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Intraamniotic inflammation

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https://www.readbyqxmd.com/read/27836365/transamniotic-stem-cell-therapy-trascet-in-a-leporine-model-of-gastroschisis
#1
Christina Feng, Christopher D Graham, Hester F Shieh, Joseph A Brazzo, John Patrick Connors, Lucas Rohrer, Alexander Papadakis, David Zurakowski, Dario O Fauza
BACKGROUND/PURPOSE: Transamniotic stem cell therapy (TRASCET) with amniotic fluid mesenchymal stem cells (afMSCs) has been shown to mitigate bowel damage in a rodent model of gastroschisis. As a prerequisite to clinical translation, we sought to study TRASCET in a larger animal model. METHODS: New Zealand rabbit fetuses (n=64) with surgically created gastroschisis were divided into three groups. One group (untreated) had no further manipulations. Two groups received volume-matched intraamniotic injections of either saline or a suspension of afMSCs...
October 26, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27265200/intraamniotic-inflammation-and-umbilical-cord-blood-interleukin-6-concentrations-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-membranes
#2
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Martin Stepan, Tomas Bestvina, Richard Spacek, Bo Jacobsson, Teresa Cobo, Marian Kacerovsky
OBJECTIVE: To evaluate umbilical cord blood interleukin (IL)-6 concentrations and the occurrence of fetal inflammatory response syndrome (FIRS) with respect to microbial invasion of the amniotic cavity (MIAC) and/or intraamniotic inflammation (IAI) in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: One-hundred-eighty-eight women with singleton pregnancies complicated by PPROM between gestational ages of 24 + 0 and 36 + 6 weeks were included in the study...
June 20, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26953684/amniotic-fluid-calreticulin-in-pregnancies-complicated-by-the-preterm-prelabor-rupture-of-membranes
#3
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Ondrej Soucek, Radka Kutova, Lenka Pliskova, Richard Spacek, Piotr Laudanski, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: This study aimed to determine the amniotic fluid calreticulin concentrations in women with the preterm prelabor rupture of membranes (PPROM) based on the microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI) and microbial-associated IAI. METHODS: One hundred sixty-eight women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for calreticulin concentrations by ELISA...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26512976/amniotic-fluid-prostaglandin-e2-in-pregnancies-complicated-by-preterm-prelabor-rupture-of-the-membranes
#4
Ivana Musilova, Ctirad Andrys, Marcela Drahosova, Helena Hornychova, Bo Jacobsson, Ramkumar Menon, Piotr Laudanski, Martin Stepan, Tomas Bestvina, Marian Kacerovsky
OBJECTIVE: To determine amniotic fluid prostaglandin E2 concentrations in women preterm prelabor rupture of the membranes (PPROM) with respect to microbial invasion of the amniotic cavity (MIAC), intraamniotic inflammation (IAI), microbial-associated IAI, histological chorioamnionitis, and short-term neonatal morbidity. METHODS: One hundred forty-five women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis and were assayed for prostaglandin E2 concentrations by ELISA...
September 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26484777/meconium-aspiration-syndrome-a-role-for-fetal-systemic-inflammation
#5
JoonHo Lee, Roberto Romero, Kyung A Lee, Eun Na Kim, Steven J Korzeniewski, Piya Chaemsaithong, Bo Hyun Yoon
BACKGROUND: Meconium aspiration syndrome (MAS) is a leading cause of morbidity and mortality in term infants. Meconium-stained amniotic fluid (MSAF) occurs in approximately 1 of every 7 pregnancies, but only 5% of neonates exposed to MSAF develop MAS. Why some infants exposed to meconium develop MAS while others do not is a fundamental question. Patients with MSAF have a higher frequency of intraamniotic inflammation/infection than those with clear fluid. We propose that fetal systemic inflammation is a risk factor for the development of MAS in patients with MSAF...
March 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26456057/novel-biomarkers-in-amniotic-fluid-for-early-assessment-of-intraamniotic-infection
#6
Consuelo Cháfer-Pericás, Vedran Stefanovic, Ángel Sánchez-Illana, Javier Escobar, María Cernada, Elena Cubells, Antonio Núñez-Ramiro, Sture Andersson, Máximo Vento, Julia Kuligowski
Intra-amniotic infection/inflammation (IAI) is associated with preterm birth, short and long-term adverse clinical outcomes and oxidative stress. The diagnosis of IAI is based on histological and clinical findings; however, often these results are unspecific. Therefore, efforts have been directed towards validating reliable methods for patients lacking overt clinical symptoms. In this study, amniotic fluid (AF) samples were prospectively collected from 23 women grouped into two categories (with or without IAI) following clinical, microbiological and histological criteria...
December 2015: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26428501/acute-chorioamnionitis-and-funisitis-definition-pathologic-features-and-clinical-significance
#7
REVIEW
Chong Jai Kim, Roberto Romero, Piya Chaemsaithong, Noppadol Chaiyasit, Bo Hyun Yoon, Yeon Mee Kim
Acute inflammatory lesions of the placenta consist of diffuse infiltration of neutrophils at different sites in the organ. These lesions include acute chorioamnionitis, funisitis, and chorionic vasculitis and represent a host response (maternal or fetal) to a chemotactic gradient in the amniotic cavity. While acute chorioamnionitis is evidence of a maternal host response, funisitis and chorionic vasculitis represent fetal inflammatory responses. Intraamniotic infection generally has been considered to be the cause of acute chorioamnionitis and funisitis; however, recent evidence indicates that "sterile" intraamniotic inflammation, which occurs in the absence of demonstrable microorganisms induced by "danger signals," is frequently associated with these lesions...
October 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26408085/outside-in-acute-fetal-systemic-inflammation-in-very-preterm-chronically-catheterized-sheep-fetuses-is-not-driven-by-cells-in-the-fetal-blood
#8
Matthew W Kemp, Timothy J Molloy, Haruo Usuda, Eleanor Woodward, Yuichiro Miura, Matthew S Payne, Demelza J Ireland, Alan H Jobe, Suhas G Kallapur, Sarah J Stock, Owen B Spiller, John P Newnham, Masatoshi Saito
BACKGROUND: The preterm birth syndrome (delivery before 37 weeks gestation) is a major contributor to the global burden of perinatal morbidity and death. The cause of preterm birth is complex, multifactorial, and likely dependent, at least in part, on the gestational age of the fetus. Intrauterine infection is frequent in preterm deliveries that occur at <32 weeks gestation; understanding how the fetus responds to proinflammatory insult will be an important step towards early preterm birth prevention...
February 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26364833/efficacy-of-midtrimester-short-cervix-interventions-is-conditional-on-intraamniotic-inflammation
#9
RANDOMIZED CONTROLLED TRIAL
Daniel G Kiefer, Morgan R Peltier, Sean M Keeler, Orion Rust, Cande V Ananth, Anthony M Vintzileos, Nazeeh Hanna
BACKGROUND: Midtrimester ultrasound is a valuable method for identifying asymptomatic women at risk for spontaneous preterm delivery (PTD). However, response to various treatments (cerclage, progestogen) has been variable in the clinical setting. It remains unclear how other biomarkers may be used to guide intervention strategies. OBJECTIVE: We applied an amniotic fluid inflammatory scoring system to determine if the degree of inflammation is associated with intervention efficacy in patients with midtrimester short cervix...
February 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26284599/uterine-overdistention-induces-preterm-labor-mediated-by-inflammation-observations-in-pregnant-women-and-nonhuman-primates
#10
Kristina M Adams Waldorf, Natasha Singh, Aarthi R Mohan, Roger C Young, Lisa Ngo, Ananya Das, Jesse Tsai, Aasthaa Bansal, Louis Paolella, Bronwen R Herbert, Suren R Sooranna, G Michael Gough, Cliff Astley, Keith Vogel, Audrey E Baldessari, Theodor K Bammler, James MacDonald, Michael G Gravett, Lakshmi Rajagopal, Mark R Johnson
OBJECTIVE: Uterine overdistention is thought to induce preterm labor in women with twin and multiple pregnancies, but the pathophysiology remains unclear. We investigated for the first time the pathogenesis of preterm birth associated with rapid uterine distention in a pregnant nonhuman primate model. STUDY DESIGN: A nonhuman primate model of uterine overdistention was created using preterm chronically catheterized pregnant pigtail macaques (Macaca nemestrina) by inflation of intraamniotic balloons (N = 6), which were compared to saline controls (N = 5)...
December 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26232508/evidence-of-perturbations-of-the-cytokine-network-in-preterm-labor
#11
Roberto Romero, Jean-Charles Grivel, Adi L Tarca, Piya Chaemsaithong, Zhonghui Xu, Wendy Fitzgerald, Sonia S Hassan, Tinnakorn Chaiworapongsa, Leonid Margolis
OBJECTIVE: Intraamniotic inflammation/infection is the only mechanism of disease with persuasive evidence of causality for spontaneous preterm labor/delivery. Previous studies about the behavior of cytokines in preterm labor have been largely based on the analysis of the behavior of each protein independently. Emerging evidence indicates that the study of biologic networks can provide insight into the pathobiology of disease and improve biomarker discovery. The goal of this study was to characterize the inflammatory-related protein network in the amniotic fluid of patients with preterm labor...
December 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26208287/intraamniotic-inflammation-in-women-with-preterm-prelabor-rupture-of-membranes
#12
Ivana Musilova, Radka Kutová, Lenka Pliskova, Martin Stepan, Ramkumar Menon, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: To characterize subgroups of preterm prelabor rupture of membranes (PPROM) and short-term neonatal outcomes based on the presence and absence of intraamniotic inflammation (IAI) and/or microbial invasion of the amniotic cavity (MIAC). METHODS: One hundred and sixty-six Caucasian women with singleton pregnancies were included in this study. Amniotic fluid samples were obtained by transabdominal amniocentesis (n=166) and were assayed for interleukin-6 levels by a lateral flow immunoassay...
2015: PloS One
https://www.readbyqxmd.com/read/25993616/cervical-microbiota-in-women-with-preterm-prelabor-rupture-of-membranes
#13
Marian Kacerovsky, Filip Vrbacky, Radka Kutova, Lenka Pliskova, Ctirad Andrys, Ivana Musilova, Ramkumar Menon, Ronald Lamont, Jana Nekvindova
OBJECTIVE: To analyze the cervical microbiota in women with preterm prelabor rupture of membranes (PPROM) by pyrosequencing and to document associations between cervical microbiota, cervical inflammatory response, microbial invasion of the amniotic cavity (MIAC), histological chorioamnionitis, and intraamniotic infection (IAI). STUDY DESIGN: Sixty-one women with singleton pregnancies complicated by PPROM were included in the study. Specimens of cervical and amniotic fluid were collected on admission...
2015: PloS One
https://www.readbyqxmd.com/read/25793992/oral-nasal-and-pharyngeal-exposure-to-lipopolysaccharide-causes-a-fetal-inflammatory-response-in-sheep
#14
Gunlawadee Maneenil, Matthew W Kemp, Paranthaman Senthamarai Kannan, Boris W Kramer, Masatoshi Saito, John P Newnham, Alan H Jobe, Suhas G Kallapur
BACKGROUND: A fetal inflammatory response (FIR) in sheep can be induced by intraamniotic or selective exposure of the fetal lung or gut to lipopolysaccharide (LPS). The oral, nasal, and pharyngeal cavities (ONP) contain lymphoid tissue and epithelium that are in contact with the amniotic fluid. The ability of the ONP epithelium and lymphoid tissue to initiate a FIR is unknown. OBJECTIVE: To determine if FIR occurs after selective ONP exposure to LPS in fetal sheep...
2015: PloS One
https://www.readbyqxmd.com/read/25775872/the-evaluation-of-the-predictive-value-of-tnf-alpha-concentration-in-maternal-serum-in-the-prediction-of-neonatal-and-maternal-infection
#15
Tomasz Łukaszewski, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz, Piotr Sieroszewski, Magdalena Barlik, Hubert Wolski, Marzena Wleklak
INTRODUCTION: The consequences of uncomplicated PPROM are serious, and the presence of overt intraamniotic infection (IAI) is associated with a significant increase in both, the maternal and fetal morbidity and mortality rate. TNF-alpha is a cytokine involved in systemic inflammation and plays an important role in modulating the acute phase reaction. AIM: The aim of this study was to evaluate the predictive value of TNF-alpha levels in maternal serum within 6 hours after pprom and in the period of up to 12 hours after delivery in the prediction of neonatal and maternal infection...
January 2015: Ginekologia Polska
https://www.readbyqxmd.com/read/25285474/responses-of-the-spleen-to-intraamniotic-lipopolysaccharide-exposure-in-fetal-sheep
#16
Elke Kuypers, Monique G M Willems, Reint K Jellema, Matthew W Kemp, John P Newnham, Tammo Delhaas, Suhas G Kallapur, Alan H Jobe, Tim G A M Wolfs, Boris W Kramer
BACKGROUND: Intrauterine inflammation activates the fetal immune system and can result in organ injury and postnatal complications in preterm infants. As the spleen is an important site for peripheral immune activation, we asked how the fetal spleen would respond to intrauterine inflammation over time. We hypothesized that intraamniotic lipopolysaccharide (IA LPS) exposure induces acute and persistent changes in the splenic cytokine profile and T-cell composition that may contribute to the sustained fetal inflammatory response after chorioamnionitis...
January 2015: Pediatric Research
https://www.readbyqxmd.com/read/24982089/maternal-intravenous-treatment-with-either-azithromycin-or-solithromycin-clears-ureaplasma-parvum-from-the-amniotic-fluid-in-an-ovine-model-of-intrauterine-infection
#17
Yuichiro Miura, Matthew S Payne, Jeffrey A Keelan, Andres Noe, Sean Carter, Rory Watts, Owen B Spiller, Alan H Jobe, Suhas G Kallapur, Masatoshi Saito, Sarah J Stock, John P Newnham, Matthew W Kemp
Intrauterine infection with Ureaplasma spp. is strongly associated with preterm birth and adverse neonatal outcomes. We assessed whether combined intraamniotic (IA) and maternal intravenous (IV) treatment with one of two candidate antibiotics, azithromycin (AZ) or solithromycin (SOLI), would eradicate intrauterine Ureaplasma parvum infection in a sheep model of pregnancy. Sheep with singleton pregnancies received an IA injection of U. parvum serovar 3 at 85 days of gestational age (GA). At 120 days of GA, animals (n=5 to 8/group) received one of the following treatments: (i) maternal IV SOLI with a single IA injection of vehicle (IV SOLI only); (ii) maternal IV SOLI with a single IA injection of SOLI (IV+IA SOLI); (iii) maternal IV AZ and a single IA injection of vehicle (IV AZ only); (iv) maternal IV AZ and a single IA injection of AZ (IV+IA AZ); or (v) maternal IV and single IA injection of vehicle (control)...
September 2014: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/24632681/intrauterine-candida-albicans-infection-elicits-severe-inflammation-in-fetal-sheep
#18
Matthew S Payne, Matthew W Kemp, Suhas G Kallapur, Paranthaman Senthamarai Kannan, Masatoshi Saito, Yuichiro Miura, John P Newnham, Sarah Stock, Demelza J Ireland, Boris W Kramer, Alan H Jobe
BACKGROUND: Preventing preterm birth and subsequent adverse neonatal sequelae is among the greatest clinical challenges of our time. Recent studies suggest a role for Candida spp. in preterm birth and fetal injury, as a result of their colonization of either the vagina and/or the amniotic cavity. We hypothesized that intraamniotic Candida albicans would cause a vigorous, acute fetal inflammatory response. METHODS: Sheep carrying singleton pregnancies received single intraamniotic injections of either saline (control) or 10(7) colony-forming units C...
June 2014: Pediatric Research
https://www.readbyqxmd.com/read/24372427/-management-of-preterm-prelabor-rupture-of-membranes-with-respect-to-the-inflammatory-complications-our-experiences
#19
REVIEW
M Kacerovský, I Musilová
OBJECTIVE: Preterm prelabor rupture of membranes is responsible for approximately one third of all preterm deliveries. The most common complications associated with this pregnancy pathology are microbial invasion of the amniotic cavity, intraamniotic inflammation, intraamniotic infection and histological chorioamnionitis. This article explains these complicatioss and their relation to the optimal management of preterm prelabor rupture of membranes. DESIGN: Overview study...
December 2013: Ceská Gynekologie
https://www.readbyqxmd.com/read/24274987/amniotic-fluid-infection-inflammation-and-colonization-in-preterm-labor-with-intact-membranes
#20
MULTICENTER STUDY
C Andrew Combs, Michael Gravett, Thomas J Garite, Durlin E Hickok, Jodi Lapidus, Richard Porreco, Julie Rael, Thomas Grove, Terry K Morgan, William Clewell, Hugh Miller, David Luthy, Leonardo Pereira, Michael Nageotte, Peter A Robilio, Stephen Fortunato, Hyagriv Simhan, Jason K Baxter, Erol Amon, Albert Franco, Kenneth Trofatter, Kent Heyborne
OBJECTIVE: The purpose of this study was to compare intraamniotic inflammation vs microbial invasion of the amniotic cavity (MIAC) as predictors of adverse outcome in preterm labor with intact membranes. STUDY DESIGN: Interleukin-6 (IL-6) was measured in prospectively collected amniotic fluid from 305 women with preterm labor. MIAC was defined by amniotic fluid culture and/or detection of microbial 16S ribosomal DNA. Cases were categorized into 5 groups: infection (MIAC; IL-6, ≥11...
February 2014: American Journal of Obstetrics and Gynecology
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