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https://www.readbyqxmd.com/read/28109045/misoprostol-for-cervical-priming-prior-to-hysteroscopy-in-postmenopausal-and-premenopausal-nulliparous-women-a-multicentre-randomised-placebo-controlled-trial
#1
M L Tasma, M Louwerse, W J Hehenkamp, P M Geomini, M Y Bongers, S Veersema, P J van Kesteren, E Tromp, J A Huirne, G C Graziosi
OBJECTIVE: To evaluate the reduction of pain by Misoprostol compared to placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. DESIGN: Randomised multicentre double-blind placebo controlled trial. SETTING: Two Dutch teaching hospitals and one Dutch university medical centre. POPULATION: Postmenopausal and premenopausal nulliparous women undergoing office hysteroscopy. METHODS: Patients were randomised to receive either 400 mcg Misoprostol or placebo 12 and 24 hours before hysteroscopy...
January 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28108773/effects-of-caffeine-on-alcohol-reinforcement-beverage-choice-self-administration-and-subjective-ratings
#2
Mary M Sweeney, Steven E Meredith, Daniel P Evatt, Roland R Griffiths
RATIONALE: Combining alcohol and caffeine is associated with increased alcohol consumption, but no prospective experimental studies have examined whether added caffeine increases alcohol consumption. OBJECTIVES: This study examined how caffeine alters alcohol self-administration and subjective reinforcing effects in healthy adults. METHODS: Thirty-one participants completed six double-blind alcohol self-administration sessions: three sessions with alcohol only (e...
January 20, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28108337/cardiovascular-and-cerebrovascular-events-among-patients-receiving-omalizumab-pooled-analysis-of-patient-level-data-from-25-randomized-double-blind-placebo-controlled-clinical-trials
#3
Carlos Iribarren, Kenneth J Rothman, Mary S Bradley, Gillis Carrigan, Mark D Eisner, Hubert Chen
Among patients who participated in randomized clinical trials of omalizumab, no substantial overall increase in the risk of cardiovascular events was observed in the treatment arms compared with placebo. <29/35 words>.
January 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28108076/safety-and-effectiveness-of-alveolar-recruitment-maneuvers-and-positive-end-expiratory-pressure-during-general-anesthesia-for-cesarean-section-a-prospective-randomized-trial
#4
D Aretha, F Fligou, P Kiekkas, C Messini, E Panteli, E Zintzaras, M Karanikolas
INTRODUCTION: During cesarean section, the supine position reduces functional residual capacity and worsens lung compliance. We tested the hypothesis that alveolar recruitment maneuvers and positive end-expiratory pressure improve lung compliance in women undergoing general anesthesia for cesarean section. METHODS: Ninety women undergoing cesarean section were randomly assigned to one of two groups in a prospective, double-blind trial. In the alveolar recruitment maneuver group, pressure-control ventilation was used and inspiratory time was increased to 50% after delivery; positive end-expiratory pressure was increased to 20cmH2O and peak airway inspiratory pressure gradually increased to 45-50cmH2O...
December 23, 2016: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28107852/efficacy-of-topical-chamomile-oil-for-mild-and-moderate-carpal-tunnel-syndrome-a-randomized-double-blind-placebo-controlled-clinical-trial
#5
Mohammad Hashem Hashempur, Mohammad Sadegh Ghasemi, Babak Daneshfard, Parissa Sadat Ghoreishi, Zeinab Nasiri Lari, Kaynoosh Homayouni, Arman Zargaran
OBJECTIVE: To evaluate the efficacy of topical chamomile oil in patients with mild and moderate carpal tunnel syndrome (CTS). METHOD: Eighty six patients with electrodiagnostic criteria of mild and moderate CTS were enrolled in this randomized double-blind placebo-controlled clinical trial and received wrist splint plus topical chamomile oil or placebo for 4 weeks. They were evaluated at the baseline and end of the study regarding functional and symptomatic scores, dynamometry, and electrodiagnostic indexes...
February 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28107559/a-randomized-double-blind-placebo-controlled-dose-escalation-first-in-man-study-phase-0-to-assess-the-safety-and-efficacy-of-topical-cytosolic-phospholipase-a2-inhibitor-avx001-in-patients-with-mild-to-moderate-plaque-psoriasis
#6
S H Omland, A Habicht, P Damsbo, J Wilms, B Johansen, R Gniadecki
BACKGROUND: Cytosolic Phospholipase A2 (cPLA2α) is an enzyme suggested as a therapeutic target in inflammatory skin diseases. AVX001, a cPLA2α-inhibitor was investigated in a randomized, double-blind, placebo-controlled, split-design, first-in-man study in patients with mild to moderate psoriasis. OBJECTIVES: The primary objective was to evaluate cutaneous safety and tolerability of AVX001 in doses from 0.002%-5.0%. Safety was assessed as local skin reaction adverse events (LSRAE) grade 3-4...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107276/the-effect-of-deep-versus-moderate-neuromuscular-block-on-surgical-conditions-and-postoperative-respiratory-function-in-bariatric-laparoscopic-surgery-a-randomized-double-blind-clinical-trial
#7
Sam Baete, Gerd Vercruysse, Margot Vander Laenen, Pieter De Vooght, Jeroen Van Melkebeek, Dimitri Dylst, Maud Beran, Jan Van Zundert, René Heylen, Willem Boer, Sam Van Boxstael, Tom Fret, Hans Verhelst, Cathy De Deyne, Frank Jans, Pascal Vanelderen
BACKGROUND: In recent literature, it has been suggested that deep neuromuscular block (NMB) improves surgical conditions during laparoscopy; however, the evidence supporting this statement is limited, and this was not investigated in laparoscopic bariatric surgery. Moreover, residual NMB could impair postoperative respiratory function. We tested the hypotheses that deep NMB could improve the quality of surgical conditions for laparoscopic bariatric surgery compared with moderate NMB and investigated whether deep NMB puts patients at risk for postoperative respiratory impairment compared with moderate NMB...
January 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28107246/reliability-and-usefulness-of-intraoperative-3-dimensional-imaging-by-mobile-c-arm-with-flat-panel-detector
#8
Takahito Fujimori, Motoki Iwasaki, Yukitaka Nagamoto, Masafumi Kashii, Masaki Takao, Tsuyoshi Sugiura, Hideki Yoshikawa
STUDY DESIGN: Reliability and agreement study. OBJECTIVE: To assess the reliability of intraoperative 3-dimensional imaging with a mobile C-arm (3D C-arm) equipped with a flat-panel detector. SUMMARY OF BACKGROUND DATA: Pedicle screws are widely used in spinal surgery. Postoperative computed tomography (CT) is the most reliable method to detect screw misplacement. Recent advances in imaging devices have enabled surgeons to acquire 3D images of the spine during surgery...
February 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28106611/time-course-of-copeptin-during-a-model-of-experimental-pain-and-hyperalgesia-a-randomised-volunteer-crossover-trial
#9
Eckhard Mauermann, Claudine A Blum, Giovanna Lurati Buse, Oliver Bandschapp, Wilhelm Ruppen
BACKGROUND: A reliable biomarker for quantifying pain or hyperalgesia has yet to be found. A surrogate marker of arginine vasopressin, copeptin, is elevated in a number of states of physiological and psychological stress and may have a role in quantifying pain and/or hyperalgesia. OBJECTIVES: To evaluate copeptin as a biomarker for pain or hyperalgesia developing after 120 min of sustained electrical stimulation. DESIGN: Secondary analysis of a randomised, double-blinded, crossover trial...
January 19, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28106245/a-randomized-controlled-trial-of-mediterranean-diet-and-metformin-to-prevent-age-related-diseases-in-people-with-metabolic-syndrome
#10
Patrizia Pasanisi, Giuliana Gargano, Maria Gaetana Di Mauro, Mauro Cortellini, Alice Casagrande, Anna Villarini, Eleonora Bruno, Eliana Roveda, Gabriella Saibene, Elisabetta Venturelli, Franco Berrino
PURPOSE: Age-related non-communicable chronic diseases (ArCDs) are the leading cause of mortality. The major metabolic risk factor for their development is the metabolic syndrome (MetS), defined as a clustering of risk factors of metabolic origin such as abdominal obesity, high blood pressure, dyslipidemia and high fasting glycemia. There is increasing observational and experimental evidence that improving diet and the use of metformin (a calorie-restriction mimetic drug) may modify the risk of developing MetS and ArCD...
January 20, 2017: Tumori
https://www.readbyqxmd.com/read/28105733/vitamin-d-supplementation-for-sickle-cell-disease
#11
REVIEW
Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Nan Nitra Than, Han Ni, Jaspal Singh, Abdul Razzak Bin Mohd Said, Ifeyinwa Osunkwo
BACKGROUND: Sickle cell disease is a genetic chronic haemolytic and pro-inflammatory disorder. The clinical manifestations of sickle cell disease result from the presence of mutations on the beta globin genes that generate an abnormal haemoglobin product (called haemoglobin S) within the red blood cell. Sickle cell disease can lead to many complications such as acute chest syndrome, stroke, acute and chronic bone complications (including painful vaso-occlusive crisis, osteomyelitis, osteonecrosis and osteoporosis)...
January 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28105731/liraglutide-effects-on-cardiovascular-risk-biomarkers-in-patients-with-type-2-diabetes-and-albuminuria-a-sub-analysis-of-a-randomised-placebo-controlled-double-blind-cross-over-trial
#12
Bernt Johan von Scholten, Frederik Persson, Signe Rosenlund, Jesper Eugen-Olsen, Tomasz Pielak, Jens Faber, Tine Willum Hansen, Peter Rossing
: We assessed the effects of liraglutide treatment on five cardiovascular risk biomarkers, reflecting different pathophysiology: 1) Tumour necrosis factor-alpha (TNF-alpha); 2) Soluble urokinase plasminogen activator receptor (suPAR); 3) Mid-regional pro-adrenomedullin (MR-proADM); 4) Mid-regional pro-atrial natriuretic peptide (MR-proANP); and 5) Copeptin, in type 2 diabetes patients with albuminuria. In a randomised, double-blind, placebo-controlled, cross-over trial we enrolled patients with type 2 diabetes and persistent albuminuria (urinary albumin-to-creatinine ratio (UACR) > 30 mg/g) and estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1...
January 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28105520/type-1-diabetic-patients-with-peripheral-neuropathy-have-pan-enteric-prolongation-of-gastrointestinal-transit-times-and-an-altered-caecal-ph-profile
#13
Adam D Farmer, Anne Grave Pedersen, Birgitte Brock, Poul Erik Jakobsen, Jesper Karmisholt, Sahar D Mohammed, S Mark Scott, Asbjørn Mohr Drewes, Christina Brock
AIMS/HYPOTHESIS: We hypothesised that type 1 diabetic patients with established diabetic sensorimotor polyneuropathy (DSPN) would have segmental and/or pan-enteric dysmotility in comparison to healthy age-matched controls. We aimed to investigate the co-relationships between gastrointestinal function, degree of DSPN and clinical symptoms. METHODS: An observational comparison was made between 48 patients with DSPN (39 men, mean age 50 years, range 29-71 years), representing the baseline data of an ongoing clinical trial (representing a secondary analysis of baseline data collected from an ongoing double-blind randomised controlled trial investigating the neuroprotective effects of liraglutide) and 41 healthy participants (16 men, mean age 49 years, range 30-78) who underwent a standardised wireless motility capsule test to assess gastrointestinal transit...
January 20, 2017: Diabetologia
https://www.readbyqxmd.com/read/28105133/a-prospective-study-to-evaluate-the-efficacy-and-safety-of-oral-acetyl-l-carnitine-for-the-treatment-of-chemotherapy-induced-peripheral-neuropathy
#14
Yuanjue Sun, Yongqian Shu, Baorui Liu, Ping Liu, Changping Wu, Rongsheng Zheng, Xiaohua Zhang, Zhixiang Zhuang, Yongchuan Deng, Leizhen Zheng, Qing Xu, Bin Jiang, Xuenong Ouyang, Jianfei Gao, Nong Xu, Xiaoyi Li, Su Jiang, Chaofan Liang, Yang Yao
The present study aimed to evaluate the efficacy and safety of acetyl-L-carnitine (ALC) for the treatment of chemotherapy-induced peripheral neuropathy (CIPN). The study was carried out as a prospective, randomized, double-blind, placebo-controlled and paralleled clinical study. A total of 239 patients with CIPN were selected as the study subjects. Of the 239 subjects, 118 subjects received 3 g/day ALC orally for 8 weeks and 121 received a placebo. The primary endpoint was improvement of peripheral neuropathy by at least one grade...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28105118/effects-of-oral-intake-of-heat-killed-lactobacillus-brevis-sbc8803-sbl88%C3%A2-on-dry-skin-conditions-a-randomized-double-blind-placebo-controlled-study
#15
Masahiro Ogawa, Asako Saiki, Yuuta Matsui, Norihiko Tsuchimoto, Yasukazu Nakakita, Yoshihiro Takata, Takeshi Nakamura
Lactobacilli are important in intestinal homeostasis, which involves the regulation of immune function, digestive health, cholesterol absorption and intestinal tumor growth amongst others. Our previous investigations have suggested that oral intake of heat-killed Lactobacillus brevis (L. brevis) SBC8803 (SBL88™) suppresses dermatitis by modulating the immune function in an atopic dermatitis mouse model. The aim of the present study was to investigate the effect of heat-killed L. brevis SBC8803 intake on skin hydration conditions in humans...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104402/racial-and-ethnic-differences-in-the-polycystic-ovary-syndrome-pcos-metabolic-phenotype
#16
Lawrence Engmann, Susan Jin, Fangbai Sun, Richard S Legro, Alex J Polotsky, Karl R Hansen, Christos Coutifaris, Michael P Diamond, Esther Eisenberg, Heping Zhang, Nanette Santoro
BACKGROUND: Women with polycystic ovarian syndrome have a high prevalence of metabolic syndrome and type 2 diabetes mellitus. Blacks and Hispanics have a high morbidity and mortality due to cardiovascular disease and diabetes mellitus in the general population. Since metabolic syndrome is a risk factor for development of type 2 diabetes and cardiovascular disease, understanding any racial and ethnic differences in metabolic syndrome amongst women with polycystic ovarian syndrome is important for prevention strategies...
January 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28104253/the-effect-of-fampridine-sr-on-cognitive-fatigue-in-a-randomized-double-blind-crossover-trial-in-patients-with-ms
#17
Sarah A Morrow, Heather Rosehart, Andrew M Johnson
BACKGROUND: Cognitive fatigue (CF) is a common complaint in persons with MS (PwMS). Fampridine-SR improves ambulation, fatigue and endurance, due to enhancing action potential formation by blocking potassium channels in demyelinated axons. Thus, through this same mechanism, it is hypothesized that Fampridine-SR could improve CF. OBJECTIVE: To determine if Fampridine-SR objectively improves CF in PwMS. METHODS: Sixty PwMS of any type with CF, defined as 3 or less correct responses when comparing the last third to the first third on the Paced Auditory Serial Addition Test (PASAT), were recruited from a tertiary care MS clinic in London (ON) Canada...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104251/efficacy-safety-and-pharmacokinetics-of-natalizumab-in-japanese-multiple-sclerosis-patients-a-double-blind-randomized-controlled-trial-and-open-label-pharmacokinetic-study
#18
Takahiko Saida, Jun-Ichi Kira, Shuji Kishida, Takashi Yamamura, Yukiko Sudo, Kazutaka Ogiwara, J T Tibung, Nisha Lucas, Meena Subramanyam
BACKGROUND: Natalizumab, an anti-α4 integrin monoclonal antibody, has demonstrated efficacy in phase 2 and 3 studies of predominantly Caucasian patients with relapsing-remitting multiple sclerosis (RRMS). OBJECTIVE: To evaluate the efficacy, safety, pharmacokinetics (PK), and pharmacodynamics (PD) of natalizumab in Japanese RRMS patients. METHODS: This multicenter, phase 2 study included an open-label PK/PD study in 12 patients (part A) and a double-blind, placebo-controlled, randomized (computer-generated sequence) study in 94 patients (part B)...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104250/impact-of-daclizumab-versus-interferon-beta-1a-on-patient-reported-outcomes-in-relapsing-remitting-multiple-sclerosis
#19
Ying Liu, Timothy Vollmer, Eva Havrdova, Katherine Riester, Andrew Lee, Glenn Phillips, Ping Wang, Guido Sabatella
BACKGROUND: Patient-reported outcomes (PROs) provide information on treatment effects from the patient's perspective that complement outcomes on clinical measures. In DECIDE, daclizumab demonstrated superior efficacy in reducing relapses, 24-week confirmed disability progression, and brain lesions (assessed by magnetic resonance imaging [MRI]) versus intramuscular interferon beta-1a in relapsing-remitting multiple sclerosis. OBJECTIVE: To examine the impact of daclizumab versus interferon beta-1a on PROs in DECIDE...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104188/maternal-multiple-micronutrient-supplementation-and-other-biomedical-and-socioenvironmental-influences-on-children-s-cognition-at-age-9-12-years-in-indonesia-follow-up-of-the-summit-randomised-trial
#20
Elizabeth L Prado, Susy K Sebayang, Mandri Apriatni, Siti R Adawiyah, Nina Hidayati, Ayuniarti Islamiyah, Sudirman Siddiq, Benyamin Harefa, Jarrad Lum, Katherine J Alcock, Michael T Ullman, Husni Muadz, Anuraj H Shankar
BACKGROUND: Brain and cognitive development during the first 1000 days from conception are affected by multiple biomedical and socioenvironmental determinants including nutrition, health, nurturing, and stimulation. An improved understanding of the long-term influence of these factors is needed to prioritise public health investments to optimise human development. METHODS: We did a follow-up study of the Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT), a double-blind, cluster-randomised trial of maternal supplementation with multiple micronutrients (MMN) or iron and folic acid (IFA) in Indonesia...
February 2017: Lancet Global Health
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