Golamreza Jadideslam, Khalil Ansarin, Ebrahim Sakhinia, Zohreh Babaloo, Alireza Abhari, Kazem Ghahremanzadeh, Mohamadreza Khalili, Rahman Radmehr, Alireza Kabbazi
MicroRNAs (miRNAs) are endogenous mediators of RNA interference and have key roles in the modulation of gene expression under healthy, inflamed, stimulated, carcinogenic, or other cells, and tissues of a pathological state. Many studies have proved the association between miRNAs and cancer. The role of miR-326 as a tumor suppressor miRNA in much human cancer confirmed. We will explain the history and the role of miRNAs changes, especially miR-326 in cancers and other pathological conditions. Attuned with these facts, this review highlights recent preclinical and clinical research performed on miRNAs as novel promising diagnostic biomarkers of patients at early stages, prediction of prognosis, and monitoring of the patients in response to treatment...
May 8, 2019: Journal of Cellular Physiology