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https://www.readbyqxmd.com/read/29232410/early-variations-of-laboratory-parameters-predicting-shunt-dependent-hydrocephalus-after-subarachnoid-hemorrhage
#1
Min Kyun Na, Yu Deok Won, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Myung-Hoon Han
BACKGROUND AND PURPOSE: Hydrocephalus is a frequent complication following subarachnoid hemorrhage. Few studies investigated the association between laboratory parameters and shunt-dependent hydrocephalus. This study aimed to investigate the variations of laboratory parameters after subarachnoid hemorrhage. We also attempted to identify predictive laboratory parameters for shunt-dependent hydrocephalus. METHODS: Multiple imputation was performed to fill the missing laboratory data using Bayesian methods in SPSS...
2017: PloS One
https://www.readbyqxmd.com/read/29230803/peri-operative-management-of-patients-with-type-2-diabetes-mellitus-undergoing-non-cardiac-surgery-using-liraglutide-glucose-insulin-potassium-infusion-or-intravenous-insulin-bolus-regimens-a-randomised-controlled-trial
#2
J A W Polderman, S C J van Steen, B Thiel, M B Godfried, P L Houweling, M W Hollmann, J H DeVries, B Preckel, J Hermanides
In this open-label multicentre randomised controlled trial, we investigated three peri-operative treatment strategies to lower glucose and reduce the need for rescue insulin in patients aged 18-75 years with type-2 diabetes mellitus undergoing non-cardiac surgery. Patients were randomly allocated using a web-based randomisation program to premedication with liraglutide (liraglutide group), glucose-insulin-potassium infusion (insulin infusion group) or insulin bolus regimen (insulin bolus group), targeting a glucose < 8...
December 12, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29230378/species-diversity-and-drivers-of-arbuscular-mycorrhizal-fungal-communities-in-a-semi-arid-mountain-in-china
#3
He Zhao, Xuanzhen Li, Zhiming Zhang, Yong Zhao, Jiantao Yang, Yiwei Zhu
Arbuscular mycorrhizal fungi (AMF) play an essential role in complex ecosystems. However, the species diversity and composition of AMF communities remain unclear in semi-arid mountains. Further, it is not well understood if the characteristics of AMF community assemblies differ for different habitat types, e.g., agricultural arable land, artificial forest land, natural grassland, and bush/wood land. Here, using the high-throughput technology by Illumina sequencing on the MiSeq platform, we explored the species diversity and composition of soil AMF communities among different habitat types in a semi-arid mountain (Taihang Mountain, Mid-western region of China)...
2017: PeerJ
https://www.readbyqxmd.com/read/29229703/orai1-plays-a-crucial-role-in-central-sensitization-by-modulating-neuronal-excitability
#4
Yannong Dou, Jingsheng Xia, Ruby Gao, Xinghua Gao, Frances M Munoz, Dongyu Wei, Yuzhen Tian, James E Barrett, Seena Ajit, Olimpia Meucci, James W Putney, Yue Dai, Huijuan Hu
Pathological pain is a common and debilitating condition that is often poorly managed. Central sensitization is an important mechanism underlying pathological pain. However, candidate molecules involved in central sensitization remain unclear. Store-operated calcium channels (SOCs) mediate important calcium signals in non-excitable and excitable cells. SOCs have been implicated in a wide variety of human pathophysiological conditions including immunodeficiency, occlusive vascular diseases and cancer. However, the role of SOCs in central nervous system (CNS) disorders has been relatively unexplored...
December 11, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29229529/evaluation-of-root-knot-nematode-disease-control-and-plant-growth-promotion-potential-of-biofertilizer-ning-shield-on-trichosanthes-kirilowii-in-the-field
#5
Chun-Hao Jiang, Ping Xie, Ke Li, Yue-Sheng Xie, Liu-Jun Chen, Jin-Suo Wang, Quan Xu, Jian-Hua Guo
Biofertilizer Ning shield was composed of different strains of plant growth promotion bacteria. In this study, the plant growth promotion and root-knot nematode disease control potential on Trichosanthes kirilowii in the field were evaluated. The application of Ning shield significantly reduced the diseases severity caused by Meloidogyne incognita, the biocontrol efficacy could reached up to 51.08%. Ning shield could also promote the growth of T. kirilowii in the field by increasing seedling emergence, height and the root weight...
November 11, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29228924/the-photosynthetic-and-structural-differences-between-leaves-and-siliques-of-brassica-napus-exposed-to-potassium-deficiency
#6
Zhifeng Lu, Yonghui Pan, Wenshi Hu, Rihuan Cong, Tao Ren, Shiwei Guo, Jianwei Lu
BACKGROUND: Most studies of photosynthesis in chlorenchymas under potassium (K) deficiency focus exclusively on leaves; however, little information is available on the physiological role of K on reproductive structures, which play a critical role in plant carbon gain. Brassica napus L., a natural organ-succession species, was used to compare the morphological, anatomical and photo-physiological differences between leaves and siliques exposed to K-deficiency. RESULTS: Compared to leaves, siliques displayed considerably lower CO2 assimilation rates (A) under K-deficient (-K) or sufficient conditions (+K), limited by decreased stomatal conductance (g s), apparent quantum yield (α) and carboxylation efficiency (CE), as well as the ratio of the maximum rate of electron transport (J max) and the maximum rate of ribulose 1,5-bisphosphate (RuBP) carboxylation (V cmax)...
December 11, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29228863/parallel-evaluation-of-two-potassium-channel-blockers-in-restoring-conduction-in-mechanical-spinal-cord-injury-in-rat
#7
Jessica Page, Jonghyuck Park, Zhe Chen, Peng Cao, Riyi Shi
Myelin damage is a hallmark of spinal cord injury (SCI) and potassium channel blocker (PCB) is proven effective to restore axonal conduction and regain neurological function. Aiming to improve this therapy beyond the FDA-approved 4-AP, we have developed multiple new PCBs, with 4-AP-3-MeOH being the most potent and effective. The current study evaluated two PCBs, 4-AP-3-MeOH and 4-AP, in parallel in both ex vivo and in vivo rat mechanical SCI models. Specifically, 4-AP-3-MeOH induced significantly greater augmentation of axonal conduction than 4-AP in both acute and chronic injury...
December 11, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29228818/evaluation-of-herbal-concoctions-sold-at-ga-maja-limpopo-province-in-south-africa-and-in-vitro-pharmacological-evaluation-of-plants-used-to-manufacture-the-concoctions
#8
Mash M Matotoka, Peter Masoko
The aim of the study was to evaluate the biological activities and safety of commercial herbal concoctions manufactured in Ga Maja (Limpopo province). Microbial contamination was evaluated by spread-plating the concoctions on agar plates. The VITEK 2 instrument was used for identification of the pure cultures. Nutritional content of the concoctions was determined. Thin layer chromatography was used to analyze the chemical constituents of the extracts. The microdilution assay and bioautography were used to evaluate antimicrobial activity against selected microorganisms...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29228805/biochemical-effects-of-aqueous-extract-of-persea-americana-mill-on-the-myocardium-of-left-ventricle-of-high-salt-fed-adult-wistar-rats
#9
Ayoola I Olushola, Komolafe O Aderibigbe, Saka O Stephen, Odukoya S Ayodeji
BACKGROUND: The cardioprotective effects of Persea americana extract was investigated on biochemical activities of high salt-fed adult Wistar rats in this study. METHOD: Forty healthy Wistar rats of both sexes weighing 120 to 150 g were randomly assigned into 8 groups of 5 rats each (groups A, B, C, D, E, F, G, and H). Rats in groups A, F, G, and H were fed with standard laboratory pellets, while groups B, C, D, and E were fed on the high-salt diet for 4 weeks. Concomitantly, daily administration of 50, 100, and 150 mg/kg of the P americana extract were given orally to groups C and F, D and G, and E and H, respectively, while rats in groups A and B were administered distilled water...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29228575/ammonium-glycyrrhizin-counteracts-liver-injury-caused-by-lipopolysaccharide-amoxicillin-clavulanate-potassium
#10
Zugong Yu, Feng Wu, Jing Tian, Xuewen Guo, Ran An, Yangyang Guo
We treated isolated chicken primary hepatocytes with lipopolysaccharide/amoxicillin clavulanate potassium (LPS/AC) to model liver injury and investigate its underlying mechanisms. We also used this model to assess the cytoprotective effects of compound ammonium glycyrrhizin (CAG) in vitro. LPS/AC-induced injury decreased cell viability and increased the activity of serum aspartate transaminase and alanine transaminase. Levels of superoxide dismutase, glutathione, and glutathione peroxidase were lower than control, while levels of the oxidative product malondialdehyde and reactive oxygen species were higher...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228526/study-of-serum-malondialdehyde-level-in-opioid-and-methamphetamine-dependent-patients
#11
Khadije Najafi, Sajad Ahmadi, Mahdi Rahpeyma, Habibolah Khazaie, Asad Vaisi-Raygani, Ali Moini, Amir Kiani
Opioid compound and methamphetamine are commonly used in drug abuse; these can disrupt the normal function of cellular and molecular systems, leading to several events such as oxidative stress, aging, apoptosis, and necrosis. Malondialdehyde (MDA) is the most important biomarker for evaluation of oxidative stress and determination of lipid peroxidation. In this study, 42 drug abusers and 22 healthy persons participated as case and control groups, respectively. MDA in volunteer sera was determined by high-performance liquid chromatography (HPLC) with fluorescence detection after pre-column derivatization using thiobarbituric acid...
October 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29227749/efficacy-and-safety-of-photoselective-vaporization-of-the-prostate-with-120-w-532%C3%A2-nm-laser-in-patients-with-benign-prostatic-hyperplasia-on-anticoagulation-or-antiplatelet-therapy-observations-on-long-term-outcomes
#12
Grzegorz Piotrowicz, Tomasz Syryło, Rafał Jedynak, Henryk Zieliński
OBJECTIVE: The objective of this study was to evaluate the safety and effectiveness of photoselective vaporization of the prostate (PVP) in the treatment of patients with benign prostatic hyperplasia (BPH) on anticoagulant or antiplatelet therapy. BACKGROUND: The "gold standard" of surgical treatment of BPH is transurethral resection of the prostate (TURP). Since the risk of complications associated with TURP is still significant, there is a continuous search for safer and equally effective procedures...
December 11, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29227129/assessment-of-a-portable-lactate-meter-for-field-use-in-the-white-rhinoceros-i-ceratotherium-simum-i
#13
Georgina C Cole, Adrian S W Tordiffe, Gerhard Steenkamp
Blood lactate is a predictor of mortality in critically ill humans and animals. Handheld lactate meters have the potential to be used in the field to evaluate the condition of severely injured rhinoceroses but have not been compared with laboratory-based methods. Agreement between a handheld lactate meter and a laboratory method was assessed, as was the stability of rhino blood lactate in the anticoagulant sodium fluoride/potassium oxalate (fluoride/oxalate). Blood samples were obtained from 53 white rhinos that had been immobilised for management reasons...
November 10, 2017: Onderstepoort Journal of Veterinary Research
https://www.readbyqxmd.com/read/29226990/a-novel-reconfigurable-logic-unit-based-on-the-dna-templated-potassium-concentration-dependent-supramolecular-assembly
#14
Chunrong Yang, Dan Zou, Jianchi Chen, Linyan Zhang, Jiarong Miao, Dan Huang, Yuanyuan Du, Shu Yang, Qianfan Yang, Yalin Tang
A plenty of molecular circuits with specific functions have been developed, however, logic units with reconfigurability which could simplify the circuits and speed up the information process are rarely reported. In this work, we designed a novel reconfigurable logic unit based on DNA-templated potassium-concentration-dependent supramolecular assembly, which could response to the input stimuli of H+ and K+. By inputting different concentrations of K+, the logic unit could implement three significant functions respectively, including half adder, half subtractor, and 2-to-4 decoder...
December 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29226289/ionophore-based-optical-nanosensors-incorporating-hydrophobic-carbon-dots-and-a-ph-sensitive-quencher-dye-for-sodium-detection
#15
A A Galyean, M R Behr, K J Cash
Nanosensors present a biological monitoring method that is biocompatible, reversible, and nano-scale, and they offer many advantages over traditional organic indicators. Typical ionophore-based nanosensors incorporate nile-blue derivative pH indicators but suffer from photobleaching while quantum dot alternatives pose a potential toxicity risk. In order to address this challenge, sodium selective nanosensors containing carbon dots and a pH-sensitive quencher molecule were developed based on an ion-exchange theory and a decoupled recognition element from the pH indicator...
December 11, 2017: Analyst
https://www.readbyqxmd.com/read/29226250/tip-enhanced-ablation-and-ionization-mass-spectrometry-for-nanoscale-chemical-analysis
#16
Zhisen Liang, Shudi Zhang, Xiaoping Li, Tongtong Wang, Yaping Huang, Wei Hang, Zhilin Yang, Jianfeng Li, Zhongqun Tian
Spectroscopic methods with nanoscale lateral resolution are becoming essential in the fields of physics, chemistry, geology, biology, and materials science. However, the lateral resolution of laser-based mass spectrometry imaging (MSI) techniques has so far been limited to the microscale. This report presents the development of tip-enhanced ablation and ionization time-of-flight mass spectrometry (TEAI-TOFMS), using a shell-isolated apertureless silver tip. The TEAI-TOFMS results indicate the capability and reproducibility of the system for generating nanosized craters and for acquiring the corresponding mass spectral signals...
December 2017: Science Advances
https://www.readbyqxmd.com/read/29226063/advances-in-antimicrobial-photodynamic-inactivation-at-the-nanoscale
#17
Nasim Kashef, Ying-Ying Huang, Michael R Hamblin
The alarming worldwide increase in antibiotic resistance amongst microbial pathogens necessitates a search for new antimicrobial techniques, which will not be affected by, or indeed cause resistance themselves. Light-mediated photoinactivation is one such technique that takes advantage of the whole spectrum of light to destroy a broad spectrum of pathogens. Many of these photoinactivation techniques rely on the participation of a diverse range of nanoparticles and nanostructures that have dimensions very similar to the wavelength of light...
August 2017: Nanophotonics
https://www.readbyqxmd.com/read/29225764/sodium-chloride-accumulation-in-glycophyte-plants-with-cyanobacterial-symbionts
#18
Thomas George Allan Green, Leopoldo G Sancho, Ana Pintado, Dolores Saco, Soledad Martín, María Arróniz-Crespo, Miguel Angel Casermeiro, Maria Teresa de la Cruz Caravaca, Steven Cameron, Ricardo Rozzi
The majority of plant species are glycophytes and are not salt-tolerant and maintain low sodium levels within their tissues; if. high tissue sodium concentrations do occur, it is in response to elevated environmental salt levels. Here we report an apparently novel and taxonomically diverse grouping of plants that continuously maintain high tissue sodium contents and share the rare feature of possessing symbiotic cyanobacteria. Leaves of Gunnera magellanica in Tierra del Fuego always had sodium contents (dry weight basis) of around 4...
November 2017: AoB Plants
https://www.readbyqxmd.com/read/29225608/transcriptomic-profiling-and-physiological-responses-of-halophyte-kochia-sieversiana-provide-insights-into-salt-tolerance
#19
Long Zhao, Zongze Yang, Qiaobing Guo, Shun Mao, Shaoqiang Li, Fasheng Sun, Huan Wang, Chunwu Yang
Halophytes are remarkable plants that can tolerate extremely high-salinity conditions, and have different salinity tolerance mechanisms from those of glycophytic plants. In this work, we investigated the mechanisms of salinity tolerance of an extreme halophyte, Kochia sieversiana (Pall.) C. A. M, using RNA sequencing and physiological tests. The results showed that moderate salinity stimulated the growth and water uptake of K. sieversiana and, even under 480-mM salinity condition, K. sieversiana maintained an extremely high water content...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29225577/if-channel-as-an-emerging-therapeutic-target-for-cardiovascular-diseases-a-review-of-current-evidence-and-controversies
#20
REVIEW
Hayelom G Mengesha, Tadesse B Tafesse, Mohammed H Bule
In 2015, non-communicable diseases accounted for 39.5 million (70%) of the total 56.4 million deaths that occurred globally, of which 17.7 million (45%) were due to cardiovascular diseases. An elevated heart rate is considered to be one of the independent predictors and markers of future cardiovascular diseases. A variety of experimental and epidemiological studies have found that atherosclerosis, heart failure, coronary artery disease, stroke, and arrhythmia are linked to elevated heart rate. Although there are established drugs to reduce the heart rate, these drugs have undesirable side effects...
2017: Frontiers in Pharmacology
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