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https://www.readbyqxmd.com/read/27905561/anti-hu-antibodies-activate-enteric-and-sensory-neurons
#1
Qin Li, Klaus Michel, Anita Annahazi, Ihsan E Demir, Güralp O Ceyhan, Florian Zeller, Lars Komorowski, Winfried Stöcker, Michael J Beyak, David Grundy, Gianrico Farrugia, Roberto De Giorgio, Michael Schemann
IgG of type 1 anti-neuronal nuclear antibody (ANNA-1, anti-Hu) specificity is a serological marker of paraneoplastic neurological autoimmunity (including enteric/autonomic) usually related to small-cell lung carcinoma. We show here that IgG isolated from such sera and also affinity-purified anti-HuD label enteric neurons and cause an immediate spike discharge in enteric and visceral sensory neurons. Both labelling and activation of enteric neurons was prevented by preincubation with the HuD antigen. Activation of enteric neurons was inhibited by the nicotinic receptor antagonists hexamethonium and dihydro-β-erythroidine and reduced by the P2X antagonist pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid (PPADS) but not by the 5-HT3 antagonist tropisetron or the N-type Ca-channel blocker ω-Conotoxin GVIA...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27789457/a-model-of-the-enteric-neural-circuitry-underlying-the-generation-of-rhythmic-motor-patterns-in-the-colon-the-role-of-serotonin
#2
Terence Keith Smith, Sang Don Koh
We discuss the multiple cell types involved in rhythmic motor patterns in the large intestine that include tonic inhibition of the muscle layers interrupted by rhythmic colonic migrating motor complexes (CMMCs), and secretomotor activity. We propose a model that assumes these motor patterns are dependent upon myenteric descending 5-Hydroxytrpamine (5-HT, serotonin) interneurons. Asynchronous firing in 5-HT neurons excite inhibitory motor neurons (IMNs) to generate tonic inhibition occurring between CMMCs. IMNs release mainly nitric oxide (NO) to inhibit the muscle, IPANs, glia cells and pacemaker ICC-MY...
October 27, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27784805/the-acute-inhibition-of-enteric-glial-metabolism-with-fluoroacetate-alters-calcium-signaling-hemichannel-function-and-the-expression-of-key-proteins
#3
Jonathon L McClain, Brian David Gulbransen
Glia play key roles in the regulation of neurotransmission in the nervous system. Fluoroacetate (FA) is a metabolic poison widely used to study glial functions by disrupting the tricarboxylic acid cycle enzyme aconitase. Despite the widespread use of FA, the effects of FA on essential glial functions such as calcium (Ca(2+)) signaling and hemichannel function remain unknown. Therefore, our goal was to specifically assess the impact of FA on essential glial cell functions that are involved with neurotransmission in the enteric nervous system...
October 26, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27776507/geminin-prevents-dna-damage-in-vagal-neural-crest-cells-to-ensure-normal-enteric-neurogenesis
#4
Chrysoula Konstantinidou, Stavros Taraviras, Vassilis Pachnis
BACKGROUND: In vertebrate organisms, the neural crest (NC) gives rise to multipotential and highly migratory progenitors which are distributed throughout the embryo and generate, among other structures, the peripheral nervous system, including the intrinsic neuroglial networks of the gut, i.e. the enteric nervous system (ENS). The majority of enteric neurons and glia originate from vagal NC-derived progenitors which invade the foregut mesenchyme and migrate rostro-caudally to colonise the entire length of the gut...
October 24, 2016: BMC Biology
https://www.readbyqxmd.com/read/27753092/neuroprotection-and-blood-brain-barrier-restoration-by-salubrinal-after-a-cortical-stab-injury
#5
M Asunción Barreda-Manso, Natalia Yanguas-Casás, Manuel Nieto-Sampedro, Lorenzo Romero-Ramírez
Following a central nervous system (CNS) injury, restoration of the blood-brain barrier (BBB) integrity is essential for recovering homeostasis. When this process is delayed or impeded, blood substances and cells enter the CNS parenchyma, initiating an additional inflammatory process that extends the initial injury and causes so-called secondary neuronal loss. Astrocytes and profibrotic mesenchymal cells react to the injury and migrate to the lesion site, creating a new glia limitans that restores the BBB. This process is beneficial for the resolution of the inflammation, neuronal survival, and the initiation of the healing process...
October 18, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27567306/altered-expression-of-retinoblastoma-1-in-hirschsprung-s-disease
#6
Anne Marie O'Donnell, David Coyle, Prem Puri
PURPOSE: The retinoblastoma 1 (RB1) tumor suppressor is a critical regulator of cell cycle progression and development, and has been widely documented to be inactivated in human cancer. A recent study using RB1 knockout mice suggested a new role for RB1 in the normal regulation of the enteric nervous system (ENS), because of knockout mice showing ENS abnormalities and severe intestinal dysmotility. The aim of our study was to investigate the expression of RB1 in the normal human colon and in Hirschsprung's disease (HD)...
November 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27533011/ilc3s-and-the-willow-tree-of-voices
#7
Milena Bogunovic
Type 3 innate lymphoid cells (ILC3s) and enteric glia, an essential structural component of gut innervation, are well-known regulators of intestinal homeostasis. Ibiza et al. (2016) uncover a new link between commensal bacteria, enteric glial cells, and ILC3s that is required for intestinal homeostasis and defense.
August 16, 2016: Immunity
https://www.readbyqxmd.com/read/27522506/vascular-glial-and-lymphatic-immune-gateways-of-the-central-nervous-system
#8
REVIEW
Britta Engelhardt, Roxana O Carare, Ingo Bechmann, Alexander Flügel, Jon D Laman, Roy O Weller
Immune privilege of the central nervous system (CNS) has been ascribed to the presence of a blood-brain barrier and the lack of lymphatic vessels within the CNS parenchyma. However, immune reactions occur within the CNS and it is clear that the CNS has a unique relationship with the immune system. Recent developments in high-resolution imaging techniques have prompted a reassessment of the relationships between the CNS and the immune system. This review will take these developments into account in describing our present understanding of the anatomical connections of the CNS fluid drainage pathways towards regional lymph nodes and our current concept of immune cell trafficking into the CNS during immunosurveillance and neuroinflammation...
September 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/27519533/phenotype-and-distribution-pattern-of-nestin-gfp-expressing-cells-in-murine-myenteric-plexus
#9
David Grundmann, Franziska Markwart, Anja Scheller, Frank Kirchhoff, Karl-Herbert Schäfer
The enteric nervous system has to adapt to altering dietary or environmental conditions and presents an enormous plasticity that is conserved over the whole lifespan. It harbours neural-crest-derived neurons, glial cells and their precursors. Based on a nestin-green fluorescent protein (NGFP) transgenic model, a histological inventory has been performed to deliver an overview of neuronal and glial markers for the various parts of the gastrointestinal tract in newborn (postnatal day 7) and adult mice under homeostatic conditions...
August 13, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27491828/hiv-1-tat-exacerbates-lipopolysaccharide-induced-cytokine-release-via-tlr4-signaling-in-the-enteric-nervous-system
#10
Joy Guedia, Paola Brun, Sukhada Bhave, Sylvia Fitting, Minho Kang, William L Dewey, Kurt F Hauser, Hamid I Akbarali
The loss of gut epithelium integrity leads to translocation of microbes and microbial products resulting in immune activation and drives systemic inflammation in acquired immunodeficiency syndrome (AIDS) patients. Although viral loads in HIV patients are significantly reduced in the post-cART era, inflammation and immune activation persist and can lead to morbidity. Here, we determined the interactive effects of the viral protein HIV-1 Tat and lipopolysaccharide (LPS) on enteric neurons and glia. Bacterial translocation was significantly enhanced in Tat-expressing (Tat+) mice...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27471254/sara-regulates-neuronal-migration-during-neocortical-development-through-l1-trafficking
#11
Iván Mestres, Jen-Zen Chuang, Federico Calegari, Cecilia Conde, Ching-Hwa Sung
Emerging evidence suggests that endocytic trafficking of adhesion proteins plays a crucial role in neuronal migration during neocortical development. However, molecular insights into these processes remain elusive. Here, we study the early endosomal protein Smad anchor for receptor activation (SARA) in the developing mouse brain. SARA is enriched at the apical endfeet of radial glia of the neocortex. Although SARA knockdown did not lead to detectable neurogenic phenotypes, SARA-suppressed neurons exhibited impaired orientation and migration across the intermediate zone...
September 1, 2016: Development
https://www.readbyqxmd.com/read/27470531/desired-and-side-effects-of-the-supplementation-with-l-glutamine-and-l-glutathione-in-enteric-glia-of-diabetic-rats
#12
Cynthia Priscilla do Nascimento Bonato Panizzon, Jacqueline Nelisis Zanoni, Catchia Hermes-Uliana, Aline Rosa Trevizan, Camila Caviquioli Sehaber, Renata Virginia Fernandes Pereira, David Robert Linden, Marcílio Hubner de Miranda Neto
BACKGROUND/AIMS: Enteric neuropathy associated with Diabetes Mellitus causes dysfunction in the digestive system, such as: nausea, diarrhea, constipation, vomiting, among others. The aim of this study was to compare the effects of supplementation with 2% l-glutamine and 1% l-glutathione on neurons and enteric glial cells of ileum of diabetic rats. METHODS: Thirty male Wistar rats have been used according to these group distributions: Normoglycemic (N), Normoglycemic supplemented with l-glutamine (NG), Normoglycemic supplemented with l-glutathione (NGO), Diabetic (D), Diabetic supplemented with l-glutamine (DG) and Diabetic supplemented with l-glutathione (DGO)...
July 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27436013/a-novel-enteric-neuron-glia-coculture-system-reveals-the-role-of-glia-in-neuronal-development
#13
Catherine Le Berre-Scoul, Julien Chevalier, Elena Oleynikova, François Cossais, Sophie Talon, Michel Neunlist, Hélène Boudin
In the nervous system, the formation of neuronal circuitry results from a complex and coordinated action of intrinsic and extrinsic factors. In the CNS, extrinsic mediators derived from astrocytes have been shown to play a key role in neuronal maturation, including dendritic shaping, axon guidance and synaptogenesis. In the enteric nervous system (ENS), the potential role of enteric glial cells (EGCs) in the maturation of developing enteric neuronal circuit is currently unknown. A major obstacle in addressing this question is the difficulty to obtain a valuable experimental model in which enteric neurons could be isolated and maintained without EGCs...
July 20, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27379633/development-of-neural-activity-in-the-enteric-nervous-system-similarities-and-differences-to-other-parts-of-the-nervous-system
#14
Marlene M Hao
All the neurons and glia of the enteric nervous system (ENS) arise from neural crest-derived cells that migrate into the gastrointestinal (GI) tract during development (Yntema and Hammond 1954; Le Douarin and Teillet 1973). Most of the ENS originates from vagal neural crest cells (NCCs), which arise from the caudal hindbrain region of the neural tube, adjacent to somites 1-7. In the developing mouse, vagal NCCs migrate into the developing oesophagus and stomach at embryonic day (E)9.5, enter the small intestine at E10...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27271278/evidence-for-a-notch1-mediated-transition-during-olfactory-ensheathing-cell-development
#15
Sophie R Miller, Surangi N Perera, Cristina Benito, Simon R W Stott, Clare V H Baker
Olfactory ensheathing cells (OECs) are a unique glial population found in both the peripheral and central nervous system: they ensheath bundles of unmyelinated olfactory axons from their peripheral origin in the olfactory epithelium to their central synaptic targets in the glomerular layer of the olfactory bulb. Like all other peripheral glia (Schwann cells, satellite glia, enteric glia), OECs are derived from the embryonic neural crest. However, in contrast to Schwann cells, whose development has been extensively characterised, relatively little is known about their normal development in vivo...
September 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27235816/enteric-nervous-system-assembly-functional-integration-within-the-developing-gut
#16
REVIEW
M M Hao, J P P Foong, J C Bornstein, Z L Li, P Vanden Berghe, W Boesmans
Co-ordinated gastrointestinal function is the result of integrated communication between the enteric nervous system (ENS) and "effector" cells in the gastrointestinal tract. Unlike smooth muscle cells, interstitial cells, and the vast majority of cell types residing in the mucosa, enteric neurons and glia are not generated within the gut. Instead, they arise from neural crest cells that migrate into and colonise the developing gastrointestinal tract. Although they are "later" arrivals into the developing gut, enteric neural crest-derived cells (ENCCs) respond to many of the same secreted signalling molecules as the "resident" epithelial and mesenchymal cells, and several factors that control the development of smooth muscle cells, interstitial cells and epithelial cells also regulate ENCCs...
September 15, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27219534/the-microglial-atp-gated-ion-channel-p2x7-as-a-cns-drug-target
#17
REVIEW
Anindya Bhattacharya, Knut Biber
Based on promising preclinical evidence, microglial P2X7 has increasingly being recognized as a target for therapeutic intervention in neurological and psychiatric diseases. However, despite this knowledge no P2X7-related drug has yet entered clinical trials with respect to CNS diseases. We here discuss the current literature on P2X7 being a drug target and identify unsolved issues and still open questions that have hampered the development of P2X7 dependent therapeutic approaches for CNS diseases. It is concluded here that the lack of brain penetrating P2X7 antagonists is a major obstacle in the field and that central P2X7 is a yet untested clinical drug target...
October 2016: Glia
https://www.readbyqxmd.com/read/27106597/enteric-glia-the-most-alimentary-of-all-glia
#18
Vladimir Grubišić, Brian D Gulbransen
Glia (from Greek γλοία meaning "glue") pertains to non-neuronal cells in the central (CNS) and peripheral nervous system (PNS) that nourish neurons and maintain homeostasis. In addition, glia are now increasingly appreciated as active regulators of numerous physiological processes initially considered exclusively under neuronal regulation. For instance, enteric glia, a collection of glial cells residing within the walls of the intestinal tract, regulate intestinal motility; a well-characterized reflex controlled by enteric neurons...
April 23, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27076429/ascl1-is-required-for-the-development-of-specific-neuronal-subtypes-in-the-enteric-nervous-system
#19
Fatima Memic, Viktoria Knoflach, Rebecca Sadler, Gunilla Tegerstedt, Erik Sundström, Francois Guillemot, Vassilis Pachnis, Ulrika Marklund
UNLABELLED: The enteric nervous system (ENS) is organized into neural circuits within the gastrointestinal wall where it controls the peristaltic movements, secretion, and blood flow. Although proper gut function relies on the complex neuronal composition of the ENS, little is known about the transcriptional networks that regulate the diversification into different classes of enteric neurons and glia during development. Here we redefine the role of Ascl1 (Mash1), one of the few regulatory transcription factors described during ENS development...
April 13, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27068404/the-enteric-nervous-system-in-patients-with-calculous-and-acalculous-gallbladder
#20
Vincenzo Villanacci, Rachele Del Sordo, Marianna Salemme, Moris Cadei, Angelo Sidoni, Gabrio Bassotti
BACKGROUND: It is generally thought that gallbladder motility plays a more or less important role in the pathogenesis of gallstones. Some studies have shown that some abnormalities of its intrinsic innervations, but these studies were usually limited to one cell component. AIMS: We investigated the main cell components of gallbladder intrinsic innervation in patients with and without gallstones. METHODS: Archival gallbladder specimens from 39 patients, 27 with gallstones (age range 45-69 yrs) and 12 patients without gallstones (age range 39-71 yrs) were obtained...
July 2016: Digestive and Liver Disease
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