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MD ANDERSON ONCOLOGY IMAGING

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https://www.readbyqxmd.com/read/27789196/local-consolidative-therapy-versus-maintenance-therapy-or-observation-for-patients-with-oligometastatic-non-small-cell-lung-cancer-without-progression-after-first-line-systemic-therapy-a-multicentre-randomised-controlled-phase-2-study
#1
Daniel R Gomez, George R Blumenschein, J Jack Lee, Mike Hernandez, Rong Ye, D Ross Camidge, Robert C Doebele, Ferdinandos Skoulidis, Laurie E Gaspar, Don L Gibbons, Jose A Karam, Brian D Kavanagh, Chad Tang, Ritsuko Komaki, Alexander V Louie, David A Palma, Anne S Tsao, Boris Sepesi, William N William, Jianjun Zhang, Qiuling Shi, Xin Shelley Wang, Stephen G Swisher, John V Heymach
BACKGROUND: Evidence from retrospective studies suggests that disease progression after first-line chemotherapy for metastatic non-small-cell lung cancer (NSCLC) occurs most often at sites of disease known to exist at baseline. However, the potential effect of aggressive local consolidative therapy for patients with oligometastatic NSCLC is unknown. We aimed to assess the effect of local consolidative therapy on progression-free survival. METHODS: In this multicentre, randomised, controlled, phase 2 study, eligible patients from three hospitals had histological confirmation of stage IV NSCLC, three or fewer metastatic disease lesions after first-line systemic therapy, an Eastern Cooperative Oncology Group performance status score of 2 or less, had received standard first-line systemic therapy, and had no disease progression before randomisation...
October 24, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27564246/dynamic-imaging-grade-of-swallowing-toxicity-digest-scale-development-and-validation
#2
Katherine A Hutcheson, Martha P Barrow, Denise A Barringer, Jodi K Knott, Heather Y Lin, Randal S Weber, Clifton D Fuller, Stephen Y Lai, Clare P Alvarez, Janhavi Raut, Cathy L Lazarus, Annette May, Joanne Patterson, Justin W G Roe, Heather M Starmer, Jan S Lewin
BACKGROUND: The National Cancer Institute's Common Terminology Criteria for Adverse Events (CTCAE) is the universal framework for toxicity reporting in oncology trials. The objective of this study was to develop a CTCAE-compatible modified barium swallow (MBS) grade for the purpose of grading pharyngeal dysphagia as a toxicity endpoint in cooperative-group organ-preservation trials for head and neck cancer (HNC). It was hypothesized that a 5-point, CTCAE-compatible MBS grade (Dynamic Imaging Grade of Swallowing Toxicity [DIGEST]) based on the interaction of pharyngeal residue and laryngeal penetration/aspiration ratings would be feasible and psychometrically sound...
August 26, 2016: Cancer
https://www.readbyqxmd.com/read/26061145/fast-gpu-based-monte-carlo-simulations-for-ldr-prostate-brachytherapy
#3
Éric Bonenfant, Vincent Magnoux, Sami Hissoiny, Benoît Ozell, Luc Beaulieu, Philippe Després
The aim of this study was to evaluate the potential of bGPUMCD, a Monte Carlo algorithm executed on Graphics Processing Units (GPUs), for fast dose calculations in permanent prostate implant dosimetry. It also aimed to validate a low dose rate brachytherapy source in terms of TG-43 metrics and to use this source to compute dose distributions for permanent prostate implant in very short times. The physics of bGPUMCD was reviewed and extended to include Rayleigh scattering and fluorescence from photoelectric interactions for all materials involved...
July 7, 2015: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/25993237/chemotherapy-for-bone-sarcomas-in-adults-the-md-anderson-experience
#4
REVIEW
Robert S Benjamin, Michael J Wagner, J Andrew Livingston, Vinod Ravi, Shreyaskumar R Patel
Increasing age is an adverse prognostic factor in the treatment of primary bone tumors. There are few published data on treatment of primary bone tumors in adults. This paper presents data from the Department of Sarcoma Medical Oncology at The University of Texas MD Anderson Cancer Center, summarizing our treatment results. To treat primary osteosarcoma, we used 90 mg/m2 of doxorubicin as a continuous intravenous infusion over 48 to 96 hours and 120 to 160 mg/m2 of cisplatin intravenously or intra-arterially...
2015: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/25031942/management-of-refractory-metastatic-anal-squamous-cell-carcinoma-following-disease-progression-on-traditional-chemoradiation-therapy
#5
Ninoska N Silva, Cathy Eng
Case Study Ms. S.G., a 56-year-old woman with a poorly differentiated squamous cell carcinoma of the anal canal, American Joint Committee on Cancer stage III (T2, N1, M0), was initially diagnosed in December, 2007 at an outside institution after she had noted blood in her stool for approximately 6 months. Her medical history was unremarkable. She had no known history of HIV or other sexually transmitted diseases. At the time of presentation, Ms. S.G. had an Eastern Cooperative Oncology Group performance status of 1 related to cancer-related pain...
May 2012: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/24710182/tools-to-expedite-the-development-of-treatment-plans
#6
Adriana L Chavez, Prachee Singh, Andrea A Aleman, Jaime E Anderson, Colleen Jernigan, Vinod Ravi
Quality improvement strategies can be used to modify existing health care processes to reduce patient wait times. We undertook a quality improvement project to reduce the time between new patients' initial visits and the finalization of their treatment plans. Initiation of treatment of new patients at the MD Anderson Sarcoma Medical Oncology Clinic can take up to 2 weeks from their initial consultation. Treatment delays result in increased costs and anxiety for the patient, adversely affecting the quality of care provided...
April 2014: Quality Management in Health Care
https://www.readbyqxmd.com/read/23867127/body-composition-and-survival-in-the-early-clinical-trials-setting
#7
H Veasey Rodrigues, V E Baracos, J J Wheler, H A Parsons, D S Hong, A Naing, S Fu, G Falchoock, A M Tsimberidou, S Piha-Paul, G Chisholm, R Kurzrock
PURPOSE: Delineate the relationships between body composition parameters, 90-day mortality and overall survival, and correlate them with known prognostic factors in an early clinical trials clinic. PATIENTS AND METHODS: We studied 306 consecutive patients with various tumours; body composition was analysed by computerised tomography images. Survival was measured from the first clinic visit, at 90-day period and until death/last follow-up visit. RESULTS: Median patient age was 56 years; 159 patients were men...
October 2013: European Journal of Cancer
https://www.readbyqxmd.com/read/22235285/body-composition-symptoms-and-survival-in-advanced-cancer-patients-referred-to-a-phase-i-service
#8
Henrique A Parsons, Vickie E Baracos, Navjot Dhillon, David S Hong, Razelle Kurzrock
BACKGROUND: Body weight and body composition are relevant to the outcomes of cancer and antineoplastic therapy. However, their role in Phase I clinical trial patients is unknown. METHODS: We reviewed symptom burden, body composition, and survival in 104 patients with advanced cancer referred to a Phase I oncology service. Symptom burden was analyzed using the MD Anderson Symptom Assessment Inventory(MDASI); body composition was evaluated utilizing computerized tomography(CT) images...
2012: PloS One
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