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intravascular lymphoma

L Abraham, H Kreipe, P Raab, K Hussein
Intravascular B‑cell lymphomas (IVL) are rare neoplasms that can manifest at any age (mean age ~62-63 years). About half of the cases are associated with Epstein-Barr virus. The most common sites of manifestation are the brain, skin, and bone marrow. The diagnosis is difficult due to unspecific clinical presentation and laboratory changes. FACS (fluorescence-activated cell sorting) and clonality analysis from peripheral blood and radiological findings are often not diagnostic. The most sensitive and most specific diagnostic method is the histopathological and immunohistochemical evaluation of a tissue biopsy...
March 14, 2018: Der Pathologe
Dayne Ashman, Liron Pantanowitz
No abstract text is available yet for this article.
March 1, 2018: International Journal of Surgical Pathology
Anne M R Schrader, Patty M Jansen, Rein Willemze, Maarten H Vermeer, Anne-Marie Cleton-Jansen, Sebastiaan F Somers, J H Hendrik Veelken, Ronald van Eijk, Willem Kraan, Marie José Kersten, Michiel van den Brand, Wendy B C Stevens, Daphne de Jong, Myrurgia Abdul Hamid, Bea C Tanis, Eduardus F M Posthuma, Marcel Nijland, Arjan Diepstra, Steven T Pals, Arjen H G Cleven, Joost S P Vermaat
No abstract text is available yet for this article.
March 7, 2018: Blood
Chieh-Lung Cheng, Yung-Cheng Su, Tsu-Yi Chao, Chung-Wu Lin, Sheng-Chieh Chou, Ming Yao, Sung-Hsin Kuo, Shan-Chi Yu
Intralymphatic spread is common in solid cancers, but has been rarely studied in lymphomas. Review of 635 extranodal specimens from 475 diffuse large B-cell lymphoma (DLBCL) patients revealed intralymphatic spread in 10 surgical resection specimens from 10 patients including 9 de novo DLBCLs and 1 Richter transformation. The prevalence in de novo DLBCL with extranodal involvements was 1.65%. The most common involved site of intralymphatic spread was the gastrointestinal tract, followed by the female genital tract and breasts...
March 2, 2018: American Journal of Surgical Pathology
Yasuhito Suehara, Mamiko Sakata-Yanagimoto, Keiichiro Hattori, Toru Nanmoku, Takayoshi Itoh, Daisuke Kaji, Go Yamamoto, Yoshiaki Abe, Kentaro Narita, Masami Takeuchi, Kosei Matsue, Taiki Sato, Masayuki Noguchi, Naoko Baba, Tatsuhiro Sakamoto, Manabu Kusakabe, Naoki Kurita, Takayasu Kato, Yasuhisa Yokoyama, Hidekazu Nishikii, Naoshi Obara, Yuichi Hasegawa, Shigeru Chiba
February 22, 2018: Haematologica
Yingwei Zhang, Lintao Bi, Yuying Qiu, Tingting Zhao, Mengshu Cao, Jingjing Ding, Fanqing Meng, Hourong Cai
The present study aimed to investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung. The clinical and histopathological data of three patients, and the literature was reviewed. The Ethics Committees of Drum Tower Hospital approved the current study based on the three cases. Fever and respiratory symptoms were the main presenting symptoms. Serum lactate dehydrogenase and C-reactive protein were significantly increased. Diffuse ground glass opacities or nodular consolidations were seen on high resolution computed tomography...
March 2018: Oncology Letters
Ayako Sakakibara, Yuichiro Inagaki, Eiki Imaoka, Eri Ishikawa, Satoko Shimada, Kazuyuki Shimada, Yuka Suzuki, Shigeo Nakamura, Akira Satou, Kei Kohno
Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically distinctive entity characterized by the almost exclusive growth of large cells within the lumen of blood vessels in particular capillaries. Reports of this peculiar disease, do not commonly address the PD-L1 expression on IVLBCL tumor cells. Here, we describe a 51-year-old Japanese woman who presented with rapidly progressive cognitive decline and higher brain dysfunction. CT scan and MRI revealed multiple ischemic foci in the cerebral hemispheres, ground-glass opacity in the lungs, and splenomegaly...
February 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
Bülent Çetin, Nalan Akyürek, Yavuz Metin, Feryal Karaca, İrem Bilgetekin, Ahmet Ozet
No abstract text is available yet for this article.
February 2, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Athiphat Banjongjit, Kanokphorn Chiratikarnwong, Pirun Saelue, Siripan Sangmala, Sauvarat Auepemkiate, Kanita Kayasut
No abstract text is available yet for this article.
March 2018: JAAD Case Reports
Catharine Pearce, Suzy Hope, Joseph Butchart
An 84-year-old woman presented with severe postural hypotension. Further assessment revealed weight loss, fatigue and fever at night. On examination, she had bilateral skin lesions on the inner thighs and skin biopsy revealed intravascular high grade B cell lymphoma. This was successfully treated with curative chemotherapy. The cause of the postural hypotension in this case was felt likely to be autonomic neuropathy caused by neurovascular infiltration by intravascular lymphoma. Treatment of the lymphoma has resolved the postural hypotension, although some symptoms of postural instability persist...
January 29, 2018: BMJ Case Reports
Marlène Cherruault, Marielle Le Goff, Jérôme Tamburini, Frédéric Pène
OBJECTIVES: Hematologic malignancies may result in multiple organ involvement including pulmonary and renal dysfunctions, and the less common acute circulatory failure. We herein addressed the outcome of patients with sepsis-like shock related to aggressive hematologic malignancies. DESIGN: A 10-year (2007-2016) monocenter retrospective study. SETTINGS: A medical ICU in a tertiary care center. PATIENTS: Patients with circulatory shock requiring vasopressors and who subsequently received chemotherapy...
January 25, 2018: Critical Care Medicine
A Kailas, D M Elston, S E Crater, C A Cerruto
Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy was performed which revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Clinical exam revealed no other evidence of lymphoma, the patient denied constitutional symptoms, and routine blood work was normal. The patient is healthy and doing well 28 months after her first visit...
January 25, 2018: Journal of Cutaneous Pathology
Joseph S Donald, Nick Barnthouse, Delphine L Chen
Intravascular lymphoma (IVL) is a rare subtype of diffuse large B-cell lymphoma characterized by a clonal proliferation of lymphocytes restricted to the intravascular space. We present the case of a 60-year-old man with hemophagocytic syndrome secondary to IVL. F-FDG PET/CT demonstrated hepatosplenomegaly with marked diffuse hepatic, splenic, and bone marrow hypermetabolism. The case report illustrates the imaging findings of this uncommon variant of IVL.
January 19, 2018: Clinical Nuclear Medicine
Corinne Maiolo, S Jan Ibbetson, Shireen K Sidhu, Daniel Kearney
No abstract text is available yet for this article.
November 2017: JAAD Case Reports
Yuichiro Ohya, Masato Osaki, Shouta Sakai, Shunsuke Kimura, Tatsuro Shimogamo, Tetsuro Ago, Takanari Kitazono, Shuji Arakawa
Intravascular lymphoma (IVL) is a rare disease characterized by the proliferation of lymphoma cells in the lumen of the small blood vessels. Although early diagnosis of IVL is important to prolong survival of the patients, its atypical symptoms and clinical course often delay its diagnosis. More than half of the patients are diagnosed at autopsy. We report a 68-year-old man who presented with transient ideomotor apraxia and mildly elevated soluble interleukin-2 receptor levels. He was initially diagnosed with aortogenic embolic stroke...
September 2017: Case Reports in Neurology
Faisal Mahmudul Huq Ronny, Margaret Ann Black, Arnaldo A Arbini
Intravascular large B-cell lymphoma (IVLBCL) is a very rare extra nodal lymphoma that tends to proliferate within small blood vessels, particularly capillaries and postcapillary venules while sparing the organ parenchyma. The cause of its affinity for the vascular bed remains unknown. Because of its rarity and unremarkable clinical presentation, a timely diagnosis of IVLBCL is very challenging. Here, we describe a case of IVLBCL presenting as pancreatic mass that was ultimately diagnosed at autopsy. A 71-year-old Caucasian female presented with a 3-month history of fatigue, abdominal pain, and weight loss...
October 2017: Autopsy & Case Reports
Takeo Uzuka, Fumi Higuchi, Hadzuki Matsuda, Ryohei Otani, Phyo Kim, Keisuke Ueki
Intravascular lymphoma (IVL) has been characterized in many case reports by multiple white matter lesions reflecting ischemic changes. In contrast, there are very few case reports of cerebral or cerebellar hemorrhage resulting from IVL. A 56-year-old woman was referred to our department with two-week history of headache, nausea, and poor appetite. Gadolinium (Gd)-enhanced magnetic resonance imaging (MRI) showed dilated veins on the cerebellar surface. No ischemic lesions were detected on diffusion-weighted images...
December 15, 2017: Neurologia Medico-chirurgica
Amy M Chan, Anita Huttner, Joachim Baehring
No abstract text is available yet for this article.
December 1, 2017: Clinical Neuroradiology
V Génin, A Enfrein, M Lecouffe-Desprets, P Gallas, C Bossard, A Moreau, C Ansquer, M Hamidou, C Agard, A Néel
No abstract text is available yet for this article.
January 1, 2018: QJM: Monthly Journal of the Association of Physicians
Jong Gwon Choi, Hwan Hwi Cho, Sang Rok Kang, Se Min Jang, Eun Hyung Yoo, Hyun Jung Cho, Sun Moon Kim, Do Yeun Cho
Myelofibrosis (MF) is often accompanied by chronic myeloid leukemia, hairy cell leukemia, or certain primary myeloproliferative neoplasms, but is rarely associated with lymphoid neoplasms. We herein describe a case of intravascular large B-cell lymphoma (IVLBCL) with MF. IVLBCL is a rare, aggressive type of extranodal B-cell lymphoma, defined by proliferation of lymphomatous cells within small-to medium-sized vessels. A 60-year-old woman was admitted to the hospital with anemia, thrombocytopenia and fever. Bone marrow biopsy findings included trilineage hematopoiesis, increased numbers of immature cells, markedly abnormal and enlarged megakaryocytes, and diffuse fibrosis in multiple focal areas throughout the entire bone marrow space...
November 2017: Molecular and Clinical Oncology
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