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https://www.readbyqxmd.com/read/29881286/clinicopathologic-features-and-radiation-therapy-utilization-in-patients-with-male-breast-cancer-a-national-cancer-database-study
#1
REVIEW
Joshua Weir, Yan Daniel Zhao, Terence Herman, Özer Algan
Male breast cancer (MBC) accounts for approximately 1% of all breast cancers, limiting the data characterizing clinicopathologic features and treatment outcomes in patients with MBC. This paucity of data has led to most of our treatment guidance being extrapolated from patients with female breast cancer (FBC). From 1998 to 2012, data were captured using the National Cancer Database to identify patients with nonmetastatic MBC (n = 23 305) and FBC (n = 2 678 061). Tumor and clinicopathologic features were obtained and compared...
2018: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29753040/outcomes-of-endoscopic-resection-for-superficial-duodenal-epithelial-neoplasia
#2
Naohisa Yahagi, Motohiko Kato, Yasutoshi Ocihai, Tadateru Maehata, Motoki Sasaki, Yoshiyuki Kiguchi, Teppei Akimoto, Atsushi Nakayama, Ai Fujimoto, Osamu Goto, Toshio Uraoka
BACKGROUND AND AIM: Pancreaticoduodenectomy is an invasive procedure, and endoscopic resection (ER) is an alternative therapy. However, details regarding the outcomes of ER are unknown, especially for superficial duodenal epithelial neoplasia (SDET). The aim of this study was to elucidate the outcomes of ER for SDET and to compare endoscopic mucosal resection (EMR) with endoscopic submucosal dissection (ESD). METHODS: This was a retrospective observational study...
May 9, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29733839/placenta-percreta-is-associated-with-more-frequent-severe-maternal-morbidity-than-placenta-accreta
#3
Louis Marcellin, Pierre Delorme, Marie Pierre Bonnet, Gilles Grange, Gilles Kayem, Vassilis Tsatsaris, François Goffinet
BACKGROUND: Abnormally invasive placentation is the leading cause of obstetric hysterectomy and can cause poor to disastrous maternal outcomes. Most previous studies of peripartum management and maternal morbidity have included variable proportions of severe and less severe cases. OBJECTIVE: The aim of this study was to compare maternal morbidity from placenta percreta and accreta. STUDY DESIGN: This retrospective study at a referral center in Paris includes all women with abnormally invasive placentation from 2003 to 2017...
May 4, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29705287/a-population-based-audit-of-surgical-practice-and-outcomes-of-oncoplastic-breast-conservations-in-scotland-an-analysis-of-589-patients
#4
Laszlo Romics, E Jane Macaskill, Teresa Fernandez, Louise Simpson, Elizabeth Morrow, Vassilis Pitsinis, Sian Tovey, Matthew Barber, Yazan Masannat, Sheila Stallard, Eva Weiler-Mithoff, Andrew Malyon, James Mansell, Esther J Campbell, Julie Doughty, J Michael Dixon
INTRODUCTION: Current evidence for oncoplastic breast conservation (OBC) is based on single institutional series. Therefore, we carried out a population-based audit of OBC practice and outcomes in Scotland. METHODS: A predefined database of patients treated with OBC was completed retrospectively in all breast units practicing OBC in Scotland. RESULTS: 589 patients were included from 11 units. Patients were diagnosed between September 2005 and March 2017...
April 13, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29685879/clinicopathological-risk-factors-for-an-invasive-breast-cancer-recurrence-after-ductal-carcinoma-in-situ-a-nested-case-control-study
#5
Lindy L Visser, Lotte E Elshof, Michael Schaapveld, Koen van de Vijver, Emma J Groen, Mathilde M Almekinders, Carolien Bierman, Flora E van Leeuwen, Emiel J Rutgers, Marjanka K Schmidt, Esther H Lips, Jelle Wesseling
Purpose: Ductal carcinoma in situ (DCIS) is treated to prevent progression to invasive breast cancer. Yet, most lesions will never progress, implying that overtreatment exists. Therefore, we aimed to identify factors distinguishing harmless from potentially hazardous DCIS using a nested case-control study. Experimental Design: We conducted a case-control study nested in a population-based cohort of patients with DCIS treated with breast-conserving surgery (BCS) alone ( N = 2,658) between 1989 and 2005. We compared clinical, pathologic, and IHC DCIS characteristics of 200 women who subsequently developed ipsilateral invasive breast cancer (iIBC; cases) and 474 women who did not (controls), in a matched setting...
April 23, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29616624/invasive-strategy-and-frailty-in-very-elderly-patients-with-acute-coronary-syndromes
#6
Isaac Llaó, Albert Ariza-Solé, Juan Sanchis, Oriol Alegre, Ramon López-Palop, Francesc Formiga, Francisco Marín, María T Vidán, Manuel Martínez-Sellés, Alessandro Sionis, Miguel Vives-Borrás, Joan Antoni Gómez-Hospital, Josep Gómez-Lara, Gerard Roura, Pablo Díez-Villanueva, Iván Núñez-Gil, Jaume Maristany, Lluis Asmarats, Héctor Bueno, Emad Abu-Assi, Àngel Cequier
AIMS: Current guidelines recommend an early invasive strategy in patients with non-ST segment elevation acute coronary syndromes (NSTEACS). The role of an invasive strategy in frail elderly patients remains controversial. METHODS AND RESULTS: The LONGEVO-SCA registry included unselected NSTEACS patients aged ≥80 years. A geriatric assessment was performed during hospitalization, including frailty. We evaluated the impact of an invasive strategy during the admission on the incidence of cardiac death, reinfarction or new revascularisation at 6-months...
April 3, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29579155/a-polymorphism-in-the-lysyl-oxidase-propeptide-domain-accelerates-carcinogen-induced-cancer
#7
Ana de la Cueva, Michael Emmerling, Sarah L Lim, Shi Yang, Philip C Trackman, Gail E Sonenshein, Kathrin H Kirsch
The propeptide (LOX-PP) domain of the lysyl oxidase proenzyme (Pro-LOX) was shown to inhibit the transformed phenotype of breast, lung and pancreatic cells in culture and the formation of Her2/neu-driven breast cancer in a xenograft model. A single nucleotide polymorphism (SNP, rs1800449) positioned in a highly conserved region of LOX-PP results in an Arg158Gln substitution (humans). This ArgGln substitution profoundly impaired the ability of LOX-PP to inhibit the invasive phenotype and xenograft tumor formation...
March 22, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29575432/efficacy-of-percutaneous-posterior-tibial-nerve-stimulation-for-the-management-of-fecal-incontinence-in-multiple-sclerosis-a-pilot-study
#8
Santosh Sanagapalli, Laura Neilan, Jack Yu Tung Lo, Lavanya Anandan, Jorge Liwanag, Amanda Raeburn, Eleni Athanasakos, Natalia Zarate-Lopez, Anton Emmanuel
BACKGROUND: Fecal incontinence is a debilitating and highly prevalent problem among multiple sclerosis patients. Conservative therapies often fail to provide benefit. Posterior tibial nerve stimulation is a minimally invasive neuromodulatory therapy with proven efficacy for fecal incontinence in non-neurological settings. OBJECTIVE: To evaluate the efficacy of posterior tibial nerve stimulation in treating multiple sclerosis-related fecal incontinence. METHODS: Consecutive multiple sclerosis patients with fecal incontinence that had failed conservative therapy received posterior tibial nerve stimulation between 2012 and 2015...
March 25, 2018: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29546481/thirty-day-postoperative-morbidity-and-mortality-in-elderly-women-with-breast-cancer-an-analysis-of-the-nsqip-database
#9
Fernando A Angarita, Sergio A Acuna, Erin Cordeiro, Ahmad Elnahas, Subir Sutradhar, Timothy Jackson, Tulin D Cil
PURPOSE: Postoperative complication rates for elderly women undergoing breast cancer surgery have not been well studied. We describe the postoperative complication rates of elderly (≥ 70 years) women with breast cancer and compare them with young (40-69 years) women. METHODS: Data were extracted from the National Surgical Quality Improvement Program database (2004-2014). We included women with invasive breast cancer who underwent surgery. Outcomes were 30-day postoperative morbidity and mortality (complications), which were compared between young and elderly women...
March 15, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29502995/epidemiology-treatment-and-outcomes-of-acute-limb-ischemia-in-the-pediatric-population
#10
Sungho Lim, Michael J Javorski, Pegge M Halandras, Paul C Kuo, Bernadette Aulivola, Paul Crisostomo
OBJECTIVE: Acute limb ischemia (ALI) in a pediatric patient is a rare condition but may result in lifelong disability. A paucity of evidence exists to derive treatment guidelines; some surgeons advocate conservative management over invasive measures. The purpose of this study was to evaluate the role of surgical revascularization in the pediatric population and outcomes of conservative vs surgical management. METHODS: The Healthcare Cost and Utilization Project State Inpatient Database (California, Iowa, and New York) between 2007 and 2013 was queried using International Classification of Diseases, Ninth Revision codes...
March 1, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29469049/safety-and-efficacy-of-laparoscopic-radiofrequency-ablation-for-hepatic-hemangiomas-a-multicenter-retrospective-study
#11
Shun-Qian Wen, Ming Wan, Kai-Ming Len, Qiu-Hui Hu, Xue-Yi Xie, Qing Wu, Guan-Qun Liao
INTRODUCTION: Radiofrequency ablation (RFA) is an effective and minimally invasive technique for the management of hepatic hemangiomas (HHs). This study aims to assess the safety and efficacy of laparoscopic RFA for HHs. MATERIAL AND METHODS: Forty-four patients with 50 hepatic hemangiomas (5-10 cm in diameter) undergoing laparoscopic RFA from January 2012 to May 2015 at three tertiary hospitals in China were retrospectively analyzed. RESULTS: Thirty-three patients with subcapsular hemangiomas were treated with a laparoscopic approach, and 11 patients with lesions in the liver parenchyma were treated with a combined laparoscopy and an ultrasound-guided percutaneous approach...
March 1, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29439832/factors-associated-with-positive-margins-in-women-undergoing-breast-conservation-surgery
#12
Brittany L Murphy, Judy C Boughey, Michael G Keeney, Amy E Glasgow, Jennifer M Racz, Gary L Keeney, Elizabeth B Habermann
OBJECTIVE: To identify factors predicting positive margins at lumpectomy prompting intraoperative reexcision in patients with breast cancer treated at a large referral center. PATIENTS AND METHODS: We reviewed all breast cancer lumpectomy cases managed at our institution from January 1, 2012, through December 31, 2013. Associations between rates of positive margin and patient and tumor factors were assessed using χ2 tests and univariate and adjusted multivariate logistic regression, stratified by ductal carcinoma in situ (DCIS) or invasive cancer...
April 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29428232/evaluating-the-effect-of-margin-consensus-guideline-publication-on-operative-patterns-and-financial-impact-of-breast-cancer-operation
#13
Neal Bhutiani, Megan K Mercer, Katelynn C Bachman, Samantha R Heidrich, Robert C G Martin, Charles R Scoggins, Kelly M McMasters, Nicolás Ajkay
BACKGROUND: This study sought to evaluate re-excision rates, patient satisfaction with their breasts, and healthcare costs before and after publication of 2014 Society of Surgical Oncology/American Society of Radiation Oncology consensus guideline on margins for breast conserving operation with whole-breast irradiation for stage I and II breast cancer at an academic institution. STUDY DESIGN: Patients with stage I and II invasive carcinomas who underwent partial mastectomy were divided into 2 groups based on whether they were treated before (PRE) or after (POST) guideline publication in March 2014...
February 9, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29428039/rationale-for-mastectomy-after-neoadjuvant-chemotherapy
#14
COMPARATIVE STUDY
Lejla Hadzikadic Gusic, Kendall Walsh, Teresa Flippo-Morton, Terry Sarantou, Danielle Boselli, Richard L White
Neoadjuvant chemotherapy (NAC) reduces tumor size, facilitating the use of breast conservation surgery (BCS). However, mastectomy remains the surgical outcome for certain women. The goal of this study was to determine the rationale for mastectomy after NAC, particularly in women eligible for BCS. Retrospective data were reviewed on patients who received NAC between February 2006 and August 2010 at our institution. Demographics and tumor characteristics were compared between patients who received BCS and mastectomy after NAC...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29425553/invasive-treatment-of-nstemi-patients-in-german-chest-pain-units-evidence-for-a-treatment-paradox
#15
Frank P Schmidt, Claus Schmitt, Matthias Hochadel, Evangelos Giannitsis, Harald Darius, Lars S Maier, Claus Schmitt, Gerd Heusch, Thomas Voigtländer, Harald Mudra, Tommaso Gori, Jochen Senges, Thomas Münzel
BACKGROUND: Patients with non ST-segment elevation myocardial infarction (NSTEMI) represent the largest fraction of patients with acute coronary syndrome in German Chest Pain units. Recent evidence on early vs. selective percutaneous coronary intervention (PCI) is ambiguous with respect to effects on mortality, myocardial infarction (MI) and recurrent angina. With the present study we sought to investigate the prognostic impact of PCI and its timing in German Chest Pain Unit (CPU) NSTEMI patients...
March 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29409490/unilateral-pedal-lymphangiography-plus-computed-tomography-angiography-for-location-of-persistent-idiopathic-chyle-leakage-not-detectable-by-ordinary-contrast-computed-tomography
#16
Dingyi Liu, Boke Liu, Weimu Xia, Qi Tang, Haidong Wang, Jian Wang, Yanfeng Zhou, Jiashun Yu, Wenmin Li, Mingwei Wang, Wenlong Zhou, Sang Hu, Yuan Shao
BACKGROUND: To identify the value of unilateral pedal lymphangiography (LPG) plus computed tomography angiography (CTA) in accurate depiction of persistent idiopathic chyluria undetectable by ordinary contrast CT. METHODS: Eighteen patients 44-63 years of age with persistent idiopathic chyluria who failed conservative management were included. Ordinary CT had not revealed a chyle leak. Cystoscopy, unilateral LPG, and post-LPG CT angiography (CTA) were sequentially performed...
February 6, 2018: BMC Urology
https://www.readbyqxmd.com/read/29395710/an-invasive-vs-a-conservative-approach-in-elderly-patients-with-non-st-segment-elevation-myocardial-infarction-systematic-review-and-meta-analysis
#17
REVIEW
Avadhesh Saraswat, Atifur Rahman, Kuljit Singh
BACKGROUND: Elderly (≥ 75 years) patients form a large sub-group of non-ST-segment elevation myocardial infarction (NSTEMI) population but are vastly under-represented in trials. Thus, the benefits of an early angiography in the elderly remain unclear. In this systematic review, we compared outcomes of "invasive" and "conservative" strategies of NSTEMI management in elderly patients. METHODS: A comprehensive search of major databases was performed...
March 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29334604/breast-conservation-therapy-versus-mastectomy-in-patients-with-t1-2n1-triple-negative-breast-cancer-pooled-analysis-of-krog-14-18-and-14-23
#18
Kyubo Kim, Hae Jin Park, Kyung Hwan Shin, Jin Ho Kim, Doo Ho Choi, Won Park, Seung Do Ahn, Su Ssan Kim, Dae Yong Kim, Tae Hyun Kim, Jin Hee Kim, Jiyoung Kim
Purpose: The aim of this study is to compare the treatment outcomes of breast conserving surgery (BCS) plus radiotherapy (RT) vs. mastectomy for patients with pT1-2N1 triple negative breast cancer (TNBC). Methods: Using two multicenter retrospective studies on breast cancer, a pooled analysis was performed among 320 patients with pT1-2N1 TNBC. All patients who underwent BCS (n=212) received whole breast RT with or without regional nodal RT, while none who underwent mastectomy (n=108) received it...
January 8, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29317757/human-mediated-and-natural-dispersal-of-an-invasive-fish-in-the-eastern-great-lakes
#19
Mattias L Johansson, Bradley A Dufour, Kyle W Wellband, Lynda D Corkum, Hugh J MacIsaac, Daniel D Heath
The globally invasive Round Goby (Neogobius melanostomus) was introduced to the Great Lakes around 1990, spreading widely and becoming the dominant benthic fish in many areas. The speed and scope of this invasion is remarkable and calls into question conventional secondary spread models and scenarios. We utilized nine microsatellites to identify large-scale genetic structure in Round Goby populations in the eastern Great Lakes, and assessed the role of colonization vs. secondary transport and dispersal in developing this structure...
January 10, 2018: Heredity
https://www.readbyqxmd.com/read/29302485/21-gene-recurrence-assay-in-patients-receiving-intraoperative-radiotherapy-are-favorable-characteristics-a-surrogate-for-low-recurrence
#20
Bridget A Oppong, Surupa Sen Gupta, Monique Gary, Patricia Wehner, Mihriye Mete, Danjing Zhao, Sulakshana Seevaratnam, Sonali Rudra, Shawna C Willey
Background: Intraoperative radiotherapy (IORT) has gained momentum for early stage and favorable breast cancers (BC). The 21-gene recurrence assay guides treatment of hormone positive and node-negative BC. Methods: Analysis of 82 invasive BC treated with breast conservation surgery (BCS) and IORT 2013-2015. Data collection included patient demographics, tumor characteristics, nodal status, recurrence test (RS) and adjuvant therapy. Results: The mean age was 68 years...
December 2017: Gland Surgery
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