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https://www.readbyqxmd.com/read/29141531/statins-in-aortic-disease
#1
Vicky Tsigkou, Gerasimos Siasos, Eva Mpletsa, Maria-Paraskevi Panoilia, Aggeliki Papastavrou, Giorgos Kokosias, Evangelos Oikonomou, Marina Zaromitidou, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
BACKGROUND: Numerous studies indicate that statins have also multiple beneficial actions (known as 'pleiotropic actions') on cardiovascular system through the improvement of endothelial dysfunction, inflammation, oxidative stress, increased arterial thrombosis, and the stabilization of the atherosclerotic plaque. Aortic disease primarily consists of aortic valve stenosis, aortic valve regurgitation, aneurysm disease, and genetic disorders such as Marfan syndrome, bicuspid aortic valve and aortic coarctation...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29129841/genetic-risk-assessment-of-elastin-gene-polymorphisms-with-intracranial-aneurysm-in-koreans
#2
Jin Pyeong Jeon, Eun Pyo Hong, Jeong Eun Kim, Eun Jin Ha, Won-Sang Cho, Young-Je Son, Jae Seung Bang, Chang Wan Oh
Elastin encoded by elastin gene (ELN) is a crucial extracellular matrix protein responsible for arterial resilience. The objective of this study was to identify single nucleotide polymorphisms (SNPs) of ELN gene susceptible to intracranial aneurysm (IA) in Korean population. Two SNPs of ELN gene, rs2071307 (Gly422Ser) and rs2856728 (intron), were genotyped in 90 patients with IA and 90 age and frequency matched controls. Fisher's exact test was conducted to evaluate allelic association with IA. Of the two SNPs in ELN gene, T allele of rs2856728 (intron) showed statistically significant association with increased development of IA (odds ratio [OR]: 2...
November 10, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29126538/recurrent-pulmonary-aneurysms-hughes-stovin-syndrome-on-the-spectrum-of-beh%C3%A3-et-disease
#3
Sami M Bennji, Leonard du Preez, Stephanie Griffith-Richards, Derrick P Smit, Jonathan Rigby, Coenraad F N Koegelenberg, Elvis M Irusen, Brian W Allwood
In this report, we describe a male patient who presented with recurrent life-threatening hemoptysis due to the sequential formation of multiple pulmonary aneurysms. Both pulmonary artery coil embolization and right lower lobectomy were performed, with limited success. The patient experienced extensive bilateral femoral DVT extending into the inferior vena cava, with massive hemoptysis, fulfilling the diagnosis of Hughes-Stovin syndrome. A final diagnosis of Behçet disease was made following extensive investigation, and the patient responded well to prednisone 20 mg orally and azathioprine 100 mg orally...
November 2017: Chest
https://www.readbyqxmd.com/read/29122467/socioeconomic-disadvantage-is-associated-with-a-higher-incidence-of-aneurysmal-subarachnoid-hemorrhage
#4
Linda Nichols, Christine Stirling, Petr Otahal, Jim Stankovich, Seana Gall
BACKGROUND AND PURPOSE: Aneurysmal subarachnoid hemorrhage (aSAH) incidence is not well studied. Varied definitions of "subarachnoid hemorrhage" have led to a lack of clarity regarding aSAH incidence. The impact of area-level socioeconomic disadvantage and geographical location on the incidence of aSAH also remains unclear. Using a population-based statewide study, we examined the incidence of aSAH in relation to socioeconomic disadvantage and geographical location. METHODS: A retrospective cohort study of nontraumatic subarachnoid hemorrhages from 2010 to 2014 was undertaken...
November 6, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29119025/parachute-like-mitral-valve-tuberculoma-a-rare-presentation
#5
Arslan Masood, Gul Zaman Khan, Irfan Bashir, Zubair Akram
There have been anecdotal reports of tuberculous cardiac involvement, mainly in cases of military tuberculosis or immune deficient individuals. The spectrum of clinical presentations of tuberculous cardiac involvements includes incidental detection of single and multiple well-circumscribed tuberculomas, symptomatic obstructive lesions, AV conduction abnormalities, and even sudden death. We present a case of cardiac tuberculoma in an immune-competent person who presented with worsening dyspnea. The unique morphology of this mass posed an imaging challenge that required 4-dimensional (4D) echocardiography and cardiac magnetic resonance (CMR) detail to differentiate the mass from an anterior mitral leaflet (AML) aneurysm...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29118800/septoplasty-scepter-balloon-angioplasty-for-vasospasm-after-aneurysmal-subarachnoid-hemorrhage
#6
Bradley A Gross, Daniel A Tonetti, Gregory M Weiner, David M Panczykowski, William J Ares, Cynthia L Kenmuir, Ashutosh P Jadhav, Tudor G Jovin, Brian T Jankowitz
Introduction: Balloon angioplasty can be a requisite approach for the treatment of symptomatic and/or severe vasospasm. Dual-lumen microcatheter balloons have multiple potential advantages for this indication including accommodating a 0.014-inch wire and the potential to deliver superselective vasodilators directly via the microcatheter prior to angioplasty. Methods: The authors reviewed a 3-year institutional experience with the Scepter XC balloon (Microvention, Tustin, CA, USA) in the treatment of postaneurysmal subarachnoid hemorrhage vasospasm, focusing on treatment methods, angiographic, and clinical results...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29117659/combined-treatment-of-ruptured-middle-cerebral-artery-aneurysm-followed-by-subarachnoid-hemorrhage-and-acute-subdural-hematoma-in-multiple-aneurysm-disease-of-cerebral-blood-vessels-case-report
#7
Nenad Novaković, Milan Lepić, Ljubodrag Minić, Ksenija Radenović, Ante Rotim, Lukas Amin
Aneurysms of blood vessels at the base of the brain are pathological focal out-pouchings, usually found at the branching points of the arteries. Aneurysm can remain silent for life. Clinical presentation is due to rupture and bleeding. In only 1.3% of cases it results in subdural hematoma, which is associated with direct interaction of the aneurysm with the basal arachnoid membrane. Multiple aneurysms are present in 15% to 33% of cases with subarachnoid hemorrhage. Assessment of these patients is more complicated, as there are no specific signs to pinpoint/detect the aneurysm that has ruptured...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29112665/long-term-risk-of-a-seizure-disorder-after-eclampsia
#8
Kara A Nerenberg, Alison L Park, Simone N Vigod, Gustavo Saposnik, Howard Berger, Michelle A Hladunewich, Shital Gandhi, Candice K Silversides, Joel G Ray
OBJECTIVE: To evaluate the incidence rate and relative risk of a seizure disorder after eclampsia. METHODS: We evaluated 1,565,733 births in a retrospective data linkage cohort study in Ontario, Canada, from April 1, 2002, to March 31, 2014. We included females aged 15-50 years and excluded patients with epilepsy, conditions predisposing to seizure, and those who died within 30 days of the delivery discharge date. The exposure was defined as a hypertensive disorder of pregnancy, namely 1) eclampsia, 2) preeclampsia, or 3) gestational hypertension...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29111330/imaging-mass-spectroscopy-delineates-the-thinned-and-thickened-walls-of-intracranial-aneurysms
#9
Taichi Ikedo, Manabu Minami, Hiroharu Kataoka, Kosuke Hayashi, Manabu Nagata, Risako Fujikawa, Fumiyoshi Yamazaki, Mitsutoshi Setou, Masayuki Yokode, Susumu Miyamoto
OBJECT: The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular diseases. To investigate the feature of phospholipid composition of IA walls, we conducted IMS in a rat model of experimentally induced IA. MATERIAL AND METHODS: IAs were surgically induced in 7-week-old male rats and analyzed by IMS in negative-ion mode...
October 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29111185/morphological-characteristics-associated-with-rupture-risk-of-multiple-intracranial-aneurysms
#10
Guang-Xian Wang, Lan-Lan Liu, Li Wen, Yun-Xing Cao, Yu-Chun Pei, Dong Zhang
OBJECTIVE: To identify the morphological parameters that are related to intracranial aneurysms (IAs) rupture using a case-control model. METHODS: A total of 107 patients with multiple IAs and aneurysmal subarachnoid hemorrhage between August 2011 and February 2017 were enrolled in this study. Characteristics of IAs location, shape, neck width, perpendicular height, depth, maximum size, flow angle, parent vessel diameter (PVD), aspect ratio (AR) and size ratio (SR) were evaluated using CT angiography...
October 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29107163/exome-sequencing-identifies-loxl2-mutation-as-a-cause-of-familial-intracranial-aneurysm
#11
YaQiu Wu, Zhili Li, Yi Shi, Longyi Chen, Haibin Tan, Zhenyu Wang, Cheng Yin, Ling Liu, Junting Hu
BACKGROUND: Genetic risk factors can contribute to the etiology of intracranial aneurysms (IAs) and the genetic predisposition of IAs is largely unknown. Our study is aimed to explore the role of rare variation in IA susceptibility. METHODS: Whole exome sequencing (WES) was performed in a representative family with history of multiple cases of IAs. WES variants were prioritized by various filtering strategies, including frequency, predicted pathogenicity and functional prediction...
October 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29103932/incidence-and-prognostic-factors-related-to-major-adverse-cerebrovascular-events-in-patients-with-complex-aortic-diseases-treated-by-the-chimney-technique
#12
Michel J Bosiers, Kenneth Tran, Jason T Lee, Konstantinos P Donas, Frank J Veith, Giovanni Torsello, Felice Pecoraro, Konstantinos Stavroulakis
OBJECTIVE: Endovascular aneurysm repair (EVAR) with the chimney technique (ch-EVAR) has been used for the treatment of aortic aneurysms as an alternative approach to fenestrated endografting or open repair. Nonetheless, the need for an upper extremity arterial access may contribute to a higher risk for periprocedural cerebrovascular events. This study reports on the perioperative cerebral and major adverse cardiac and cerebrovascular events (MACCE) after ch-EVAR. METHODS: The PERICLES registry (PERformance of the chImney technique for the treatment of Complex aortic pathoLogiES) is an international, retrospective multicenter study evaluating the performance of ch-EVAR for the treatment of complex aortic pathologies...
November 2, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29103480/risk-factors-analysis-of-mirror-aneurysms-a-multi-center-retrospective-study-based-on-clinical-and-demographic-profile-of-patients
#13
Zhong-Qing Huang, Xin-Wei Zhou, Zhong-Jun Hou, Sui-Qiao Huang, Zhi-Hua Meng, Xian-Long Wang, Hao Yu, Lv-Jin Feng, Qiu-Jing Wang, Ping-An Li, Zhi-Bo Wen
As a special subgroup of multiple intracranial aneurysms, mirror aneurysms are located bilaterally on the corresponding intracranial arteries. The current study sought to compare the clinical and demographic features of patients harboring mirror aneurysm, and to elucidate the corresponding risk factors. We performed a retrospective cohort study of 2641 intracranial aneurysms patients, who were admitted to our hospitals between January 2005 and June 2014. Patients were subdivided into three groups based on the inclusion criteria: (i) single (n=2250); (ii) non-mirror multiple (n=285); and (iii) mirror aneurysms (n=106)...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29101897/estimation-of-in-vivo-mechanical-properties-of-the-aortic-wall-a-multi-resolution-direct-search-approach
#14
Minliang Liu, Liang Liang, Wei Sun
The patient-specific biomechanical analysis of the aorta requires in vivo mechanical properties of individual patients. Existing approaches for estimating in vivo material properties often demand high computational cost and mesh correspondence of the aortic wall between different cardiac phases. In this paper, we propose a novel multi-resolution direct search (MRDS) approach for estimation of the nonlinear, anisotropic constitutive parameters of the aortic wall. Based on the finite element (FE) updating scheme, the MRDS approach consists of the following three steps: (1) representing constitutive parameters with multiple resolutions using principal component analysis (PCA), (2) building links between the discretized PCA spaces at different resolutions, and (3) searching the PCA spaces in a 'coarse to fine' fashion following the links...
October 20, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29100674/size-and-location-correlations-with-higher-rupture-risk-of-intracranial-aneurysms
#15
Cezary Grochowski, Jakub Litak, Bartłomiej Kulesza, Paweł Szmygin, Dominik Ziemianek, Piotr Kamieniak, Dariusz Szczepanek, Radosław Rola, Tomasz Trojanowski
AIM: The purpose of this study was to investigate the impact of size and location of the intracranial aneurysm on rupture probability. MATERIAL AND METHODS: 265 patients with diagnosis of intracranial aneurysms were admitted to the department from January 2012 to December 2013. The characteristic of aneurysm, such as median size, location, single and multiple aneurysms and presentation were retrospectively reviewed using cerebral angiography reports. RESULTS: There were 265 patients admitted with the diagnosis of intracranial aneurysms, 193 with single and 72 with multiple aneurysms...
October 31, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29100509/correction-to-robot-assisted-laparoscopic-reconstructed-management-of-multiple-aneurysms-in-renal-artery-primary-bifurcations-a-case-report-and-literature-review
#16
Hai-Bin Wei, Xiao-Long Qi, Feng Liu, Jie Wang, Xiao-Feng Ni, Qi Zhang, En-Hui Li, Xuan-Yu Chen, Da-Hong Zhang
After publication of this work [1] it was noticed the author - Jie Wang's name was in the wrong order. The original article was corrected. The publisher apologises for this error.
November 3, 2017: BMC Urology
https://www.readbyqxmd.com/read/29097416/hemodynamic-changes-caused-by-multiple-stenting-in-vertebral-artery-fusiform-aneurysms-a-patient-specific-computational-fluid-dynamics-study
#17
N Lv, W Cao, I Larrabide, C Karmonik, D Zhu, J Liu, Q Huang, Y Fang
BACKGROUND AND PURPOSE: The multiple stent placement technique has largely improved the long-term outcomes of intracranial fusiform aneurysms, but the hemodynamic mechanisms remain unclear. In this study, we analyzed the hemodynamic changes caused by different stent-placement strategies in patient-specific models using the computational fluid dynamics technique, aiming to provide evidence for clinical decision-making. MATERIALS AND METHODS: Ten vertebral artery fusiform aneurysms were included, and their patient-specific computational fluid dynamics models were reconstructed...
November 2, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29091248/multiple-intracranial-aneurysms-concurrent-with-a-clinoid-meningioma-a-case-report
#18
Xiangyang Zhou, Zhengbin Din, Hong Liu, Yimin Li
The coexistence of intracranial aneurysms and a meningioma is not a clinically common phenomenon. Here we present the case of a meningioma of the left anterior clinoid process concurrent with a right clinoid aneurysm and a ruptured aneurysm of the left post communicating artery (PcomA). Immediately after radiographically establishing a diagnosis of multiple aneurysms and to reduce the risk of rebleeding, we performed a microscopic surgery to clip the aneurysms using a left frontotemporal approach. During the surgery, an unexpected clinoid meningioma was detected and simultaneously resected...
September 20, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29076891/a-review-of-current-management-of-vasculo-behcet-s
#19
Mira Merashli, Rozana El Eid, Imad Uthman
PURPOSE OF REVIEW: To give an overview of recently published articles about the management of vasculo-Behcet's with particular emphasis on anticoagulation. RECENT FINDINGS: Biologic agents are emerging as a potential therapeutic option in refractory vasculo-Behcet with a good safety profile. Evidence further shows that following nonpulmonary aneurysm repair, there is a reduced risk of recurrent aneurysmal formation at the operative site in patients treated with immunosuppressants in addition to their surgery, than those undergoing surgical intervention alone...
October 25, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29062224/idiopathic-retinal-vasculitis-aneurysms-and-neuroretinitis-irvan-syndrome-clinical-perspectives
#20
REVIEW
Priya Bajgai, Deeksha Katoch, Mangat Ram Dogra, Ramandeep Singh
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome typically affects young, healthy individuals. Despite the dramatic fundus appearance seen in this syndrome, these patients are usually asymptomatic. The syndrome includes peculiar vascular abnormalities in the form of multiple aneurysmal dilatations seen along retinal arterioles and optic nerve-head arterioles, which are best appreciated on fluorescein angiography. Neuroretinitis and retinal vasculitis are seen in all patients, and manifested by staining of the optic nerve head and diffuse leakage from vessels, mainly arterioles, on fluorescein angiography...
2017: Clinical Ophthalmology
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