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https://www.readbyqxmd.com/read/29909490/heavy-metals-in-indigenous-preparations-used-for-sex-selection-during-pregnancy-in-india
#1
Abhijit Ganguli, Pragya Rai, Sarala Balachandran, Rakesh Gupta, Rashmi Sharma, Sutapa Bandyopadhyay Neogi
Indigenous preparations (IPs) have evoked a considerable interest in alleviating infections and chronic diseases and improving wellbeing. While such formulations have been a part of traditional practice in several countries and many have been reviewed scientifically for their claims, several of them until date remain to be investigated. A class of IPs for sex selection by Indian pregnant women exists with an aim of begetting a male offspring. In view of the leads obtained from our previous studies on detrimental effects of the newborn, for instance stillbirths and congenital malformations, we attempted to investigate the samples for heavy metal toxicity...
June 16, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29909268/the-relationship-between-intrapartum-cerebroplacental-ratio-and-adverse-perinatal-outcomes-in-term-fetuses
#2
Natthicha Chainarong, Chusana Petpichetchian
OBJECTIVES: The cerebroplacental ratio (CPR) Doppler has been proposed as an instrument for predicting adverse perinatal outcomes particularly during antepartum period. Abnormal CPR is associated with non-reassuring fetal status requiring operative delivery, low Apgar score and neonatal complications. The aim of this study was to assess the role of CPR Doppler in the labor triage suite, so as to identify fetuses at risk for non-reassuring status as well as other adverse perinatal outcomes...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909267/how-to-make-an-accurate-diagnosis-of-fetal-pyriform-sinus-fistula-in-utero-experience-at-a-single-medical-center-in-mainland-china
#3
Zequn Liu, Jin Han, Fang Fu, H S Liu, Qiu-Ming He, Wei Zhong, Hongying Wang, Xin Yang, Dongzhi Li, Can Liao
OBJECTIVE: The aim of this study was to make an accurate diagnosis of pyriform sinus fistula (PSF) for prenatal diagnosis. STUDY DESIGN: Medical records were reviewed for all 35 pyriform sinus fistula patients presenting between 2011 and 2017. Ultrasonography (US), fetal magnetic resonance imaging (MRI) and karyotyping were offered during gestation, while computer tomography (CT) and barium esophagography were performed after birth. RESULTS: Patients included 21 males (60%) and 14 females (40%) with a sex ratio of 1...
June 6, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29909266/perinatal-mortality-or-severe-neonatal-encephalopathy-among-normally-formed-singleton-pregnancies-according-to-obstetric-risk-status-is-low-risk-the-new-high-risk-a-population-based-cohort-study
#4
Niamh M Joyce, Elizabeth Tully, Colin Kirkham, Patrick Dicker, Fionnuala M Breathnach
OBJECTIVE: To evaluate the capacity of the current system of obstetric risk stratification at the outset of pregnancy to predict severe adverse perinatal outcome. STUDY DESIGN: This retrospective cohort study of singleton pregnancies over a five year period (2009-2013) was performed at the Rotunda Hospital, Dublin, Ireland. High-risk or low-risk status was assigned retrospectively to a large consecutive cohort of women with a normally-formed singleton pregnancy on the basis of factors analyzed at the first prenatal hospital visit...
June 5, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908641/gestational-changes-in-prmt1-expression-of-murine-placentas
#5
Anna Sato, Jun-Dal Kim, Hayase Mizukami, Misaki Nakashima, Koichiro Kako, Junji Ishida, Atsuo Itakura, Satoru Takeda, Akiyoshi Fukamizu
INTRODUCTION: In mammals, the placenta is an organ that is required to maintain the development of fetus during pregnancy. Although the proper formation of placenta is in part regulated by the post-translational modifications of proteins, little is known regarding protein arginine methylation during placental development. Here, we characterized developmental expression of protein arginine methyltransferase 1 (PRMT1) in mouse placentas. METHODS: Expression levels of PRMT1 mRNA and protein in placentas were investigated using the real-time quantitative PCR and Western blot, respectively...
May 2018: Placenta
https://www.readbyqxmd.com/read/29908461/air-pollution-and-the-fetal-origin-of-disease-a-systematic-review-of-the-molecular-signatures-of-air-pollution-exposure-in-human-placenta
#6
REVIEW
Leen J Luyten, Nelly D Saenen, Bram G Janssen, Karen Vrijens, Michelle Plusquin, Harry A Roels, Florence Debacq-Chainiaux, Tim S Nawrot
BACKGROUND: Fetal development is a crucial window of susceptibility in which exposure-related alterations can be induced on the molecular level, leading to potential changes in metabolism and development. The placenta serves as a gatekeeper between mother and fetus, and is in contact with environmental stressors throughout pregnancy. This makes the placenta as a temporary organ an informative non-invasive matrix suitable to investigate omics-related aberrations in association with in utero exposures such as ambient air pollution...
June 13, 2018: Environmental Research
https://www.readbyqxmd.com/read/29908375/the-change-of-fetal-heart-rate-short-term-variability-during-the-course-of-histological-chorioamnionitis-in-fetal-sheep
#7
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29908081/relationships-between-meconium-concentrations-of-acute-phase-proteins
#8
Barbara Lisowska-Myjak, Ewa Skarżyńska, Maria Płazińska, Artur Jakimiuk
Meconium concentrations of naturally accumulated ceruloplasmin (CER), lactoferrin (LF), and neutrophil gelatinase-associated lipocalin (NGAL) and their relationships considered as a panel of acute phase proteins could be used for the assessment of fetal homeostasis. CER, LF and NGAL concentrations were measured using ELISA kits in meconium portions (n=80) collected from 19 healthy neonates. The coefficients of variation (CV) of the meconium LF (1.77) and NGAL (1.26) were about 2-fold higher than that of CER (0...
June 16, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29907852/predictors-of-anemia-and-iron-status-at-birth-in-neonates-born-to-women-carrying-multiple-fetuses
#9
Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29907801/comparative-assessment-of-gene-specific-variant-distribution-in-prenatal-and-postnatal-cohorts-tested-for-noonan-syndrome-and-related-conditions
#10
N L Leach, D R Wilson Mathews, L S Rosenblum, Z Zhou, H Zhu, R A Heim
PURPOSE: To compare the pattern of gene-specific involvement and the spectrum of variants observed in prenatal and postnatal (mean ± SD, 8.9 ± 9.4 years) cohorts tested for Noonan syndrome and related conditions. METHODS: Outcomes of sequencing panel testing were compared between prenatal (n = 845) and postnatal (n = 409) cohorts. RESULTS: PTPN11 and SOS1 harbored the majority of observed variants in both prenatal and postnatal cohorts, and BRAF, HRAS, KRAS, MAP2K1, MAP2K2, RAF1, and SHOC2 had similarities in their pattern of involvement in both cohorts...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29907759/bisphenol-a-exposure-during-early-pregnancy-impairs-uterine-spiral-artery-remodeling-and-provokes-intrauterine-growth-restriction-in-mice
#11
Judith Elisabeth Müller, Nicole Meyer, Clarisa Guillermina Santamaria, Anne Schumacher, Enrique Hugo Luque, Maria Laura Zenclussen, Horacio Adolfo Rodriguez, Ana Claudia Zenclussen
Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways. No studies dissected its short-term effects on pregnancy and possible underlying mechanisms. Here, we studied how BPA exposure around implantation affects pregnancy, particularly concentrating on placentation and uterine remodeling. We exposed pregnant female mice to 50 µg/kg BPA/day or 0.1% ethanol by oral gavage from day 1 to 7 of gestation...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#12
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29906665/reproductive-performance-of-bos-indicus-beef-cows-treated-with-different-doses-of-equine-chorionic-gonadotropin-at-the-end-of-a-progesterone-estrogen-based-protocol-for-fixed-time-artificial-insemination
#13
Rafael Herrera Alvarez, Guilherme Pugliesi, Fabio Luis Nogueira Natal, Cecilia Constantino Rocha, Gilmar Arantes Ataide Júnior, Alfredo José Ferreira Melo, Ivani Posar Otzuk, Claudio Alvarenga de Oliveira, Patrice Humblot
Two experiments were performed to evaluate the reproductive performance of zebu beef cows treated with different doses of eCG at the end of a progesterone (P4)/estrogen based protocol for timed artificial insemination (TAI). In Experiment 1, suckling Bos indicus Nelore cows (n = 261) received, on day 0, a progesterone (P4) intravaginal device (PD) and an injection of 1 mg estradiol benzoate (EB). On day 8, the PD was removed, 500 μg of cloprostenol was injected, and cows were assigned to one of the following groups: Control (no treatment), 300 (300 IU of eCG), 600 (600 IU of eCG), and 900 (900 IU of eCG)...
June 8, 2018: Theriogenology
https://www.readbyqxmd.com/read/29905543/importance-of-isolated-gestational-hypothyroxinemia-in-the-development-of-obstetric-and-somatic-pathologies
#14
N Morchiladze, B Tkeshelashvili, T Gagua, D Gagua
The isolated hypothyroxinemia of pregnancy (IHP) has gained specific attention in the specialized literature during the recent years as the possible factor impeding the intellectual development of fetus and increasing the risk of complications related with pregnancy, delivery and perinatal period. Aim of the study was to define the importance of isolated hypothyroxinemia in the development of obstetric and somatic pathologies in outpatient population of pregnant females. The study of prospective design was performed at the base of "David Gagua Clinic" Ltd...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904776/translocation-of-silver-nanoparticles-in-the-ex-vivo-human-placenta-perfusion-model-characterized-by-single-particle-icp-ms
#15
Janja Vidmar, Katrin Loeschner, Manuel Correia, Erik H Larsen, Pius Manser, Adrian Wichser, Kailen Boodhia, Zahraa S Al-Ahmady, Jaimé Ruiz, Didier Astruc, Tina Buerki-Thurnherr
With the extensive use of silver nanoparticles (AgNPs) in various consumer products their potential toxicity is of great concern especially for highly sensitive population groups such as pregnant women and even the developing fetus. To understand if AgNPs are taken up and cross the human placenta, we studied their translocation and accumulation in the human ex vivo placenta perfusion model by single particle ICP-MS (spICP-MS). The impact of different surface modifications on placental transfer was assessed by AgNPs with two different modifications: polyethylene glycol (AgPEG NPs) and sodium carboxylate (AgCOONa NPs)...
June 15, 2018: Nanoscale
https://www.readbyqxmd.com/read/29904479/massive-fetal-cervical-teratoma-managed-with-the-ex-utero-intrapartum-treatment-exit-procedure
#16
Emily Olivares, Justin Castellow, Jamil Khan, Susanne Grasso, Victor Fong
Teratomas are rare congenital tumors typically comprising all 3 germ cell layers. Cervical teratomas arise in the neck and represent a minority of all teratomas. These are associated with high morbidity and mortality because of their propensity to cause airway obstruction. Demonstration on prenatal magnetic resonance imaging is uncommon, especially for a tumor of this size. Fetuses diagnosed with large neck masses are managed through cesarean section with the ex utero intrapartum treatment procedure to secure the airway, such as in our case of a large cervical teratoma in the female fetus of a 30-year-old mother who went into preterm labor...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29904338/spanol-spectral-analysis-of-lobes-a-spectral-clustering-framework-for-individual-and-group-parcellation-of-cortical-surfaces-in-lobes
#17
Julien Lefèvre, Antonietta Pepe, Jennifer Muscato, Francois De Guio, Nadine Girard, Guillaume Auzias, David Germanaud
Understanding the link between structure, function and development in the brain is a key topic in neuroimaging that benefits from the tremendous progress of multi-modal MRI and its computational analysis. It implies, inter alia , to be able to parcellate the brain volume or cortical surface into biologically relevant regions. These parcellations may be inferred from existing atlases (e.g., Desikan) or sets of rules, as would do a neuroanatomist for lobes, but also directly driven from the data (e.g., functional or structural connectivity) with minimum a priori...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29903435/cerebellar-networks-and-neuropathology-of-cerebellar-developmental-disorders
#18
Harvey B Sarnat
The cerebellar system is a series of axonal projections and synaptic circuits as networks, similar to those of the limbic system and those subserving the propagation and spread of seizures. Three principal cerebellar networks are identified and cerebellar disease often affects components of the networks other than just the cerebellar cortex. Contemporary developmental neuropathology of the cerebellum is best considered in the context of alterations of developmental processes: embryonic segmentation and genetic gradients along the three axes of the neural tube, individual neuronal and glial cell differentiation, migration, synaptogenesis, and myelination...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29903417/did-zika-virus-mutate-to-cause-severe-outbreaks
#19
REVIEW
Shannan L Rossi, Gregory D Ebel, Chao Shan, Pei-Yong Shi, Nikos Vasilakis
Zika virus (ZIKV) has challenged the assumed knowledge regarding the pathobiology of flaviviruses. Despite causing sporadic and mild disease in the 50 years since its discovery, Zika virus has now caused multiple outbreaks in dozens of countries worldwide. Moreover, the disease severity in recent outbreaks, with neurological disease in adult and devastating congenital malformations in fetuses, was not previously seen. One hypothesis is that the virus has acquired mutations that have increased its virulence...
June 11, 2018: Trends in Microbiology
https://www.readbyqxmd.com/read/29902813/-uterine-torsion-in-cattle-treatment-risk-of-injury-for-the-cow-and-prognosis-for-the-calf
#20
Daniela Klaus-Halla, Bettina Mair, Carola Sauter-Louis, Holm Zerbe
OBJECTIVE: In cows with uterine torsion, clinical parameters and different treatments were evaluated with regards to their success. The aim of the study was to investigate important factors for diagnosis and prognosis of uterine torsion and their consequences for treatment decisions. MATERIAL AND METHODS: The study presents 114 cases of uterine torsion documented under field conditions. The cows were examined before retorsion of the uterus and immediately post partum...
June 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
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