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Alejandro Adolfo Aragaki-Nakahodo, Robert P Baughman, Ralph T Shipley, Sadia Benzaquen
PURPOSE: Transbronchial lung cryobiopsy (TBLC) is a novel technique that has proved to be useful in diagnosing various interstitial lung diseases (ILD). The use of TBLC to diagnose sarcoidosis in an unselected patient population is unknown, and could be complimentary to endobronchial ultrasound fine needle aspiration (EBUS-FNA). METHODS: A retrospective analysis of 36 patients in a single, tertiary-care, academic medical center was conducted to describe the yield of both EBUS-FNA and TBLC in the diagnosis of suspected sarcoidosis over a three year period...
October 2017: Respiratory Medicine
Ali I Saeed, Fares Qeadan, Akshay Sood, Dorothy J VanderJagt, Shiraz I Mishra, Deirdre A Hill, Tobias Peikert, Mohan L Sopori
Cancer metastasis to the lymph nodes is indicative of a poor prognosis. An endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) biopsy is increasingly being used to sample paratracheal lymph nodes for simultaneous cancer diagnosis and staging. In this prospective, single-center study, we collected dedicated EBUS-FNA biopsies from 27 patients with enlarged paratracheal and hilar lymph nodes. Cytokines were assayed using Bio-Plex Pro human cancer biomarker panels (34 cytokines), in a Bio-Rad 200 suspension array system...
January 2017: Cytokine
Lester J Layfield, Sinchita Roy-Chowdhuri, Zubair Baloch, Hormoz Ehya, Kim Geisinger, Susan J Hsiao, Oscar Lin, Neal I Lindeman, Michael Roh, Fernando Schmitt, Nikoletta Sidiropoulos, Paul A VanderLaan
The Papanicolaou Society of Cytopathology has developed a set of guidelines for respiratory cytology including indications for sputum examination, bronchial washings and brushings, CT-guided FNA and endobronchial ultrasound guided fine needle aspiration (EBUS-FNA), as well as recommendations for classification and criteria, ancillary testing and post-cytologic diagnosis management and follow-up. All recommendation documents are based on the expertise of committee members, an extensive literature review, and feedback from presentations at national and international conferences...
December 2016: Diagnostic Cytopathology
Vidya Nair, Deepak Prajapat, Deepak Talwar
Literature on concurrent association of sarcoidosis with lymphoproliferative malignancies other than lymphoma e.g. multiple myeloma is meager. The rarity of the situation prompted us to report this patient who was a 51-year-old woman with a 2-years history of breathlessness, cough with expectoration, chest pain and backache. Initial evaluation revealed mild anemia, increased alkaline phosphatase with chest skiagram showing both lower zone non homogenous opacities with calcified hilar lymph nodes. CECT chest showed mediastinal with bilateral hilar lymphadenopathy, parenchymal fibrosis, traction bronchiectasis, ground glass opacities, septal and peribronchovascular thickening affecting mid and lower lung zones bilaterally...
January 2016: Lung India: Official Organ of Indian Chest Society
Shaesta Naseem Zaidi, Emad Raddaoui
BACKGROUND: Endobronchial ultrasound-guided transbronchial fine-needle aspiration is a minimally invasive technique for diagnosis of mediastinal lesions. Although most studies have reported the utility of EBUS-FNA in malignancy, its use has been extended to the benign conditions as well. OBJECTIVE: To evaluate the diagnostic yield and cytologic accuracy of endobronchial ultrasound-guided transbronchial fine-needle aspiration (EBUS-FNA) in cases of clinically and radiologically suspected granulomatous diseases...
2015: CytoJournal
A Badaoui, C Dahlqvist, Jf Rahier, B Weynand, S Ocak, Ph Deprez, P Eucher, F Duplaquet
OBJECTIVES: Endoscopic ultrasonography (EUS) and endobronchial ultrasound-fine-needle aspiration (EBUS-FNA), is an accurate technique for evaluation of mediastinal lymph nodes (MLN) and stadification of lung cancer. The aims of the study are to evaluate the feasibility and the efficacy of the combined technique compared with mediastinoscopy for the diagnosis of MLN. DESIGN AND METHODS: All patients with suspected malignant MLN and/or lung lesion identified by positron emission tomography-computed tomography underwent combined EUS-EBUS-FNA...
April 2014: Endoscopic Ultrasound
Lester J Layfield, Leslie Dodd, Ben Witt
BACKGROUND: Endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) is frequently used for the workup of pulmonary nodules. While no universally accepted diagnostic classification exists, many cytopathologists use the categories: Non-diagnostic, benign, atypical, suspicious and malignant. Sensitivity and specificity for the EBUS technique have been documented, but little information is available for malignancy risk associated with these categories. METHODS: Departments of Pathology records at the University of Utah and University of North Carolina, Chapel Hill were searched for EBUS-FNAs of pulmonary nodules...
November 2015: Diagnostic Cytopathology
Matthew J Bott, Bryce James, Brian T Collins, Benjamin A Murray, Varun Puri, Daniel Kreisel, A Sasha Krupnick, G Alexander Patterson, Stephen Broderick, Bryan F Meyers, Traves D Crabtree
BACKGROUND: Cytopathologic interpretation of endobronchial ultrasound with fine needle aspiration (EBUS-FNA) samples by a pathologist can be time-consuming and costly, and an onsite cytopathologist may not always be readily available. A telecytopathology system was instituted and evaluated to examine the effect on operative time for EBUS. METHODS: A prospective study was performed of sequential patients undergoing EBUS-FNA for the evaluation of mediastinal lymphadenopathy...
July 2015: Annals of Thoracic Surgery
H Erhan Dincer, Eitan Podgaetz Gliksberg, Rafael S Andrade
BACKGROUND AND OBJECTIVES: It is usually challenging to diagnose intraparenchymal pulmonary nodules and masses that are not adjacent to central airways or esophagus. We evaluated the diagnostic accuracy and safety of endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA) and/or endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) for these lesions. MATERIALS AND METHODS: We performed an Internal Review Board-approved retrospective analysis of all patients who underwent EBUS, EUS, or both for the diagnosis of centrally located pulmonary nodules and masses between November 2008 and July 2013...
January 2015: Endoscopic Ultrasound
Dae Hyun Song, Boram Lee, Yooju Shin, In Ho Choi, Sang Yun Ha, Jae Jun Lee, Min Eui Hong, Yoon-La Choi, Joungho Han, Sang-Won Um
BACKGROUND: Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutation in pulmonary adenocarcinoma is clinically important due to its association with resistance to EGFR inhibitors and poor prognosis. To our knowledge, there has not been a comparative study focusing on cytological nuclear features of pulmonary adenocarcinoma harboring KRAS mutation (KRAS-AD). Hence, we compared the cytomorphology of metastatic KRAS-AD and EGFR-positive adenocarcinoma (EGFR-AD) in aspiration specimens from lymph nodes...
July 2015: Diagnostic Cytopathology
Sarah J Kallas, Santhi Ganesan
No abstract text is available yet for this article.
September 2015: Diagnostic Cytopathology
W Bohle, W G Zoller
BACKGROUND: EUS-FNA of lymph nodes is believed to harbour no risk of serious complications. However, recently, a case series of mediastinal abscess formation after EUS-FNA in patients with sarcoidosis has been published. Here, we describe a patient with sarcoidosis and mediastinitis after EUS-FNA. CASE REPORT: Two years before EUS-FNA, the patient with a history of sarcoidosis, was operated because of esophageal adenocarcinoma. Due to progredient mediastinal lymphoma, we performed EUS-FNA to exclude tumor recurrence...
October 2014: Zeitschrift Für Gastroenterologie
Jordan P Reynolds, Raymond R Tubbs, Eugen C Minca, Stephen MacNamara, Francisco A Almeida, Patrick C Ma, Nathan A Pennell, Joseph C Cicenia
OBJECTIVES: Epidermal growth factor receptor (EGFR) gene mutation status should be determined in all patients with advanced, non-squamous non-small cell lung carcinoma (NSCLC) to guide targeted therapy with EGFR tyrosine kinase inhibitors. EGFR mutations are commonly tested by Sanger sequencing or allele specific polymerase chain reaction (ASPCR) on formalin-fixed paraffin-embedded (FFPE) samples including cell blocks (CB) that may fail due to absence of tumor cells. The cell pellet from cytology specimens obtained at the time of endobronchial guided ultrasound fine needle aspiration (EBUS FNA) (EBUS-TBNA, transbronchial needle aspiration) represents an alternative resource for additional tissue...
November 2014: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Karim El-Kersh, Udit Chaddha, Rodrigo Cavallazzi, Mohamed Saad
No abstract text is available yet for this article.
2014: BMJ Case Reports
Hiren J Mehta, Nichole T Tanner, Gerard Silvestri, Suzanne M Simkovich, Clayton Shamblin, Stephanie R Shaftman, Paul J Nietert, Jack Yang
BACKGROUND: Endobronchial ultrasound-guided transbronchial fine-needle aspiration (EBUS-FNA) has gained acceptance as the diagnostic procedure of choice with which to sample hilar and mediastinal lymph nodes (LNs) for diagnosing and staging patients with lung cancer. Studies have shown that EBUS has a high positive predictive value; however, its negative predictive value (NPV) varies significantly. The aim of the current study was to evaluate the clinical outcome surrounding negative and nondiagnostic EBUS-FNA of mediastinal LNs...
February 2015: Cancer Cytopathology
Brett Matthew Lowenthal, Sepi Mahooti
Endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) is a safe and minimally invasive bronchoscopic technique that allows both visualization and cytologic sampling with a high diagnostic yield in a patient with mediastinal lymphadenopathy. Besides the most common indication of staging for a patient with a primary lung carcinoma, EBUS-FNA can be used to identify benign infectious and noninfectious processes as well as lymphoma and malignancy of unknown primary. Triaging of procured specimen for diagnostic, prognostic, and therapeutic ancillary studies requires appropriate clinical information at the time of rapid on site evaluation (ROSE) of smears...
March 2015: Diagnostic Cytopathology
Jeff F Wang, Cletus Baidoo, Brian T Collins
OBJECTIVE: Endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) cytology and EBUS-miniforceps biopsy (MFB) have emerged as less invasive tools for evaluating mediastinal lymph nodes and pulmonary lesions. The aim of this study is to compare the diagnostic yields of EBUS-FNA cytology to EBUS-MFB. STUDY DESIGN: A retrospective cohort study was performed by reviewing the database at our institution between December 12, 2010, and August 10, 2012. A total of 476 consecutive cases were identified...
2014: Acta Cytologica
Cynthia L Harris, Eric M Toloza, Jason B Klapman, Shivakumar Vignesh, Kathryn Rodriguez, Frank J Kaszuba
BACKGROUND: Mediastinal staging in patients with non-small-cell lung cancer (NSCLC) is crucial in dictating surgical vs nonsurgical treatment. Cervical mediastinoscopy is the "gold standard" in mediastinal staging but is invasive and limited in assessing the posterior subcarinal, lower mediastinal, and hilar lymph nodes. Less invasive approaches to NSCLC staging have become more widely available. METHODS: This article reviews several of these techniques, including noninvasive mediastinal staging of NSCLC, endobronchial ultrasound (EBUS) and fine-needle aspiration (FNA), endoscopic ultrasound (EUS) and FNA, and the combination of EBUS/EUS...
January 2014: Cancer Control: Journal of the Moffitt Cancer Center
Arivarasan Karunamurthy, Guoping Cai, Sanja Dacic, Walid E Khalbuss, Liron Pantanowitz, Sara E Monaco
BACKGROUND: Endobronchial ultrasound-guided fine-needle aspiration (EBUS-FNA) is a minimally invasive modality for diagnosing mediastinal lesions. When determining adequacy, EBUS-FNAs are evaluated for diagnostic material or sufficient lymphoid tissue. In this study, the authors evaluated their experience with EBUS-FNAs and correlated the findings with adequacy and histologic follow-up. METHODS: EBUS-FNAs were retrospectively reviewed over a 3-year period and correlated with the clinicopathologic findings, adequacy, and histologic follow-up...
January 2014: Cancer Cytopathology
Enrique Vázquez-Sequeiros, Fernando González-Panizo-Tamargo, Ángel Barturen, Ángel Calderón, José Miguel Esteban, Gloria Fernández-Esparrach, Antonio Gimeno-García, Angels Ginés, José Lariño, Mercedes Pérez-Carreras, Rafael Romero, José Carlos Súbtil, Juan Vila
Lung cancer is one of the most frequent neoplasms in our environment, and represents the first cause of cancer related death in western countries. Diagnostic and therapeutic approach to these patients may be complicated, with endoscopic ultrasound guided fine needle aspiration (EUS-FNA), classically performed by gastroenterologists, playing a very important role. As this disease is not closely related to the "digestive tract", gastroenterologists have been forced to update their knowledge on this field o adequately diagnose this significant group of patients...
April 2013: Revista Española de Enfermedades Digestivas
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