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frailty and comorbidity

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https://www.readbyqxmd.com/read/29158063/frailty-and-the-quality-of-life-in-hemodialysis-patients-the-importance-of-waist-circumference
#1
Nazanin Noori, Arti Sharma Parpia, Rajiv Lakhani, Sabrina Janes, Marc B Goldstein
OBJECTIVE: Frailty among the end-stage renal disease (ESRD) population is highly prevalent and has been associated with mortality. Little is known about the relation of different aspects of body composition, a modifiable risk factor, with the risk of frailty in ESRD population. DESIGN AND METHODS: One hundred and fifty-one patients including 85 men and 66 women, aged ≥18 years with ESRD who had been receiving conventional maintenance hemodialysis (HD) for at least 3 months were included...
November 18, 2017: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29153753/an-easy-assessment-of-frailty-at-baseline-independently-predicts-prognosis-in-very-elderly-patients-with-acute-coronary-syndromes
#2
Oriol Alegre, Francesc Formiga, Ramón López-Palop, Francisco Marín, María T Vidán, Manuel Martínez-Sellés, Antoni Carol, Alessandro Sionis, Pablo Díez-Villanueva, Jaime Aboal, Anna Palau-Vendrel, Héctor Bueno, Angel Perez Rivera, Juan Sanchís, Emad Abu-Assi, Miguel Corbí, Juan C Castillo, Jordi Bañeras, Violeta González-Salvado, Àngel Cequier, Albert Ariza-Solé
BACKGROUND: Information about the impact of frailty in patients with acute coronary syndromes (ACS) is scarce. No study has assessed the prognostic impact of frailty as measured by the FRAIL scale in very elderly patients with ACS. METHODS: The prospective multicenter LONGEVO-SCA registry included unselected patients with ACS aged 80 years or older. A comprehensive geriatric assessment was performed during hospitalization, including frailty assessment by the FRAIL scale...
November 16, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29153536/frailty-in-hospitalized-older-adults-comparing-different-frailty-measures-in-predicting-short-and-long-term-patient-outcomes
#3
Edward Chong, Esther Ho, Jewel Baldevarona-Llego, Mark Chan, Lynn Wu, Laura Tay, Yew Yoong Ding, Wee Shiong Lim
OBJECTIVES: Data for the assessment of frailty in acutely ill hospitalized older adults remains limited. Using the Frailty Index (FI) as "gold standard," we compared (1) the diagnostic performance of 3 frailty measures (FRAIL, Clinical Frailty Scale [CFS], and Tilburg Frailty Indicator [TFI]) in identifying frailty, and (2) their ability to predict negative outcomes at 12 months after enrollment. DESIGN: Prospective cohort study. PARTICIPANTS: We recruited 210 patients (mean age 89...
November 15, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29150094/-geriatric-assessment-and-prognostic-scores-in-older-cancer-patient-additional-support-to-the-therapeutic-decision
#4
REVIEW
Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Mathilde Gisselbrecht, Stéphane Herbaud, Pascaline Boudou-Rouquette, Laurent Zelek, Elena Paillaud
Cancer is a disease of the elderly as demonstrated by the epidemiological evolution of Western countries. Indeed, two third of cancers newly diagnosed occur over 65 years. However, older cancer patients have been often excluded from clinical trials in oncology and the extrapolation of cancer treatments in this population remains difficult in practice. Scientific societies recommend that a comprehensive geriatric assessment (CGA) be performed in patients aged 70 and over and selected using screening tools for frailty such as the G8 index...
November 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29149866/prevalence-and-risk-factors-of-frailty-among-home-care-clients
#5
Minna Miettinen, Miia Tiihonen, Sirpa Hartikainen, Irma Nykänen
BACKGROUND: Frailty is a common problem among older people and it is associated with an increased risk of death and long-term institutional care. Early identification of frailty is necessary to prevent a further decline in the health status of home care clients. The aims of the present study were to determine the prevalence of frailty and associated factors among 75-year-old or older home care clients. METHODS: The study participants were 75-year-old or older home care clients living in three cities in Eastern and Central Finland...
November 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29142985/low-urinary-creatinine-excretion-is-associated-with-self-reported-frailty-in-patients-with-advanced-chronic-kidney-disease
#6
Harmke A Polinder-Bos, Hakan Nacak, Friedo W Dekker, Stephan J L Bakker, Carlo A J M Gaillard, Ron T Gansevoort
Introduction: Frailty and muscle wasting, a component of frailty, are common in advanced stage chronic kidney disease (CKD). Whether frailty is associated with low urinary creatinine excretion (UCrE) as a measure of muscle mass in this population is unknown. Furthermore, reference values of UCrE are lacking. We first defined low UCrE and studied correlates of low UCrE, and subsequently studied cross-sectional associations of frailty with low UCrE in patients with advanced CKD. Methods: A total of 2748 healthy individuals of the general population-based PREVEND study were included to define low UCrE (UCrE indexed for height, below the age- and sex-specific 5th percentile of the distribution)...
July 2017: KI Reports
https://www.readbyqxmd.com/read/29140924/the-association-between-pain-and-frailty-among-chinese-community-dwelling-older-adults-depression-as-a-mediator-and-its-interaction-with-pain
#7
Xiaoyu Tian, Cuili Wang, Xiaoxia Qiao, Na Liu, Lijuan Dong, Mary Butler, Huaxin Si, Yaru Jin
Pain and frailty are both prevalent and have severe health impacts among older adults. We conducted a cross-sectional observational study to examine the association between pain and frailty, and depression as a mediator and its interaction with pain on frailty among 1788 Chinese community-dwelling older adults. Physical frailty, pain intensity and depressive symptoms were assessed using the Frailty Phenotype, the revised Faces Pain Scale (FPS-R), and the 5-item Geriatric Depression Scale (GDS-5), respectively...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29129389/adjuvant-therapy-in-patients-with-clear-cell-endometrial-carcinoma-an-analysis-of-the-national-cancer-database
#8
Karina Nieto, William Adams, Nghia Pham, Alec M Block, Surbhi Grover, William Small, Matthew M Harkenrider
OBJECTIVE: To assess the impact of adjuvant treatment, sociodemographic and tumor factors on the survival of patients with non-metastatic clear cell endometrial carcinoma (CCC). METHODS: 4298 patients treated from 1998 to 2011 with Stage I-IVA CCC were identified within the National Cancer Database. FIGO 2009 staging system was used. Adjuvant groups included: hysterectomy (HYS); HYS+vaginal brachytherapy (VBT); HYS+chemotherapy (CT); HYS+external beam radiation therapy (EBRT); HYS+CT+EBRT; and HYS+CT+VBT...
November 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29128413/association-of-citizenship-status-with-kidney-transplantation-in-medicaid-patients
#9
Jenny I Shen, Daniel Hercz, Lilly M Barba, Holly Wilhalme, Erik L Lum, Edmund Huang, Uttam Reddy, Leslie Salas, Sitaram Vangala, Keith C Norris
BACKGROUND: Although individuals classified as nonresident aliens, including undocumented immigrants, are entitled to receive emergency dialysis in the United States regardless of their ability to pay, most states do not provide them with subsidized care for maintenance dialysis or kidney transplantation. We explored whether nonresident aliens have similar outcomes to US citizens after receiving kidney transplants covered by Medicaid, a joint federal and state health insurance program...
November 8, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29128297/role-of-geriatric-oncologists-in-optimizing-care-of-urological-oncology-patients
#10
REVIEW
Jean-Pierre Droz, Helen Boyle, Gilles Albrand, Nicolas Mottet, Martine Puts
CONTEXT: Urological cancers are common. Since the median age of diagnosis is 60-70 yr, many patients require geriatric as well as urological evaluation if treatment is to be tailored to individual health status including comorbidities and frailty. OBJECTIVE: To review the most important features of geriatric assessment and its expected benefits. We also consider ways in which collaboration between urologists and geriatricians and geriatric teams can benefit patient well-being...
November 8, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29115022/self-care-agency-lifestyle-and-physical-condition-predict-future-frailty-in-community-dwelling-older-people
#11
Chika Tanimura, Hiromi Matsumoto, Yasuko Tokushima, Junko Yoshimura, Shinji Tanishima, Hiroshi Hagino
The purpose of this 2 year longitudinal study was to identify the relationship between self-care agency, lifestyle, physical condition, and frailty among community-dwelling older people in a rural area of Japan. The participants were 133 older individuals aged 65 years or above. Data collection was conducted via face-to-face interviews using self-administered questionnaires. Background information, such as age, sex, current employment status, family structure, medication use, comorbidities, and knee and lower back pain, were assessed...
November 8, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29106478/physical-activity-and-frailty-among-older-adults-in-the-u-s-based-on-hourly-accelerometry-data
#12
Megan Huisingh-Scheetz, Kristen Wroblewski, Masha Kocherginsky, Elbert Huang, Dale William, Linda Waite, L Philip Schumm
Background/Objectives: Accelerometry measures older adult (in)activity with high resolution. Most studies summarize activity over the entire wear time. We extend prior work by analyzing hourly activity data to determine how frailty and other characteristics relate to activity among older adults. Methods: Using wrist accelerometry data collected from the National Social Life, Health and Aging Project (n=651), a nationally-representative probability sample of older adults, we used mixed effects linear regression to model the logarithm of hourly counts per minute (CPM) as a function of an adapted phenotypic frailty score, adjusting for demographic and health characteristics, season, day of week and time of day...
November 2, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29105991/hypertension-and-frailty-in-older-adults
#13
Ivan Aprahamian, Eduardo Sassaki, Marília F Dos Santos, Rafael Izbicki, Rafael C Pulgrossi, Marina M Biella, Ana Camila N Borges, Marcela M Sassaki, Leonardo M Torres, Ícaro S Fernandez, Olívia A Pião, Paula L M Castro, Pedro A Fontenele, Mônica S Yassuda
The association between hypertension and frailty syndrome in older adults remains unclear. There is scarce information about the prevalence of hypertension among frail elderly patients or on its relationship with frailty. Up to one quarter of frail elderly patients present without comorbidity or disability, yet frailty is a leading cause of death. The knowledge and better control of frailty risk factors could influence prognosis. The present study evaluated: (1) the prevalence of hypertension in robust, prefrail, and frail elderly; and (2) factors that might be associated with frailty including hypertension...
November 5, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29100219/healthcare-utilization-by-frail-community-dwelling-older-veterans-a-1-year-follow-up-study
#14
Miriam Zylberglait Lisigurski, Yolin A Bueno, Chandana Karanam, Allen D Andrade, Sisir Akkineni, Victor Cevallos, Jorge G Ruiz
OBJECTIVES: Frailty is a prevalent clinical syndrome associated with a high risk of adverse health outcomes, including disability, morbidity, and mortality, that has become a major challenge for the healthcare system. The aim of this prospective study was to determine the level of healthcare utilization in prefrail and frail community-dwelling older military veterans. METHODS: We studied a cohort of community-dwelling older veterans aged 65 years and older 1 year at the Miami Veterans Affairs Medical Center to determine their levels of healthcare utilization...
November 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/29097287/palliative-and-end-of-life-care-of-people-with-diabetes-issues-challenges-and-strategies
#15
REVIEW
Trisha Dunning, Peter Martin
Palliative and end of life care are essential, but largely overlooked, aspects of comprehensive, personalised diabetes care. Life expectancy is lower in people with diabetes than in the general population due to complications and comorbidities, especially those associated with obesity such as cardiovascular disease, frailty and cancer. This paper makes the case for early initiation of palliative care and proactive planning for end of life. Early use of palliative care improves symptom management, comfort and quality of life, and often improves function...
October 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29094528/care-of-older-people-with-diabetes
#16
Trisha Dunning
The global population is ageing, and increasingly developing long-term conditions and comorbidities associated with functional changes, reduced quality of life and reduced life expectancy. Diabetes mellitus is a common long-term condition in older people, with many individuals experiencing microvascular and/or macrovascular complications, alongside frailty and dementia. Symptoms of conditions such as hypoglycaemia and hyperglycaemia may change as a result of older age and long duration of, and complications associated with, diabetes; therefore, such symptoms can be challenging to recognise in older people...
September 13, 2017: Nursing Standard
https://www.readbyqxmd.com/read/29084201/frailty-the-missing-piece-of-the-pre-hematopoietic-cell-transplantation-assessment
#17
REVIEW
A Hegde, H S Murthy
Hematopoietic stem cell transplantation (HSCT) represents a curative option for those afflicted with numerous hematologic malignancies and bone marrow failure syndromes. Advances and refinement of the HSCT process have resulted in increasing number of transplants performed on older patients in the recent years. Pre-transplant assessments (PTA) function to risk stratify patients prior to undergoing HSCT in an effort to predict those at higher risk of treatment-related toxicity, to inform risk/benefit assessments and to aid clinical decision making...
October 30, 2017: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29083438/global-performance-of-executive-function-is-predictor-of-risk-of-frailty-and-disability-in-older-adults
#18
C Rosado-Artalejo, J A Carnicero, J Losa-Reyna, C Castillo, B Cobos-Antoranz, A Alfaro-Acha, L Rodríguez-Mañas, F J García-García
INTRODUCTION: The executive function is a complex set of skills affected during the aging process and translate into subclinical cerebrovascular disease. Postural instability or motor slowness are some clinical manifestations, being consubstantial with the frailty phenotype, genuine expression of aging. Executive dysfunction is also considered a predictor of adverse health events in the elderly. AIM: To study whether the executive dysfunction can be used as an early marker for frailty and the viability of use as a predictor of mortality, hospitalization and/or disability in a Mediterranean population...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29079156/septic-arthritis-and-prosthetic-joint-infections-in-older-adults
#19
REVIEW
Rajeshwari Nair, Marin L Schweizer, Namrata Singh
Older adults are at increased risk for septic arthritis and prosthetic joint infections (PJI), owing at least in part to comorbid conditions and frailty. An increasing number of older adults undergo total joint arthroplasty to improve their quality of life. Infections in older adults differ from younger populations by the causative organisms, a great proportion of which are Staphylococcal infections. Targeting important modifiable and nonmodifiable risk factors may prevent or reduce the burden of joint infections in older adults...
December 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29076762/surgical-site-infection-after-transoral-versus-posterior-approach-for-atlantoaxial-fusion-a-matched-cohort-study
#20
Mohamed Macki, Azam Basheer, Ian Lee, Ryan Kather, Ilan Rubinfeld, Muwaffak M Abdulhak
OBJECTIVE In the past, spine surgeons have avoided the transoral approach to the atlantoaxial segment because of concerns for unacceptable patient morbidity. The objective of this study was to measure 30-day postoperative complications, especially surgical site infection (SSI), after transoral versus posterior approach to atlantoaxial fusion. METHODS The source population was provided by the American College of Surgeons National Surgical Quality Improvement Program database, which was queried for all patients who underwent atlantoaxial fusion for degenerative/spondylotic disease and/or trauma between 2005 and 2014...
October 27, 2017: Journal of Neurosurgery. Spine
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