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coronary arteries calcification grading

Jacobo Kirsch, Felipe Martinez, David Lopez, Gian M Novaro, Craig R Asher
Coronary artery calcification (CAC) is a known risk factor for adverse outcomes in the general population and in patients with coronary artery disease. We performed a survey of United States radiologists to evaluate the trends in reporting the presence or absence of CAC on NCCT examinations. An 11 multiple-choice questionnaire was distributed to members of the American College of Radiology, and 530 members participated in the study. Eighty-seven percent of the analyzed group report the presence of CAC on standard CT scans of the chest, and approximately half them (52 %) use a qualitative modifier...
September 27, 2016: International Journal of Cardiovascular Imaging
Armelle Meershoek, Rogier A van Dijk, Sander Verhage, Jaap F Hamming, Antoon J van den Bogaerdt, Ad J J C Bogers, Alexander F Schaapherder, Jan H Lindeman
BACKGROUND/OBJECTIVES: Carotid intimal media thickness (IMT) and coronary calcium scores (CCS) are thought to reflect atherosclerotic burden. The validity of this assumption for IMT is challenged by recent meta-analyses; for CCS by absence of a relationship between negative scores, and freedom of future events. As such, we considered evaluation of the relationship between tissue IMT and CCS, and extend of atherosclerotic disease relevant. METHODS: Analyses were performed on donor aortas obtained during renal graft procurement, and on coronary arteries collected during heart valve procurement for tissue donation...
September 17, 2016: International Journal of Cardiology
Bengt Wahlin, Thomas Meedt, Fredrik Jonsson, Michael Y Henein, Solveig Wållberg-Jonsson
Objective. A long-term follow-up of patients with rheumatoid arthritis (RA) to evaluate factors related to coronary artery calcification (CAC). Methods. All 22 eligible patients (4 males/18 females, mean age 65 years, and RA-duration 30-36 years) from the original (baseline; n = 39) study of atherosclerosis were included. Inflammation, cardiovascular risk factors, and biomarkers were measured at baseline. At follow-up 13 years later, CAC was assessed by computed tomography (CT) and the grade of inflammation was measured...
2016: BioMed Research International
Naohiro Osugi, Susumu Suzuki, Yohei Shibata, Yosuke Tatami, Shingo Harata, Tomoyuki Ota, Mutsuharu Hayashi, Yoshinari Yasuda, Hideki Ishii, Atsuya Shimizu, Toyoaki Murohara
BACKGROUND: Coronary artery calcification (CAC) is an independent predictor of cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients. The aim of the present study was to evaluate the predictive value of CAC scores for the incidence of contrast-induced nephropathy (CIN) after cardiac catheterization in non-dialyzed CKD patients. METHODS: The present study evaluated a total of 140 CKD patients who underwent cardiac catheterization. Patients were stratified into two groups based on the optimal cut-off value of the CAC score, which was graded by a non-triggered, routine diagnostic chest computed tomography scan: CAC score ≥8 (high CAC group); and CAC score <8 (low CAC group)...
June 23, 2016: Clinical and Experimental Nephrology
Louise Nissen, Simon Winther, Christin Isaksen, June Anita Ejlersen, Lau Brix, Grazina Urbonaviciene, Lars Frost, Lene Helleskov Madsen, Lars Lyhne Knudsen, Samuel Emil Schmidt, Niels Ramsing Holm, Michael Maeng, Mette Nyegaard, Hans Erik Bøtker, Morten Bøttcher
BACKGROUND: Coronary computed tomography angiography (CCTA) is an established method for ruling out coronary artery disease (CAD). Most patients referred for CCTA do not have CAD and only approximately 20-30 % of patients are subsequently referred to further testing by invasive coronary angiography (ICA) or non-invasive perfusion evaluation due to suspected obstructive CAD. In cases with severe calcifications, a discrepancy between CCTA and ICA often occurs, leading to the well-described, low-diagnostic specificity of CCTA...
2016: Trials
Roberto Martín-Reyes, Juan Antonio Franco-Peláez, Óscar Lorenzo, María Luisa González-Casaus, Ana María Pello, Álvaro Aceña, Rocío Carda, José Luis Martín-Ventura, Luis Blanco-Colio, María Luisa Martín-Mariscal, Juan Martínez-Milla, Ricardo Villa-Bellosta, Antonio Piñero, Felipe Navarro, Jesús Egido, José Tuñón
BACKGROUND AND OBJECTIVES: We investigated the relationship of the Syntax Score (SS) and coronary artery calcification (CAC), with plasma levels of biomarkers related to cardiovascular damage and mineral metabolism, as there is sparse information in this field. METHODS: We studied 270 patients with coronary disease that had an acute coronary syndrome (ACS) six months before. Calcidiol, fibroblast growth factor-23, parathormone, phosphate and monocyte chemoattractant protein-1 [MCP-1], high-sensitivity C-reactive protein, galectin-3, and N-terminal pro-brain natriuretic peptide [NT-proBNP] levels, among other biomarkers, were determined...
2016: PloS One
Shu-Ping Chao, Jyh-Gang Leu, Wai-Yip Law, Chu-Jen Kuo, Kou-Gi Shyu
PURPOSE: To assess the image quality of 256-slice computed tomographic angiography (CTA) and to identify possible impact factors associated with image quality. METHODS: From November 2009 to January 2010, 506 patients underwent 256-slice CTA at our institute. A total of 451 patients were enrolled in our study, after 55 patients were excluded because of prior bypass surgery and stenting. CTA image quality was graded by two observers using a 4-point scale: excellent (score 1), good (score 2), moderate (score 3), poor and non-diagnostic (score 4)...
September 2013: Acta Cardiol Sin
Jong Shin Woo, Weon Kim, Se Hwan Kwon, Hyo Chul Youn, Hyun Soo Kim, Jin Bae Kim, Soo Joong Kim, Woo-Shik Kim, Kwon Sam Kim
BACKGROUND: The coronary artery calcium (CAC) and aortic arch calcification (AoAC) are individually associated with cardiovascular disease and outcome. This study investigated the predictive value of AoAC combined with CAC for cardiovascular diagnosis and outcome in patients with angina. METHODS: A total of 2018 stable angina patients who underwent chest X-ray and cardiac multi-detector computed tomography were followed up for four years to assess adverse events, which were categorized as cardiac death, stroke, myocardial infarction, or repeated revascularization...
March 2016: Journal of Geriatric Cardiology: JGC
Ioana Pasca, Patricia Dang, Gaurav Tyagi, Ramdas G Pai
BACKGROUND: Severe mitral annular calcification causing degenerative mitral stenosis (DMS) is increasingly encountered in patients undergoing mitral and aortic valve interventions. However, its clinical profile and natural history and the factors affecting survival remain poorly characterized. The goal of this study was to characterize the factors affecting survival in patients with DMS. METHODS: An institutional echocardiographic database was searched for patients with DMS, defined as severe mitral annular calcification without commissural fusion and a mean transmitral diastolic gradient of ≥2 mm Hg...
May 2016: Journal of the American Society of Echocardiography
Kazuhisa Takamura, Takeshi Kondo, Shinichiro Fujimoto, Makoto Hiki, Rie Matsumori, Yuko Kawaguchi, Makoto Amanuma, Shinichi Takase, Hiroyuki Daida
AIMS: Recent study suggests that algorithms such as the Duke Clinical score (DCS) may overestimate the pretest probability. The Agatston score representing the grade of coronary artery calcification can be simply calculated from low-radiation exposure ECG-gated plain CT. In this study, we investigated whether or not more superior diagnostic performance for obstructive coronary artery disease (CAD) can be obtained by combining DCS with the Agatston score. METHODS AND RESULTS: Of 3939 consecutive patients suspected of having stable angina without known CAD who underwent Coronary Computed Tomography Angiography (CCTA) as well as calculation of the DCS and Agatston score at our hospital, 3688 patients were selected as subjects...
May 2016: European Heart Journal Cardiovascular Imaging
Clifton T P Lewis, Richard L Stephens, Jennifer L Cline, Charles M Tyndal
An 89-year-old man and an 80-year-old woman were treated surgically for critical aortic stenosis secondary to senile calcific aortic disease and high-grade calcified lesions in the ostium of the right coronary artery. Minimally invasive aortic valve replacement and concurrent coronary artery bypass grafting were performed concurrently through a 5-cm right anterior thoracotomy in the second intercostal space. Surgery was uncomplicated in both cases, with no adverse events. Both patients were alive and well at midterm follow-up...
July 2015: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Olivier Ghekiere, Willem Dewilde, Michel Bellekens, Denis Hoa, Thierry Couvreur, Julien Djekic, Tim Coolen, Isabelle Mancini, Piet K Vanhoenacker, Paul Dendale, Alain Nchimi
Fractional flow reserve (FFR) during invasive coronary angiography has become an established tool for guiding treatment. However, only one-third of intermediate-grade coronary artery stenosis (ICAS) are hemodynamically significant and require coronary revascularization. Additionally, the severity of stenosis visually established by coronary computed tomography angiography (CCTA) does not reliably correlate with the functional severity. Therefore, additional angiographic morphologic descriptors affecting hemodynamic significance are required...
December 2015: International Journal of Cardiovascular Imaging
Gunnar Tepe, Ulrich Beschorner, Charlotte Ruether, Imma Fischer, Peter Pfaffinger, Elias Noory, Thomas Zeller
PURPOSE: To assess the association of patient, lesion, and procedure variables, including calcification, with late lumen loss (LLL) after use of drug-eluting balloon (DEB) therapy in patients with femoropopliteal arterial disease. METHODS: In this retrospective study, 91 patients (mean age 72.0±8.62 years; 50 men) were analyzed at 6 months after DEB treatment. Lesions were located in the superficial femoral artery (SFA, n=68) and popliteal artery (n=23). Lesion calcification was graded by a core laboratory using 2 published scoring indices: the peripheral artery calcification scoring system and a grading system based on circumference (arc) and length of calcium...
October 2015: Journal of Endovascular Therapy
Kimihiro Igari, Toshifumi Kudo, Takahiro Toyofuku, Yoshinori Inoue
BACKGROUND: Endovascular treatment (EVT) for chronic total occlusion (CTO) is a technically challenging problem in peripheral arterial disease (PAD). The Crosser system is a CTO device with high frequency vibrational energy to cross the CTO, which has been adopted for coronary CTO. We performed EVT procedure by the device for PAD with CTO, and the purpose of this study was to evaluate the efficacy and safety of a high-frequency vibrational device, the Crosser™ system, in the EVT for the infrainguinal arteries with CTO...
April 2016: International Angiology: a Journal of the International Union of Angiology
Maksymilian P Opolski, Stephan Achenbach
Coronary computed tomography angiography (CTA) is increasingly used to diagnose and rule out coronary artery disease. Beyond stenosis detection, the ability of CTA to visualize and characterize coronary atherosclerotic plaque, as well as to obtain 3-dimensional coronary vessel trajectories, has generated considerable interest in the context of pre-procedural planning for revascularization of chronic total occlusions (CTOs). Coronary CTA can characterize features that influence the success rate of percutaneous coronary intervention (PCI) for CTOs such as the extent of calcification, vessel tortuosity, stump morphology, presence of multiple occlusions, and lesion length...
July 2015: JACC. Cardiovascular Imaging
Yohei Takayama, Yoshinari Yasuda, Susumu Suzuki, Yohei Shibata, Yosuke Tatami, Kanako Shibata, Misao Niwa, Akihiro Sawai, Ryota Morimoto, Sawako Kato, Hideki Ishii, Shoichi Maruyama, Toyoaki Murohara
The purpose of this study was to investigate the relationship between abdominal aortic calcification (AAC) and coronary artery calcification (CAC) in chronic kidney disease (CKD) patients. We evaluated 126 asymptomatic CKD patients (mean estimated glomerular filtration rate: 36.1 ± 14.1 mL/min/1.73 m(2), mean age 70.3 ± 10.1 years). A non-contrast computed tomography scan was used to determine the abdominal aortic calcification index (ACI) and CAC score, and this relationship was investigated. Among the subjects, AAC was present in 109 patients (86...
July 2016: Heart and Vessels
F Ciolina, P Sedati, F Zaccagna, N Galea, V Noce, F Miraldi, E Cavarretta, M Francone, I Carbone
AIM: In patients affected by aortic valve stenosis (AS) it is mandatory to rule out coronary artery disease (CAD). The role of retrospectively ECG-gated 64-slice CT angiography (64-SCTA) was assessed in patients with AS referred for surgical valve replacement. METHODS: Forty-two patients with AS underwent ECG-gated 64-SCTA of thoracic aorta, including the heart and coronary arteries, before surgical valve replacement. Images were evaluated by two independent readers and compared with surgical findings in terms of aortic valve calcification grading, valvular morphology, aortic valve annulus and sino-tubular junction diameters, and valvular area planimetry...
October 2015: Journal of Cardiovascular Surgery
Geoffrey H Tison, Mengye Guo, Michael J Blaha, Robyn L McClelland, Matthew A Allison, Moyses Szklo, Nathan D Wong, Roger S Blumenthal, Matthew J Budoff, Khurram Nasir
BACKGROUND: Cardiovascular calcification outside of the coronary tree, known as extracoronary calcification (ECC), is highly prevalent, often occurs concurrently in multiple sites, and yet its prognostic value is unclear. OBJECTIVE: To determine whether multisite ECC is associated with coronary heart disease (CHD) events, CHD mortality, and all-cause mortality. METHODS: We evaluated 5903 participants from the Multi-Ethnic Study of Atherosclerosis without diabetes who underwent CT imaging for calcification of the aortic valve, aortic root, mitral valve, and thoracic aorta...
September 2015: Journal of Cardiovascular Computed Tomography
Rodrigo Modolo, Valeria N Figueiredo, Filipe A Moura, Breno Almeida, José C Quinaglia e Silva, Wilson Nadruz, Pedro A Lemos, Otavio R Coelho, Michael J Blaha, Andrei C Sposito
AIM/BACKGROUND: Abundant evidence shows that coronary artery calcification (CAC) is a strong marker of structural and functional changes within the artery wall. Thus far, the implications of CAC in patients with acute coronary syndromes remain unclear. We aimed to investigate whether the CAC score is associated with impaired reperfusion during the acute phase of ST-elevation myocardial infarction (STEMI). METHODS: We enrolled 60 consecutive STEMI patients to undergo cardiac computed tomography for assessment of the CAC score within 1 week after STEMI...
November 2015: Coronary Artery Disease
Sandeep A Saha, Alexis L Beatty, Rakesh K Mishra, Mary A Whooley, Nelson B Schiller
Mitral annular calcium and aortic valve sclerosis on transthoracic echocardiography (TTE) are independently associated with cardiovascular (CV) events in patients with coronary artery disease (CAD). However, the prognostic value of calcific deposits at multiple sites is unknown. We performed TTEs in a prospective cohort of 595 outpatients with stable CAD and graded the severity of calcific deposition at 6 sites: mitral annulus, aortic valve, aortic ring, sinotubular junction, papillary muscle tip, and left main coronary artery...
July 1, 2015: American Journal of Cardiology
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