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Caterina Fraschetti, Antonello Filippi, Maria Elisa Crestoni, Claudio Villani, Graziella Roselli, Stefano Levi Mortera, Maurizio Speranza
The enantioselective interactions between chiral tetra-amidic receptors and nucleosides have been investigated by the ESI-IT-MS and ESI-FT-ICR-MS methodologies. Configurational effects on the CID fragmentation of diastereomeric [M(H)(2)•H•A](+) aggregates (A = 2'-deoxycytidine dC, citarabine (ara-C) were found to be mostly offset by isotope effect in [S(X)(2)•H•A](+) (X = H, D) differently from the results obtained on the analogues (A = cytidine C and gemcitabine G). This result points the involvement of two different nucleoside/tetraamide isoforms...
October 2012: Journal of the American Society for Mass Spectrometry
Gilberto Schwartsmann, Adriana Brondani Da Rocha, Jane Mattei, RafaelMartins Lopes
Anticancer agents may be derived either from the isolation of an active lead compound occurring spontaneously in nature or by novel chemical synthesis in the laboratory. There are examples of successful drugs being derived from both sources, which have had a profound impact on the natural history of various types of cancer. The treatment of lymphomas and acute leukaemias with the use of combination chemotherapy, including anthracyclines and vinca alkaloids, are examples of the contribution of nature. In contrast, agents such as 5-fluorouracil, methotrexate and more recently, the humanised anti-CD20 antibody rituximab and the tyrosine kinase inhibitor imatinib are examples of synthetic compounds, which were designed with a clear rationale, that are routinely used in patients with solid tumours and haematological malignancies...
August 2003: Expert Opinion on Investigational Drugs
Kênya Silva Cunha, Maria Luíza Reguly, Ulrich Graf, Heloisa Helena Rodrigues de Andrade
Two deoxycytidine analogues, 1-beta-D-arabinofuranosylcytosine (cytosine arabinoside, citarabine, araC) and 5-aza-2'-deoxycytidine (decitabine, DAC, 5-aza-dC), are the drugs of choice in the treatment of acute myeloid leukaemia. The araC-induced cytotoxicity is a direct result of its interference with nucleic acids synthesis, whereas 5-aza-dC is a potent suppressor of DNA methylation. We employed the standard version of the wing somatic mutation and recombination test (SMART) in Drosophila melanogaster to evaluate the genotoxic potential of these two antimetabolites as a function of exposure concentration...
February 15, 2002: Mutation Research
A B da Rocha, R M Lopes, G Schwartsmann
Many pharmaceutical agents have been discovered by screening natural products from plants, animals, marine organisms and microorganisms. Vincristine, irinotecan, etoposide and paclitaxel are examples of plant-derived compounds that are being employed in cancer treatment, and dactinomycin, bleomycin and doxorubicin are anticancer agents derived from microbial sources. Citarabine is an example of an anticancer agent originating from a marine source. Other agents originating from marine sources are bryostatin-1, aplidine, dolastatin 10 and ET-743, which have recently entered phase I and II clinical trials...
August 2001: Current Opinion in Pharmacology
J de Diego-Floreschapa, M López-Hernández, J R Borbolla-Escoboza, E Trueba-Christy, T Carrillo-Rosales, M González-Avante
This paper reports the long-term, disease-free survival of children with high-risk (HR) acute lymphoblastic leukemia (ALL) treated with two different chemotherapy regimens. HR was defined in children with ALL, younger than 2 or older than 10 years, with or without initial extrahematopoietic disease, with a leukocyte count higher than 25 x 10(9)L, or with L3 FAB type. The first group, LAL1, included 67 patients; they received induction with vincristine (VCR) and prednisone (PDN), early consolidation with 3 cycles of 6-mercaptopurine (6MP), citarabine (ARA) and VCR: central nervous system (CNS) prophylaxis (PFX) consisted of both chemotherapy in induction, consolidation and maintenance, radiotherapy (RT) in consolidation...
May 1999: Gaceta Médica de México
M Campbell, C Salgado, J Quintana, A Becker, L Vargas, M E Cabrera, V Beresi, J Rojas, E Paez, S Tapia, P Zolezzi, P Advis
BACKGROUND: The National Chilean Pediatric Oncology Group, PINDA, reports the first prospective, nonrandomized trial for acute lymphoblastic leukemia (ALL), using a modified version of the Berlin-Frankfurt-Munster protocol (ALL BFM 86). The aim of this study was to classify immunophenotypes, to decrease cranial irradiation, and to assess whether this protocol would improve the survival rate. PROCEDURE: From June, 1987, to June, 1992, 444 unselected children were diagnosed with ALL...
August 1999: Medical and Pediatric Oncology
J S de Oliveira, M de L Chauffaille, G W Colleoni, V M Morelli, O M Hauache, V N Alberti, J Kerbauy
The authors report the case of a chronic myeloid leukemia (CML) patient submitted to allogenic bone marrow transplantation, who had probably never entered complete remission. The disease was reactivated as a granulocytic sarcoma, next to a platinum plate installed to correct a tibia fracture 11 years earlier. Its final event was a myeloid Ph1 + blastic crisis that was unsuccessfully treated with high doses of sc interferon and citarabine.
March 1998: São Paulo Medical Journal, Revista Paulista de Medicina
A L Brodsky, M J Melero, C J Minissale, J C Sánchez Avalos
In a study undertaken to evaluate fluoroquinolone prophylaxis in afebrile granulocytopenic patients, an unexpected association between chemotherapy schedule and a later development of bacteremia--during the subsequent febrile neutropenic episodes--was found. Twenty five febrile neutropenic episodes consecutive to chemotherapy for acute leukemia were studied. Patients received either etoposide and mitoxantrone or citarabine--in standard, intermediate or high doses--combined with daunomicin or mitoxantrone. Microbiologic data analysis showed an increased incidence of bacteremia with combined anthracycline and intermediate or high dose citarabine administration, when compared to etoposide and mitoxantrone use (p = 0...
1996: Medicina
S Shishkov, S Pancheva
Comparative studies were carried out of the antiviral efficacy of 11 substances on the replication of Herpes simplex virus type 1 (strain DA), including compounds with selective antiherpes action--bromovinyldeoxyuridine, virazole, phosphonoformic acid, acycloguanosine, citarabine, vidarabine, iododeoxyuridine, and some nonspecific viral inhibitors with antiherpes effect as distamycin A, tunicamycin and deoxyglucose. The antiherpes activity of the substances was tested in two cell systems: cell strain of human embryonic skin-muscle fibroblasts and a cell line of green monkey kidneys...
1989: Acta Microbiologica Bulgarica
G Molas, P Ponsot, P Solal-Celigny, M Amar, J A Paolaggi, F Potet, D Henin
A 41-year-old woman with a myelodysplastic syndrome complained of diarrhea with malabsorption and protein-losing enteropathy after splenectomy. No cause was found and various therapeutic regimens were not effective. Pathological examination of biopsies from stomach, small intestine, and large bowel showed infiltrations interpreted as inflammatory on routine technics. Blast cell infiltration was found on electron microscopy. Treatment by citarabine induced normalization of leukocytosis, and diarrhea disappeared...
1992: Gastroentérologie Clinique et Biologique
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