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M. Liberman

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https://www.readbyqxmd.com/read/27891649/control-of-arabidopsis-lateral-root-primordium-boundaries-by-myb36
#1
María Fernández-Marcos, Bénédicte Desvoyes, Concepción Manzano, Louisa M Liberman, Philip N Benfey, Juan C Del Pozo, Crisanto Gutierrez
Root branching in plants relies on the de novo formation of lateral roots. These are initiated from founder cells, triggering new formative divisions that generate lateral root primordia (LRP). The LRP size and shape depends on the balance between positive and negative signals that control cell proliferation. The mechanisms controlling proliferation potential of LRP cells remains poorly understood. We found that Arabidopsis thaliana MYB36, which have been previously shown to regulate genes required for Casparian strip formation and the transition from proliferation to differentiation in the primary root, plays a new role in controlling LRP development at later stages...
January 2017: New Phytologist
https://www.readbyqxmd.com/read/27857212/gr-independent-down-modulation-on-gm-csf-bone-marrow-derived-dendritic-cells-by-the-selective-glucocorticoid-receptor-modulator-compound-a
#2
Andres E Barcala Tabarrozzi, Luz Andreone, Julie Deckers, Carla N Castro, María L Gimeno, Laura Ariolfo, Paula M Berguer, María Antunica-Noguerol, Ana C Liberman, Sabine Vettorazzi, Jan P Tuckermann, Karolien De Bosscher, Marcelo J Perone
Dendritic cells (DC) initiate the adaptive immune response. Glucocorticoids (GCs) down-modulate the function of DC. Compound A (CpdA, (2-(4-acetoxyphenyl)-2-chloro-N-methyl-ethylammonium chloride) is a plant-derived GR-ligand with marked dissociative properties. We investigated the effects of CpdA on in vitro generated GM-CSF-conditioned bone marrow-derived DC (BMDC). CpdA-exposed BMDC exhibited low expression of cell-surface molecules and diminution of the release of proinflammatory cytokines upon LPS stimulation; processes associated with BMDC maturation and activation...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27618300/toward-a-differential-diagnosis-of-hidden-hearing-loss-in-humans
#3
M Charles Liberman, Michael J Epstein, Sandra S Cleveland, Haobing Wang, Stéphane F Maison
Recent work suggests that hair cells are not the most vulnerable elements in the inner ear; rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate first in the aging or noise-exposed ear. This primary neural degeneration does not affect hearing thresholds, but likely contributes to problems understanding speech in difficult listening environments, and may be important in the generation of tinnitus and/or hyperacusis. To look for signs of cochlear synaptopathy in humans, we recruited college students and divided them into low-risk and high-risk groups based on self-report of noise exposure and use of hearing protection...
2016: PloS One
https://www.readbyqxmd.com/read/27570826/type-ii-cochlear-ganglion-neurons-do-not-drive-the-olivocochlear-reflex-re-examination-of-the-cochlear-phenotype-in-peripherin-knock-out-mice
#4
Stéphane Maison, Leslie D Liberman, M Charles Liberman
The cochlear nerve includes a small population of unmyelinated sensory fibers connecting outer hair cells to the brain. The functional role of these type II afferent neurons is controversial, because neurophysiological data are sparse. A recent study (Froud et al., 2015) reported that targeted deletion of peripherin, a type of neurofilament, eliminated type II afferents and inactivated efferent feedback to the outer hair cells, thereby suggesting that type II afferents were the sensory drive to this sound-evoked, negative-feedback reflex, the olivocochlear pathway...
July 2016: ENeuro
https://www.readbyqxmd.com/read/27476586/patients-with-poor-baseline-walking-capacity-are-most-likely-to-improve-their-functional-status-with-multimodal-prehabilitation
#5
Enrico M Minnella, Rashami Awasthi, Chelsia Gillis, Julio F Fiore, A Sender Liberman, Patrick Charlebois, Barry Stein, Guillaume Bousquet-Dion, Liane S Feldman, Francesco Carli
BACKGROUND: Evidence suggests that multimodal prehabilitation programs comprising interventions directed at physical activity, nutrition, and anxiety coping can improve functional recovery after colorectal cancer operations; however, such programs may be more clinically meaningful and cost-effective if targeted to specific subgroups. This study aimed to estimate the extent to which patients with poor baseline functional capacity improve their functional capacity. METHODS: Data for 106 participants enrolled in a multimodal, prehabilitation program before colorectal operations were analyzed...
October 2016: Surgery
https://www.readbyqxmd.com/read/27410544/broadband-optical-switch-based-on-liquid-crystal-dynamic-scattering
#6
M W Geis, P J Bos, V Liberman, M Rothschild
This work demonstrates a novel broadband optical switch, based on dynamic-scattering effect in liquid crystals (LCs). Dynamic-scattering-mode technology was developed for display applications over four decades ago, but was displaced in favor of the twisted-nematic LCs. However, with the recent development of more stable LCs, dynamic scattering provides advantages over other technologies for optical switching. We demonstrate broadband polarization-insensitive attenuation of light directly passing thought the cell by 4 to 5 orders of magnitude at 633 nm...
June 27, 2016: Optics Express
https://www.readbyqxmd.com/read/27384746/significant-cooperativity-between-ruthenium-and-silicon-in-catalytic-transformations-of-an-isocyanide
#7
Mark C Lipke, Allegra L Liberman-Martin, T Don Tilley
Complexes [PhBP3]RuH(η(3)-H2SiRR') (RR' = Me,Ph, 1a; RR' = Ph2, 1b; RR' = Et2, 1c) react with XylNC to form carbene complexes [PhBP3]Ru(H)═[C(H)(N(Xyl)(η(2)-H-SiRR'))] (2a-c; previously reported for 2a,b). Reactions of 1a-c with XylNC were further investigated to assess how metal complexes with multiple M-H-Si bonds can mediate transformations of unsaturated substrates. Complex 2a eliminates an N-methylsilacycloindoline product (3a) that results from hydrosilylation, hydrogenation, and benzylic C-H activation of XylNC...
August 3, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27324650/long-range-wetting-transparency-on-top-of-layered-metal-dielectric-substrates
#8
M A Noginov, Yuri A Barnakov, Vladimir Liberman, Srujana Prayakarao, Carl E Bonner, Evgenii E Narimanov
It has been recently shown that scores of physical and chemical phenomena (including spontaneous emission, scattering and Förster energy transfer) can be controlled by nonlocal dielectric environments provided by metamaterials with hyperbolic dispersion and simpler metal/dielectric structures. At this time, we have researched van der Waals interactions and experimentally studied wetting of several metallic, dielectric and composite multilayered substrates. We have found that the wetting angle of water on top of MgF2 is highly sensitive to the thickness of the MgF2 layer and the nature of the underlying substrate that could be positioned as far as ~100 nm beneath the water/MgF2 interface...
June 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27288592/postnatal-maturation-of-auditory-nerve-heterogeneity-as-seen-in-spatial-gradients-of-synapse-morphology-in-the-inner-hair-cell-area
#9
Leslie D Liberman, M Charles Liberman
Auditory nerve fibers in the adult ear are divided into functional subgroups according to spontaneous rate (SR) and threshold sensitivity. The high-threshold, low-SR fibers are morphologically and spatially distinct from the low-threshold high-SR fibers at their synaptic contacts with inner hair cells. This distinction between SR groups in the adult ear is visible in confocal microscopy as complementary size gradients of presynaptic ribbons and post-synaptic glutamate receptor patches across the modiolar-pillar and habenular-cuticular axes in the inner hair cell area...
September 2016: Hearing Research
https://www.readbyqxmd.com/read/27177020/the-activity-of-the-glucocorticoid-receptor-is-regulated-by-sumo-conjugation-to-fkbp51
#10
M Antunica-Noguerol, M L Budziñski, J Druker, N C Gassen, M C Sokn, S Senin, F Aprile-Garcia, F Holsboer, T Rein, A C Liberman, E Arzt
FK506-binding protein 51 (FKBP51) regulates the activity of the glucocorticoid receptor (GR), and is therefore a key mediator of the biological actions of glucocorticoids. However, the understanding of the molecular mechanisms that govern its activity remains limited. Here, we uncover a novel regulatory switch for GR activity by the post-translational modification of FKBP51 with small ubiquitin-like modifier (SUMO). The major SUMO-attachment site, lysine 422, is required for FKBP51-mediated inhibition of GR activity in hippocampal neuronal cells...
October 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27108594/round-window-delivery-of-neurotrophin-3-regenerates-cochlear-synapses-after-acoustic-overexposure
#11
Jun Suzuki, Gabriel Corfas, M Charles Liberman
In acquired sensorineural hearing loss, such as that produced by noise or aging, there can be massive loss of the synaptic connections between cochlear sensory cells and primary sensory neurons, without loss of the sensory cells themselves. Because the cell bodies and central projections of these cochlear neurons survive for months to years, there is a long therapeutic window in which to re-establish functional connections and improve hearing ability. Here we show in noise-exposed mice that local delivery of neurotrophin-3 (NT-3) to the round window niche, 24 hours after an exposure that causes an immediate loss of up to 50% loss of synapses in the cochlear basal region, can regenerate pre- and post-synaptic elements at the hair cell / cochlear nerve interface...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27105161/a-superior-method-for-cell-block-preparation-for-fine-needle-aspiration-biopsies
#12
Ronald Balassanian, Geoffrey D Wool, Jill C Ono, Jolanta Olejnik-Nave, Molinda M Mah, Brenda J Sweeney, Hava Liberman, Britt-Marie Ljung, Martha B Pitman
BACKGROUND: Cell block (CB) techniques for fine-needle aspiration biopsies (FNABs) vary. A direct comparison of CB techniques with statistical validation was performed to identify the best method. METHODS: Three CB techniques were compared: 1) FNAB rinsed in saline and clotted with plasma and thrombin (SPT); 2) FNAB rinsed in formalin and clotted with HistoGel (HG); and 3) FNAB rinsed in formalin, centrifuged, and the pellet captured in a collodion bag (ColB). FNAB was performed on 35 random surgical specimens for smears and each CB technique...
July 2016: Cancer Cytopathology
https://www.readbyqxmd.com/read/27067448/terminal-microdeletions-of-13q34-chromosome-region-in-patients-with-intellectual-disability-delineation-of-an-emerging-new-microdeletion-syndrome
#13
Eyal Reinstein, Meytal Liberman, Michal Feingold-Zadok, Tamar Tenne, John M Graham
The increasing use of chromosomal microarray studies in patients with intellectual disability has led to the description of new microdeletion and microduplication syndromes. We report terminal microdeletions in 13q34 chromosome region in 5 adult patients of two unrelated families. Patients harboring 13q34 microdeletions display common clinical features, including intellectual disability, obesity, and mild facial dysmorphism. These individuals can become fairly self-sufficient, however they do not live independently, and require community and social support...
May 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27058660/a-friend-in-need-of-nutrients-is-a%C3%A2
#14
COMMENT
Louisa M Liberman, Philip N Benfey
Endophytic fungi are found within the roots of healthy plants, but their function is poorly understood. In this issue, Hiruma et al. demonstrate that, under phosphate-limiting conditions, the endophytic fungus, Colletotrichum tofieldiae, provides growth-promoting and fitness benefits to Arabidopsis, but the plant must restrict fungal growth or risk pathogenesis.
April 7, 2016: Cell
https://www.readbyqxmd.com/read/27030760/auditory-brainstem-response-latency-in-noise-as-a-marker-of-cochlear-synaptopathy
#15
Golbarg Mehraei, Ann E Hickox, Hari M Bharadwaj, Hannah Goldberg, Sarah Verhulst, M Charles Liberman, Barbara G Shinn-Cunningham
UNLABELLED: Evidence from animal and human studies suggests that moderate acoustic exposure, causing only transient threshold elevation, can nonetheless cause "hidden hearing loss" that interferes with coding of suprathreshold sound. Such noise exposure destroys synaptic connections between cochlear hair cells and auditory nerve fibers; however, there is no clinical test of this synaptopathy in humans. In animals, synaptopathy reduces the amplitude of auditory brainstem response (ABR) wave-I...
March 30, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27028099/early-introduction-of-palliative-care-and-advanced-care-planning-for-children-with-complex-chronic-medical-conditions-a-pilot-study
#16
D B Liberman, E Song, L M Radbill, P K Pham, S F Derrington
BACKGROUND: Children with complex chronic medical conditions benefit from early introduction of palliative care services and advanced care planning for symptom management and to support quality of life and medical decision-making. This study evaluated whether introducing palliative care during primary care appointments (1) was feasible; (2) increased access and improved knowledge of palliative care; and (3) facilitated advanced care planning. METHODS: Pilot study of a multi-modal intervention including targeted education for primary care providers (PCPs), an informational packet for families and presence of a palliative care team member in the outpatient clinic...
May 2016: Child: Care, Health and Development
https://www.readbyqxmd.com/read/26986975/co-expression-of-wild-type-p2x7r-with-gln460arg-variant-alters-receptor-function
#17
Fernando Aprile-Garcia, Michael W Metzger, Marcelo Paez-Pereda, Herbert Stadler, Matías Acuña, Ana C Liberman, Sergio A Senin, Juan Gerez, Esteban Hoijman, Damian Refojo, Mišo Mitkovski, Markus Panhuysen, Walter Stühmer, Florian Holsboer, Jan M Deussing, Eduardo Arzt
The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg) substitution at codon 460 of the purinergic P2X7 receptor (P2X7R) has been associated with mood disorders. No change in function (loss or gain) has been described for this SNP so far. Here we show that although the P2X7R-Gln460Arg variant per se is not compromised in its function, co-expression of wild-type P2X7R with P2X7R-Gln460Arg impairs receptor function with respect to calcium influx, channel currents and intracellular signaling in vitro...
2016: PloS One
https://www.readbyqxmd.com/read/26962539/prevalence-of-scapular-dyskinesis-in-overhead-and-nonoverhead-athletes-a-systematic-review
#18
Matthew B Burn, Patrick C McCulloch, David M Lintner, Shari R Liberman, Joshua D Harris
BACKGROUND: Scapular dyskinesis, or abnormal dynamic scapular control, is a condition that is commonly associated with shoulder pathology but is also present in asymptomatic individuals. Literature varies on whether it represents a cause or symptom of shoulder pathology, but it is believed to be a risk factor for further injury. Clinical identification focuses on visual observation and examination maneuvers. Treatment of altered scapular motion has been shown to improve shoulder symptoms...
February 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/26955300/mechanically-tunable-hollow-silica-ultrathin-nanoshells-for-ultrasound-contrast-agents
#19
A Liberman, J Wang, N Lu, R D Viveros, C A Allen, R F Mattrey, S L Blair, W C Trogler, M J Kim, A C Kummel
Perfluoropentane (PFP) gas filled biodegradable iron-doped silica nanoshells have been demonstrated as long-lived ultrasound contrast agents. Nanoshells are synthesized by a sol-gel process with tetramethyl orthosilicate (TMOS) and iron ethoxide. Substituting a fraction of the TMOS with R-substituted trialkoxysilanes produces ultrathin nanoshells with varying shell thicknesses and morphologies composed of fused nanoflakes. The ultrathin nanoshells had continuous ultrasound Doppler imaging lifetimes exceeding 3 hours, were twice as bright using contrast specific imaging, and had decreased pressure thresholds compared to control nanoshells synthesized with just TMOS...
July 8, 2015: Advanced Functional Materials
https://www.readbyqxmd.com/read/26944177/perinatal-thiamine-deficiency-causes-cochlear-innervation-abnormalities-in-mice
#20
Stéphane F Maison, Yanbo Yin, Leslie D Liberman, M Charles Liberman
Neonatal thiamine deficiency can cause auditory neuropathy in humans. To probe the underlying cochlear pathology, mice were maintained on a thiamine-free or low-thiamine diet during fetal development or early postnatal life. At postnatal ages from 18 days to 22 wks, cochlear function was tested and cochlear histopathology analyzed by plastic sections and cochlear epithelial whole-mounts immunostained for neuronal and synaptic markers. Although none of the thiamine-deprivation protocols resulted in any loss of hair cells or any obvious abnormalities in the non-sensory structures of the cochlear duct, all the experimental groups showed significant anomalies in the afferent or efferent innervation...
May 2016: Hearing Research
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