keyword
MENU ▼
Read by QxMD icon Read
search

Diabetic retinopathy

keyword
https://www.readbyqxmd.com/read/28538980/downregulation-of-lysyl-oxidase-protects-retinal-endothelial-cells-from-high-glucose-induced-apoptosis
#1
Dongjoon Kim, Robert P Mecham, Philip C Trackman, Sayon Roy
Purpose: To investigate the effect of reducing high glucose (HG)-induced lysyl oxidase (LOX) overexpression and increased activity on retinal endothelial cell apoptosis. Methods: Rat retinal endothelial cells (RRECs) were grown in normal (N) or HG (30 mM glucose) medium for 7 days. In parallel, RRECs were grown in HG medium and transfected with LOX small interfering RNA (siRNA), scrambled siRNA as control, or exposed to β-aminopropionitrile (BAPN), a LOX inhibitor...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28538221/retinal-microvasculature-in-nonproliferative-diabetic-retinopathy-automated-quantitative-optical-coherence-tomography-angiography-assessment
#2
Marco Lupidi, Gabriel Coscas, Florence Coscas, Tito Fiore, Elisa Spaccini, Daniela Fruttini, Carlo Cagini
PURPOSE: To perform a qualitative and quantitative assessment of the foveal microvasculature in eyes with diabetic maculopathy using optical coherence tomography angiography (OCT-A). METHODS: Retrospective case series of 48 eyes with diabetic maculopathy and 47 healthy eyes evaluated by Spectralis OCT-A. Perifoveal arcade disruptions, linear vascular dilations, microaneurysms, intraretinal microvascular abnormalities and flow-void areas were qualitatively analyzed on OCT angiograms both for the superficial (SCP) and deep (DCP) capillary plexuses...
May 25, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28535269/increased-retinal-oxygen-metabolism-precedes-microvascular-alterations-in-type-1-diabetic-mice
#3
Wenzhong Liu, Shoujian Wang, Brian Soetikno, Ji Yi, Kevin Zhang, Siyu Chen, Robert A Linsenmeier, Christine M Sorenson, Nader Sheibani, Hao F Zhang
Purpose: To investigate inner retinal oxygen metabolic rate (IRMRO2) during early stages of type 1 diabetes in a transgenic mouse model. Methods: In current study, we involved seven diabetic mice (Akita/+, TSP1-/-) and seven control mice (TSP1-/-), and applied visible-light optical coherence tomography (vis-OCT) to image functional parameters including retinal blood flow rate, oxygen saturation (sO2) and the IRMRO2 value longitudinally from 5 weeks of age to 13 weeks of age...
February 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28535208/sodium-glucose-cotransporter-2-in-mesangial-cells-and-retinal-pericytes-and-its-implications-for-diabetic-nephropathy-and-retinopathy
#4
Masarori Wakisaka, Tetsuhiko Nagao
Retinopathy and nephropathy are life-threatening diabetic complications that decrease patient quality of life. Although the mechanisms underlying these conditions have been extensively studied, they remain unknown. Recent reports have demonstrated the presence of SGLT2 in retinal pericytes and mesangial cells. Hyperglycemia results in functional and morphological changes in these cells, but these effects are attenuated by phlorizin, a non-selective SGLT inhibitor. Based on these findings, we hypothesized that SGLT2 plays a pivotal role in the development of diabetic nephropathy and retinopathy and that SGLT2 inhibitors may directly protect against these complications...
May 23, 2017: Glycobiology
https://www.readbyqxmd.com/read/28534786/evolutionary-computing-enriched-computer-aided-diagnosis-system-for-diabetic-retinopathy-a-survey
#5
Romany Mansour
The alterations caused due to diabetes mellitus results into significant micro-vasculature that eventually causes diabetic retinopathy (DR) that keeps on increasing as per time and eventually causes complete vision loss. Identifying subtle variations in morphological changes in retinal blood vessels, optic disk, exudates, micro-aneurysms, hemorrhage etc is complicate and requires robust computer aided diagnosis (CAD) system so as to enable earlier and efficient DR diagnosis practices. In majority of the existing CAD systems, the need of functional enhancement has been realized time by time to ensure accurate and time efficient DR...
May 17, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28534343/predictors-and-outcomes-of-vitrectomy-and-silicone-oil-injection-in-advanced-diabetic-retinopathy
#6
Alireza Ramezani, Hamid Ahmadieh, Amin Rozegar, Masoud Soheilian, Morteza Entezari, Siamak Moradian, Mohammad H Dehghan, Homayoun Nikkhah, Mehdi Yaseri
PURPOSE: To evaluate visual and anatomical results and identify factors that influence vitrectomy and silicone oil (SO) injection outcomes in proliferative diabetic retinopathy (PDR). METHODS: This retrospective study included 236 eyes with PDR that were undergoing vitrectomy and SO injection with >3-month follow-up. The primary outcomes were final best-corrected visual acuity (BCVA) and retinal attachment rate. RESULTS: At the final visit (mean, 88 ± 58 weeks), complete, partial, and no retinal attachment were observed in 86...
May 12, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28534174/the-il-1%C3%AE-phenomena-in-neuroinflammatory-diseases
#7
REVIEW
Andrew S Mendiola, Astrid E Cardona
It is becoming increasingly clear that neuroinflammation has a causal role in the pathogenesis of central nervous system (CNS)-related diseases, and therefore therapeutic strategies targeting the regulation or availability of inflammatory mediators can be used to prevent or mitigate pathology. Interestingly, the proinflammatory cytokine, interleukin-1 beta (IL-1β), has been implicated in perpetuating immune responses and contributing to disease severity in a variety of CNS diseases ranging from multiple sclerosis, neurodegenerative diseases, traumatic brain injury, and diabetic retinopathy...
May 22, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28533296/glp-1r-as-a-target-for-the-treatment-of-diabetic-retinopathy-friend-or-foe
#8
Rafael Simó, Cristina Hernández
Glucagon-like peptide 1 receptor (GLP-1R) agonists are increasingly being used as treatment for type 2 diabetes. Since the U.S. Food and Drug Administration published recommendations about the cardiovascular safety of new antidiabetes therapies for treating type 2 diabetes in 2008, the results of two outstanding clinical trials using GLP-1R agonists addressing this issue (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results-A Long Term Evaluation [LEADER] and Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes [SUSTAIN-6]) have been published...
June 2017: Diabetes
https://www.readbyqxmd.com/read/28533105/prevalence-of-overactive-bladder-and-its-impact-on-quality-of-life-in-1025-patients-with-type-2-diabetes-in-mainland-china
#9
Dongjuan Xu, Jie Gao, Xiaojuan Wang, Liqun Huang, Kefang Wang
AIMS: This study examined the prevalence of overactive bladder (OAB) and investigated the impact of OAB on quality of life (QOL) in patients with type 2 diabetes in Mainland China. METHODS: A total of 1025 patients with type 2 diabetes were surveyed. Patients were grouped into no OAB, dry OAB, and wet OAB groups according to the presence of OAB and urge incontinence. Descriptive analyses, one-way analysis of variance (ANOVA) and multivariable regression models were conducted to assess the prevalence of OAB and the effect of OAB on QOL...
May 10, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28530383/diabetes-update-prevention-and-management-of-diabetes-complications
#10
Beth Choby
Macrovascular complications of diabetes include cardiovascular events, whereas common microvascular complications include neuropathy, retinopathy, and diabetic kidney disease. Control of hypertension and dyslipidemia is an important step in minimizing the risk of complications. Blood pressure (BP) levels should be maintained at less than 140 mm Hg systolic and less than 90 mm Hg diastolic. In older adults, medical therapy to reduce BP to less than 130/70 mm Hg is not recommended. In these patients, a systolic BP level less than 130 mm Hg has not been shown to improve atherosclerotic cardiovascular disease (ASCVD) outcomes, and a diastolic BP less than 70 mm Hg is associated with a higher mortality risk...
May 2017: FP Essentials
https://www.readbyqxmd.com/read/28530075/-diabetes-and-road-accidents
#11
REVIEW
Alon Haim, Michal Shimshi, Eli Hershkovitz
Many countries restrict people with diabetes from driving. These restrictions are based on the assumption that drivers with diabetes are prone to road accidents more than the general population. There are factors that can affect the driving ability of people with diabetes that are related to the immediate effects of the disease such as hypoglycemia, hyperglycemia or disease complications such as retinopathy or neuropathy. Restrictions on driving of people with diabetes have implications both on the patients and the society...
November 2016: Harefuah
https://www.readbyqxmd.com/read/28529759/high-frequency-based-features-for-low-and-high-retina-haemorrhage-classification
#12
Salim Lahmiri
Haemorrhages (HAs) presence in fundus images is one of the most important indicators of diabetic retinopathy that causes blindness. In this regard, accurate grading of HAs in fundus images is crucial for appropriate medical treatment. The purpose of this Letter is to assess the relative performance of statistical features obtained with three different multi-resolution analysis (MRA) techniques and fed to support vector machine in grading retinal HAs. Considered MRA techniques are the common discrete wavelet transform (DWT), empirical mode decomposition (EMD), and variational mode decomposition (VMD)...
February 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28529276/association-between-the-risk-of-falls-and-osteoporotic-fractures-in-patients-with-type-2-diabetes-mellitus
#13
Maki Yokomoto-Umakoshi, Ippei Kanazawa, Shiori Kondo, Toshitsugu Sugimoto
Diabetes mellitus is associated with an increased risk of falls, which increases the incidence of osteoporotic fractures and accordingly decreases quality of life. However, the association between fall risk and diabetic complications is not completely understood. Therefore, the aim of this study was to examine the association between fall risk and osteoporotic fractures in patients with type 2 diabetes mellitus (T2DM). We enrolled 194 Japanese patients with T2DM and assessed their fall risk using a brief interview form that included five items covering physical and social aspects of functioning and environmental factors...
May 19, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28529214/improving-diabetic-retinopathy-in-an-indigent-population
#14
Renee Rosati, Adrienne Z Ables, Petra Warren
Diabetic retinopathy is the leading cause of preventable blindness in working-age American adults. This study hypothesized that patients with diabetes types I and II at St.Luke's Free Medical Clinic in Spartanburg, South Carolina were not being systematically referred for annual diabetic retinopathy screening. We evaluated the number of patients referred for screening, those patients who actually went for the screening, and the rate at which retinopathy was found in those who went. Of the 111 charts reviewed, only 49...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28529157/protective-treatments-and-their-target-retinal-ganglion-cells-in-diabetic-retinopathy
#15
REVIEW
Jing Zhang, Rong Liu, Hong-Yu Kuang, Xin-Yuan Gao, Hao-Ling Liu
Diabetic retinopathy(DR)is one of the complications of diabetes which could cause severe vision loss. Retinal ganglion cell(RGC)injury has been confirmed prior to micro-vascular damage. Over the past few decades, a number of animal and clinical studies have confirmed that RGC impairment leads to an early deterioration of vision in DR. Inhibition of aldose reductase (AR), advanced glycation end product (AGE), oxidative stress, glutamate toxicity, and an inflammatory response may play important roles in protecting RGCs in DR...
May 18, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28528826/profound-macular-ischemia-on-optical-coherence-tomography-angiography-in-severe-diabetic-retinopathy
#16
Yi Jiang, Jennifer Lim, Andrea Degillio
No abstract text is available yet for this article.
June 2017: Ophthalmology
https://www.readbyqxmd.com/read/28528076/systematic-review-can-non-mydriatic-cameras-accurately-detect-diabetic-retinopathy
#17
REVIEW
Chloe Bedard, Siying Sherry Liu, Christopher Patterson, Hertzel Gerstein, Lauren Griffith
AIMS: Diabetes puts many individuals at risk for developing diabetic retinopathy (DR). Non-mydriatic (NM) retinal photography without pharmacological pupil dilation can be used to detect DR, however, its value in a general clinical setting has not been established. The objective of this review is to evaluate the validity of NM retinal photos, as compared to the reference standard of seven standard stereoscopic 30 degree field photographs (7SF), for their use of detecting DR in community-dwelling adults...
May 10, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28526993/microvascular-complications-associated-with-rapid-improvements-in-glycemic-control-in-diabetes
#18
REVIEW
Christopher H Gibbons, Ann Goebel-Fabbri
PURPOSE OF REVIEW: Aggressive glycemic control has become the standard clinical approach to diabetes care. Unintended consequences have included the development of microvascular complications that are related to the rapidity of glycemic improvement. RECENT FINDINGS: Diabetic neuropathy may develop in up to 10% of individuals secondary to aggressive glycemic control. The neuropathy is predominantly small fiber sensory and autonomic, and the severity of the neuropathy is tied to the change in the glycosylated hemoglobin A1C...
July 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28526441/conceptual-analysis-of-diabetic-retinopathy-in-ayurveda
#19
REVIEW
Prasanta Kumar Sahoo, Shamsa Fiaz
Inclusion of Prameha among the eight major disorders in Charaka Samhita shows the significance of the disease given by ancient seers. The risk of development of blindness in diabetics increases by 20-25 times as compared to the normal population. High prevalence rate of Diabetic Retinopathy (34.6%), proliferative diabetic retinopathy (7%), diabetic macular edema (6.8%), and Vision threatening Diabetic retinopathy (10.2%) in diabetics was great concerns which led to search and analyze the disease process on the basis of modern pathogenesis and different Timirvyadhi mentioned in Ayurvedic authoritative texts...
May 16, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28525563/omics-biomarkers-in-ophthalmology
#20
Susette Lauwen, Eiko K de Jong, Dirk J Lefeber, Anneke I den Hollander
"Omics" refers to high-throughput analyses of genes, proteins, or metabolites in a biological system, and is increasingly used for ophthalmic research. These system-based approaches can unravel disease-related processes and are valuable for biomarker discovery. Furthermore, potential therapeutic targets can be identified based on omics results, and targeted follow-up experiments can be designed to gain molecular understanding of the disease and to test new therapies. Here, we review the application of omics techniques in eye diseases, focusing on age-related macular degeneration (AMD), diabetic retinopathy (DR), retinal detachment (RD), myopia, glaucoma, Fuchs' corneal dystrophy (FCD), cataract, keratoconus, and dry eyes...
May 1, 2017: Investigative Ophthalmology & Visual Science
keyword
keyword
1136
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"