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https://www.readbyqxmd.com/read/29743854/microsatellite-instability-in-colorectal-cancer
#1
REVIEW
Jafar Nouri Nojadeh, Shahin Behrouz Sharif, Ebrahim Sakhinia
Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of genetic and environmental factors. Although it is one of the most common cancers worldwide, CRC would be one of the most curable cancers if it is detected in the early stages. Molecular changes that occur in colorectal cancer may be categorized into three main groups: 1) Chromosomal Instability (CIN), 2) Microsatellite Instability (MSI), and 3) CpG Island Methylator phenotype (CIMP). Microsatellites, also known as Short Tandem Repeats (STRs) are small (1-6 base pairs) repeating stretches of DNA scattered throughout the entire genome and account for approximately 3 % of the human genome...
2018: EXCLI journal
https://www.readbyqxmd.com/read/29739090/expression-analysis-of-microrna-222-in-breast-cancer
#2
Sima Amini, Atefeh Abak, Mehrdad A Estiar, Vahid Montazeri, Alireza Abhari, Ebrahim Sakhinia
BACKGROUND: miR-221 and miR-222 are homologous miRNAs located in tandem, within 1 kb from each other, on human x chromosome. Recent studies declared that microRNA-222 is aberrantly expressed in various malignancies. The goal of this research was to measure the expression level of has-miR-222-3P and reveal its diagnostic and prognostic importance in breast malignancy. METHODS: In this study, 40 pairs of cancerous and matched adjacent non-cancerous breast tissue were collected from patients, and real-time PCR was used to measure the relative expression of miR-222...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29739049/expression-patterns-of-cxcl12-and-its-receptor-in-colorectal-carcinoma
#3
Ashraf Mousavi, Shahryar Hashemzadeh, Tayyeb Bahrami, Mehrdad Asghari Estiar, Mohammad A H Feizi, Nasser Pouladi, Leila Rostamizadeh, Ebrahim Sakhinia
BACKGROUND: Stromal cell-derived factor-1 (also called CXCL12) and its receptor, CXCR4, have a key role in the pathogenesis and tumorigenesis of various cancers. The aims of the current study were to quantitatively examine the expression of CXCR4 and CXCL12 genes in colorectal cancer and to correlate their expression degree with clinicopathological features. METHODS: Tumor tissue samples were collected from 47 patients with CRC. Total RNA was isolated from resection tissues and real-time PCR analysis was performed to examine mRNA levels of CXCL12 and CXCR4 genes...
May 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29611475/gene-silencing-strategies-in-cancer-therapy-an-update-for-drug-resistance
#4
Sanaz Naghizadeh, Behzad Mansoori, Ali Mohammadi, Sakhinia Ebrahim, Behzad Baradaran
RNAi, post-transcriptional gene silencing mechanism, could be considered as one of the most important breakthroughs and rapidly growing fields in science. Researchers are trying to use this discovery in the treatment of various diseases and cancer is one of them. Multiple treatment procedures for treatments-resistance cancers remain as unsolvable problem yet. The current review summarizes both transcriptional and post-transcriptional gene silencing mechanisms, and highlights mechanisms leading to drug-resistance such as, drug efflux, drug inactivation, drug target alteration, DNA damages repair, and the epithelial-mesenchymal transition, as well as the role of tumor cell heterogeneity and tumor microenvironment, involved genes in these processes...
April 3, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29602972/the-potential-role-of-toll-like-receptor-4-asp299gly-polymorphism-and-its-association-with-recurrent-cystic-echinococcosis-in-postoperative-patients
#5
Jafar Noori, Adel Spotin, Ehsan Ahmadpour, Mahmoud Mahami-Oskouei, Homayoun Sadeghi-Bazargani, Tohid Kazemi, Ebrahim Sakhinia, Leili Aghebati-Maleki, Firooz Shahrivar
The study of pathogenesis mechanisms of larval stages in the Taeniidae has recently focused on host genetic factors, particularly toll-like receptor (TLR) variations. However, the potential role of TLR4 polymorphism in hydatidosis has not yet been sufficiently elucidated in postoperative patients. In this case-control investigation, 80 patients from Iran, including 40 with acute hydatidosis (AH) and 40 with recurrent hydatidosis (RH), and 80 ethnically matched controls were evaluated from February 2015 to February 2017...
March 30, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29558042/deregulated-expression-of-hdac3-in-colorectal-cancer-and-its-clinical-significance
#6
Masoumeh Nemati, Naser Ajami, Mehrdad Asghari Estiar, Saleheh Rezapour, Reyhaneh Ravanbakhsh Gavgani, Shahryar Hashemzadeh, Hossein Samadi Kafil, Ebrahim Sakhinia
BACKGROUND: To date, 4 classes of histone deacetylases (HDACs) have been identified in humans. Class I HDACs are zinc-dependent and NAD+-independent enzymes, and include 4 isoforms closely related to yeast RPD3: HDAC1, 2, 3, and 8. OBJECTIVES: The aims of the study were to quantitatively evaluate the expression of HDAC3 in colorectal cancer (CRC) and to correlate its expression levels with clinicopathological parameters. MATERIAL AND METHODS: We characterized expression patterns of HDAC3 as class I HDAC isoforms in a cohort of 48 CRC patients by quantitative (real-time) reverse transcription polymerase chain reaction (RT-PCR)...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29479893/analysis-of-mirna-221-expression-level-in-tumors-and-marginal-biopsies-from-patients-with-breast-cancer-cross-sectional-observational-study
#7
Atefe Abak, Sima Amini, Mehrdad A Estiar, Vahid Montazeri, Ebrahim Sakhinia, Alireza Abhari
BACKGROUND: miRNA-221 and miRNA-222 are two homologous microRNAs, the high-expression levels of which have been commonly demonstrated in the most current human cancer types as well as breast cancer. The purpose of this research was to determine the clinical value of measuring the expression level of hsa-miR-221-3p in breast cancer tissues and evaluate its biological and prognostic importance in breast cancer (BC). METHODS: A total of 40 tumor samples and matched tumor-free margin specimens were obtained during surgery from patients with BC...
January 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29375860/rare-48-xyyy-syndrome-case-report-and-review-of-the-literature
#8
Maryam Abedi, Arash Salmaninejad, Ebrahim Sakhinia
48, XYYY syndrome is a rare condition. A male with 32-year-old and three Y chromosomes is described. This syndrome is phenotypically similar to Klinefelter syndrome. In this patient, Semi-Klinefelter characteristics such as tall stature, teeth dysmorphology, long length of fingers, partial deformity of the joints, likewise mental health problems were obvious.
January 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29289611/variants-in-gnptab-gnptg-and-nagpa-genes-are-associated-with-stutterers
#9
Nima Kazemi, Mehrdad Asghari Estiar, Hassan Fazilaty, Ebrahim Sakhinia
Non-syndromic stuttering is a neurodevelopmental disorder characterized by disruptions in normal flow of speech in the form of repetition, prolongation and involuntary halts. Previously, mutations with more severe effects on GNPTAB and GNPTG have been reported to cause Mucolipidosisll (ML-ll) and Mucolipidosislll (ML-lll), two lysosomal storage disorders with multiple pathologies. We used homozygosity mapping and Sanger sequencing to investigate variants of the three genes in 25 Iranian families with at least two first degree related non-syndromic stutterers...
March 20, 2018: Gene
https://www.readbyqxmd.com/read/29182754/pharmacogenetics-based-warfarin-dosing-in-patients-with-cardiac-valve-replacement-the-effects-of-cyp2c9-and-vkorc1-gene-polymorphisms
#10
Negin Farzamikia, Ebrahim Sakhinia, Abbas Afrasiabirad
Many lines of evidence suggest that warfarin dosing variability is significantly associated with cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) variant alleles. Therefore, we investigated the influence of CYP2C9*2 (430C/T), *3 (1075A/C) and VKORC1 (-1639G/A) polymorphisms on warfarin dose requirements in patients who underwent cardiac valve surgery during the postoperative period.A total of 100 patients with heart valve replacement who had a prescribed target international normalized ratio (INR) range of 2-3 were enrolled in the study...
December 22, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28802665/no-evidence-of-association-between-optic-neuritis-and-secondary-lhon-mtdna-mutations-in-patients-with-multiple-sclerosis
#11
Sasan Andalib, Mahnaz Talebi, Ebrahim Sakhinia, Mehdi Farhoudi, Homayoun Sadeghi-Bazargani, Nooshin Masoudian, Manouchehr Seyedi Vafaee, Albert Gjedde
Leber's Hereditary Optic Neuropathy (LHON) shares features with Multiple Sclerosis (MS). Both diseases develop optic lesions. Frequent secondary LHON mutations in MS patients may explain the optic damage. Here, we tested the hypothesis that secondary LHON mutations are associated with optic neuritis (ON) in MS patients. We recruited 56 MS subjects with ON and 47 MS subjects without ON. DNA was extracted by salting out, after sampling of peripheral blood from each participant. We completed Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) analysis with appropriate primers and restriction endonucleases for seven secondary LHON mutations...
August 10, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28504924/mrna-expression-of-nuclear-factor-of-activated-t-cells-cytoplasmic-2-nfatc2-and-peroxisome-proliferator-activated-receptor-gamma-pparg-transcription-factors-in-colorectal-carcinoma
#12
Venus Zafari, Shahryar Hashemzadeh, Mohammadali Hosseinpour Feizi, Nasser Pouladi, Leila Rostami Zadeh, Ebrahim Sakhinia
Transcription factors are involved in cell cycle and apoptosis regulation and thus have a key role in the carcinogenesis of different tumors. Nuclear factor of activated T-cells, cytoplasmic 2 (NFATc2) and peroxisome proliferator-activated receptor gamma (PPARG) transcription factors are important in the carcinogenesis of colorectal cancer (CRC). In this study, we examined whether the expression of NFATc2 and PPARG genes is significantly altered during the carcinogenesis of CRC. A total of 47 tumor samples and matched normal tissue margins were collected during surgery from patients with CRC...
August 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28482290/epigenetic-alterations-in-chronic-disease-focusing-on-beh%C3%A3-et-s-disease-review
#13
REVIEW
Shahriar Alipour, Mohammad Nouri, Ebrahim Sakhinia, Nasser Samadi, Neda Roshanravan, Abed Ghavami, Alireza Khabbazi
OBJECTIVE: 'Epigenetics' is specified as the inheritable changes in gene expression with no alterations in DNA sequences. Epigenetics is a rapidly overspreading scientific field, and the study of epigenetic regulation in chronic disease is emerging. This study aims to evaluate epigenetic changes including DNA methylation, histone modification, and non-coding RNAs (ncRNAs) in inflammatory disease, with focus on Behçet's disease. In this review, first we describe the history and classification of epigenetic changes, and then the role of epigenetic alterations in chronic diseases is explained...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28164646/analysis-of-the-association-between-mdm4-rs4245739-single-nucleotide-polymorphism-and-breast-cancer-susceptibility
#14
Negar Pedram, Nasser Pouladi, Mohammad A Hosseinpour Feizi, Vahid Montazeri, Ebrahim Sakhinia, Mehrdad A Estiar
BACKGROUND: MDM4 is a negative regulator of the p53 tumor suppression pathway. Recent studies have revealed that the rs4245739 A>C polymorphism of MDM4 in the 3-untranslated region makes it a miR-191 target site which leads to lower MDM4 expression. This study is aimed to detect if rs4245739 single nucleotide polymorphism (SNP) of the MDM4 gene influences the breast cancer development in Iranian-Azeri women. METHODS: Blood samples were taken from 260 healthy controls and 220 breast cancer women with ethnicity of Iranian-Azeri...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28140749/aberrant-methylated-ednrb-can-act-as-a-potential-diagnostic-biomarker-in-sporadic-colorectal-cancer-while-kiss1-is-controversial
#15
Reza Mousavi Ardehaie, Shahriar Hashemzadeh, Shahin Behrouz Sharif, Morteza Ghojazadeh, Ladan Teimoori-Toolabi, Ebrahim Sakhinia
Cancers are among the most serious threats of human health worldwide. Survival and mortality rates of colorectal cancer (CRC) strongly depend on the early diagnosis. The aberrant methylation pattern of genes as a diagnostic biomarker can serve as a practical option for timely detection and contribute subsequently to the enhancement of survival rate in CRC patients, since methylation changes are not only frequent but also can occur in initial tumorogenesis stages. It has been indicated that EDNRB and KISS1 genes are hypermethylated through progression and development of CRC...
September 3, 2017: Bioengineered
https://www.readbyqxmd.com/read/28105243/detection-of-aberrant-methylated-sept9-and-ntrk3-genes-in-sporadic-colorectal-cancer-patients-as-a-potential-diagnostic-biomarker
#16
Shahin Behrouz Sharif, Shahriar Hashemzadeh, Reza Mousavi Ardehaie, Amirtaher Eftekharsadat, Mortaza Ghojazadeh, Amir Hossein Mehrtash, Mehrdad Asghari Estiar, Ladan Teimoori-Toolabi, Ebrahim Sakhinia
Colorectal cancer (CRC) is one of the most common malignancies, and the third leading cause of cancer mortality worldwide. Timely detection of CRC in patients with earlier stages provides the highest rate of survival. Epigenetic alterations are important in the occurrence and progression of CRC, and represent the primary modifications of cancer cells. Therefore, detection of these alterations in CRC cases are thought to hold great promise as diagnostic biomarkers. It has been shown that the SEPT9 and NTRK3 genes are aberrantly methylated and their detection can be used as biomarkers for early diagnosis of CRC...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/27957452/molecular-analysis-of-mefv-gene-polymorphisms-and-mutations-in-iranian-azeri-patients-with-rheumatoid-arthritis
#17
Alireza Khabbazi, Farideh Zolrahim, Mehrdad Asghari Estiar, Ebrahim Sakhinia, Sousan Kolahi
No abstract text is available yet for this article.
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27793577/a-novel-tnfrsf1a-gene-mutation-in-a-patient-with-tumor-necrosis-factor-receptor-associated-periodic-syndrome
#18
Alireza Khabazi, Mahafarin Maralani, Sasan Andalib, Ebrahim Sakhinia
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a periodic fever syndrome inherited in an autosomal dominant fashion. It stems from mutations in the TNFRSF1A (accession number: NM_001065) gene expressing the receptor for tumor necrosis factor α. A patient with TRAPS may present with prolonged episodes of fever attacks, abdominal pain, severe myalgia, and painful erythema on the trunk or extremities. Here, we report an 8-year-old boy with febrile attacks occurring every 1-2months and continuing for 3-4days...
October 19, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27352258/detection-of-t-8-14-c-myc-igh-gene-rearrangement-by-long-distance-polymerase-chain-reaction-in-patients-with-diffuse-large-b-cell-lymphoma
#19
Arezoo Kiaei, Habib Onsori, Aylar Alijani, Sasan Andalib, Saeid Ghorbian, Ebrahim Sakhinia
OBJECTIVE/BACKGROUND: Specific chromosomal translocations are found in human leukemias and lymphomas. These translocations are closely related to particular histological and immunological phenotypes. In Burkitt's lymphoma, translocation t(8;14)(q24;q32), which involves the c-myc gene (8q24) and the immunoglobulin heavy-chain (IgH) locus (14q32), accounts for 90-95% of all chromosomal translocations. This translocation can be found in 2-5% of diffuse large B-cell lymphoma (DLBCL). Long-distance polymerase chain reaction (LD-PCR) assays, which can identify oncogene/Ig gene rearrangement, can detect these fusion genes...
December 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27349013/ret-gene-analysis-in-patients-with-medullary-thyroid-carcinoma
#20
Parastoo Kheiroddin, Seyed-Ziaeddin Rasihashemi, Mehrdad-Asghariari Estiar, Babak Mahmudian, Monireh Halimi, Fatemeh Mousavi, Masoumeh Nemati, Ebrahim Sakhinia
BACKGROUND: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor from the para follicular C cells of the thyroid gland. It occurs either sporadically or as part of an inherited syndrome. It is caused by an autosomal dominant mutation in the RET (Rearranged during Transfection) proto-oncogene. METHODS: The studied population consisted of 47 patients diagnosed with MTC in a specific population of northwest Iran along with their three children. Blood samples were collected from all subjects, genomic DNA was extracted and RET exons 10, 11, 13, 14, 15, and 16 were analyzed using PCR and direct sequencing...
2016: Clinical Laboratory
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