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ebrahim sakhinia

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https://www.readbyqxmd.com/read/28802665/no-evidence-of-association-between-optic-neuritis-and-secondary-lhon-mtdna-mutations-in-patients-with-multiple-sclerosis
#1
Sasan Andalib, Mahnaz Talebi, Ebrahim Sakhinia, Mehdi Farhoudi, Homayoun Sadeghi-Bazargani, Nooshin Masoudian, Manouchehr Seyedi Vafaee, Albert Gjedde
Leber's Hereditary Optic Neuropathy (LHON) shares features with Multiple Sclerosis (MS). Both diseases develop optic lesions. Frequent secondary LHON mutations in MS patients may explain the optic damage. Here, we tested the hypothesis that secondary LHON mutations are associated with optic neuritis (ON) in MS patients. We recruited 56 MS subjects with ON and 47 MS subjects without ON. DNA was extracted by salting out, after sampling of peripheral blood from each participant. We completed Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis with appropriate primers and restriction endonucleases for seven secondary LHON mutations...
August 10, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28504924/mrna-expression-of-nuclear-factor-of-activated-t-cells-cytoplasmic-2-nfatc2-and-peroxisome-proliferator-activated-receptor-gamma-pparg-transcription-factors-in-colorectal-carcinoma
#2
Venus Zafari, Shahryar Hashemzadeh, Mohammadali Hosseinpour Feizi, Nasser Pouladi, Leila Rostami Zadeh, Ebrahim Sakhinia
Transcription factors are involved in cell cycle and apoptosis regulation and thus have a key role in the carcinogenesis of different tumors. Nuclear factor of activated T-cells, cytoplasmic 2 (NFATc2) and peroxisome proliferator-activated receptor gamma (PPARG) transcription factors are important in the carcinogenesis of colorectal cancer (CRC). In this study, we examined whether the expression of NFATc2 and PPARG genes is significantly altered during the carcinogenesis of CRC. A total of 47 tumor samples and matched normal tissue margins were collected during surgery from patients with CRC...
August 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28482290/epigenetic-alterations-in-chronic-disease-focusing-on-beh%C3%A3-et-s-disease-review
#3
REVIEW
Shahriar Alipour, Mohammad Nouri, Ebrahim Sakhinia, Nasser Samadi, Neda Roshanravan, Abed Ghavami, Alireza Khabbazi
OBJECTIVE: 'Epigenetics' is specified as the inheritable changes in gene expression with no alterations in DNA sequences. Epigenetics is a rapidly overspreading scientific field, and the study of epigenetic regulation in chronic disease is emerging. This study aims to evaluate epigenetic changes including DNA methylation, histone modification, and non-coding RNAs (ncRNAs) in inflammatory disease, with focus on Behçet's disease. In this review, first we describe the history and classification of epigenetic changes, and then the role of epigenetic alterations in chronic diseases is explained...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28164646/analysis-of-the-association-between-mdm4-rs4245739-single-nucleotide-polymorphism-and-breast-cancer-susceptibility
#4
Negar Pedram, Nasser Pouladi, Mohammad A Hosseinpour Feizi, Vahid Montazeri, Ebrahim Sakhinia, Mehrdad A Estiar
BACKGROUND: MDM4 is a negative regulator of the p53 tumor suppression pathway. Recent studies have revealed that the rs4245739 A>C polymorphism of MDM4 in the 3-untranslated region makes it a miR-191 target site which leads to lower MDM4 expression. This study is aimed to detect if rs4245739 single nucleotide polymorphism (SNP) of the MDM4 gene influences the breast cancer development in Iranian-Azeri women. METHODS: Blood samples were taken from 260 healthy controls and 220 breast cancer women with ethnicity of Iranian-Azeri...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28140749/aberrant-methylated-ednrb-can-act-as-a-potential-diagnostic-biomarker-in-sporadic-colorectal-cancer-while-kiss1-is-controversial
#5
Reza Mousavi Ardehaie, Shahriar Hashemzadeh, Shahin Behrouz Sharif, Morteza Ghojazadeh, Ladan Teimoori-Toolabi, Ebrahim Sakhinia
Cancers are among the most serious threats of human health worldwide. Survival and mortality rates of colorectal cancer (CRC) strongly depend on the early diagnosis. The aberrant methylation pattern of genes as a diagnostic biomarker can serve as a practical option for timely detection and contribute subsequently to the enhancement of survival rate in CRC patients, since methylation changes are not only frequent but also can occur in initial tumorogenesis stages. It has been indicated that EDNRB and KISS1 genes are hypermethylated through progression and development of CRC...
September 3, 2017: Bioengineered
https://www.readbyqxmd.com/read/28105243/detection-of-aberrant-methylated-sept9-and-ntrk3-genes-in-sporadic-colorectal-cancer-patients-as-a-potential-diagnostic-biomarker
#6
Shahin Behrouz Sharif, Shahriar Hashemzadeh, Reza Mousavi Ardehaie, Amirtaher Eftekharsadat, Mortaza Ghojazadeh, Amir Hossein Mehrtash, Mehrdad Asghari Estiar, Ladan Teimoori-Toolabi, Ebrahim Sakhinia
Colorectal cancer (CRC) is one of the most common malignancies, and the third leading cause of cancer mortality worldwide. Timely detection of CRC in patients with earlier stages provides the highest rate of survival. Epigenetic alterations are important in the occurrence and progression of CRC, and represent the primary modifications of cancer cells. Therefore, detection of these alterations in CRC cases are thought to hold great promise as diagnostic biomarkers. It has been shown that the SEPT9 and NTRK3 genes are aberrantly methylated and their detection can be used as biomarkers for early diagnosis of CRC...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/27957452/molecular-analysis-of-mefv-gene-polymorphisms-and-mutations-in-iranian-azeri-patients-with-rheumatoid-arthritis
#7
Alireza Khabbazi, Farideh Zolrahim, Mehrdad Asghari Estiar, Ebrahim Sakhinia, Sousan Kolahi
No abstract text is available yet for this article.
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27793577/a-novel-tnfrsf1a-gene-mutation-in-a-patient-with-tumor-necrosis-factor-receptor-associated-periodic-syndrome
#8
Alireza Khabazi, Mahafarin Maralani, Sasan Andalib, Ebrahim Sakhinia
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a periodic fever syndrome inherited in an autosomal dominant fashion. It stems from mutations in the TNFRSF1A gene that expresses the receptor for tumor necrosis factor α. A patient with TRAPS may present with prolonged episodes of fever attacks, abdominal pain, severe myalgia, and painful erythema on the trunk or extremities. Here, we report the case of an 8-year-old boy with febrile attacks occurring every 1-2months and continuing for 3-4days...
October 19, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27352258/detection-of-t-8-14-c-myc-igh-gene-rearrangement-by-long-distance-polymerase-chain-reaction-in-patients-with-diffuse-large-b-cell-lymphoma
#9
Arezoo Kiaei, Habib Onsori, Aylar Alijani, Sasan Andalib, Saeid Ghorbian, Ebrahim Sakhinia
OBJECTIVE/BACKGROUND: Specific chromosomal translocations are found in human leukemias and lymphomas. These translocations are closely related to particular histological and immunological phenotypes. In Burkitt's lymphoma, translocation t(8;14)(q24;q32), which involves the c-myc gene (8q24) and the immunoglobulin heavy-chain (IgH) locus (14q32), accounts for 90-95% of all chromosomal translocations. This translocation can be found in 2-5% of diffuse large B-cell lymphoma (DLBCL). Long-distance polymerase chain reaction (LD-PCR) assays, which can identify oncogene/Ig gene rearrangement, can detect these fusion genes...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27349013/ret-gene-analysis-in-patients-with-medullary-thyroid-carcinoma
#10
Parastoo Kheiroddin, Seyed-Ziaeddin Rasihashemi, Mehrdad-Asghariari Estiar, Babak Mahmudian, Monireh Halimi, Fatemeh Mousavi, Masoumeh Nemati, Ebrahim Sakhinia
BACKGROUND: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor from the para follicular C cells of the thyroid gland. It occurs either sporadically or as part of an inherited syndrome. It is caused by an autosomal dominant mutation in the RET (Rearranged during Transfection) proto-oncogene. METHODS: The studied population consisted of 47 patients diagnosed with MTC in a specific population of northwest Iran along with their three children. Blood samples were collected from all subjects, genomic DNA was extracted and RET exons 10, 11, 13, 14, 15, and 16 were analyzed using PCR and direct sequencing...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27349011/il-27-gene-polymorphisms-in-iranian-patients-with-behcet-s-disease
#11
Rashedeh Dehghanzadeh, Zohreh Babaloo, Ebrahim Sakhinia, Alireza Khabazi, Dariush Shanehbandi, Saeed Sadigh-Eteghad, Tohid Gharibi
BACKGROUND: Behcet's Disease (BD) is a chronic systemic inflammatory disease of unknown etiology, principally characterized by relapsing periods of a broad range of clinical symptoms. Cytokines play fundamental roles in the pathogenesis of BD. Polymorphisms within cytokine genes have been found to play a pathogenic role in the development of autoimmune/inflammatory disorders. Interleukin 27 (IL-27), a new pro-/anti-inflammatory cytokine, is a great candidate for chronic inflammatory disease studies...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27156337/stc1-and-nf-%C3%AE%C2%BAb-p65-rel-a-is-constitutively-activated-in-colorectal-cancer
#12
Saleheh Rezapour, Tayyeb Bahrami, Shahryar Hashemzadeh, Mehrdad Asghari Estiar, Masoumeh Nemati, Reyhaneh Ravanbakhsh, Mohammad Ali Hosseinpour Feizi, Hossein Samadi Kafil, Nasser Pouladi, Morteza Ghojazadeh, Ebrahim Sakhinia
BACKGROUND: Stanniocalcin-1 (STC1) and nuclear factor (NF)-κB subunit p65 transcription factor are involved in various types of human malignancies. The roles of STC1 and NFκB-p65 in colorectal cancer (CRC) are still not fully understood. We investigated expression levels of NF-κB p65 and STC1 and also correlations between STC1 and NF-κB p65 expression and clinicopathological features in CRC. METHODS: Tumor tissue samples were collected from 48 patients with CRC...
2016: Clinical Laboratory
https://www.readbyqxmd.com/read/27045402/bcl-1-gene-rearrangements-in-iranian-non-hodgkin-lymphoma-patients
#13
Manoush Tohidirad, Mehrdad Asghari Estiar, Azim Rezamand, Saeid Ghorbian, Sasan Andalib, Issa Jahanzad, Tayyeb Bahrami, Ebrahim Sakhinia
In the present study, our aim was to assess the incidence of BCL-1 gene rearrangements in formalin-fixed paraffin embedded (FFPE) tissue in patients with non-Hodgkin lymphomas (NHL). The BIOMED-2 protocol was applied to assess the BCL-1 gene rearrangements in NHL patients. PCR amplification was carried out on FFPE in 100 patients with B-cell lymphoma including 89 cases with diffused large B-cell lymphoma (DLBCL) (15 cases under 18 years old) and 11 cases with mantle cell lymphoma (MCL). Out of the 100 patients, 19 cases (19%) were identified to have concurrent translocation involving BCL-1...
August 1, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/26882813/a-single-nucleotide-polymorphism-in-the-foxp3-gene-associated-with-beh%C3%A3-et-s-disease-in-an-iranian-population
#14
Arezoo Hosseini, Dariush Shanehbandi, Mehrdad Asghari Estiar, Saber Gholizadeh, Alireza Khabbazi, Hamidreza Khodadadi, Ebrahim Sakhinia, Zohreh Babaloo
UNLABELLED: Background: Behçet's Disease (BD) is a rare autoimmune disease that involves the dysfunction of regulatory T cells. FOXP3 is a key transcription factor in the development and function of T(reg) cells. Recent studies have shown SNPs in the FOXP3 contribute to the susceptibility to some autoimmune disorders. METHODS: To clarify the association between the FOXP3 gene and the risk of BD, 50 patients diagnosed with BD and 50 healthy controls from north-western Iran were genotyped by PCR-RFLP (Mun I and Pst I) for two SNPs including rs3761547 (-3499T/C) and rs3761548 (-3279 C/A) in the promoter region of the FOXP3 gene...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26427138/molecular-analysis-of-igh-and-incomplete-igh-d-j-clonality-gene-rearrangements-in-hodgkin-lymphoma-malignancies
#15
Saeid Ghorbian, Issa Jahanzad, Mehrdad Asghari Estiar, Jamal Eivazi Ziae, Iraj Asvadi-Kermani, Sasan Andalib, Gholam Reza Javadi, Ebrahim Sakhinia
BACKGROUND: We evaluated molecular clonality in immunoglobulin heavy chain (IGH) and incomplete IGH D-J genes for improvement of clinical diagnosis of Hodgkin's lymphoma (HL). We applied BIOMED-2 protocols in HL cases, which were previously approved by clonality detection in non-Hodgkin lymphoma (NHL) cases. METHODS: We investigated 50 consecutive FFPE samples of classical HL (cHL) patients to assess IGH and IGH D-J clonal gene rearrangements by multiplex PCR protocols, which were provided by the European Biomedicine and Health (BIOMED-2) Concerted Action Project BMH4-CT98-3936...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/26233806/lack-of-association-between-mitochondrial-dna-g15257a-and-g15812a-variations-and-multiple-sclerosis
#16
Sasan Andalib, Mahnaz Talebi, Ebrahim Sakhinia, Mehdi Farhoudi, Homayoun Sadeghi-Bazargani, Albert Gjedde
BACKGROUND: Multiple sclerosis (MS) is a debilitating disease of the central nervous system for which no definitive therapy has yet been developed. The etiology remains uncertain, but there is evidence of genetic susceptibility to the disease, including contributions from mitochondrial DNA (mtDNA) variations to the pathogenesis of MS. G15257A and G15812A are variations of the mtDNA tRNA(Thr) gene in MS sufferers of different populations. The present study tested the hypothesis of an association of the G15257A and G15812A variations of the mtDNA tRNA(Thr) gene to the susceptibility to MS in an Iranian population...
September 15, 2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26201854/mitochondrial-dna-t4216c-and-a4917g-variations-in-multiple-sclerosis
#17
Sasan Andalib, Mahnaz Talebi, Ebrahim Sakhinia, Mehdi Farhoudi, Homayoun Sadeghi-Bazargani, Albert Gjedde
BACKGROUND: Multiple sclerosis (MS) affects the brain and spinal cord and long has been the topic of global research; yet there is no commonly accepted cause and no cure for the disease. Mounting evidence supports the role of genetics in susceptibility to MS. From this perspective, a current effort focuses on the neurogenetics of the complex pathogenesis of MS in relation to factors such as mitochondrial DNA (mtDNA) variations. T4216C and A4917G are common mitochondrial gene variations associated with MS...
September 15, 2015: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26183240/evaluation-of-igk-and-igl-molecular-gene-rearrangements-according-to-the-biomed-2-protocols-for-clinical-diagnosis-of-hodgkin-lymphoma
#18
Saeid Ghorbian, Issa Jahanzad, Gholam Reza Javadi, Ebrahim Sakhinia
BACKGROUND: Although the analysis of molecular clonality rearrangements of the immunoglobulin light chains (IGK and IGL) is an alternative approach for diagnosis of B cell non-Hodgkin lymphomas (NHLs) using BIOMED-2 protocols, NHLs have not been extensively confirmed for Hodgkin lymphoma (HL) cases. We evaluated BIOMED-2 protocols in HL cases, which have been suggested previously as gold standard method for molecular clonality analysis on formalin fixed, paraffin-embedded (FFPE) tissue in NHL patients...
April 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/26118178/expression-analysis-of-aurora-c-and-survivin-two-testis-specific-genes-in-patients-with-colorectal-cancer
#19
Saba Hosseini, Shahryar Hashemzadeh, Mehrdad Asghari Estiar, Reza Ebrahimzadeh, Mohammad Bassir Abolghassemi Fakhree, Bahman Yousefi, Sara Sheikholeslami, Mohammad Hossein Modarresi, Ebrahim Sakhinia
BACKGROUND: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. The high frequency of positive families shows the importance of public awareness and screening strategies in those families. Cancer/testis (CT) antigens such as Aurora-C and Survivin are a group of antigens expressed in various tumor types of human cancers. Therefore, the aim of this study was to investigate the expression of Aurora-C and Survivin genes in malignant and normal tissues and their correlation to clinicopathological characteristics...
2015: Clinical Laboratory
https://www.readbyqxmd.com/read/25796019/association-of-chronic-thromboembolic-pulmonary-hypertension-with-hereditary-and-acquired-risk-factors-for-thromboembolism
#20
Mohammad Reza Ghaffary, Khalil Ansarin, Ebrahim Sakhinia, Ali Reza Khoramifar
Thrombophilia increases the incidence of pulmonary thrombosis significantly. Various hereditary and acquired factors are known for thromboembolism. The hereditary factors are two common genetic autosomal mutations including factor V leidan mutation and prothrombin gene mutation. A descriptive- analytical design was conducted on 60 patients with thromboembolism who met the inclusion criteria. Two groups with hereditary and acquired risk factors for thromboembolism (group A, B, each 30 people) were evaluated...
2015: Acta Medica Iranica
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