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https://www.readbyqxmd.com/read/29771797/measuring-in-hospital-recovery-after-colorectal-surgery-within-a-well-established-enhanced-recovery-pathway-a-comparison-between-hospital-length-of-stay-and-time-to-readiness-for-discharge
#1
Saba Balvardi, Nicolò Pecorelli, Tanya Castelino, Petru Niculiseanu, A Sender Liberman, Patrick Charlebois, Barry Stein, Franco Carli, Nancy E Mayo, Liane S Feldman, Julio F Fiore
BACKGROUND: Hospital length of stay is often used as a measure of in-hospital recovery but may be confounded by organizational factors. Time to readiness for discharge may provide a superior index of recovery. OBJECTIVE: The purpose of this study was to contribute evidence for the construct validity of time to readiness for discharge and length of stay as measures of in-hospital recovery after colorectal surgery in the context of a well-established enhanced recovery pathway...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29736808/serial-dependence-promotes-the-stability-of-perceived-emotional-expression-depending-on-face-similarity
#2
Alina Liberman, Mauro Manassi, David Whitney
Individuals can quickly and effortlessly recognize facial expressions, which is critical for social perception and emotion regulation. This sensitivity to even slight facial changes could result in unstable percepts of an individual's expression over time. The visual system must therefore balance accuracy with maintaining perceptual stability. However, previous research has focused on our sensitivity to changing expressions, and the mechanism behind expression stability remains an open question. Recent results demonstrate that perception of facial identity is systematically biased toward recently seen visual input...
May 7, 2018: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/29715900/highly-efficient-all-optical-beam-modulation-utilizing-thermo-optic-effects
#3
Vladimir Liberman, Paul D Robinson, Geoffrey P Geurtsen, Shane M Tysk, Michael W Geis
Suspensions of plasmonic nanoparticles can diffract optical beams due to the combination of thermal lensing and self-phase modulation. Here, we demonstrate extremely efficient optical continuous wave (CW) beam switching across the visible range in optimized suspensions of 5-nm Au and Ag nanoparticles in non-polar solvents, such as hexane and decane. On-axis modulation of greater than 30 dB is achieved at incident beam intensities as low as 100 W/cm2 with response times under 200 μs, at initial solution transparency above 70%...
April 16, 2018: Optics Express
https://www.readbyqxmd.com/read/29695468/misdiagnosis-of-cerebral-vein-thrombosis-in-the-emergency-department
#4
Ava L Liberman, Gino Gialdini, Ekaterina Bakradze, Abhinaba Chatterjee, Hooman Kamel, Alexander E Merkler
BACKGROUND AND PURPOSE: Rates of cerebral venous thrombosis (CVT) misdiagnosis in the emergency department and outcomes associated with misdiagnosis have been underexplored. METHODS: Using administrative data, we identified adults with CVT at New York, California, and Florida hospitals from 2005 to 2013. Our primary outcome was probable misdiagnosis of CVT, defined as a treat-and-release emergency department visit for headache or seizure within 14 days before CVT...
April 25, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29682808/stress-alcohol-and-infection-during-early-development-a-brief-review-of-common-outcomes-and-mechanisms
#5
REVIEW
Pablo Nicolás Surkin, Heather Brenhouse, Terrence Deak, Ana Clara Liberman, Mercedes Lasaga
Although stress is an adaptive physiological response to deal with adverse conditions, its occurrence during early stages of life such as infancy or adolescence can induce adaptations in multiple physiological systems, including the reproductive axis (HPG), the hypothalamic-pituitary-adrenal (HPA) axis, the limbic cortex and the immune system. These early changes have consequences in adult life, as seen in the physiological and behavioral responses to stress. This review highlights the impact of several stress challenges incurred at various stages of development (peri-natal, juvenile, adolescent periods) and how developmental timing of early life stress confers unique physiological adaptations that may persist across the lifespan...
April 22, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29661475/usefulness-of-high-dose-oral-flecainide-for-termination-of-recent-onset-atrial-fibrillation-in-children
#6
Leonardo Liberman, Thomas J Starc, Eric S Silver
A high dose of oral flecainide has been used for acute termination of atrial fibrillation (AF) and atrial flutter or intra-atrial re-entry tachycardia (AFL-IART) in adults. The use of flecainide for these conditions in children has not been well described. We describe our institutional experience on acute termination of AF or AFL-IART in children with a single high dose of oral flecainide in a hospital setting. All patients who received a single high dose of oral flecainide from 2009 to 2016 who were <21 years of age were included...
March 21, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29658974/physician-rating-scales-do-not-accurately-rate-physicians
#7
Matthew B Burn, David M Lintner, Pedro E Cosculluela, Kevin E Varner, Shari R Liberman, Patrick C McCulloch, Joshua D Harris
The purpose of this study was to determine the proportion of questions used by online physician rating scales to directly rate physicians themselves. A systematic review was performed of online, patient-reported physician rating scales. Fourteen websites were identified containing patient-reported physician rating scales, with the most common questions pertaining to office staff courtesy, wait time, overall rating (entered, not calculated), trust/confidence in physician, and time spent with patient. Overall, 28% directly rated the physician, 48% rated both the physician and the office, and 24% rated the office alone...
April 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29621881/disentangling-ligand-effects-on-metathesis-catalyst-activity-experimental-and-computational-studies-of-ruthenium-aminophosphine-complexes
#8
Crystal K Chu, Tzu-Pin Lin, Huiling Shao, Allegra L Liberman-Martin, Peng Liu, Robert H Grubbs
Second-generation ruthenium olefin metathesis catalysts bearing aminophosphine ligands were investigated with systematic variation of the ligand structure. The rates of phosphine dissociation ( k1 ; initiation rate) and relative phosphine reassociation ( k-1 ) were determined for two series of catalysts bearing cyclohexyl(morpholino)phosphine and cyclohexyl(piperidino)phosphine ligands. In both cases, incorporating P-N bonds into the architecture of the dissociating phosphine accelerates catalyst initiation relative to the parent [Ru]-PCy3 complex; however, this effect is muted for the tris(amino)phosphine-ligated complexes, which exhibit higher ligand binding constants in comparison to those with phosphines containing one or two cyclohexyl substituents...
April 5, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29614896/modeling-strengthens-molecular-link-between-circadian-polymorphisms-and-major-mood-disorders
#9
Amanda R Liberman, Lumbardh Halitjaha, Ahmet Ay, Krista K Ingram
Anxiety and other mood disorders, such as major depressive disorder (MDD) and seasonal affective disorder (SAD), affect nearly one-fifth of the global population and disproportionately affect young adults. Individuals affected by mood disorders are frequently plagued by sleep and circadian problems, and recent genetic studies provide ample support for the association of circadian and sleep syndromes with depression and anxiety. Mathematical modeling has been crucial in understanding some of the essential features of the mammalian circadian clock and is now a vital tool for dissecting how circadian genes regulate the molecular mechanisms that influence mood...
April 1, 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29598837/effects-of-cochlear-synaptopathy-on-middle-ear-muscle-reflexes-in-unanesthetized-mice
#10
Michelle D Valero, Kenneth E Hancock, Stéphane F Maison, M Charles Liberman
Cochlear synaptopathy, i.e. the loss of auditory-nerve connections with cochlear hair cells, is seen in aging, noise damage, and other types of acquired sensorineural hearing loss. Because the subset of auditory-nerve fibers with high thresholds and low spontaneous rates (SRs) is disproportionately affected, audiometric thresholds are relatively insensitive to this primary neural degeneration. Although suprathreshold amplitudes of wave I of the auditory brainstem response (ABR) are attenuated in synaptopathic mice, there is not yet a robust diagnostic in humans...
March 13, 2018: Hearing Research
https://www.readbyqxmd.com/read/29582377/serial-dependence-in-position-occurs-at-the-time-of-perception
#11
Mauro Manassi, Alina Liberman, Anna Kosovicheva, Kathy Zhang, David Whitney
Observers perceive objects in the world as stable over space and time, even though the visual experience of those objects is often discontinuous and distorted due to masking, occlusion, camouflage, or noise. How are we able to easily and quickly achieve stable perception in spite of this constantly changing visual input? It was previously shown that observers experience serial dependence in the perception of features and objects, an effect that extends up to 15 seconds back in time. Here, we asked whether the visual system utilizes an object's prior physical location to inform future position assignments in order to maximize location stability of an object over time...
March 26, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29572431/a-gain-of-function-mutation-in-the-%C3%AE-9-nicotinic-acetylcholine-receptor-alters-medial-olivocochlear-efferent-short-term-synaptic-plasticity
#12
Carolina Wedemeyer, Lucas G Vattino, Marcelo J Moglie, Jimena Ballestero, Stéphane F Maison, Mariano N Di Guilmi, Julian Taranda, M Charles Liberman, Paul A Fuchs, Eleonora Katz, Ana Belén Elgoyhen
Gain control of the auditory system operates at multiple levels. Cholinergic medial olivocochlear (MOC) fibers originate in the brainstem and make synaptic contacts at the base of the outer hair cells (OHCs), the final targets of several feedback loops from the periphery and higher processing centers. Efferent activation inhibits OHC active amplification within the mammalian cochlea, through the activation of a calcium permeable α9α10 ionotropic cholinergic nicotinic receptor (nAChR), functionally coupled to calcium activated SK2 potassium channels...
March 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29508102/the-impact-of-complications-after-elective-colorectal-resection-within-an-enhanced-recovery-pathway
#13
L Lee, S Liberman, P Charlebois, B Stein, P Kaneva, F Carli, L S Feldman
BACKGROUND: Despite the implementation of enhanced recovery pathways (ERP), morbidity following colorectal surgery remains high. The aim of the present study was to estimate the impact of postoperative complications on excess hospital length of stay (LOS) in patients undergoing elective colorectal resection. METHODS: A retrospective study of patients undergoing elective colorectal surgery at a single institution from 2003 to 2010 was performed. Patients managed by an ERP were compared to conventional care (CC), matched by propensity score radius matching...
March 2018: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29504475/morbidity-of-first-rib-resection-in-the-surgical-repair-of-thoracic-outlet-syndrome
#14
Kevin T Jubbal, Dmitry Zavlin, Joshua D Harris, Shari R Liberman, Anthony Echo
BACKGROUND: Thoracic outlet syndrome (TOS) is a complex entity resulting in neurogenic or vascular manifestations. A wide array of procedures has evolved, each with its own benefits and drawbacks. The authors hypothesized that treatment of TOS with first rib resection (FRR) may lead to increased complication rates. METHODS: A retrospective case control study was performed on the basis of the National Surgical Quality Improvement Program database from 2005 to 2014...
March 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29500079/explicit-instructions-facilitate-performance-of-ocd-participants-but-impair-performance-of-non-ocd-participants-on-a-serial-reaction-time-task
#15
Assaf Soref, Nira Liberman, Amitai Abramovitch, Reuven Dar
Previous studies have shown that individuals diagnosed with OCD tend to rely on explicit processing while performing implicit learning tasks. We sought to investigate whether individuals with OCD are capable of implicit learning, but would demonstrate improved performance when explicit processing strategies are enhanced. Twenty-four participants with OCD and 24 non-psychiatric control (NPC) participants performed an implicit learning task in which they responded to a single target stimulus that successively appears at one of four locations according to an underlying sequence...
April 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29496474/generation-of-variation-and-a-modified-mean-fitness-principle-necessity-is-the-mother-of-genetic-invention
#16
Yoav Ram, Lee Altenberg, Uri Liberman, Marcus W Feldman
Generation of variation may be detrimental in well-adapted populations evolving under constant selection. In a constant environment, genetic modifiers that reduce the rate at which variation is generated by processes such as mutation and migration, succeed. However, departures from this reduction principle have been demonstrated. Here we analyze a general model of evolution under constant selection where the rate at which variation is generated depends on the individual. We find that if a modifier allele increases the rate at which individuals of below-average fitness generate variation, then it will increase in frequency and increase the population mean fitness...
February 26, 2018: Theoretical Population Biology
https://www.readbyqxmd.com/read/29488275/evaluation-of-salivary-heme-oxygenase-1-as-a-potential-biomarker-of-early-parkinson-s-disease
#17
Wei Song, Vimal Kothari, Ana M Velly, Marisa Cressatti, Adrienne Liberman, Mervyn Gornitsky, Hyman M Schipper
BACKGROUND AND HYPOTHESIS: To date, there are no chemical analytes, including biochemical indices of oxidative stress, metabolites of α-synuclein protein, and differential protein expression patterns on proteomic profiling, for use in clinics as a diagnostic biomarker of idiopathic PD. OBJECTIVES: Heme oxygenase-1 has been implicated in the pathogenesis of PD. The objective of this study is to ascertain whether salivary heme oxygenase-1 may serve as a biomarker for early idiopathic PD...
April 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29487703/network-analysis-of-micrornas-genes-and-their-regulation-in-diffuse-and-follicular-b-cell-lymphomas
#18
Oshrat Hershkovitz-Rokah, Polina Geva, Mali Salmon-Divon, Ofer Shpilberg, Stella Liberman-Aronov
MicroRNAs (miRs) are short non-coding regulatory RNAs that control gene expression at the post-transcriptional level and play an important role in cancer development and progression, acting either as oncogenes or as tumor suppressors. Identification of aberrantly expressed miRs in patients with hematological malignancies as compared to healthy individuals has suggested that these molecules may serve as novel clinical diagnostic and prognostic biomarkers. We conducted a systematic literature review of articles published between 2007 and 2017 and re-analyzed experimentally-validated human miR expression signatures in diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) from various biological sources (tumor tissue, peripheral blood, bone marrow and cell lines)...
January 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29480741/performance-and-return-to-sport-after-thumb-ulnar-collateral-ligament-surgery-in-national-football-league-players
#19
Kyle R Sochacki, Robert A Jack, Richard Nauert, Shari R Liberman, Patrick C McCulloch, David M Lintner, Joshua D Harris
BACKGROUND: Acute ruptures of the ulnar collateral ligament (UCL) of the thumb are common injuries in sports. Surgical repair of complete tears has yielded excellent results in elite athletes. METHODS: National Football League (NFL) players who underwent thumb UCL surgery and matched controls were identified. Demographic and performance data were collected. Performance scores were calculated using a standardized scoring system. Return to sport (RTS) in the NFL was defined as playing in at least 1 NFL game after thumb UCL surgery...
February 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29451415/clinical-and-economic-impact-of-an-enhanced-recovery-pathway-for-open-and-laparoscopic-rectal-surgery
#20
Richard Garfinkle, Marylise Boutros, Gabriela Ghitulescu, Carol-Ann Vasilevsky, Patrick Charlebois, Sender Liberman, Barry Stein, Liane S Feldman, Lawrence Lee
BACKGROUND: The short-term benefits of laparoscopy for rectal surgery are equivocal. The objective of this study was to determine the clinical and economic impact of an enhanced recovery pathway (ERP) for laparoscopic and open rectal surgery. MATERIALS AND METHODS: All patients who underwent elective rectal resection with primary anastomosis between January 2009 and March 2012 at two tertiary-care, university-affiliated institutions were identified. Patients who met inclusion criteria were divided into four groups, according to surgical approach (laparoscopic [lap] or open) and perioperative management (ERP or conventional care [CC])...
February 16, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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