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Intention Tremor

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https://www.readbyqxmd.com/read/27874491/movement-disorders-in-multiple-sclerosis-and-their-treatment
#1
Günther Deuschl
Hyperkinetic movement disorders such as tremors are not uncommon in patients with multiple sclerosis (MS). The classical feature is intention tremor, whereas rest tremors appear not to occur. Treatment is mainly invasive, with options of Gamma Knife surgery, thalamotomy or deep brain stimulation depending on individual circumstances. Deep brain stimulation is the only option for patients who require a bilateral intervention. All treatment recommendations have only low evidence. Tremors can also be cured spontaneously by a subsequent strategic MS lesion...
December 2016: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/27858575/chronic-electrocorticography-for-sensing-movement-intention-and-closed-loop-deep-brain-stimulation-with-wearable-sensors-in-an-essential-tremor-patient
#2
Jeffrey A Herron, Margaret C Thompson, Timothy Brown, Howard J Chizeck, Jeffrey G Ojemann, Andrew L Ko
Deep brain stimulation (DBS) has become a widespread and valuable treatment for patients with movement disorders such as essential tremor (ET). However, current DBS treatment constantly delivers stimulation in an open loop, which can be inefficient. Closing the loop with sensors to provide feedback may increase power efficiency and reduce side effects for patients. New implantable neuromodulation platforms, such as the Medtronic Activa PC+S DBS system, offer important data sources by providing chronic neural sensing capabilities and a means of investigating dynamic stimulation based on symptom measurements...
November 18, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27783098/-degenerative-cerebellar-diseases-and-differential-diagnoses
#3
W Reith, S Roumia, P Dietrich
CLINICAL/METHODICAL ISSUE: Cerebellar syndromes result in distinct clinical symptoms, such as ataxia, dysarthria, dysmetria, intention tremor and eye movement disorders. STANDARD RADIOLOGICAL METHODS: In addition to the medical history and clinical examination, imaging is particularly important to differentiate other diseases, such as hydrocephalus and multi-infarct dementia from degenerative cerebellar diseases. Degenerative diseases with cerebellar involvement include Parkinson's disease, multiple system atrophy as well as other diseases including spinocerebellar ataxia...
October 25, 2016: Der Radiologe
https://www.readbyqxmd.com/read/27693821/post-traumatic-tremor-and-thalamic-deep-brain-stimulation-evidence-for-use-of-diffusion-tensor-imaging
#4
Sandra G J Boccard, Pedro Rebelo, Binith Cheeran, Alexander Green, James J FitzGerald, Tipu Z Aziz
BACKGROUND: Deep brain stimulation (DBS) is a well-established treatment to reduce tremor, notably in Parkinson disease. DBS may also be effective in post-traumatic tremor, one of the most common movement disorders caused by head injury. However, the cohorts of patients often have multiple lesions that may impact the outcome depending on which fiber tracts are affected. CASE DESCRIPTION: A 20-year-old man presented after road traffic accident with severe closed head injury and polytrauma...
September 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27658421/progressive-gait-ataxia-following-deep-brain-stimulation-for-essential-tremor-adverse-effect-or-lack-of-efficacy
#5
Martin M Reich, Joachim Brumberg, Nicolò G Pozzi, Giorgio Marotta, Jonas Roothans, Mattias Åström, Thomas Musacchio, Leonardo Lopiano, Michele Lanotte, Ralph Lehrke, Andreas K Buck, Jens Volkmann, Ioannis U Isaias
Thalamic deep brain stimulation is a mainstay treatment for severe and drug-refractory essential tremor, but postoperative management may be complicated in some patients by a progressive cerebellar syndrome including gait ataxia, dysmetria, worsening of intention tremor and dysarthria. Typically, this syndrome manifests several months after an initially effective therapy and necessitates frequent adjustments in stimulation parameters. There is an ongoing debate as to whether progressive ataxia reflects a delayed therapeutic failure due to disease progression or an adverse effect related to repeated increases of stimulation intensity...
September 21, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27603204/investigation-of-motor-cortical-plasticity-and-corticospinal-tract-diffusion-tensor-imaging-in-patients-with-parkinsons-disease-and-essential-tremor
#6
Ming-Kuei Lu, Chun-Ming Chen, Jeng-Ren Duann, Ulf Ziemann, Jui-Cheng Chen, Shang-Ming Chiou, Chon-Haw Tsai
Parkinson's disease (PD) and essential tremor (ET) are characterized with motor dysfunctions. Motor circuit dysfunctions can be complementarily investigated by paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like plasticity and diffusion tensor imaging (DTI) of the corticospinal tract (CST). Three groups of twelve subjects with moderate severity PD, ET with intention tremor and healthy controls (HC) were studied. The primary motor cortex (M1) excitability, measured by motor evoked potential (MEP) amplitude and by short-interval and long-interval intracortical inhibition (SICI and LICI) was compared between the three groups before and after PAS...
2016: PloS One
https://www.readbyqxmd.com/read/27566131/genome-sequencing-reveals-a-splice-donor-site-mutation-in-the-snx14-gene-associated-with-a-novel-cerebellar-cortical-degeneration-in-the-hungarian-vizsla-dog-breed
#7
Joe Fenn, Mike Boursnell, Rebekkah J Hitti, Christopher A Jenkins, Rebecca L Terry, Simon L Priestnall, Patrick J Kenny, Cathryn S Mellersh, Oliver P Forman
BACKGROUND: Cerebellar cortical degeneration (CCD) is an increasingly recognised neurodegenerative disease process affecting many dog breeds. Typical presentation consists of a progressive cerebellar ataxia, with a variable age at onset and rate of progression between different breeds. Cerebellar histopathological findings typically consist of primary Purkinje neuronal degeneration and loss, with variable secondary depletion of the granular and molecular cell layers. Causative genes have been identified associated with CCD in several breeds, allowing screening for selective breeding to reduce the prevalence of these conditions...
2016: BMC Genetics
https://www.readbyqxmd.com/read/27504927/bupropion-abuse-reported-to-us-poison-centers
#8
Gina L Stassinos, Wendy Klein-Schwartz
OBJECTIVES: Bupropion use to obtain nonmedical psychoactive effects has been reported. The objective was to determine the prevalence, characteristics, clinical effects, and outcomes of bupropion "abuse." METHODS: A 14-year retrospective review was conducted of single substance bupropion cases with "intentional abuse" as the coded reason for exposure in individuals 13 and older reported to the National Poison Data System. Data were evaluated for prevalence, demographics, clinical effect, route, final management site, and coded outcome...
September 2016: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/27399415/136%C3%A2-field-steering-rescue-lead-therapy-for-patients-with-essential-tremor-refractory-to-ventralis-intermedius-deep-brain-stimulation
#9
Vishad Sukul, David A Isaacs, Srivatsan Pallavaram, William Rodriguez, Jonathan Butler, Hong Yu, Joseph Samir Neimat, Peter Konrad
INTRODUCTION: Nucleus ventralis intermedius (VIM) deep brain stimulation (DBS) is an effective therapy for the treatment of refractory essential tremor (ET). Therapy may fail in as many as 9% of patients despite positive initial results. In cases where good placement has been confirmed, evidence suggests that anterior adjacent lead placement can improve symptoms. We describe our cumulative surgical experience. METHODS: A total of 6 patients were reviewed retrospectively...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27373127/5-hydroxytryptamine-and-lyme-disease-opportunity-for-a-novel-therapy-to-reduce-the-cerebellar-tremor
#10
G K Maximov, K G Maximov, A A Chokoeva, T Lotti, U Wollina, J W Patterson, C Guarneri, C Tana, M Fioranelli, M G Roccia, N Kanazawa, G Tchernev
Lyme boreliosis is caused by the spirochete Borrelia burdorferi, which is transmitted by ticks. A 59 year-old woman developed pyrexia, strong headaches, ataxia, dysarthria and tremor of the limbs after a tick bite. She was unable to work and eat on her own. She was hospitalized three times and diagnosed with cerebellar intention tremor, cerebellar ataxia, dysarthria, bilateral horizontal gaze paralysis and a central lesion of the left facial nerve. There were no pyramidal, sensory or psychiatric disturbances...
April 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27346607/how-typical-are-typical-tremor-characteristics-sensitivity-and-specificity-of-five-tremor-phenomena
#11
A M M van der Stouwe, J W Elting, J H van der Hoeven, T van Laar, K L Leenders, N M Maurits, M A J Tijssen
INTRODUCTION: Distinguishing between different tremor disorders can be challenging. Some tremor disorders are thought to have typical tremor characteristics: the current study aims to provide sensitivity and specificity for five 'typical' tremor phenomena. METHODS: Retrospectively, we examined 210 tremor patients referred for electrophysiological recordings between January 2008 and January 2014. The final clinical diagnosis was used as the gold standard. The first step was to determine whether patients met neurophysiological criteria for their type of tremor...
September 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27340021/fragile-x-associated-tremor-ataxia-syndrome-features-mechanisms-and-management
#12
REVIEW
Randi J Hagerman, Paul Hagerman
Many physicians are unaware of the many phenotypes associated with the fragile X premutation, an expansion in the 5' untranslated region of the fragile X mental retardation 1 (FMR1) gene that consists of 55-200 CGG repeats. The most severe of these phenotypes is fragile X-associated tremor/ataxia syndrome (FXTAS), which occurs in the majority of ageing male premutation carriers but in fewer than 20% of ageing women with the premutation. The prevalence of the premutation is 1 in 150-300 females, and 1 in 400-850 males, so physicians are likely to see people affected by FXTAS...
July 2016: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/27222084/-autosomal-recessive-gtpch-1-deficiency-the-importance-of-the-analysis-of-neurotransmitters-in-cerebrospinal-fluid
#13
E E Moreno-Medinilla, M D Mora-Ramirez, R Calvo-Medina, J Martinez-Anton
INTRODUCTION: A deficiency of the enzyme guanosine triphosphate cyclohydrolase I (GTPCH 1) causes a reduction in the synthesis of tetrahydrobiopterin (BH4), a cofactor that is essential in the synthesis of tyrosine, dopamine and serotonin. It is an infrequent disease that produces psychomotor delay or regression and movement disorders, although treatment can improve or even correct the clinical signs and symptoms. CASE REPORT: We report the case of a girl with autosomal recessive GTPCH deficiency, who was diagnosed at 14 months by means of an analysis of the cerebrospinal fluid with pterin, HVA and 5-HIAA deficiency, and positive phenylalanine overload test and genetic study...
June 1, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27066477/voluntary-driven-elbow-orthosis-with-speed-controlled-tremor-suppression
#14
Gil Herrnstadt, Carlo Menon
Robotic technology is gradually becoming commonplace in the medical sector and in the service of patients. Medical conditions that have benefited from significant technological development include stroke, for which rehabilitation with robotic devices is administered, and surgery assisted by robots. Robotic devices have also been proposed for assistance of movement disorders. Pathological tremor, among the most common movement disorders, is one such example. In practice, the dissemination and availability of tremor suppression robotic systems has been limited...
2016: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/27057232/sylvian-fissure-epidermoid-cyst-presenting-with-intention-tremor
#15
Abhidha Shah, Feda Makkiyah, Atul Goel
Epidermoid tumors are benign tumors which contain keratin, cellular debris, and cholesterol, and are lined with stratified squamous epithelium. They grow in discreet silence sustained over a multitude of years. The tumors most commonly present with headache and seizures. We report the case of a 24-year-old male with a large sylvian fissure epidermoid tumor who presented with intention tremor. The patient was operated, and a near-total excision of the tumor was performed with a resolution of the tremor.
April 2016: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/27039056/tremor-in-progressive-supranuclear-palsy
#16
Shinsuke Fujioka, Avi A Algom, Melissa E Murray, Monica Y Sanchez-Contreras, Pawel Tacik, Yoshio Tsuboi, Jay A Van Gerpen, Ryan J Uitti, Rosa Rademakers, Owen A Ross, Zbigniew K Wszolek, Dennis W Dickson
INTRODUCTION: Tremor is thought to be a rare feature of progressive supranuclear palsy (PSP). METHODS: We retrospectively reviewed the database of the CurePSP brain bank at Mayo Clinic Florida to retrieve all available clinical information for PSP patients. All patients underwent a standard neuropathological assessment and an immunohistochemical evaluation for tau and α-synuclein. DNA was genotyped for the MAPT H1/H2 haplotype. RESULTS: Of the 375 PSP patients identified, 344 had a documented presence or absence of tremor, which included 146 (42%) with tremor, including 29 (20%) with postural/action tremors, 16 (11%) with resting tremor, 7 (5%) with intention tremor, 20 (14%) with a combination of different types of tremor, and 74 (51%) patients who had tremor at some point during their illness, but details were unavailable...
June 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27020458/movement-disorders-in-non-wilsonian-hepatic-cirrhotic-patients-the-subgroup-analysis-of-various-phenotypes-and-associated-risk-factors
#17
Kulthida Methawasin, Piyanant Chonmaitree, Chatchawan Wongjitrat, Suthee Rattanamongkolgul, Thanin Asawavichienjinda
OBJECTIVE: The aim of this subgroup analysis was to identify the risk factors associated with the development of various movement disorder phenotypes. METHODS: Eighty-three non-Wilsonian cirrhotic patients with abnormal movements were allocated into the following groups: intention tremor, bradykinesia, Parkinsonism, and abnormal ocular movements. These movement types were considered the primary outcomes as there was a sufficient sample size. Researchers took into consideration the gender, etiologies of cirrhosis, cirrhosis-related complications, hepatic encephalopathy, medical illness, and some neurological deficits as potential factors associated with these movement disorders...
May 2016: Journal of Movement Disorders
https://www.readbyqxmd.com/read/26977216/massage-therapy-treatment-and-outcomes-for-a-patient-with-parkinson-s-disease-a-case-report
#18
Yolanda Casciaro
INTRODUCTION: Parkinson's disease (PD) is a complex neurological disorder. The disease is progressive and, in time, results in severe disability. Many patients turn to massage in an attempt to alleviate symptoms of pain and rigidity, though the effects of massage with respect to PD are not well studied. This case adds one more instance in which massage therapy has provided temporary respite from resting tremor, one unrelenting symptom of PD. OBJECTIVE: To determine if massage therapy can produce favorable outcomes with respect to the severity of rigidity and tremor in a patient with PD...
March 2016: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/26960276/endoscope-assisted-microsurgical-removal-of-an-intraventricular-ependymal-cyst-that-manifested-with-tremor
#19
Murat Kutlay, Ibrahim Yavan, Cahit Kural, Ilker Ozer, Mehmet K Daneyemez, Yusuf Izci
BACKGROUND: Intraventricular ependymal cysts (ECs) are rare, histologically benign neuroepithelial cysts. Most of these cysts are clinically silent and discovered incidentally. Rarely, they become symptomatic, leading to obstruction of the cerebrospinal fluid circulation. ECs located inside the ventricles may manifest with signs of increased intracranial pressure. CASE DESCRIPTION: A 32-year-old woman presented with a 6-year history of tremor affecting her left hand...
June 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26959537/leigh-syndrome-associated-with-a-novel-mutation-in-the-cox15-gene
#20
Mohammad Miryounesi, Majid Fardaei, Seyed Mohammadbagher Tabei, Soudeh Ghafouri-Fard
Leigh syndrome (LS) is a subacute necrotizing encephalomyelopathy with a diverse range of symptoms, such as psychomotor delay or regression, weakness, hypotonia, truncal ataxia, intention tremor as well as lactic acidosis in the blood, cerebrospinal fluid or urine. Both nuclear gene defects and mutations of the mitochondrial genome have been detected in these patients. Here we report a 7-year-old girl with hypotonia, tremor, developmental delay and psychomotor regression. However, serum lactate level as well as brain magnetic resonance imaging were normal...
June 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
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