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M. Liberman

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https://www.readbyqxmd.com/read/29166359/incisional-hernia-after-midline-versus-transverse-specimen-extraction-incision-a-randomized-trial-in-patients-undergoing-laparoscopic-colectomy
#1
Lawrence Lee, Juan Mata, Raoul A Droeser, Pepa Kaneva, Sender Liberman, Patrick Charlebois, Barry Stein, Gerald M Fried, Liane S Feldman
OBJECTIVE: To compare the incidence of incisional hernia (IH) between midline and transverse specimen extraction site in patients undergoing laparoscopic colectomy. BACKGROUND: Midline specimen extraction incision is most commonly used in laparoscopic colectomy, but has high IH risk. IH may be lower for transverse incision. METHODS: A single-center superiority trial was conducted. Eligible patients undergoing laparoscopic colectomy were randomly assigned to midline or transverse specimen extraction...
November 21, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29117478/design-synthesis-and-self-assembly-of-polymers-with-tailored-graft-distributions
#2
Alice B Chang, Tzu-Pin Lin, Niklas B Thompson, Shao-Xiong Luo, Allegra Lauren Liberman-Martin, Hsiang-Yun Chen, Byeongdu Lee, Robert H Grubbs
Grafting density and graft distribution impact the chain dimensions and physical properties of polymers. However, achieving precise control over these structural parameters presents long-standing synthetic challenges. In this report, we introduce a versatile strategy to synthesize polymers with tailored architectures via grafting-through ring-opening metathesis polymerization (ROMP). One-pot copolymerization of an ω-norbornenyl macromonomer and a discrete norbornenyl co-monomer (diluent) provides opportunities to control the backbone sequence and therefore the side chain distribution...
November 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29101302/disability-sex-rights-and-the-scope-of-sexual-exclusion
#3
Alida Liberman
In response to three papers about sex and disability published in this journal, I offer a critique of existing arguments and a suggestion about how the debate should be reframed going forward. Jacob M. Appel argues that disabled individuals have a right to sex and should receive a special exemption to the general prohibition of prostitution. Ezio Di Nucci and Frej Klem Thomsen separately argue contra Appel that an appeal to sex rights cannot justify such an exemption. I argue that Appel's argument fails, but not (solely) for the reasons Di Nucci and Thomsen propose, as they have missed the most pressing objection to Appel's argument: Appel falsely presumes that we never have good reasons to restrict someone's sexual liberty rights...
November 3, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29100769/arthroscopic-debridement-for-primary-degenerative-osteoarthritis-of-the-elbow-leads-to-significant-improvement-in-range-of-motion-and-clinical-outcomes-a-systematic-review
#4
REVIEW
Kyle R Sochacki, Robert A Jack, Takashi Hirase, Patrick C McCulloch, David M Lintner, Shari R Liberman, Joshua D Harris
PURPOSE: The purpose of this investigation was to determine whether arthroscopic debridement of primary elbow osteoarthritis results in statistically significant and clinically relevant improvement in (1) elbow range of motion and (2) clinical outcomes with (3) low complication and reoperation rates. METHODS: A systematic review was registered with PROSPERO and performed using PRISMA guidelines. Databases were searched for studies that investigated the outcomes of arthroscopic debridement for the treatment of primary osteoarthritis of the elbow in adult human patients...
October 31, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28981901/improving-work-outcome-in-supported-employment-for-serious-mental-illness-results-from-2-independent-studies-of-errorless-learning
#5
Robert S Kern, Roberto Zarate, Shirley M Glynn, Luana R Turner, Kellie M Smith, Sharon S Mitchell, Catherine A Sugar, Morris D Bell, Robert P Liberman, Alex Kopelowicz, Michael F Green
Background: Heterogeneity in work outcomes is common among individuals with serious mental illness (SMI). Objective: In 2 studies, we sought to examine the efficacy of adding errorless learning, a behavioral training intervention, to evidence-based supported employment to improve SMI work outcomes. Work behavior problems were targeted for intervention. We also explored associations between early work behavior and job tenure. Methods: For both studies (VA: n = 71; community mental health center: n = 91), randomization occurred at the time of job obtainment with participants randomized (1:1) to either errorless learning plus ongoing supported employment or ongoing supported employment alone and then followed for 12 months...
July 26, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28916861/predictors-of-adherence-to-enhanced-recovery-pathway-elements-after-laparoscopic-colorectal-surgery
#6
Juan Mata, Julio F Fiore, Nicolo Pecorelli, Barry L Stein, Sender Liberman, Patrick Charlebois, Liane S Feldman
INTRODUCTION: Enhanced recovery pathways (ERP) include a bundle of evidence-based preoperative, intraoperative, and postoperative interventions that together reduce morbidity and length of stay after colorectal surgery. Increased adherence with the bundle is associated with better postoperative outcomes, but adherence is lowest in the postoperative period. Identifying risk factors for lower adherence may help design quality improvement strategies. The aim of this study was to estimate the extent to which patient, procedural, and organizational factors predict adherence to postoperative ERP elements in laparoscopic colorectal surgery...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28905502/prevalence-trends-of-selected-major-birth-defects-a-multi-state-population-based-retrospective-study-united-states-1999-to-2007
#7
Amanda M St Louis, Keewan Kim, Marilyn L Browne, Gang Liu, Rebecca F Liberman, Wendy N Nembhard, Mark A Canfield, Glenn Copeland, Jane Fornoff, Russell S Kirby
BACKGROUND: We evaluated selected birth defects over a 9-year period to assess prevalence trends by selected maternal and infant factors. METHODS: Data were pooled from 11 population-based birth defects surveillance programs in the United States for children born between 1999 and 2007. Overall prevalence, as well as 3-year interval prevalence, was calculated for 26 specific birth defects, stratified by maternal age, maternal race/ethnicity, and infant sex. Average annual percent change (AAPC) was calculated for each birth defect...
September 14, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/28857625/ats-core-curriculum-2017-part-iv-adult-pulmonary-medicine
#8
Gaëtane C Michaud, Colleen L Channick, Caralee Caplan-Shaw, Jonathan M Iaccarino, Christopher G Slatore, Brett Bade, Nichole Tanner, Catherine Robitaille, Anne V Gonzalez, Eric Goudie, Moishe Liberman, Deepankar Sharma, Samira Shojaee, Christopher M Merrick, Fabien Maldonado, Quyen L Nguyen, Belinda Rivera-Lebron, Jason T Poston
No abstract text is available yet for this article.
August 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28853024/does-experience-matter-a-meta-analysis-of-physician-rating-websites-of-orthopaedic-surgeons
#9
R A Jack, M B Burn, P C McCulloch, S R Liberman, K E Varner, J D Harris
PURPOSE: To perform a systematic review evaluating online ratings of Orthopaedic Surgeons to determine: (1) the number of reviews per surgeon by website, (2) whether the number of reviews and rate of review acquisition correlated with years in practice, and (3) whether the use of ratings websites varied based on the surgeons' geographic region of practice. METHODS: The USA was divided into nine geographic regions, and the most populous city in each region was selected...
August 29, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28746897/parkinsonian-features-in-aging-gfap-hmox1-transgenic-mice-overexpressing-human-ho-1-in-the-astroglial-compartment
#10
Wei Song, Marisa Cressatti, Hillel Zukor, Adrienne Liberman, Carmela Galindez, Hyman M Schipper
Epigenetic influences mediating brain iron deposition, oxidative mitochondrial injury, and macroautophagy in Parkinson disease and related conditions remain enigmatic. Here, we show that selective overexpression of the stress protein, heme oxygenase-1 (HO-1) in astrocytes of GFAP.HMOX1 transgenic mice between 8.5 and 19 months of age results in nigrostriatal hypodopaminergia associated with locomotor incoordination and stereotypy; downregulation of tyrosine hydroxylase, DAT, LMX1B, Nurr1, Pitx3 and DJ-1 mRNA and/or protein; overproduction of α-synuclein and ubiquitin; oxidative stress; basal ganglia siderosis; mitochondrial damage/mitophagy; and augmented GABAergic systems (increased GABA, GAD67 and reelin)...
June 28, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28720043/open-arthroscopic-and-percutaneous-surgical-treatment-of-lateral-epicondylitis-a-systematic-review
#11
Matthew B Burn, Ronald J Mitchell, Shari R Liberman, David M Lintner, Joshua D Harris, Patrick C McCulloch
BACKGROUND: Approximately 10% of patients with lateral epicondylitis go on to have surgical treatment; however, multiple surgical treatment options exist. The purpose of this study was to review the literature for the clinical outcomes of open, arthroscopic, and percutaneous treatment of lateral epicondylitis. The authors hypothesized that the clinical outcome of all 3 analyzed surgical treatments would be equivalent. METHODS: A systematic review was performed using PubMed, Cochrane Central Register of Controlled Trials, and Google Scholar in July 2016 to compare the functional outcome, pain, grip strength, patient satisfaction, and return to work at 1-year follow-up for open, arthroscopic, and percutaneous treatment of lateral epicondylitis...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28712672/noise-induced-cochlear-synaptopathy-in-rhesus-monkeys-macaca-mulatta
#12
M D Valero, J A Burton, S N Hauser, T A Hackett, R Ramachandran, M C Liberman
Cochlear synaptopathy can result from various insults, including acoustic trauma, aging, ototoxicity, or chronic conductive hearing loss. For example, moderate noise exposure in mice can destroy up to ∼50% of synapses between auditory nerve fibers (ANFs) and inner hair cells (IHCs) without affecting outer hair cells (OHCs) or thresholds, because the synaptopathy occurs first in high-threshold ANFs. However, the fiber loss likely impairs temporal processing and hearing-in-noise, a classic complaint of those with sensorineural hearing loss...
September 2017: Hearing Research
https://www.readbyqxmd.com/read/28690836/noise-induced-and-age-related-hearing-loss-%C3%A2-new-perspectives-and-potential-therapies
#13
REVIEW
M Charles Liberman
The classic view of sensorineural hearing loss has been that the primary damage targets are hair cells and that auditory nerve loss is typically secondary to hair cell degeneration. Recent work has challenged that view. In noise-induced hearing loss, exposures causing only reversible threshold shifts (and no hair cell loss) nevertheless cause permanent loss of >50% of the synaptic connections between hair cells and the auditory nerve. Similarly, in age-related hearing loss, degeneration of cochlear synapses precedes both hair cell loss and threshold elevation...
2017: F1000Research
https://www.readbyqxmd.com/read/28680767/a-resident-boot-camp-for-reducing-door-to-needle-times-at-academic-medical-centers
#14
REVIEW
Ilana M Ruff, Ava L Liberman, Fan Z Caprio, Matthew B Maas, Scott J Mendelson, Farzaneh A Sorond, Deborah Bergman, Richard A Bernstein, Yvonne Curran, Shyam Prabhakaran
BACKGROUND: We sought to determine if a structured educational program for neurology residents can lower door-to-needle (DTN) times at an academic institution. METHODS: A neurology resident educational stroke boot camp was developed and implemented in April 2013. Using a prospective database of 170 consecutive acute ischemic stroke (AIS) patients treated with IV tissue plasminogen activator (tPA) in our emergency department (ED), we evaluated the effect of the intervention on DTN times...
June 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28603087/cysteine-rich-whey-protein-isolate-immunocal%C3%A2-ameliorates-deficits-in-the-gfap-hmox1-mouse-model-of-schizophrenia
#15
Wei Song, Ayda Tavitian, Marisa Cressatti, Carmela Galindez, Adrienne Liberman, Hyman M Schipper
Schizophrenia is a neuropsychiatric disorder that features neural oxidative stress and glutathione (GSH) deficits. Oxidative stress is augmented in brain tissue of GFAP.HMOX1 transgenic mice which exhibit schizophrenia-relevant characteristics. The whey protein isolate, Immunocal® serves as a GSH precursor upon oral administration. In this study, we treated GFAP.HMOX1 transgenic mice daily with either Immunocal (33mg/ml drinking water) or equivalent concentrations of casein (control) between the ages of 5 and 6...
June 8, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28530226/corrigendum-cochlear-gene-therapy-with-ancestral-aav-in-adult-mice-complete-transduction-of-inner-hair-cells-without-cochlear-dysfunction
#16
Jun Suzuki, Ken Hashimoto, Ru Xiao, Luk H Vandenberghe, M Charles Liberman
This corrects the article DOI: 10.1038/srep45524.
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521479/association-between-non-melanoma-and-melanoma-skin-cancer-rates-vitamin-d-and-latitude
#17
Miguel Rivas, Elisa Rojas, Gloria M Calaf, Marcela Barberán, Claudio Liberman, Marcelo De Paula Correa
Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28503234/error-reporting-from-the-da-vinci-surgical-system-in-robotic-surgery-a-canadian-multispecialty-experience-at-a-single-academic-centre
#18
Emad Rajih, Côme Tholomier, Beatrice Cormier, Vanessa Samouëlian, Thomas Warkus, Moishe Liberman, Hugues Widmer, Jean-Baptiste Lattouf, Abdullah M Alenizi, Malek Meskawi, Roger Valdivieso, Pierre-Alain Hueber, Pierre I Karakewicz, Assaad El-Hakim, Kevin C Zorn
INTRODUCTION: The goal of the study is to evaluate and report on the third-generation da Vinci surgical (Si) system malfunctions. METHODS: A total of 1228 robotic surgeries were performed between January 2012 and December 2015 at our academic centre. All cases were performed by using a single, dual console, four-arm, da Vinci Si robot system. The three specialties included urology, gynecology, and thoracic surgery. Studied outcomes included the robotic surgical error types, immediate consequences, and operative side effects...
May 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28450351/prospective-study-of-adenosine-on-atrioventricular-nodal-conduction-in-pediatric-and-young-adult-patients-after-heart-transplantation
#19
Jonathan N Flyer, Warren A Zuckerman, Marc E Richmond, Brett R Anderson, Tamar G Mendelsberg, Jennie M McAllister, Leonardo Liberman, Linda J Addonizio, Eric S Silver
BACKGROUND: Supraventricular tachycardia is common after heart transplantation. Adenosine, the standard therapy for treating supraventricular tachycardia in children and adults without transplantation, is relatively contraindicated after transplantation because of a presumed risk of prolonged atrioventricular block in denervated hearts. This study tested whether adenosine caused prolonged asystole after transplantation and if it was effective in blocking atrioventricular nodal conduction in these patients...
June 20, 2017: Circulation
https://www.readbyqxmd.com/read/28444496/incidence-of-incisional-hernia-in-the-specimen-extraction-site-for-laparoscopic-colorectal-surgery-systematic-review-and-meta-analysis
#20
Lawrence Lee, Maria Abou-Khalil, Sender Liberman, Marylise Boutros, Gerald M Fried, Liane S Feldman
INTRODUCTION: The incidence of incisional hernia(IH) may be affected by the choice of specimen extraction incision. The objective of this study was to perform a systematic review and meta-analysis comparing the incidence of IH after midline and off-midline incisions in patients undergoing laparoscopic colorectal surgery. METHODS: A systematic search was performed according to PRISMA guidelines to identify all comparative studies from January 1991-August 2016 on the incidence of IH after midline and off-midline(transverse or Pfannenstiel) incisions in patients undergoing laparoscopic colorectal surgery...
April 25, 2017: Surgical Endoscopy
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