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https://www.readbyqxmd.com/read/28087419/cochlear-synaptopathy-in-acquired-sensorineural-hearing-loss-manifestations-and-mechanisms
#1
REVIEW
M Charles Liberman, Sharon G Kujawa
Common causes of hearing loss in humans - exposure to loud noise or ototoxic drugs and aging - often damage sensory hair cells, reflected as elevated thresholds on the clinical audiogram. Recent studies in animal models suggest, however, that well before this overt hearing loss can be seen, a more insidious, but likely more common, process is taking place that permanently interrupts synaptic communication between sensory inner hair cells and subsets of cochlear nerve fibers. The silencing of affected neurons alters auditory information processing, whether accompanied by threshold elevations or not, and is a likely contributor to a variety of perceptual abnormalities, including speech-in-noise difficulties, tinnitus and hyperacusis...
January 10, 2017: Hearing Research
https://www.readbyqxmd.com/read/28077455/symptomatic-carotid-occlusion-is-frequently-associated-with-microembolization
#2
Ava L Liberman, Ali Zandieh, Caitlin Loomis, Jonathan M Raser-Schramm, Christina A Wilson, Jose Torres, Koto Ishida, Swaroop Pawar, Rebecca Davis, Michael T Mullen, Steven R Messé, Scott E Kasner, Brett L Cucchiara
BACKGROUND AND PURPOSE: Symptomatic carotid artery disease is associated with significant morbidity and mortality. The pathophysiologic mechanisms of cerebral ischemia among patients with carotid occlusion remain underexplored. METHODS: We conducted a prospective observational cohort study of patients hospitalized within 7 days of ischemic stroke or transient ischemic attack because of ≥50% carotid artery stenosis or occlusion. Transcranial Doppler emboli detection was performed in the middle cerebral artery ipsilateral to the symptomatic carotid...
January 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28074327/when-should-negative-endobronchial-ultrasonography-findings-be-confirmed-by-a-more-invasive-procedure
#3
Basil S Nasir, Kazuhiro Yasufuku, Moishe Liberman
The treatment of non-small cell lung cancer is largely dependent on accurate staging in order to determine appropriate therapy. Despite advances in imaging, such as computed tomography and positron emission tomography, invasive mediastinal staging is frequently needed to rule out mediastinal involvement prior to curative-intent stereotactic ablative radiotherapy or surgical resection. Surgical mediastinal staging with mediastinoscopy, or anterior mediastinotomy, were traditionally considered the gold standard for invasive mediastinal staging...
January 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28074323/changes-in-cerebral-metabolism-during-ketogenic-diet-in-patients-with-primary-brain-tumors-1-h-mrs-study
#4
Moran Artzi, Gilad Liberman, Nachum Vaisman, Felix Bokstein, Faina Vitinshtein, Orna Aizenstein, Dafna Ben Bashat
Normal brain cells depend on glucose metabolism, yet they have the flexibility to switch to the usage of ketone bodies during caloric restriction. In contrast, tumor cells lack genomic and metabolic flexibility and are largely dependent on glucose. Ketogenic-diet (KD) was suggested as a therapeutic option for malignant brain cancer. This study aimed to detect metabolic brain changes in patients with malignant brain gliomas on KD using proton magnetic-resonance-spectroscopy ((1)H-MRS). Fifty MR scans were performed longitudinally in nine patients: four patients with recurrent glioblastoma (GB) treated with KD in addition to bevacizumab; one patient with gliomatosis-cerebri treated with KD only; and four patients with recurrent GB who did not receive KD...
January 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28061041/other-ways-of-knowing
#5
Negin Hajizadeh, Melissa J Basile, Andrzej Kozikowski, Meredith Akerman, Tara Liberman, Thomas McGinn, Michael A Diefenbach
BACKGROUND: Patients with advanced-stage chronic obstructive pulmonary disease (COPD) may suffer severe respiratory exacerbations and need to decide between accepting life-sustaining treatments versus foregoing these treatments (choosing comfort care only). We designed the InformedTogether decision aid to inform this decision and describe results of a pilot study to assess usability focusing on participants' trust in the content of the decision aid, acceptability, recommendations for improvement, and emotional reactions to this emotionally laden decision...
December 1, 2016: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/28017313/percutaneous-pulmonary-embolus-mechanical-thrombectomy
#6
Deepali Nivas Tukaye, Michael McDaniel, Henry Liberman, Yelena Burkin, Wissam Jaber
No abstract text is available yet for this article.
December 1, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28017304/e-cigarettes-what-a-practicing-cardiologist-needs-to-know
#7
EDITORIAL
Joshua Liberman, Samuel Wann
Cardiologists and other physicians caring for patients who either smoke tobacco or are potential or active users of E-cigarettes have many questions about this increasingly popular method for delivering nicotine to the brain: (1) What are E-cigarettes? (2) What harm do E-cigarettes pose to users and bystanders? (3) Can E-cigarettes help tobacco smokers quit? (4) Are E-cigarettes a gateway to tobacco smoking, addicting new users, particularly the young, to nicotine? and (5) Should E-cigarettes be tolerated, or even favored over tobacco, as a less harmful substitute for those unable to stop smoking tobacco? This editorial summarizes evidence and expert opinion, preparing the physician for informed discussion of this controversial subject with their patients and colleagues...
November 19, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28006066/serial-dependence-promotes-object-stability-during-occlusion
#8
Alina Liberman, Kathy Zhang, David Whitney
Object identities somehow appear stable and continuous over time despite eye movements, disruptions in visibility, and constantly changing visual input. Recent results have demonstrated that the perception of orientation, numerosity, and facial identity is systematically biased (i.e., pulled) toward visual input from the recent past. The spatial region over which current orientations or face identities are pulled by previous orientations or identities, respectively, is known as the continuity field, which is temporally tuned over the past several seconds (Fischer & Whitney, 2014)...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/28005565/comparing-the-financial-impact-of-several-hospitals-on-their-local-markets
#9
Timothy Rotarius, Aaron Liberman
Several studies that measured the financial impact of hospitals on their local markets are examined. Descriptive analyses were performed to ascertain if there are any identifying characteristics and emerging patterns in the data. After hospitals were categorized into small, medium, and large classifications based on the number of employees, various predictive insights were discovered. Smaller hospitals could be expected to contribute approximately 7.3% to the local economy, whereas medium-sized hospitals would likely contribute approximately 11...
December 21, 2016: Health Care Manager
https://www.readbyqxmd.com/read/28004246/reproducibility-of-three-dimensional-posterior-cranial-base-angles-using-low-dose-computed-tomography
#10
R Olszewski, L Frison, N Schoenarts, R H Khonsari, G A Odri, F Zech, H Reychler
OBJECTIVES: One of the key aspects of three-dimensional (3D) craniofacial cephalometry is the measurement of posterior cranial base angle as this area is deeply involved in craniofacial development. The purpose of our retrospective study was to define the best reproducible 3D posterior cranial base angles among five 3D angles transposed from 2D cephalometry (Cousin, BL1 of Ross and Ravosa, Bjork, Delaire, CBA4 of Liberman) and seven 3D angles based on physical anthropology studies and on new concepts (R1 to R7)...
December 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27997472/ensuring-early-mobilization-within-an-enhanced-recovery-program-for-colorectal-surgery-a-randomized-controlled-trial
#11
Julio Flavio Fiore, Tanya Castelino, Nicolò Pecorelli, Petru Niculiseanu, Saba Balvardi, Olivia Hershorn, Sender Liberman, Patrick Charlebois, Barry Stein, Franco Carli, Nancy Mayo, Liane S Feldman
OBJECTIVE: To estimate the extent to which the addition of staff-directed facilitation of early mobilization to an Enhanced Recovery Program (ERP) impacts recovery after colorectal surgery, compared with usual care. SUMMARY BACKGROUND DATA: Early mobilization is considered an important component of ERPs but, despite guidelines recommendations, adherence remains quite low. The value of dedicating specific resources (eg, staff time) to increase early mobilization is unknown...
December 16, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27994780/single-posterior-approach-for-en-bloc-resection-and-stabilization-for-locally-advanced-pancoast-tumors-involving-the-spine-single-centre-experience
#12
Fahed Zairi, Tarek Sunna, Moishe Liberman, Ghassan Boubez, Zhi Wang, Daniel Shedid
STUDY DESIGN: Monocentric prospective study. PURPOSE: To assess the safety and effectiveness of the posterior approach for resection of advanced Pancoast tumors. OVERVIEW OF LITERATURE: In patients with advanced Pancoast tumors invading the spine, most surgical teams consider the combined approach to be necessary for "en-bloc" resection to control visceral, vascular, and neurological structures. We report our preliminary experience with a single-stage posterior approach...
December 2016: Asian Spine Journal
https://www.readbyqxmd.com/read/27992760/the-antecedents-and-consequences-of-a-beyond-choice-view-of-decision-situations-a-construal-level-theory-perspective
#13
Vered Halamish, Leah Borovoi, Nira Liberman
Evaluating alternatives and comparing them to each other are integral to decision-making. In addition, however, decision makers may adopt a view that goes beyond choice and make inferences about the entire set of alternatives, about the dimensions that are relevant in similar decisions, and about the range of values on a specific dimension. We examined some antecedents and consequences of adopting a beyond-choice view of decision situations. Based on Construal Level Theory we suggest that a beyond-choice view entails high (vs...
December 16, 2016: Acta Psychologica
https://www.readbyqxmd.com/read/27970168/tct-781-safety-and-outcomes-of-catheter-directed-thrombolytic-therapy-in-high-risk-pulmonary-embolism
#14
Tyler Bloomer, Pete Fong, Michael McDaniel, Breck Sandvall, Henry Liberman, Chandan Devireddy, Wissam Jaber
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27970158/tct-769-ultrasound-assisted-catheter-directed-thrombolysis-in-the-treatment-of-high-risk-pulmonary-embolism-a-meta-analysis
#15
Georges El Hayek, Michael McDaniel, Henry Liberman, Chandan Devireddy, Pete Fong, Gautam Kumar, Wissam Jaber
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27931124/the-contribution-of-role-satisfaction-meaning-in-life-and-work-home-conflict-to-explaining-well-being-among-working-grandparents
#16
Liat Kulik, Sagit Shilo-Levin, Gabriel Liberman
BACKGROUND AND OBJECTIVES: The study aimed to examine the relationship of satisfaction with occupied roles as well as the sense of meaning in life and experience of work-home conflict to well-being among working grandparents in Israel. DESIGN AND METHODS: The research sample consisted of 316 employed grandparents aged 50-80 (153 grandfathers and 163 grandmothers), who were employed in various types of organizations. Data were collected using structured questionnaires...
December 22, 2016: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/27892908/regional-interrelationships-a-leadership-opportunity-for-health-care
#17
Timothy Rotarius, Aaron Liberman
Given the impact that the health care industry has on the national economy, health care executives need to move beyond simply providing health care treatments and instead focus on strategically leading their regions, including the other key industry contributors in their specific regions. Geographic and economic regions can be viewed as concentric circles of influence, with each circle recognizing the resources and contributions that are specific to a region. An acknowledgement by health care executives of the regional interrelationships that exist in a specific region is necessary for health care managers to strategically lead regional interrelationships...
January 2016: Health Care Manager
https://www.readbyqxmd.com/read/27891783/population-based-microcephaly-surveillance-in-the-united-states-2009-to-2013-an-analysis-of-potential-sources-of-variation
#18
Janet D Cragan, Jennifer L Isenburg, Samantha E Parker, C J Alverson, Robert E Meyer, Erin B Stallings, Russell S Kirby, Philip J Lupo, Jennifer S Liu, Amanda Seagroves, Mary K Ethen, Sook Ja Cho, MaryAnn Evans, Rebecca F Liberman, Jane Fornoff, Marilyn L Browne, Rachel E Rutkowski, Amy E Nance, Marlene Anderka, Deborah J Fox, Amy Steele, Glenn Copeland, Paul A Romitti, Cara T Mai
BACKGROUND: Congenital microcephaly has been linked to maternal Zika virus infection. However, ascertaining infants diagnosed with microcephaly can be challenging. METHODS: Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcephaly per 10,000 live births was estimated overall and by maternal/infant characteristics. Variation in prevalence was examined across case finding methods...
November 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27891649/control-of-arabidopsis-lateral-root-primordium-boundaries-by-myb36
#19
María Fernández-Marcos, Bénédicte Desvoyes, Concepción Manzano, Louisa M Liberman, Philip N Benfey, Juan C Del Pozo, Crisanto Gutierrez
Root branching in plants relies on the de novo formation of lateral roots. These are initiated from founder cells, triggering new formative divisions that generate lateral root primordia (LRP). The LRP size and shape depends on the balance between positive and negative signals that control cell proliferation. The mechanisms controlling proliferation potential of LRP cells remains poorly understood. We found that Arabidopsis thaliana MYB36, which have been previously shown to regulate genes required for Casparian strip formation and the transition from proliferation to differentiation in the primary root, plays a new role in controlling LRP development at later stages...
January 2017: New Phytologist
https://www.readbyqxmd.com/read/27869041/wolff-parkinson-white-syndrome-a-single-exercise-stress-test-might-be-misleading
#20
Arash Salavitabar, Eric S Silver, Leonardo Liberman
Risk stratification of patients with Wolff-Parkinson-White syndrome for sudden death is a complex process, particularly in understanding the utility of the repeat exercise stress test. We report a case of an 18-year-old patient who was found to have a high-risk pathway by both invasive and exercise stress testing after an initial exercise stress test showing beat-to-beat loss of pre-excitation.
November 21, 2016: Cardiology in the Young
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