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https://www.readbyqxmd.com/read/28206957/young-breast-cancer-patients-who-develop-distant-metastasis-after-surgery-have-better-survival-outcomes-compared-with-elderly-counterparts
#1
Jingjing Wang, Jiayu Wang, Qing Li, Pin Zhang, Peng Yuan, Fei Ma, Yang Luo, Ruigang Cai, Ying Fan, Shanshan Chen, Qiao Li, Binghe Xu
To investigate the recurrence pattern and subsequent survival outcomes in young breast cancer population, 483 young patients (≤ 35) and 739 elderly patients (≥ 65), who received mastectomy or breast-conserving surgery from 2008 to 2012, were included in this study. The young population presented with a higher rate of pathologic tumor stage (P < 0.001), positive pathologic lymph node (P < 0.001), grade III tumors (P < 0.001), and lymphovascular invasion (P < 0.001). With a median follow-up of 56...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28191804/does-alternative-and-traditional-wasam-local-cautery-therapy-facilitate-an-early-and-more-extensive-locoregional-metastasis-of-breast-cancer
#2
(no author information available yet)
INTRODUCTION: A large heterogeneous group of unproven remedies exist to treat cancer in both developed and developing countries. Some of these remedies often do more harm than good to the patients. The traditional medicine is the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures. The traditional medicine in Oman is based on herbal treatment and skin treatment (massage, Cupping and skin burn "cautery" treatment-known as Wasam or Kaiy)...
September 2016: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28171797/efficacy-of-repair-techniques-of-the-achilles-tendon-a-meta-analysis-of-human-cadaveric-biomechanical-studies
#3
REVIEW
Kaissar Yammine, Chahine Assi
PURPOSE: Achilles injuries are very common, mainly among young athletes. When indicated, the surgical treatment aims for strong repairs that can resist distraction and consequently ruptures. The majority of the published clinical meta-analyses reported comparisons between broad treatment modalities such as conservative treatment, open, and minimally invasive surgery. METHODS: A meta-analysis has been conducted to assess further clinical and biomechanical variables on human cadavers related to the efficacy of Achilles repair...
January 28, 2017: Foot
https://www.readbyqxmd.com/read/28157265/atserpin1-is-an-inhibitor-of-the-metacaspase-atmc1-mediated-cell-death-and-autocatalytic-processing-in-planta
#4
Saul Lema Asqui, Dominique Vercammen, Irene Serrano, Marc Valls, Susana Rivas, Frank van Breusegem, Frank L Conlon, Jeffery L Dangl, Núria S Coll
The hypersensitive response (HR) is a localized programmed cell death phenomenon that occurs in response to pathogen recognition at the site of attempted invasion. Despite more than a century of research on HR, little is known about how it is so tightly regulated and how it can be contained spatially to a few cells. AtMC1 is an Arabidopsis thaliana plant metacaspase that positively regulates the HR. Here, we used an unbiased approach to identify new AtMC1 regulators. Immunoaffinity purification of AtMC1-containing complexes led us to the identification of the protease inhibitor AtSerpin1...
February 3, 2017: New Phytologist
https://www.readbyqxmd.com/read/28120505/dopamine-receptor-type-2-drd2-and-somatostatin-receptor-type-2-sstr2-agonists-are-effective-in-inhibiting-proliferation-of-progenitor-stem-like-cells-isolated-from-nonfunctioning-pituitary-tumors
#5
E Peverelli, E Giardino, D Treppiedi, M Meregalli, M Belicchi, V Vaira, S Corbetta, C Verdelli, E Verrua, A L Serban, M Locatelli, G Carrabba, G Gaudenzi, E Malchiodi, L Cassinelli, A G Lania, S Ferrero, S Bosari, G Vitale, Y Torrente, A Spada, G Mantovani
The role of progenitor/stem cells in pituitary tumorigenesis, resistance to pharmacological treatments and tumor recurrence is still unclear. This study investigated the presence of progenitor/stem cells in non-functioning pituitary tumors (NFPTs) and tested the efficacy of dopamine receptor type 2 (DRD2) and somatostatin receptor type 2 (SSTR2) agonists to inhibit in vitro proliferation. They found that 70% of 46 NFPTs formed spheres co-expressing stem cell markers, transcription factors (DAX1, SF1, ERG1) and gonadotropins...
January 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28119293/nutrient-foraging-strategies-are-associated-with-productivity-and-population-growth-in-forest-shrubs
#6
Joshua S Caplan, Bram W G Stone, Cara A Faillace, Jonathan J Lafond, Joni M Baumgarten, Thomas J Mozdzer, John Dighton, Scott J Meiners, Jason C Grabosky, Joan G Ehrenfeld
BACKGROUND AND AIMS: Temperate deciduous forest understoreys are experiencing widespread changes in community composition, concurrent with increases in rates of nitrogen supply. These shifts in plant abundance may be driven by interspecific differences in nutrient foraging (i.e. conservative vs. acquisitive strategies) and, thus, adaptation to contemporary nutrient loading conditions. This study sought to determine if interspecific differences in nutrient foraging could help explain patterns of shrub success and decline in eastern North American forests...
January 23, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28105662/preoperative-mri-of-the-breast-and-ipsilateral-breast-tumor-recurrence-long-term-follow-up
#7
Mai-Kim Gervais, Ellen Maki, Dan E Schiller, Pavel Crystal, David R McCready
BACKGROUND: Local recurrence after breast conserving surgery is reported in 5-10% of cases. This study aims to determine if preoperative MRI is associated with reduced IBTR rates in the longer term and evaluate IBTR rates of a high risk (TN and Her-2 positive) subgroup in those receiving MRI or not. METHODS: Between 1999 and 2005, patients with invasive breast cancer undergoing BCS and radiation were identified. Primary endpoint was IBTR rate. RESULTS: The cohort consisted of 470 cases: 27% underwent MRI and 73% did not...
January 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28094198/late-side-effects-and-cosmetic-results-of-accelerated-partial-breast-irradiation-with-interstitial-brachytherapy-versus-whole-breast-irradiation-after-breast-conserving-surgery-for-low-risk-invasive-and-in-situ-carcinoma-of-the-female-breast-5-year-results
#8
Csaba Polgár, Oliver J Ott, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, José Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Rainer Fietkau, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Wolfgang Uter, Vratislav Strnad
BACKGROUND: We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial. METHODS: We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries...
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28070213/lower-gastrointestinal-bleeding-computed-tomographic-angiography-colonoscopy-or-both
#9
Daniel Clerc, Fabian Grass, Markus Schäfer, Alban Denys, Nicolas Demartines, Martin Hübner
BACKGROUND: Lower endoscopy (LE) is the standard diagnostic modality for lower gastrointestinal bleeding (LGIB). Conversely, computed tomographic angiography (CTA) offers an immediate non-invasive diagnosis visualizing the entire gastrointestinal tract. The aim of this study was to compare these 2 modalities with regards to diagnostic value and bleeding control. METHODS: Tertiary center retrospective analysis of consecutive patients admitted for LGIB between 2006 and 2012...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/28067674/a-pathology-of-mesh-and-time-dysejaculation-sexual-pain-and-orchialgia-resulting-from-polypropylene-mesh-erosion-into-the-spermatic-cord
#10
Vladimir Iakovlev, Andreas Koch, Kevin Petersen, John Morrison, David Grischkan, Vali Oprea, Robert Bendavid
OBJECTIVE: The ubiquitous use of polypropylene mesh in hernia surgery has spawned a new clinical syndrome: chronic post-herniorrhaphy neuralgia. A subset of that clinical picture is dysejaculation, sexual pain, and orchialgia. We propose to identify the processes that lead to that pain. SUMMARY OF BACKGROUND DATA: Specimens of vas adherent to polypropylene mesh, explanted in an attempt to control severe, life-changing inguinodynia are extremely difficult to obtain...
January 6, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28044238/vaporize-anatomically-vaporize-or-enucleate-the-prostate-the-flexible-use-of-the-greenlight-laser
#11
Luca Cindolo, Lorenzo Ruggera, Paolo Destefanis, Claudio Dadone, Giovanni Ferrari
PURPOSES: GreenLight laser has gained increasing acceptance as a less invasive treatment for lower urinary tract symptoms due to benign prostatic hyperplasia (BPH/LUTS). Three surgical options were developed: standard photovaporization (PVP), anatomical PVP and GreenLight enucleation of prostate (GreenLEP); however, literature lacks a direct comparison among the procedures. Aim of the present study is to compare the three techniques in a multicentre series of patients. METHODS: Data were collected from consecutive patients with indication to surgical management of BPH/LUTS in five institutions...
January 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28041648/short-term-safety-of-oncoplastic-breast-conserving-surgery-for-larger-tumors
#12
D J Wijgman, B Ten Wolde, N R A van Groesen, M E Keemers-Gels, F J H van den Wildenberg, L J A Strobbe
BACKGROUND: Oncoplastic surgery (OPS) replaces lumpectomy as standard technique in breast conserving surgery (BCS). OPS has shown to give good cosmetic results, but is it as safe as standard lumpectomy? We conducted a retrospective cohort study to determine postoperative complications, resection margins and re-excision rates for OPS compared to standard lumpectomy. METHODS: Based on data from the 'Netherlands Cancer Registry' and medical records we scored patient, treatment and follow-up related variables...
December 18, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28040858/multicenter-analysis-of-neoadjuvant-docetaxel-carboplatin-and-trastuzumab-in-her2-positive-breast-cancer
#13
Isabel Echavarria, Mónica Granja, Coralia Bueno, Sara Lopez-Tarruella, Paloma Peinado, Miguel Sotelo, Yolanda Jerez, Fernando Moreno, Gabriela Torres, Miriam Lobo, Ivan Marquez-Rodas, Maria Del Monte-Millan, Miguel Martín, Jose Angel García-Saenz
PURPOSE: In an era where neoadjuvant dual blockade is emerging as the standard of care for early and locally advanced HER2-positive breast cancer, we aimed to identify predictors of response to single-blockade chemotherapy. METHODS: This retrospective analysis reviewed all the incident stage I-III HER2-positive breast cancer patients who received neoadjuvant docetaxel, carboplatin, and trastuzumab (TCH) in three institutions. pCR was defined as the absence of invasive tumor in breast and axillary nodes (ypT0/isypN0)...
December 31, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28033508/pathological-complete-response-in-invasive-breast-cancer-treated-by-skin-sparing-mastectomy-and-immediate-reconstruction-following-neoadjuvant-chemotherapy-and-radiation-therapy-comparison-between-immunohistochemical-subtypes
#14
J Barrou, M Bannier, M Cohen, E Lambaudie, A Gonçalves, P Bertrand, M Buttarelli, P Opinel, N Sterkers, A Tallet, C Zinzindohoué, G Houvenaeghel
CONTEXT: Even if neoadjuvant chemotherapy (NACT) and oncoplastic techniques have increased the breast conserving surgery rate, mastectomy is still a standard for multifocal or extensive breast cancers (BC). In the prospect of increasing breast reconstruction, an alternative therapeutic protocol was developed combining NACT with neoadjuvant radiation therapy (NART), followed by mastectomy with immediate breast reconstruction (IBR). The oncological safety of this therapeutic plan still needs further exploration...
December 26, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28026205/preoperative-breast-mri-surgeons-patient-selection-patterns-and-potential-bias-in-outcomes-analyses
#15
Jiyon Lee, Elaine Tanaka, Peter R Eby, Shouhao Zhou, Wei Wei, Christine Eppelheimer, Vilert A Loving
OBJECTIVE: The purpose of this study is to determine which patient- and tumor-related and clinical variables influence dedicated breast surgeons' and general surgeons' referrals for preoperative breast MRI for patients with newly diagnosed breast cancer. MATERIALS AND METHODS: Surgeons who perform breast surgery responded to a survey from June 16, 2014, through August 11, 2014. Participants self-identified as breast or general surgeons and provided professional practice details...
December 27, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28002557/reoperation-rates-in-ductal-carcinoma-in-situ-vs-invasive-breast-cancer-after-wire-guided-breast-conserving-surgery
#16
Linnea Langhans, Maj-Britt Jensen, Maj-Lis M Talman, Ilse Vejborg, Niels Kroman, Tove F Tvedskov
Importance: New techniques for preoperative localization of nonpalpable breast lesions may decrease the reoperation rate in breast-conserving surgery (BCS) compared with rates after surgery with the standard wire-guided localization. However, a valid reoperation rate for this procedure needs to be established for comparison, as previous studies on this procedure include a variety of malignant and benign breast lesions. Objectives: To determine the reoperation rate after wire-guided BCS in patients with histologically verified nonpalpable invasive breast cancer (IBC) or ductal carcinoma in situ (DCIS) and to examine whether the risk of reoperation is associated with DCIS or histologic type of the IBC...
December 21, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27984658/no-impact-of-breast-magnetic-resonance-imaging-on-15-year-outcomes-in-patients-with-ductal-carcinoma-in-situ-or-early-stage-invasive-breast-cancer-managed-with-breast-conservation-therapy
#17
Neha Vapiwala, Wei-Ting Hwang, Carolyn J Kushner, Mitchell D Schnall, Gary M Freedman, Lawrence J Solin
BACKGROUND: For women undergoing breast conservation therapy (BCT), the added value of breast magnetic resonance imaging (MRI) at the time of initial diagnosis remains controversial. The current study was performed to determine long-term outcomes after BCT for women with and without pretreatment breast MRI. METHODS: Between 1992 and 2001, a total of 755 women with ductal carcinoma in situ or early-stage invasive breast cancer underwent breast-conserving surgery (with axillary lymph node staging for invasive carcinoma) followed by definitive breast radiotherapy...
December 16, 2016: Cancer
https://www.readbyqxmd.com/read/27935160/surgical-treatment-of-mature-cystic-teratomas-a-comparison-of-emergent-and-elective-surgeries
#18
Hadas Ganer Herman, Ron Sagiv, Hagit Raphaeli, Ram Kerner, Ran Keidar, Jacob Bar, Shimon Ginath
AIM: To compare patient characteristics, imaging and surgical management of mature cystic teratomas (MCTs) according to surgery type - elective versus emergent. METHODS: The study included surgeries performed between 1990 and 2016, during which histologically verified ovarian MCT material was obtained. The elective management group included surgeries performed at a pre-set date or incidental finding of MCT as part of a different surgery. Emergent surgeries were considered as such if performed as a result of suspected adnexal torsion...
December 9, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27926784/preoperative-characteristics-and-cytological-features-of-136-histologically-confirmed-pancreatic-mucinous-cystic-neoplasms
#19
Aristana Scourtas, Jonathan C Dudley, William R Brugge, Abdurrahman Kadayifci, Mari Mino-Kenudson, Martha B Pitman
BACKGROUND: Mucinous cystic neoplasms (MCNs) of the pancreas present a management conundrum. The majority are benign but all are resected due to their malignant potential. Recent studies have recommended nonsurgical management. In the current study, the authors analyzed the preoperative imaging, cytology, and cyst fluid characteristics of 136 histologically confirmed MCNs to assess predictors of a high-risk (HR) cyst for surgical triage. METHODS: MCNs resected at the Massachusetts General Hospital between 1990 and 2014 formed the study cohort...
December 7, 2016: Cancer
https://www.readbyqxmd.com/read/27872526/progesterone-receptors-pathological-complete-response-and-early-outcome-for-locally-advanced-breast-cancer-a-single-centre-study-pplb-01
#20
Sanjit Agrawal, Lalit Banswal, Animesh Saha, Indu Arun, Soumitra Shankar Datta, Sanjoy Chatterjee, Rosina Ahmed
Neoadjuvant chemotherapy (NACT) for locally advanced breast cancer (LABC), apart from increasing breast conservation rates, also provides an opportunity to assess tumour response to chemotherapy, with Pathological Complete Response (pCR) described as an independent prognostic factor and a surrogate marker for better outcome and survival. Our primary aim was to identify clinical and pathological factors associated with pCR following NACT in patients with LABC treated at our institution. Our secondary aim was to analyze the impact of pCR and associated factors on disease free survival (DFS) and overall survival (OS)...
December 2016: Indian Journal of Surgical Oncology
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