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Chiaki Yoshioka, Yoshimasa Ito, Noriaki Nagai
Cilostazol (CLZ), an anti-platelet agent, is primarily used following the onset of cerebral infarction. However, as CLZ is only marginally soluble in water, a strategy for patients with serious secondary conditions, such as impaired consciousness or aphagia, is required. In the present study, topical formulations containing CLZ nanocrystals (CLZnano ) were designed to enhance percutaneous absorption. In addition, the mechanism of penetration of CLZnano through rat skin was investigated. A topical formulation containing CLZ nanoparticles (CLZnano gel patch) was prepared using a combination of recrystallization and ball milling of an aqueous gel...
April 2018: Experimental and Therapeutic Medicine
S Mantziari, C Mariette, G Piessen
A Zenker's or pharyngoesophageal diverticulum may represent a rare cause of upper digestive obstruction, or more often, cervical dysphagia, regurgitations and cough. It develops most often on the posterior left side of cervical oesophagus in elderly patients, and depending on the severity of clinical symptoms may warrant surgical or endoscopic treatment. For large lesions with a difficult endoscopic access to the diverticular neck, surgery is recommended. In our case, we illustrate a giant right-sided Zenker's diverticulum responsible for complete aphagia in a 78-year-old male patient...
February 23, 2018: Journal of Visceral Surgery
Narin N Carmel-Neiderman, Boaz Sagi, Daniel Zikk, Yael Oestreicher-Kedem
No abstract text is available yet for this article.
May 2017: Israel Medical Association Journal: IMAJ
Kazuaki Nagashima, Natsumi Furuta, Kouki Makioka, Yukio Fujita, Masaki Ikeda, Yoshio Ikeda
A percutaneous endoscopic gastrostomy (PEG) is an useful intervention for feeding of amyotrophic lateral sclerosis (ALS) patients who have lost oral intake function. The aim of this study was to investigate the risk factors for early death and the survival after PEG placement. A total of 102 ALS patients who underwent PEG placement were enrolled in this study. Patients were divided into two groups; the poor prognosis group included patients who died or needed permanent mechanical ventilation within 30days after PEG placement, and the good prognosis group included patients who did not meet the criteria of the poor prognosis group...
May 15, 2017: Journal of the Neurological Sciences
Dennis Y Kim, Joanna Yu, Ryan K Mui, Rieko Niibori, Hamza Bin Taufique, Rukhsana Aslam, John W Semple, Sabine P Cordes
Severe appetite and weight loss define the eating disorder anorexia nervosa, and can also accompany the progression of some neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS). Although acute loss of hypothalamic neurons that produce appetite-stimulating neuropeptide Y (Npy) and agouti-related peptide (Agrp) in adult mice or in mice homozygous for the anorexia (anx) mutation causes aphagia, our understanding of the factors that help maintain appetite regulatory circuitry is limited. Here we identify a mutation (C19T) that converts an arginine to a tryptophan (R7W) in the TYRO3 protein tyrosine kinase 3 (Tyro3) gene, which resides within the anx critical interval, as contributing to the severity of anx phenotypes...
May 1, 2017: Disease Models & Mechanisms
Elena Bresciani, Laura Rizzi, Laura Molteni, Monica Ravelli, Antonella Liantonio, Khoubaib Ben Haj Salah, Jean-Alain Fehrentz, Jean Martinez, Robert J Omeljaniuk, Giuseppe Biagini, Vittorio Locatelli, Antonio Torsello
Oncologic patients subjected to chemotherapy frequently present aphagia, malnutrition, and cachexia. The purpose of this study was to investigate whether selected growth hormone secretagogues including hexarelin, JMV2894 and JMV2951 could antagonize body weight loss and wasting induced by cisplatin administration in rats. The three growth hormone secretagogues behaved as full agonists of the growth hormone secretagogues receptor both in terms of ability to stimulate calcium mobilization in Chinese hamster ovary cells and stimulation of growth hormone release in neonatal rats...
October 2017: Endocrine
A Podboy, D Sunjaya, T C Smyrk, J A Murray, M Binder, D A Katzka, J A Alexander, M Halland
BACKGROUND: Oesophageal lichen planus is an idiopathic inflammatory disorder characterized by significant oesophageal stricturing. Oesophageal lichen planus is a rare, difficult to diagnose, and likely an under recognized disease. As a result, there is no standardized approach to therapy and treatment strategies vary. AIM: To examine the utility of topical steroid therapy (fluticasone or budesonide) in the management of oesophageal lichen planus. METHODS: A retrospective chart review was conducted of patients diagnosed with oesophageal lichen planus who underwent baseline and follow up endoscopy pre and post topical steroid therapy between 1995 and 2016 at Mayo Clinic, Rochester MN...
January 2017: Alimentary Pharmacology & Therapeutics
Mihir S Wagh, Peter V Draganov
BACKGROUND AND AIMS: Total aphagia from complete esophageal obstruction (CEO) can be seen in patients with head-neck or thoracic malignancies undergoing chemoradiation or surgery. Combined antegrade and retrograde endoscopy (via gastrostomy tube [G-tube] tract) is often performed for esophageal reconstruction but is limited by the length of the obstructed esophagus. We describe per-oral endoscopic tunneling for restoration of the esophagus (POETRE) for patients with longer segments of esophageal obstruction...
April 2017: Gastrointestinal Endoscopy
G Desuter, V Van Parijs, Q Gardiner
We present the case of a 79 year-old patient with megaesophagus and aphagia, who required percutaneous endoscopic gastrostomy (PEG) feeding. Megaesophagus was considered the sole cause of aphagia by the referring secondary hospital. Solid state sensor videofluoromanometry (VFM) showed a substantial decrease in manometric values within the hypopharynx along with good relaxation of the upper-esophageal sphincter (UES). This led to electromyography (EMG), which showed features compatible with the diagnosis of Myasthenia Gravis (MG)...
2015: B-ENT
John P Kostrzewa, Rose Anna Kostrzewa, Richard M Kostrzewa, Ryszard Brus, Przemysław Nowak
The classic rodent model of Parkinson's disease (PD) is produced by unilateral lesioning of pars compacta substantia nigra (SNpc) in adult rats, producing unilateral motor deficits which can be assessed by dopamine (DA) D2 receptor (D2-R) agonist induction of measurable unilateral rotations. Bilateral SNpc lesions in adult rats produce life-threatening aphagia, adipsia, and severe motor disability resembling paralysis-a PD model that is so compromised that it is seldom used. Described in this paper is a PD rodent model in which there is bilateral 99 % loss of striatal dopaminergic innervation, produced by bilateral intracerebroventricular or intracisternal 6-hydroxydopamine (6-OHDA) administration to perinatal rats...
October 17, 2015: Current Topics in Behavioral Neurosciences
Farzan F Bahin, Mahesh Jayanna, Stephen J Williams, Eric Y T Lee, Michael J Bourke
BACKGROUND AND AIMS: Complete endoscopic resection (CER) of short-segment Barrett's esophagus with high grade dysplasia (HGD) and early esophageal adenocarcinoma (EEA) is a precise staging tool and achieves durable disease control. The major drawback is development of post-endoscopic resection esophageal stricture (PERES). No effective therapy to prevent PERES has been described. Viscous budesonide slurry (VBS) may have a role in the prevention of PERES by suppressing the post-CER inflammatory process...
January 2016: Endoscopy
J Riancho, Y Jiménez-López, E Marco-de Lucas, J Berciano
No abstract text is available yet for this article.
December 2015: Revista Clínica Española
Babita Gupta, Sarita Ramchandani, Ira Balakrishnan, Atin Kumar
Subarachnoid block with local anaesthetic agent and opiod as an adjuvant is a well-known technique with a good record of safety. However, some rare neurological complications like aphonia, dysphagia and tingling sensation have been reported following their administration in pregnant females posted for labour analgesia or caesarean section. We report a case of transient aphonia, aphagia and facial tingling following intrathecal administration of bupivacaine along with fentanyl for lower limb wound debridement in a male patient...
January 2014: Anesthesia, Essays and Researches
Yuki Takeda, Noritaka Wakui, Yasutsugu Asai, Nobuhiro Dan, Yoshiya Yamauchi, Nobuo Ueki, Takafumi Otsuka, Nobuyuki Oba, Shuta Nishinakagawa, Masami Minagawa, Yasushi Takeda, Saori Shiono, Tatsuya Kojima
The present study reports the case of a 68-year-old male patient who presented to Tokyo Rosai Hospital for the treatment of alcoholic liver disease. A high density was observed in liver segment S2, while a tumor, 30 mm in size, exhibiting a low density was observed in the delayed phase upon contrast-enhanced computed tomography (CT), which was performed prior to admission. The tumor appeared slightly poorly defined upon abdominal ultrasound and was observed as a 30 mm low-echoic nodule that was internally heterogeneous...
April 2015: Oncology Letters
V M Kartsev
In general, there are no drastic differences in phenoptosis patterns in plant and animal organisms. However, there are some specific features characteristic for insects and other arthropods: 1) their development includes metamorphosis with different biochemical laws at consecutive developmental stages; 2) arthropods can reduce or stop development and aging when in a state of diapause or temporal cold immobility; 3) their life cycle often correlates with seasonal changes of surroundings; 4) polymorphism is widespread - conspecifics differ by their lifespans and phenoptosis features; 5) lifespan-related sexual dimorphism is common; 6) significant situational plasticity of life cycle organization is an important feature; for example, the German wasp (Paravespula germanica) is obligatorily univoltine in the temperate zone, while in tropical regions its lifespan increases and leads to repeated reproduction; 7) life cycles of closely related species may differ significantly, for example, in contrast to German wasp, some tropical hornets (Vespa) have only one reproduction period...
October 2014: Biochemistry. Biokhimii︠a︡
Yu-Ichi Aoyama, Shinsuke Ohta, Saburou Sakaki, Shigeru Nishizawa, Toyohisa Fujita
A 51 year old male was admitted to our hospital with sudden consciousness disturbance, global aphagia and right hemiparesis. Magnetic resonance imaging (MRI) revealed fresh infarctions in the territory of the left middle cerebral artery, and MR angiography (MRA) showed occlusion of the left carotid artery and the left middle cerebral artery. We started conservative therapy, including antiplatelet drug and blood pressure control. Three days later, cervical MRA revealed hematoma in the intracranial carotid wall of the petrous portion, leading to a diagnosis of spontaneous intracranial carotid artery dissection of the petrous portion...
December 1, 2014: Journal of UOEH
José Ruiz Pardo, Luisa F Martínez de Haro, Angeles Ortiz Escandell, Vicente Munitiz Ruiz
No abstract text is available yet for this article.
January 2015: Cirugía Española
Amir Dagan, Doron Markovits, Yolanda Braun-Moscovici, Alexander Rozin, Kohava Toledano, Alexandra Balbir-Gurman
No abstract text is available yet for this article.
August 2013: Israel Medical Association Journal: IMAJ
Murat Cakir, Esin Celik, Fatma Betul Tuncer, Ahmet Tekin
Diseases of the thyroid gland are frequently seen in general practice. Lymphoma of the thyroid is one of the rarest tumors. Its coexistence with papillary thyroid carcinoma is even rarer. Here, we present a 50-year-old female patient, who presented to our clinic with complaints of a rapidly growing lump on her neck, aphagia, and shortness of breath. A total thyroidectomy was performed. Histopathological analysis revealed the concomitant existence of papillary tumor. It should be noted that tumors with different histopathological behavior may rarely coexist with lymphoma in the thyroid gland...
July 2013: Annals of African Medicine
Qi Wu, Ruimao Zheng, Dollada Srisai, G Stanley McKnight, Richard D Palmiter
Diphtheria toxin-mediated, acute ablation of hypothalamic neurons expressing agouti-related protein (AgRP) in adult mice leads to anorexia and starvation within 7 d that is caused by hyperactivity of neurons within the parabrachial nucleus (PBN). Because NMDA glutamate receptors are involved in various synaptic plasticity-based behavioral modifications, we hypothesized that modulation of the NR2A and NR2B subunits of the NMDA receptor in PBN neurons could contribute to the anorexia phenotype. We observed by Western blot analyses that ablation of AgRP neurons results in enhanced expression of NR2B along with a modest suppression of NR2A...
September 3, 2013: Proceedings of the National Academy of Sciences of the United States of America
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