Read by QxMD icon Read

Screening multiples

Yuyang Liu, Zhaoliang Li, Mao Pan
There are many heavy oil reservoirs in offshore oilfields in China. Steam and multiple thermal fluid stimulation technologies are of increasing interest and have been applied to an increasing number of projects. During the stimulation or displacement of heavy oil reservoirs during thermal recovery, several factors, such as reservoir heterogeneity, are prone to cause channeling phenomena and affect the thermal recovery effect of steam stimulation. According to the unique requirements for the stimulation of multiple thermal fluids for offshore heavy oil, this study used transmission, blocking and relieving, heat resistance and a comprehensive evaluation of parallel sand tube experiments to conduct a screening evaluation of plugging systems for the stimulation of multiple thermal fluids, screen out a commonly used plugging agent in the current stage and propose corresponding guidance for the selection basis...
2018: PloS One
Brian J Albanese, Richard J Macatee, Lauren A Stentz, Norman B Schmidt, Craig J Bryan
Growing research links Traumatic Brain Injury (TBI) with greater posttraumatic stress disorder (PTSD) symptoms. Much of this research has focused on the influence of the presence or severity of a single TBI while neglecting the potential cumulative effects of multiple TBIs incurred across an individual's lifetime on combat-related PTSD. The present study addressed this gap using a sample of 157 military service members and 4 civilian contractors who underwent structured TBI interviews at a military hospital in Iraq and completed the Combat Experiences Scale (CES) and Posttraumatic Checklist - Military (PCL-M)...
June 22, 2018: Cognitive Behaviour Therapy
Kyoichi Adachi, Takumi Notsu, Tomoko Mishiro, Hiroo Yoshikawa, Yoshikazu Kinoshita
AIM: The relationship of H. pylori infection with periodontitis was examined. METHODS: The study subjects were 686 individuals (males 504, females 182; mean age 53.8 years) who underwent a screening test for periodontitis between April 2015 and March 2018 and whose H. pylori infection status could be determined. The periodontitis test was performed by examining saliva concentrations of lactate dehydrogenase (LDH) and hemoglobin (Hb), with an LDH level ≥350 U/L and/or Hb level ≥2 μg/mL defined as positive for periodontitis...
June 22, 2018: Journal of Gastroenterology and Hepatology
Alexandra E Quimby, Diana Khalil, Stephanie Johnson-Obaseki
OBJECTIVE: Controversy exists regarding the surgical management of cutaneous melanoma and the optimal timing of reconstruction. One approach to ensuring an oncologically sound outcome is a two-stage procedure, with reconstruction delayed for negative permanent section margins. Alternatively, a single-stage excision with immediate reconstruction is advantageous because it limits both resource use and patient morbidity from multiple procedures. We sought to examine available published data on the oncologic outcomes associated with immediate versus delayed reconstruction of cutaneous melanoma in the head and neck region...
June 22, 2018: Laryngoscope
Jorge Arce-Molina, Ricardo Grau-Crespo, Dewi W Lewis, A Rabdel Ruiz-Salvador
We introduce a method to allow the screening of large configurational spaces of heteroatom distributions in zeotype materials. Based on interatomic potential calculations of configurations containing up to two heteroatoms per cell, we parameterize an atomistic effective Hamiltonian to describe the energy of multiple substitutions, with consideration of both short- and long-range interactions. Then, the effective Hamiltonian is used to explore the full configurational space at other compositions, allowing the identification of the most stable structures for further analysis...
June 22, 2018: Physical Chemistry Chemical Physics: PCCP
Minwon Seo, Jong-Mo Seo, Dong-Il Dan Cho, Kyoin Koo
In nature, arthropods have evolved to utilize a multiaperture vision system with a micro-optical structure which has advantages, such as compact size and wide-angle view, compared to that of a single-aperture vision system. In this paper, we present a multiaperture imaging system using a microlens array fabricated by a patterned-layer integrating soft lithography (PLISL) process which is based on a molding technique that can transfer three-dimensional structures and a gold screening layer simultaneously. The imaging system consists of a microlens array, a lens-adjusting jig, and a conventional (charge-coupled device) CCD image sensor...
June 22, 2018: Sensors
Mustafa Tosur, Susan M Geyer, Henry Rodriguez, Ingrid Libman, David A Baidal, Maria J Redondo
AIMS/HYPOTHESIS: We hypothesised that progression of islet autoimmunity and type 1 diabetes mellitus differs among races/ethnicities in at-risk individuals. METHODS: In this study, we analysed the data from the Type 1 Diabetes TrialNet Pathway to Prevention Study. We studied 4873 non-diabetic, autoantibody-positive relatives of individuals with type 1 diabetes followed prospectively (11% Hispanic, 80.9% non-Hispanic white [NHW], 2.9% non-Hispanic black [NHB] and 5...
June 21, 2018: Diabetologia
Xiang-Qun Chi, Long Wang, Ruoyu Guo, Dexi Zhao, Jia Li, Yongyu Zhang, Nianzhi Jiao
The protein coding genes (rbcL/cbbL/cbbM) for RuBisCO large subunit, the most abundant protein on earth that drives biological CO2 fixation, were considered as useful marker genes in characterizing CO2-assimilating plankton. However, their community specificity has hindered comprehensive screening of genetic diversity. In this study, six different rbcL/cbbL/cbbM primers were employed to screen clone libraries to identify CO2-assimilating plankton in Jiaozhou Bay. The following community compositions were observed: the community components in Form I A/B rbcL/cbbL clone library mainly comprised Chlorophyta and Proteobacteria, Form ID2 and ID3 libraries consisted of Bacillariophyta, Form II cbbM library consisted of Proteobacteria and Alveolata, and both Form I green and red libraries included Proteobacteria, respectively...
June 19, 2018: FEMS Microbiology Letters
Nilotpal Sanyal, Min-Tzu Lo, Karolina Kauppi, Srdjan Djurovic, Ole A Andreassen, Valen E Johnson, Chi-Hua Chen
Motivation: Multiple marker analysis of the genome-wide association study (GWAS) data has gained ample attention in recent years. However, because of the ultra high-dimensionality of GWAS data, such analysis is challenging. Frequently used penalized regression methods often lead to large number of false positives, whereas Bayesian methods are computationally very expensive. Motivated to ameliorate these issues simultaneously, we consider the novel approach of using nonlocal priors in an iterative variable selection framework...
June 19, 2018: Bioinformatics
Rahul Raj, Miikka Korja, Päivi Koroknay-Pál, Mika Niemelä
Background: Exogenous sex hormones may play a role in meningioma development and growth. Thus, transsexual patients being on long-standing hormone replacement therapy (HRT) may be at particular risk for meningioma development and growth. Here we present two cases of two male-to-female transsexual patients taking HRT for an extended period of time with both patients requiring surgical treatment at our institution due to multiple growing meningiomas. Case Description: The first patient was a 50-year-old genetic male (male-to-female transsexual) who presented 7 years after an extensive sex-change operation due to progressive bitemporal visual defects...
2018: Surgical Neurology International
James I Ausman, David S Liebeskind, Nestor Gonzalez, Jeffrey Saver, Neil Martin, J Pablo Villablanca, Paul Vespa, Gary Duckwiler, Reza Jahan, Tianyi Niu, Noriko Salamon, Bryan Yoo, Satoshi Tateshima, Manuel M Buitrago Blanco, Sidney Starkman
We have reviewed the English literature published in the last 70 years on Diseases of the Vertebral Basilar Circulation, or Posterior Circulation Disease (PCD). We have found that errors have been made in the conduct and interpretation of these studies that have led to incorrect approaches to the management of PCD. Because of the difficulty in evaluating the PC, the management of PCD has been incorrectly applied from anterior circulation disease (ACD) experience to PCD. PCD is a common form of stroke affecting 20-40% patients with stroke...
2018: Surgical Neurology International
Shira Dishon, Adi Schumacher, Joseph Fanous, Alaa Talhami, Ibrahim Kassis, Dimitrios Karussis, Chaim Gilon, Amnon Hoffman, Gabriel Nussbaum
MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that MyD88 plays a critical role in EAE, the murine model of multiple sclerosis, and showed that the MyD88 BB-loop decoy peptide RDVLPGT ameliorates EAE. We now designed and screened a library of backbone cyclized peptides based on the linear BB loop peptide, to identify a metabolically stable inhibitor of MyD88 that retains the binding properties of the linear peptide...
June 21, 2018: Scientific Reports
Lukasz Kowalski, Piotr Bragoszewski, Anton Khmelinskii, Edyta Glow, Michael Knop, Agnieszka Chacinska
BACKGROUND: The proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. Multiple lines of evidence indicate a significant contribution of the major cytosolic protein degradation machinery, the ubiquitin-proteasome system, to the quality control of mitochondrial proteins. Proteins that are directed to the mitochondrial intermembrane space (IMS) exemplify an entire class of mitochondrial proteins regulated by proteasomal degradation...
June 22, 2018: BMC Biology
Fujika Katsuki, Hiroshi Takeuchi, Takahiko Inagaki, Tohru Maeda, Yosuke Kubota, Nao Shiraishi, Hideaki Tabuse, Tadashi Kato, Atsurou Yamada, Norio Watanabe, Tatsuo Akechi, Toshiaki A Furukawa
BACKGROUND: Major depressive disorder (MDD) is a common and often chronic problem. Patients with chronic MDD often have negative impacts on the health of their families. Family psychoeducation is recognized as part of the optimal treatment for patients with psychotic disorder, and has been shown to reduce the rate of relapse in individuals with schizophrenia and to reduce the burden on their caregivers. Thus, we predict that family psychoeducation has the potential to reduce the burden on the caregivers of patients with chronic MDD...
June 22, 2018: BMC Psychiatry
Ori Wand, Oshrat E Tayer-Shifman, Shafik Khoury, Alon Y Hershko
INTRODUCTION: There are insufficient data on the aetiologic factors underlying splenic infarction (SI). Therefore, there is no consensus regarding the appropriate diagnostic approach. METHODS: We conducted a retrospective analysis of all patients admitted with SI from 1/2004 to 12/2014. Medical records were screened for the clinical presentation, underlying causes, associated medical conditions and methods of patient evaluation. RESULTS: We found 89 subjects with 90 episodes of SI...
June 21, 2018: Annals of Medicine
Ross Kent, Samantha Halliwell, Kate Young, Neil Swainston, Neil Dixon
The ability of RNA to sense, regulate and store information is an attractive attribute for a variety of functional applications including the development of regulatory control devices for synthetic biology. RNA folding and function is known to be highly context sensitive, which limits the modularity and reuse of RNA regulatory devices to control different heterologous sequences and genes. We explored the cause and effect of sequence context sensitivity for translational ON riboswitches located in the 5' UTR, by constructing and screening a library of N-terminal synonymous codon variants...
June 21, 2018: ACS Synthetic Biology
Roya Abolfazli, Shirin Pournourmohammadi, Ahmadreza Shamshiri, Sara Samadzadeh
Background: The aim of this study was to evaluate the safety, tolerability, and efficacy of a brand-generic glatiramer acetate product in patients with relapsing-remitting multiple sclerosis over a 12-month period. A noninterventional cohort study was conducted on 185 patients. The patients had a confirmed and documented diagnosis of relapsing-remitting multiple sclerosis as defined by the Revised McDonald Criteria (2010), were ambulatory with a Kurtzke Expanded Disability Status Scale score of 0 to 5...
2018: Current Therapeutic Research, Clinical and Experimental
Weiqing Li, Xugang Zhang, Zhitian Li, Fusheng Jiang, Hongwei Zhao, Bo Wei
The aim of the present study was to identify genes with similar function to that of matrix metalloproteinases (MMPs) in invasive lung adenocarcinoma (AC) and to screen the transcription factors that regulate MMPs. The gene expression dataset GSE2514, including 20 invasive lung AC samples and 19 adjacent normal lung samples, was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were screened using the limma package in R. Genes with similar function to MMPs were identified by K-means clustering...
July 2018: Oncology Letters
Alexander Kirpich, Elizabeth A Ainsworth, Jessica M Wedow, Jeremy R B Newman, George Michailidis, Lauren M McIntyre
In omics experiments, variable selection involves a large number of metabolites/ genes and a small number of samples (the n < p problem). The ultimate goal is often the identification of one, or a few features that are different among conditions- a biomarker. Complicating biomarker identification, the p variables often contain a correlation structure due to the biology of the experiment making identifying causal compounds from correlated compounds difficult. Additionally, there may be elements in the experimental design (blocks, batches) that introduce structure in the data...
2018: PloS One
Chanane Wanapirak, Wirawit Piyamomgkol, Supatra Sirichotiyakul, Fuanglada Tongprasert, Kasemsri Srisupundit, Suchaya Luewan, Kuntharee Traisrisilp, Phudit Jatavan, Theera Tongsong
OBJECTIVE: To determine the effectiveness of second-trimester maternal serum screening (MSS) for Down syndrome as a screening test for fetal hemoglobin (Hb) Bart's disease among an unselected population. METHODS: A secondary analysis of a large prospective database (20,254 pregnancies) was conducted to compare the levels of MSS, alpha-fetoprotein (AFP), free beta-human chorionic gonadotropin (hCG) and unconjugated estriol (uE3) between pregnancies with Hb Bart's disease and unaffected pregnancies...
June 21, 2018: Prenatal Diagnosis
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"