Viktor Rotbain Curovic, Brede A Sørland, Tine W Hansen, Siddhi Y Jain, Karolina Sulek, Ismo Matias Mattila, Marie Frimodt-Moller, Kajetan Trost, Cristina Legido-Quigley, Simone Theilade, Nete Tofte, Signe Abitz Winther, Christian Stevns Hansen, Peter Rossing, Tarunveer S Ahluwalia
INTRODUCTION: Diabetic retinopathy (DR), diabetic kidney disease (DKD) and distal symmetric polyneuropathy (DSPN) share common pathophysiology and pose an additive risk of early mortality. RESEARCH DESIGN AND METHODS: In adults with type 1 diabetes, 49 metabolites previously associated with either DR or DKD were assessed in relation to presence of DSPN. Metabolites overlapping in significance with presence of all three complications were assessed in relation to microvascular burden severity (additive number of complications-ie, presence of DKD±DR±DSPN) using linear regression models...
April 11, 2024: BMJ Open Diabetes Research & Care