shown that EAAT5 is differentially spliced and exists in many variant forms. The chief aim of the present study was to examine whether EAAT5 is also alternately spliced in human retina and, if so, what significance this might have for retinal function in health and disease...
October 28, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27943296/safety-of-the-wearable-cardioverter-defibrillator-wcd-in-patients-with-implanted-pacemakers
#7
Joern Schmitt, Guezine Abaci, V Johnson, Damir Erkapic, Christopher Gemein, Ritvan Chasan, Kay Weipert, Christian W Hamm, Helmut U Klein
BACKGROUND: The wearable cardioverter defibrillator (WCD) is an important approach for better risk stratification, applied to patients considered to be at high risk of sudden arrhythmic death. Patients with implanted pacemakers may also become candidates for use of the WCD. However, there is a potential risk that pacemaker signals may mislead the WCD detection algorithm and cause inappropriate WCD shock delivery. The aim of the study was to test the impact of different types of pacing, various RV lead positions and pacing modes for potential misleading of the WCD detection algorithm...
December 10, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27941079/the-international-college-of-neuro-psychopharmacology-cinp-treatment-guidelines-for-bipolar-disorder-in-adults-cinp-bd-2017-part-3-the-clinical-guidelines
#8
REVIEW
Konstantinos N Fountoulakis, Heinz Grunze, Eduard Vieta, Allan Young, Lakshmi Yatham, Pierre Blier, Siegfried Kasper, Hans Jurgen Moeller
BACKGROUND: The current paper introduces the actual CINP clinical guidelines for the treatment of Bipolar disorder (BD). CONCEPT AND STRUCTURE OF THE GUIDELINES: The current clinical guidelines are based on evidence based data, but they also intend to be clinically useful, while a rigid algorithm was developed on the basis of firm evidence alone. Monotherapy was prioritised over combination therapy. There are separate recommendations for each of the major phases of BD expressed as a five-step algorithm...
December 10, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27938391/false-data-positive-results-in-neurobiology-moving-beyond-the-epigenetics-of-blood-and-saliva-samples-in-mental-disorders
#9
EDITORIAL
A Cariaga-Martinez, R Alelú-Paz
Many psychiatric diseases are influenced by a set of several genetic and environmental factors that genetics alone cannot explain. Specifically, in schizophrenia and bipolar disorder the absence of consistently replicated genetic effects together with evidence for lasting changes in gene expression after environmental exposures suggest a role of epigenetic mechanisms in its pathophysiological mechanisms. In this field, the presence of positive results could potentially uncover molecular mechanisms of deregulated gene expression in these complex disorders...
December 12, 2016: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/27936451/onset-polarity-in-bipolar-disorder-a-strong-association-between-first-depressive-episode-and-suicide-attempts
#10
Laura Cremaschi, Bernardo Dell'Osso, Matteo Vismara, Cristina Dobrea, Massimiliano Buoli, Terence A Ketter, A Carlo Altamura
BACKGROUND: The role of onset polarity (OP) in patients with bipolar disorder (BD) has been increasingly investigated over the last few years, for its clinical, prognostic, and therapeutic implications. The present study sought to assess whether OP was associated with specific correlates, in particular with a differential suicidal risk in BD patients. METHODS: A sample of 362 recovered BD patients was dichotomized by OP: depressed (DO) or elevated onset (EO: hypomanic/manic/mixed)...
February 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27913259/-postoperative-delayed-paradoxical-depression-pdpd-after-uncomplicated-intracranial-aneurysm-surgery
#11
Tomas Garzon-Muvdi, Wuyang Yang, Andrew S Luksik, Alejandro Ruiz-Valls, Rafael John Tamargo, Justin Caplan, Rafael J Tamargo
BACKGROUND: Postoperative delayed paradoxical depression (PDPD) is a psychiatric condition described in patients who undergo a major surgery without complications, do not have a history of mood disorders, but nevertheless become clinically depressed. PDPD has been recognized in major surgical interventions such as coronary artery bypass surgery. We sought to determine the incidence and potential factors associated with PDPD after surgical treatment of intracranial aneurysms. METHODS: The cohort of 105 patients was derived from a prospective observational dataset of 3788 consecutive cases of intracranial aneurysms accrued from 1991-2015...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27876122/a-hypothesis-on-the-mechanism-of-action-of-high-dose-thyroid-in-refractory-mood-disorders
#12
Tammas Kelly
Multiple lines of evidence suggest the hypothesis that high dose thyroid therapy corrects for cellular hypothyroidism found in bipolar disorders. Evidence indicates that bipolar disorders are associated with mitochondrial dysfunction which results in low cellular adenosine 5'-triphosphate (ATP) levels. Transport of thyroid hormones into cells is energy intensive and dependent on ATP except in the pituitary gland. Inadequate ATP levels makes it difficult to get thyroid hormone into cells leading to cellular hypothyroidism...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27864917/genetic-variation-in-the-mir-708-gene-and-its-binding-targets-in-bipolar-disorder
#13
Alessia Fiorentino, Niamh Louise O'Brien, Sally Isabel Sharp, David Curtis, Nicholas James Bass, Andrew McQuillin
OBJECTIVE: rs12576775 was found to be associated with bipolar disorder (BD) in a genome-wide association study (GWAS). The GWAS signal implicates genes for the microRNAs miR-708 and miR-5579 and the first exon of the Odd Oz/ten-m homolog 4 gene (ODZ4). In the present study, miR-708, its surrounding region, and its targets were analyzed for potential BD-associated functional variants. METHODS: The miR-708 gene and surrounding regions were screened for variation using high-resolution melting (HRM) analysis in 1099 cases of BD, followed by genotyping of rare variants in an enlarged sample of 2078 subjects with BD, 1303 subjects with schizophrenia, and 1355 healthy controls...
December 2016: Bipolar Disorders
https://www.readbyqxmd.com/read/27837282/the-chromosomal-basis-of-meiotic-acentrosomal-spindle-assembly-and-function-in-oocytes
#14
REVIEW
Sarah J Radford, Alexandra L Nguyen, Karen Schindler, Kim S McKim
Several aspects of meiosis are impacted by the absence of centrosomes in oocytes. Here, we review four aspects of meiosis I that are significantly affected by the absence of centrosomes in oocyte spindles. One, microtubules tend to assemble around the chromosomes. Two, the organization of these microtubules into a bipolar spindle is directed by the chromosomes. Three, chromosome bi-orientation and attachment to microtubules from the correct pole require modification of the mechanisms used in mitotic cells. Four, chromosome movement to the poles at anaphase cannot rely on polar anchoring of spindle microtubules by centrosomes...
November 11, 2016: Chromosoma
https://www.readbyqxmd.com/read/27830632/alcohol-use-is-associated-with-thinner-cerebral-cortex-and-larger-ventricles-in-schizophrenia-bipolar-disorder-and-healthy-controls
#15
E H Lange, S Nerland, K N Jørgensen, L Mørch-Johnsen, R Nesvåg, C B Hartberg, U K Haukvik, K Osnes, I Melle, O A Andreassen, I Agartz
BACKGROUND: Excessive alcohol use is associated with brain damage but less is known about brain effects from moderate alcohol use. Previous findings indicate that patients with severe mental illness, particularly schizophrenia, are vulnerable to alcohol-related brain damage. We investigated the association between levels of alcohol consumption and cortical and subcortical brain structures in schizophrenia and bipolar disorder patients and healthy controls, and investigated for group differences for this association...
November 10, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27819790/-correlation-between-psychological-state-and-emotional-intelligence-in-residents-of-gynecology-and-obstetrics
#16
Sebastián Carranza-Lira
BACKGROUND: Emotional intelligence is our capacity to acknowledge our own emotions, and the emotions of other people; it also has to do with the way emotions must be understood, and used productively. Given that an altered state of mind can have an impact on emotional intelligence, our objective was to correlate the psychological state with emotional intelligence in residents of gynecology, and obstetrics. METHODS: We assessed 76 gynecology and obstetrics residents by using What's my M3 and TMMS-24 instruments, in order to know the influence of psychological state on emotional intelligence...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27816846/bipolar-i-disorder-in-remission-vs-schizophrenia-in-remission-is-there-a-difference-in-burden
#17
Oluyomi Esan, Christopher Osunbote, Oluremi Oladele, Sina Fakunle, Christopher Ehindero, Konstantinos N Fountoulakis
INTRODUCTION: Bipolar disorder (BD) is considered to have a better outcome in comparison to schizophrenia. However, recent data dispute this notion. The current study aimed to compare the burden of patients with BD type I (BD-I) in remission with similar patients with schizophrenia (SZ) in remission. MATERIALS AND METHODS: Patients with schizophrenia (n=75) and BD-I (n=54) aged 18-64years were included in the study. The diagnosis was made with the SCID-I/P. Patients were assessed for sociodemographic variables, stigma, quality of life, disability, suicidality and current symptomatology...
January 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27806863/children-of-parents-with-serious-mental-illness-with-whom-do-they-grow-up-a-prospective-population-based-study
#18
Anne Ranning, Thomas Munk Laursen, Anne Thorup, Carsten Hjorthøj, Merete Nordentoft
OBJECTIVE: To provide an overview of living arrangements during childhood for children of parents with schizophrenia, bipolar disorder, and depression. METHOD: Information was obtained from Danish registers on children's addresses and used to calculate the proportion living in different household living arrangements. The study was conducted as a prospective, register-based cohort study covering all children in the entire Danish population born after 1982 (N = 1,823,625) and their parents with a diagnosis of schizophrenia, bipolar disorder, depression, or none of these disorders...
November 2016: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/27792970/an-actigraphy-study-investigating-sleep-in-bipolar-i-patients-unaffected-siblings-and-controls
#19
Sanne Verkooijen, Annet H van Bergen, Stefan E Knapen, Annabel Vreeker, Lucija Abramovic, Lucia Pagani, Yoon Jung, Rixt Riemersma-van der Lek, Robert A Schoevers, Joseph S Takahashi, René S Kahn, Marco P M Boks, Roel A Ophoff
OBJECTIVES: Disturbances in sleep and waking patterns are highly prevalent during mood episodes in bipolar disorder. The question remains whether these disturbances persist during phases of euthymia and whether they are heritable traits of bipolar disorder. The current study investigates objective sleep measures in a large sample of bipolar I patients, non-affected siblings and controls. METHODS: A total of 107 bipolar disorder I patients, 74 non-affected siblings, and 80 controls were included...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27788777/test-for-association-of-common-variants-in-grm7-with-alcohol-consumption
#20
Whitney E Melroy-Greif, Csaba Vadasz, Helen M Kamens, Matthew B McQueen, Robin P Corley, Michael C Stallings, Christian J Hopfer, Kenneth S Krauter, Sandra A Brown, John K Hewitt, Marissa A Ehringer
Recent work using a mouse model has identified the glutamate metabotropic receptor 7 (Grm7) gene as a strong candidate gene for alcohol consumption. Although there has been some work examining the effect of human glutamate metabotropic receptor 7 (GRM7) polymorphisms on human substance use disorders, the majority of the work has focused on other psychiatric disorders such as ADHD, major depressive disorder, schizophrenia, bipolar disorder, panic disorder, and autism spectrum disorders. The current study aimed to evaluate evidence for association between GRM7 and alcohol behaviors in humans using a single nucleotide polymorphism (SNP) approach, as well as a gene-based approach...
September 2016: Alcohol
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