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https://www.readbyqxmd.com/read/27872526/progesterone-receptors-pathological-complete-response-and-early-outcome-for-locally-advanced-breast-cancer-a-single-centre-study-pplb-01
#1
Sanjit Agrawal, Lalit Banswal, Animesh Saha, Indu Arun, Soumitra Shankar Datta, Sanjoy Chatterjee, Rosina Ahmed
Neoadjuvant chemotherapy (NACT) for locally advanced breast cancer (LABC), apart from increasing breast conservation rates, also provides an opportunity to assess tumour response to chemotherapy, with Pathological Complete Response (pCR) described as an independent prognostic factor and a surrogate marker for better outcome and survival. Our primary aim was to identify clinical and pathological factors associated with pCR following NACT in patients with LABC treated at our institution. Our secondary aim was to analyze the impact of pCR and associated factors on disease free survival (DFS) and overall survival (OS)...
December 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27867847/retroperitoneal-and-laparoscopic-heminephrectomy-in-duplex-kidney-in-infants-and-children
#2
Ciro Esposito, Maria Escolino, Marco Castagnetti, Antonio Savanelli, Angela La Manna, Alessandra Farina, Francesco Turrà, Agnese Roberti, Alessandro Settimi, Francois Varlet, Holger Till, Jean Stephan Valla
BACKGROUND: Two main techniques are adopted to perform partial nephrectomy in children: laparoscopy and retroperitoneoscopy. The aim of this paper is to review the larger multicentric experience recently published by our group to review indications, techniques and results of both approaches. METHODS: Data of 102 patients underwent partial nephrectomy in a 5-year period using minimally invasive surgery (MIS) procedures were analyzed. Fifty-two children underwent laparoscopic partial nephrectomy (LPN), and 50 children underwent retroperitoneoscopic partial nephrectomy (RPN)...
October 2016: Translational pediatrics
https://www.readbyqxmd.com/read/27846840/exclusive-intraoperative-radiotherapy-for-invasive-breast-cancer-in-elderly-patients-70%C3%A2-years-proportion-of-eligible-patients-and-local-recurrence-free-survival
#3
Eric Lambaudie, Gilles Houvenaeghel, Amira Ziouèche, Sophie Knight, François Dravet, Jean Remy Garbay, Sylvie Giard, Hélène Charitansky, Monique Cohen, Christelle Faure, Delphine Hudry, Paul Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Agnès Tallet, Marie Bannier, Mathieu Minsat, Michel Resbeut
BACKGROUND: To estimate the proportion of elderly patients (>70 years) with breast cancer eligible for an Exclusive IntraOperative RadioTherapy (E-IORT) and to evaluate their local recurrence-free survival rate. METHODS: This retrospective study examining two cohorts focuses on patients over 70 years old: a multi-centric cohort of 1411 elderly patients and a mono-centric cohort of 592 elderly patients. All patients underwent conservative surgery followed by external radiotherapy for T0-T3 N0-N1 invasive breast cancer, between 1980 and 2008...
November 15, 2016: BMC Surgery
https://www.readbyqxmd.com/read/27846456/management-and-outcomes-of-acute-myocardial-infarction-in-patients-with-chronic-kidney-disease
#4
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, Rina Mauricio, Sripal Bangalore
BACKGROUND: Chronic kidney disease (CKD) is associated with cardiovascular disease and acute myocardial infarction (AMI). Contemporary management and outcomes of AMI in patients with CKD have not been reported. METHODS: We analyzed United States National Inpatient Sample data for patients admitted with AMI with or without CKD from 2007 to 2012. Propensity score matching was used to identify patients with AMI and CKD with similar baseline characteristics who were managed invasively (cardiac catheterization, percutaneous coronary intervention [PCI], or coronary artery bypass graft surgery [CABG]) or conservatively...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27822630/outcomes-of-sentinel-lymph-node-positive-breast-cancer-patients-treated-with-mastectomy-without-axillary-therapy
#5
Elizabeth FitzSullivan, Roland L Bassett, Henry M Kuerer, Elizabeth A Mittendorf, Min Yi, Kelly K Hunt, Gildy V Babiera, Abigail S Caudle, Dalliah M Black, Isabelle Bedrosian, Chantal Reyna, Mediget Teshome, Funda Meric-Bernstam, Rosa Hwang
PURPOSE: Early-stage breast cancer patients with minimal axillary disease identified by sentinel lymph node dissection (SLND) have low regional recurrence rates when treated with breast-conserving surgery and radiation therapy (XRT) and many avoid a completion axillary lymph node dissection (CLND). As the incidence of total mastectomy (TM) has increased, it has become important to characterize which TM patients with a positive SLN may not benefit from further axillary treatment. METHODS: An institutional database was utilized to identify patients treated with a TM for invasive breast cancer and who had a positive SLN from 1994 to 2010...
October 3, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27822113/danish-quality-database-for-mammography-screening
#6
REVIEW
Ellen M Mikkelsen, Sisse H Njor, Ilse Vejborg
AIM: The Danish Quality Database for Mammography Screening (DKMS) was established in 2007, with the aim to monitor, sustain, and improve the quality of the Danish national breast cancer screening program. STUDY POPULATION: All Danish women aged 50-69 years who were invited every 2 years for breast cancer screening in the nationwide program since July 10, 2007. MAIN VARIABLES: The DKMS consists of data retrieved from the five regional invitation systems, the National Pathology Registry, and the National Registry of Patients...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27815003/an-assessment-of-the-effectiveness-of-a-long-term-ecosystem-restoration-project-in-a-fynbos-shrubland-catchment-in-south-africa
#7
Jennifer M Fill, Greg G Forsyth, Suzaan Kritzinger-Klopper, David C Le Maitre, Brian W van Wilgen
The long-term effectiveness of ecological restoration projects is seldom reported in the scientific literature. This paper reports on the outcomes of ecosystem restoration following the clearing of alien Pinus plantations and associated alien plant invasions over 13 years from an 8000 ha mountain catchment in the Western Cape Province, South Africa. We examined the goals, methods and costs of management, and the ecological outcomes in terms of reduced alien plant cover and native vegetation recovery. While the goals were not explicitly formulated at the outset, they were implicitly focussed on the conservation of water resources, the restoration of biodiversity, and the provision of employment...
January 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/27781045/local-fibrinolysis-in-spontaneous-supratentorial-hematomas-comparison-with-surgical-and-medical-treatment
#8
Eugeniu Condrea, Valeriu Timirgaz, Stanislav Groppa, Ion Codreanu, Natalia Rotaru
OBJECTIVE: To evaluate the effectiveness of minimally invasive craniopuncture with local fibrinolysis in the management of supratentorial spontaneous intracerebral hemorrhage (SICH). METHODS: The study included 218 consecutive patients with supratentorial SICH who were assigned to one of three groups: treated with minimally invasive craniopuncture with local fibrinolysis, treated with craniotomy or other minimally invasive techniques without local fibrinolysis, or receiving conservative management alone...
September 2016: Interventional Neurology
https://www.readbyqxmd.com/read/27779099/ductal-carcinoma-in-situ-of-breast-detection-and-treatment-pattern-in-hong-kong
#9
T K Yau, A Chan, P Sy Cheung
INTRODUCTION: The treatment of ductal carcinoma in situ has been widely reported in the western and other Asian countries, but the relevant data in Hong Kong are relatively limited. This study aimed to evaluate the latest detection and treatment pattern for ductal carcinoma in situ in Hong Kong so as to guide planning of future service provision. METHODS: This was a retrospective case series study. A total of 573 patients who registered with the Hong Kong Breast Cancer Registry, and were diagnosed and treated in Hong Kong from January 2001 to December 2011 were reviewed...
October 24, 2016: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/27773373/is-sentinel-lymph-node-biopsy-indicated-in-patients-with-a-diagnosis-of-ductal-carcinoma-in%C3%A2-situ-a-systematic-literature-review-and-meta-analysis
#10
Hiba El Hage Chehade, Hannah Headon, Umar Wazir, Houssam Abtar, Abdul Kasem, Kefah Mokbel
BACKGROUND: Recent discussion has suggested that some cases of ductal carcinoma in situ (DCIS) with high risk of invasive disease may require sentinel lymph node biopsy (SLNB). METHODS: Systematic literature review identified 48 studies (9,803 DCIS patients who underwent SLNB). Separate analyses for patients diagnosed preoperatively by core sampling and patients diagnosed postoperatively by specimen pathology were conducted to determine the percentage of patients with axillary nodal involvement...
September 6, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27707564/a-systematic-review-and-meta-analysis-examining-the%C3%A2-differences-between-nonsurgical-management-and%C3%A2-percutaneous-fixation-of-minimally-and-nondisplaced-scaphoid-fractures
#11
Hassan Alnaeem, Salah Aldekhayel, Johnathan Kanevsky, Omar Fouda Neel
PURPOSE: The optimal management of undisplaced scaphoid fractures remains controversial. A systematic review was conducted to assess the outcomes of acute, undisplaced scaphoid fractures managed with cast immobilization versus percutaneous or miniopen screw fixation in terms of time to return to work (RTW), time to union, and morbidity. METHODS: PubMed MEDLINE, Ovid MEDLINE, EMBASE, SCOPUS, and Cochrane electronic databases were searched over the period 1974 to 2015...
October 1, 2016: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27705890/influence-of-human-immunodeficiency-virus-seropositive-status-on-the-in-hospital-management-and-outcomes-of-patients-presenting-with-acute-myocardial-infarction
#12
Nathaniel R Smilowitz, Navdeep Gupta, Yu Guo, John T Coppola, Sripal Bangalore
OBJECTIVES: Human immunodeficiency virus (HIV) seropositive individuals are predisposed to acute myocardial infarction (AMI). We sought to evaluate management strategies and outcomes of AMI in patients with HIV in the contemporary era. METHODS: We analyzed data from the National Inpatient Sample from 2002 to 2011 for patients admitted with AMI with or without HIV. Propensity-score matching was used to identify HIV seropositive AMI patients with similar characteristics who were managed invasively (cardiac catheterization, percutaneous coronary intervention [PCI], or coronary artery bypass graft surgery [CABG]) or conservatively...
October 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27689969/an-international-randomised-controlled-trial-to-compare-targeted-intraoperative-radiotherapy-targit-with-conventional-postoperative-radiotherapy-after-breast-conserving-surgery-for-women-with-early-stage-breast-cancer-the-targit-a-trial
#13
Jayant S Vaidya, Frederik Wenz, Max Bulsara, Jeffrey S Tobias, David J Joseph, Christobel Saunders, Chris Brew-Graves, Ingrid Potyka, Stephen Morris, Hrisheekesh J Vaidya, Norman R Williams, Michael Baum
BACKGROUND: Based on our laboratory work and clinical trials we hypothesised that radiotherapy after lumpectomy for breast cancer could be restricted to the tumour bed. In collaboration with the industry we developed a new radiotherapy device and a new surgical operation for delivering single-dose radiation to the tumour bed - the tissues at highest risk of local recurrence. We named it TARGeted Intraoperative radioTherapy (TARGIT). From 1998 we confirmed its feasibility and safety in pilot studies...
September 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27679301/long-term-abdominopelvic-surgical-morbidity-after-abdominal-vs-minimally-invasive-hysterectomy-with-ovarian-conservation-a-population-based-cohort-study
#14
Z Khan, S K Laughlin-Tommaso, A L Weaver, C D Schleck, W A Rocca, E A Stewart
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27670264/a-strategy-to-expeditious-invasive-treatment-improves-clinical-outcome-in-comatose-patients-with-aneurysmal-subarachnoid-haemorrhage
#15
J Hoogmoed, R van den Berg, B A Coert, G J E Rinkel, W P Vandertop, D Verbaan
BACKGROUND: In patients with poor clinical condition after aneurysmal subarachnoid haemorrhage (aSAH), treatment is often deferred until patients show signs of improvement. Early external ventricular drainage and aneurysm occlusion may improve prognosis also in poor grade patients. The clinical outcome of an expeditious approach was compared with that of a conservative approach. METHODS: In all, 285 consecutive World Federation of Neurological Surgeons (WFNS) grade V aSAH patients admitted to three university hospitals between January 2000 and June 2007 were included...
September 26, 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27663190/the-efficacy-of-combined-use-of-rivaroxaban-and-tranexamic-acid-on-blood-conservation-in-minimally-invasive-total-knee-arthroplasty-a-double-blind-randomized-controlled-trial
#16
Jun-Wen Wang, Bradley Chen, Po-Chun Lin, Shih-Hsiang Yen, Chung-Cheng Huang, Feng-Chih Kuo
BACKGROUND: Tranexamic acid (TXA) was reportedly to decrease postoperative blood loss after standard total knee arthroplasty (TKA). However, the blood-conservation effect of TXA in minimally invasive TKA, in particular, receiving a direct oral anticoagulant was unclear. The aim of the study was to investigate the efficacy of combined use of TXA and rivaroxaban on postoperative blood loss in primary minimally invasive TKA. METHODS: In a prospective, randomized, controlled trial, 198 patients were assigned to placebo (98 patients, normal saline injection) and study group (100 patients, 1g TXA intraoperative injection) during primary unilateral minimally invasive TKA...
August 27, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27641221/heal-rate-of-metatarsal-fractures-a-propensity-matching-study-of-patients-treated-with-low-intensity-pulsed-ultrasound-lipus-vs-surgical-and-other-treatments
#17
Peter Nolte, Robert Anderson, Elton Strauss, Zhe Wang, Liuyi Hu, Zekun Xu, R Grant Steen
INTRODUCTION: Whether to treat metatarsal fractures conservatively or surgically is controversial. We test a hypothesis that metatarsal fractures treated conservatively with non-invasive low-intensity pulsed ultrasound (LIPUS) obtain heal rates comparable to current surgical techniques. PATIENTS AND METHODS: This is a retrospective observational cohort study, using patient outcomes from a prospectively-collected LIPUS registry required by the U.S. Food & Drug Administration...
September 13, 2016: Injury
https://www.readbyqxmd.com/read/27639749/surgical-management-of-benign-adnexal-masses-in-the-pediatric-adolescent-population-an-11-year-review
#18
Lauren M Bergeron, Katherine C Bishop, Holly R Hoefgen, Margaret S Abraham, Nhial T Tutlam, Diane F Merritt, Jeffrey F Peipert
STUDY OBJECTIVE: The purpose of this study was to compare ovarian conservation rates and surgical approach in benign adnexal surgeries performed by surgeons versus gynecologists at a tertiary care institution. DESIGN: A retrospective cohort review. SETTING: Children's and Adult tertiary care university-based hospital. PARTICIPANTS: Patients ≤21 years of age undergoing surgery for an adnexal mass from January 2003 through December 2013...
September 14, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27607734/prognostic-factors-for-local-control-in-breast-cancer-after-long-term-follow-up-in-the-eortc-boost-vs-no-boost-trial-a-randomized-clinical-trial
#19
Conny Vrieling, Erik van Werkhoven, Philippe Maingon, Philip Poortmans, Caroline Weltens, Alain Fourquet, Dominic Schinagl, Bing Oei, Carla C Rodenhuis, Jean-Claude Horiot, Henk Struikmans, Erik Van Limbergen, Youlia Kirova, Paula Elkhuizen, Rudolf Bongartz, Raymond Miralbell, David A L Morgan, Jean-Bernard Dubois, Vincent Remouchamps, René-Olivier Mirimanoff, Guus Hart, Sandra Collette, Laurence Collette, Harry Bartelink
Importance: Prognostic factors of ipsilateral breast tumor recurrence (IBTR) may change over time following breast-conserving therapy. Objective: The EORTC "boost no boost" trial showed that young age and high-grade invasive carcinoma were the most important risk factors for IBTR. This study reanalyses pathological prognostic factors related to IBTR using long-term follow-up. Design, Setting, and Participants: Participants included 5569 early-stage breast cancer patients, treated with breast-conserving surgery (BCS) and whole-breast irradiation (WBI), who were randomized between no boost and a 16-Gy boost in the EORTC phase III "boost no boost" trial (1989-1996)...
September 8, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/27586875/schwannoma-of-the-trochlear-nerve-an-illustrated-case-series-and-a-systematic-review-of-management
#20
Nurhan Torun, Yosef Laviv, Kianush Karimian Jazi, Anand Mahadevan, Rafeeque A Bhadelia, Anderson Matthew, Mitchell Strominger, Ekkehard M Kasper
Schwannomas of cranial nerves in the absence of systemic neurofibromatosis are relatively rare. Among these, schwannomas of the trochlear nerve are even less common. They can be found incidentally or when they cause diplopia or other significant neurological deficits. Treatment options include observation only, neuro-ophthalmological intervention, and/or neurosurgical management via resection or sterotactic radiosurgery (SRS). In recent years, the latter has become an attractive therapeutic tool for a number of benign skull base neoplasm including a small number of reports on its successful use for trochlear Schwannomas...
September 1, 2016: Neurosurgical Review
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