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Postural ET

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https://www.readbyqxmd.com/read/29749618/distinguishing-features-between-valproate-induced-tremor-and-essential-tremor
#1
M Alonso-Juarez, J F Baizabal-Carvallo
BACKGROUND: Tremor frequently occurs in patients taking valproate and may resemble that observed in patients with essential tremor (ET). We aimed to compare the distribution, severity, and functional impact of both types of tremor. METHODS: Among 118 consecutive individuals taking valproate, we identified 28 patients with valproate-induced tremor severe enough to require pharmacological treatment; through evaluations using the Clinical Rating Scale for Tremor (CRST), they were compared with 29 consecutive patients with ET...
May 10, 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29725318/could-wearable-and-mobile-technology-improve-the-management-of-essential-tremor
#2
Jean-Francois Daneault
Essential tremor (ET) is the most common movement disorder. Individuals exhibit postural and kinetic tremor that worsens over time and patients may also exhibit other motor and non-motor symptoms. While millions of people are affected by this disorder worldwide, several barriers impede an optimal clinical management of symptoms. In this paper, we discuss the impact of ET on patients and review major issues to the optimal management of ET; from the side-effects and limited efficacy of current medical treatments to the limited number of people who seek treatment for their tremor...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29704608/comparison-of-one-and-three-lead-ecg-to-measure-cardiac-intervals-and-differentiate-drug-induced-multi-channel-block
#3
Robert Brockway, Marina Brockway, Brian Brockway, Robert Hamlin
INTRODUCTION: FDA has established initiatives to characterize clinical and non-clinical biomarkers to enable more precise prediction of proarrhythmia risk based upon knowledge of drug effect on multiple cardiac ion channels (Colatsky et al., 2016). The FDA has recently demonstrated superiority of early ventricular repolarization interval (JTp) in differentiating pure hERG block from multi-channel block in human subjects. Preclinical studies often acquire a single lead ECG, whereas FDA measurements of JTp were derived ​from a spatial vectorcardiogram computed using multiple leads...
April 25, 2018: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/29678370/the-response-of-the-central-and-peripheral-tremor-component-to-octanoic-acid-in-patients-with-essential-tremor
#4
Hongmei Cao, Johanna Thompson-Westra, Mark Hallett, Dietrich Haubenberger
OBJECTIVE: To investigate the effect of octanoic acid (OA) on the peripheral component of tremor, as well as OA's differential effects on the central and peripheral tremor component in essential tremor (ET) patients. METHODS: We analyzed postural tremor accelerometry data from a double-blind placebo-controlled cross-over study evaluating the effect of 4 mg/kg OA in ET. The weighted condition was used to identify tremor power for both the central and peripheral tremor components...
April 3, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29487515/modulation-of-emg-emg-coherence-in-a-choice-stepping-task
#5
Ippei Nojima, Tatsunori Watanabe, Kotaro Saito, Shigeo Tanabe, Hoshinori Kanazawa
The voluntary step execution task is a popular measure for identifying fall risks among elderly individuals in the community setting because most falls have been reported to occur during movement. However, the neurophysiological functions during this movement are not entirely understood. Here, we used electromyography (EMG) to explore the relationship between EMG-EMG coherence, which reflects common oscillatory drive to motoneurons, and motor performance associated with stepping tasks: simple reaction time (SRT) and choice reaction time (CRT) tasks...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29481820/essential-tremor-quantification-based-on-the-combined-use-of-a-smartphone-and-a-smartwatch-the-netmd-study
#6
Roberto López-Blanco, Miguel A Velasco, Antonio Méndez-Guerrero, Juan Pablo Romero, María Dolores Del Castillo, J Ignacio Serrano, Julián Benito-León, Félix Bermejo-Pareja, Eduardo Rocon
BACKGROUND: The use of wearable technology is an emerging field of research in movement disorders. This paper introduces a clinical study to evaluate the feasibility, clinical correlation and reliability of using a system based in smartwatches to quantify tremor in essential tremor (ET) patients and check its acceptance as clinical monitoring tool. NEW METHOD: The system is based on a commercial smartwatch and an Android smartphone. An investigational Android application controls the process of recording raw data from the smartwatch three-dimensional gyroscopes...
June 1, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29473479/distinguishing-statistical-and-clinical-significance-in-meta-analysis-comment-on-the-effectiveness-of-hydrokinesiotherapy-on-postural-balance-of-hemiplegic-patients-after-stroke-a-systematic-review-and-meta-analysis-by-iatridou-g-et-al
#7
https://www.readbyqxmd.com/read/29455947/the-neural-exploitation-hypothesis-and-its-implications-for-an-embodied-approach-to-language-and-cognition-insights-from-the-study-of-action-verbs-processing-and-motor-disorders-in-parkinson-s-disease
#8
REVIEW
Vittorio Gallese, Valentina Cuccio
As it is widely known, Parkinson's disease is clinically characterized by motor disorders such as the loss of voluntary movement control, including resting tremor, postural instability, and bradykinesia (Bocanegra et al., 2015; Helmich, Hallett, Deuschl, Toni, & Bloem, 2012; Liu et al., 2006; Rosin, Topka, & Dichgans, 1997). In the last years, many empirical studies (e.g., Bocanegra et al., 2015; Spadacenta et al., 2012) have also shown that the processing of action verbs is selectively impaired in patients affected by this neurodegenerative disorder...
March 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29428341/a-method-for-characterizing-essential-tremor-from-the-shoulder-to-the-wrist
#9
Daniel W Geiger, Dennis L Eggett, Steven K Charles
BACKGROUND: Despite the pervasive and devastating effect of Essential Tremor (ET), the distribution of ET throughout the upper limb is unknown. We developed a method for characterizing the distribution of ET and performed a preliminary characterization in a small number of subjects with ET. METHODS: Using orientation sensors and inverse kinematics, we measured tremor in each of the seven major degrees of freedom (DOF) from the shoulder to the wrist while ten patients with mild ET assumed 16 different postures...
February 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29428293/impact-of-spine-alignment-on-the-rotator-cuff-in-long-term-wheelchair-users
#10
Yasser Kentar, Manuela Brunner, Thomas Bruckner, Andreas Hug, Patric Raiss, Felix Zeifang, Markus Loew, Haidara Almansour, Michael Akbar
BACKGROUND: We investigated the impact of poor seated posture on the prevalence of rotator cuff tears (RCTs) among wheelchair-dependent individuals with long-standing paraplegia. METHODS: The study included 319 patients. Lateral radiographs of the spine were collected from a database and analyzed to assess the global spinopelvic alignment (SPA). Magnetic resonance images of both shoulders were obtained to detect the presence of cuff tears. Patients were divided into 2 groups: Group RCT-I included all patients with cuff tears (right, left, or bilateral), whereas group RCT-II consisted exclusively of patients with bilateral cuff tears...
February 8, 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29404647/-essential-tremor-state-of-the-art
#11
REVIEW
G Deuschl, D Berg
Essential tremor (ET) is currently classified as a syndrome rather than a unique disease, primarily involving monosymptomatic action tremor in both hands. Different etiologies are presumed to underlie this condition. Currently only a few monogenetic conditions are known to present with this syndrome. If accompanied by additional symptoms that do not in themselves constitute a new syndrome, such as abnormal tandem gait or postures, the syndrome should be diagnosed as "ET plus". ET is associated with abnormal rhythmic activation of the cerebello-thalamo-cortical tremor circuit...
April 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29320970/modelling-endurance-and-resumption-times-for-repetitive-one-hand-pushing
#12
Linda M Rose, Catherine A A Beauchemin, W Patrick Neumann
This study's objective was to develop models of endurance time (ET), as a function of load level (LL), and of resumption time (RT) after loading as a function of both LL and loading time (LT) for repeated loadings. Ten male participants with experience in construction work each performed 15 different one-handed repetaed pushing tasks at shoulder height with varied exerted force and duration. These data were used to create regression models predicting ET and RT. It is concluded that power law relationships are most appropriate to use when modelling ET and RT...
February 15, 2018: Ergonomics
https://www.readbyqxmd.com/read/29246454/reliability-construct-validity-and-interpretability-of-the-brazilian-version-of-the-rapid-upper-limb-assessment-rula-and-strain-index-si
#13
Daniela Pereira Valentim, Tatiana de Oliveira Sato, Maria Luiza Caíres Comper, Anderson Martins da Silva, Cristiana Villas Boas, Rosimeire Simprini Padula
BACKGROUND: There are very few observational methods for analysis of biomechanical exposure available in Brazilian-Portuguese. OBJECTIVE: This study aimed to cross-culturally adapt and test the measurement properties of the Rapid Upper Limb Assessment (RULA) and Strain Index (SI). METHODS: The cross-cultural adaptation and measurement properties test were established according to Beaton et al. and COSMIN guidelines, respectively. Several tasks that required static posture and/or repetitive motion of upper limbs were evaluated (n>100)...
November 26, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29211712/synchrotron-scanning-reveals-amphibious-ecomorphology-in-a-new-clade-of-bird-like-dinosaurs
#14
Andrea Cau, Vincent Beyrand, Dennis F A E Voeten, Vincent Fernandez, Paul Tafforeau, Koen Stein, Rinchen Barsbold, Khishigjav Tsogtbaatar, Philip J Currie, Pascal Godefroit
Maniraptora includes birds and their closest relatives among theropod dinosaurs. During the Cretaceous period, several maniraptoran lineages diverged from the ancestral coelurosaurian bauplan and evolved novel ecomorphologies, including active flight, gigantism, cursoriality and herbivory. Propagation X-ray phase-contrast synchrotron microtomography of a well-preserved maniraptoran from Mongolia, still partially embedded in the rock matrix, revealed a mosaic of features, most of them absent among non-avian maniraptorans but shared by reptilian and avian groups with aquatic or semiaquatic ecologies...
December 21, 2017: Nature
https://www.readbyqxmd.com/read/29195805/-symptomatic-remission-and-its-relationship-to-social-functioning-in-tunisian-out-patients-with-schizophrenia
#15
I El Gharbi, M Chhoumi, A Mechri
INTRODUCTION: The concept of symptomatic and functional remission represents an important challenge in the care of the mentally ill, particularly in patients with schizophrenia. Operational criteria for symptomatic remission in schizophrenia have been proposed by Andreasen et al. (2005). Over the last decade, these criteria have been widely validated; however few studies have been conducted outside developed countries. Moreover, the association of symptomatic remission with functional outcome has not yet been established in developing countries including Tunisia, as there may be variability in the social and familial environment...
November 28, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29181555/predicting-vection-and-visually-induced-motion-sickness-based-on-spontaneous-postural-activity
#16
Stephen Palmisano, Benjamin Arcioni, Paul J Stapley
Evidence is mounting that differences in postural instability can be used to predict who will experience strong illusory self-motions (vection) and become sick when exposed to global patterns of optical flow (e.g., Apthorp et al., PLoS One 9(12):e113897, 2014; Stoffregen and Smart, Brain Res Bull 47:437-448, 1998). This study compared the predictive ability of traditional and recurrence quantification analysis (RQA) based measures of postural activity. We initially measured spontaneous fluctuations in the centre of foot pressure (CoP) of our subjects as they stood quietly with their eyes open and closed...
January 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29151141/mechanical-perturbations-can-elicit-triggered-reactions-in-the-absence-of-a-startle-response
#17
Christopher J Forgaard, Ian M Franks, Kimberly Bennett, Dana Maslovat, Romeo Chua
Perturbations delivered to the upper limbs elicit reflexive responses in stretched muscle at short- (M1: 25-50 ms) and long- (M2: 50-100 ms) latencies. When presented in a simple reaction time (RT) task, the perturbation can also elicit a preprogrammed voluntary response at a latency (< 100 ms) that overlaps the M2 response. This early appearance of the voluntary response following a proprioceptive stimulus causing muscle stretch is called a triggered reaction. Recent work has demonstrated that a perturbation also elicits activity in sternocleidomastoid (SCM) over a time-course consistent with the startle response and it was, therefore, proposed that the StartReact effect underlies triggered reactions (Ravichandran et al...
February 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/29140159/athletes-rated-as-poor-single-leg-squat-performers-display-measureable-differences-in-single-leg-squat-biomechanics-compared-to-good-performers
#18
Lachlan E Garrick, Bryce C Alexander, Anthony G Schache, Marcus G Pandy, Kay M Crossley, Natalie J Collins
CONTEXT: It is important to validate single-leg squat visual rating criteria used in clinical practice and research. Foot orthoses may improve single-leg squat performance in those who demonstrate biomechanics associated with increased risk of lower-limb injury. OBJECTIVE: Validate visual rating criteria proposed by Crossley et al, by determining whether athletes rated as poor single-leg squat performers display different single-leg squat biomechanics than good performers; and evaluate immediate effects of foot orthoses on single-leg squat biomechanics in poor performers...
November 15, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29136548/wavelet-coherence-analysis-a-new-approach-to-distinguish-organic-and-functional-tremor-types
#19
G Kramer, A M M Van der Stouwe, N M Maurits, M A J Tijssen, J W J Elting
OBJECTIVE: To distinguish tremor subtypes using wavelet coherence analysis (WCA). WCA enables to detect variations in coherence and phase difference between two signals over time and might be especially useful in distinguishing functional from organic tremor. METHODS: In this pilot study, polymyography recordings were studied retrospectively of 26 Parkinsonian (PT), 26 functional (FT), 26 essential (ET), and 20 enhanced physiological (EPT) tremor patients. Per patient one segment of 20 s in duration, in which tremor was present continuously in the same posture, was selected...
January 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29102253/square-biphasic-pulse-deep-brain-stimulation-for-essential-tremor-the-bip-tremor-study
#20
Sol De Jesus, Leonardo Almeida, Leili Shahgholi, Daniel Martinez-Ramirez, Jaimie Roper, Chris J Hass, Umer Akbar, Aparna Wagle Shukla, Robert S Raike, Michael S Okun
BACKGROUND: Conventional deep brain stimulation (DBS) utilizes regular, high frequency pulses to treat medication-refractory symptoms in essential tremor (ET). Modifications of DBS pulse shape to achieve improved effectiveness is a promising approach. OBJECTIVES: The current study assessed the safety, tolerability and effectiveness of square biphasic pulse shaping as an alternative to conventional ET DBS. METHODS: This pilot study compared biphasic pulses (BiP) versus conventional DBS pulses (ClinDBS)...
January 2018: Parkinsonism & related Disorders
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