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Hang Sun, Shan Zeng, Yinxing Shang, Qinrong He
Developing an effective and reliable method for trace arsenic (As) detection is a prerequisite for improving the safety of drinking water. In this paper, we designed and prepared Ag@Fe3O4 core-shell nanoparticles (NPs), which were then used as Surface-Enhanced Raman Scattering (SERS) probe for trace arsenate (As(V)) detection. The Ag@Fe3O4 core-shell NPs were prepared by in situ growth of Fe3O4 NPs on the surface of AgNPs, which can effectively combine the strong adsorption ability of Fe3O4 nanoshells to As(V) with high SERS activity of Ag nanocores to decrease the detection limit...
February 1, 2018: Journal of Nanoscience and Nanotechnology
Regivaldo G Sobral-Filho, Lindsay DeVorkin, Sarah Macpherson, Andrew Jirasek, Julian J Lum, Alexandre G Brolo
The detection of circulating tumor cells (CTCs) from blood samples can predict prognosis, response to systemic chemotherapy, and metastatic spread of carcinoma. Therefore, approaches for CTC identification is an important aspect of current cancer research. Here, a method for the direct visualization of nanoparticle-coated CTCs under dark field illumination is presented. A metastatic breast cancer cell line (4T1) was transduced with a non-native target protein (Thy1.1). Positive 4T1-Thy1.1 cells incubated with antibody-coated metallic nanoshells appeared overly bright at low magnification, allowing a quick screening of samples and easy visual detection of even single isolated CTCs...
February 7, 2018: ACS Nano
Wei Geng, Li Wang, Nan Jiang, Jian Cao, Yu-Xuan Xiao, Hao Wei, Ali K Yetisen, Xiao-Yu Yang, Bao-Lian Su
Inspired by the characteristics of cells in live organisms, new types of hybrids have been designed comprising live cells and abiotic materials having a variety of structures and functionalities. The major goal of these studies is to uncover hybridization approaches that promote cell stabilization and enable the introduction of new functions into living cells. Single-cells in nanoshells have great potential in a large number of applications including bioelectronics, cell protection, cell therapy, and biocatalysis...
February 2, 2018: Nanoscale
Xiu-Ying Zheng, Xiang-Jian Kong, Zhiping Zheng, La-Sheng Long, Lan-Sun Zheng
High-nuclearity cluster-type metal complexes are a unique class of compounds, many of which have aesthetically pleasing molecular structures. Their interesting physical and chemical properties arise primarily from the electronic and/or magnetic interplay between the component metal ions. Among the extensive studies in the past two decades, those on lanthanide-containing clusters, lanthanide-exclusive or heterometallic with transition metal elements, are most notable. The research was driven by both the synthetic challenges for these generally elusive species and their intriguing magnetic properties, which are useful for the development of energy-efficient and environmentally friendly magnetic cooling technologies...
February 2, 2018: Accounts of Chemical Research
Kisun Kim, Junyong Park, Seokkyoon Hong, Sun Hwa Park, Seong Gi Jeon, Changui Ahn, Jae Yong Song, Seokwoo Jeon
ZnO is a potential thermoelectric material because of its non-toxicity, high thermal stability, and relatively high Seebeck coefficient (S) of metal oxides. However, the extremely low figure of merit (zT), which comes from a high thermal conductivity (κ) over 40 W m-1 K-1, limits the thermoelectric application of ZnO. In particular, below 500 K, ZnO exhibits a nearly negligible zT (<10-3), unless a dopant is incorporated into the crystal structure. Here, we propose a new strategy for achieving a reduced κ and a correspondingly increased zT of pure ZnO over a wide temperature range from 333 K to 723 K by forming an ∼72 nm thick, 3D continuous ultrathin nanoshell structure...
January 29, 2018: Nanoscale
Sung Gyu Kang, Dae-Young Moon, Jeonghwan Jang, Ju-Young Kim, Jin-Yoo Suh, Euijoon Yoon, Heung Nam Han, In-Suk Choi
In the present study, we found that α-alumina hollow nanoshell structure can exhibit an ultrahigh fracture strength even though it contains a significant number of nanopores. By systematically performing in-situ mechanical testing and finite element simulations, we could measure that the fracture strength of an α-alumina hollow nanoshell structure is about four times higher than that of the conventional bulk size α-alumina. The high fracture strength of the α-alumina hollow nanoshell structure can be explained in terms of conventional fracture mechanics, in that the position and size of the nanopores are the most critical factors determining the fracture strength, even at the nanoscales...
January 23, 2018: Nano Letters
Longwei Liang, Xuan Sun, Chen Wu, Linrui Hou, Jinfeng Sun, Xiaogang Zhang, Changzhou Yuan
Surface modifications are established well as efficient methodologies to enhance comprehensive Li-storage behaviors of the cathodes, and play a significant role in cutting edge innovations towards lithium-ion batteries (LIBs). Herein, we first logically devised a pilot-scale coating strategy to integrate solid state electrolyte NaTi2(PO4)3 (NTP) and layered LiNi0.5Mn0.3Co0.2O2 (NMC) for smart construction of core-shell NMC@NTP cathodes. The NASICON-type NTP nanoshell with exceptional ion conductivity effectively suppressed gradual encroachment and/or loss of electroactive NMC, guaranteed stable phase-interfaces, and rendered small sur-/interfacial eletron/ion-diffusion resistance meanwhile...
January 22, 2018: ACS Applied Materials & Interfaces
Zhong Feng Gao, Asmerom Yohannes Ogbe, Ei Ei Sann, Xudong Wang, Fan Xia
Monitoring blood glucose has attracted considerable attention because diabetes mellitus is a global public health problem. Herein, we reported a turn-on fluorescence detection strategy based on manganese dioxide (MnO2)-phenol formaldehyde resin (PFR) nanocomposite for rapid, sensitive, and selective detection of glucose levels in human blood. In this biosensing system, MnO2 nanoshell on the PFR nanoparticle surfaces serve as a quencher. PFR fluorescence can make a recovery in the presence of H2O2, reducing MnO2 to Mn2+...
April 1, 2018: Talanta
N Kostevšek, I Abramovič, S Hudoklin, M E Kreft, I Serša, A Sepe, J Vidmar, S Šturm, M Spreitzer, J Ščančar, S Kobe, K Žužek Rožman
We have produced an innovative, theranostic material based on FePt/SiO2/Au hybrid nanoparticles (NPs) for both, photo-thermal therapy and magnetic resonance imaging (MRI). Furthermore, a new synthesis approach, i.e., Au double seeding, for the preparation of Au nanoshells around the FePt/SiO2 cores, is proposed. The photo-thermal and the MRI response were first demonstrated on an aqueous suspension of hybrid FePt/SiO2/Au NPs. The cytotoxicity together with the internalization mechanism and the intracellular fate of the hybrid NPs were evaluated in vitro on a normal (NPU) and a half-differentiated cancerous cell line (RT4)...
January 3, 2018: Nanoscale
Catherine Christie, Steen J Madsen, Qian Peng, Henry Hirschberg
Macrophages (Ma) loaded with gold based nanoparticles, which convert near infrared light to heat, have been studied as targeted transport vectors for photothermal therapy (PTT) of tumors. The purpose of the experiments reported here was to compare the efficacy of gold-silica nanoshells (AuNS) and gold nanorods (AuNR) in macrophage mediated PTT. PTT efficacy was evaluated in hybrid glioma spheroids consisting of human glioma cells and either AuNS or AuNR loaded Ma, designated MaNS and MaNR respectivly. Spheroids were irradiated for 10 min...
2017: Journal of Environmental Pathology, Toxicology and Oncology
K Ehrlich, A Kufcsák, S McAughtrie, H Fleming, N Krstajic, C J Campbell, R K Henderson, K Dhaliwal, R R Thomson, M G Tanner
Full exploitation of fibre Raman probes has been limited by the obstruction of weak Raman signals by background fluorescence of the sample and the intrinsic Raman signal of the delivery fibre. Here we utilised functionalised gold nanoshells (NS) to take advantage of the surface-enhanced Raman spectroscopy (SERS) effect to enhance the pH responsive spectrum of 4-mercaptobenzoic acid (MBA). However, the fibre background is still dominant. Using the photon arrival time-resolving capability of a CMOS single-photon avalanche diode (SPAD) based line sensor, we recover the SERS spectrum without a fibre background in a 10 s measurement...
December 11, 2017: Optics Express
Asifkhan Shanavas, Aravind Kumar Rengan, Deepak Chauhan, Liya George, Mukti Vats, Navneet Kaur, Pranjali Yadav, Purvi Mathur, Swaroop Chakraborty, Appidi Tejaswini, Abhijit De, Rohit Srivastava
Multifunctional biodegradable nanomaterials that could be used for both imaging and therapy are being researched extensively. A simple technique to synthesize multifunctional nanoparticles without compromising on any of their functionality is a challenge. We have attempted to optimize a two-step procedure of gold coated polymeric template involving 1) Single pot synthesis of PLGA nanoparticles with cationic surface charge using glycol chitosan and 2) in situ gold coating for formation of gold coated PLGA nanoshell (AuPLGA-NS)...
November 22, 2017: International Journal of Biological Macromolecules
Akbar Samadi, Poul Martin Bendix, Lene B Oddershede
Nanostructures with exceptional absorption in the near infrared (NIR) regime are receiving significant attention due to their ability to promote controlled local heating in biological material upon irradiation. Also, such nano-structures have numerous applications in nano-electronics and for bio-exploration. Therefore, significant effort is being put into controlling and understanding plasmonic nanostructures. However, essentially all focus has been on NIR resonant gold nanoparticles and remarkably little attention has been given to nanoparticles of other materials that may have superior properties...
November 21, 2017: Nanoscale
Lev A Dykman, Sergey A Staroverov, Alexander S Fomin, Vitaly A Khanadeev, Boris N Khlebtsov, Vladimir A Bogatyrev
Gold nanoparticles (GNPs) are advantageous as an adjuvant in the design of effective vaccines and in the preparation of high-affinity antibodies to haptens and complete antigens. Another method of activating immunocompetent cells with colloidal gold is to conjugate GNPs with CpG oligodeoxynucleotides (ODNs). We examined how the size and shape of GNPs and various combinations of GNPs and CpG ODNs 1826 affect the immune response. When animals were injected with a model antigen (BSA) coupled to gold nanospheres (diameters, 15 and 50nm), nanorods, nanoshells, and nanostars, the titers of the resultant antibodies differed substantially...
November 14, 2017: International Immunopharmacology
Yuying Zhang, Xinping Wang, Sven Perner, Ágnes Bánkfalvi, Sebastian Schlücker
Immunohistochemical analysis of FFPE tissues provides important diagnostic and prognostic information in pathology. Metal nanoparticles (NPs) and in particular surface-enhanced Raman scattering (SERS) nanotags as a new class of labelling reagents are promising to be used for multiplexed protein profiling on tissue sections. However, non-specific binding of NPs onto the tissue specimens greatly hampers their clinical applications. In this study, we found that the antigen retrieval method strongly influences the extent of non-specific binding of the antibody-SERS NP conjugates to the tissue...
November 17, 2017: Analytical Chemistry
Hongyang Shao, Xiaoming Zhang, Hao Huang, Kan Zhang, Menglong Wang, Cai Zhang, Yifan Yang, Mao Wen, Weitao Zheng
The idea of a core-shell structure can promote the utilization of nonprecious metallic catalysts by enhancing their activity and stability for the oxygen reduction reaction (ORR). Developing a low-cost, high-efficiency, and high-reproducibility method for synthesizing core-shell-structured materials represents an urgent challenge. Here, we fabricate encapsulated Cu nanoparticles with nitrogen-doped onion-like graphite nanoshells (Cu@onion-like N-C) as an efficient ORR catalyst by magnetron sputtering, in which the graphite shells grow by an in situ self-assembly process activated by the surface-catalyzed behavior with Cu nanoparticles...
November 17, 2017: ACS Applied Materials & Interfaces
Jie Ying, Christoph Janiak, Yu-Xuan Xiao, Hao Wei, Xiao-Yu Yang, Bao-Lian Su
Cubic Pd nanocrystals with shape-controlled mesoporous silica shells have been theoretically designed and successfully synthesized for investigating the effect of a porous nanoshell on catalytic performance of the core. Cubic Pd@cubic mesoporous silica keeps activity of all facets and shows highest catalytic activity and enhanced reusability in the hydrogenation of nitrobenzene.
November 14, 2017: Chemistry, An Asian Journal
D El Khoury, V Fedorenko, J Castellon, M Bechelany, J-C Laurentie, S Balme, M Fréchette, M Ramonda, R Arinero
Nanocomposites physical properties unexplainable by general mixture laws are usually supposed to be related to interphases, highly present at the nanoscale. The intrinsic dielectric constant of the interphase and its volume need to be considered in the prediction of the effective permittivity of nanodielectrics, for example. The electrostatic force microscope (EFM) constitutes a promising technique to probe interphases locally. This work reports theoretical finite-elements simulations and experimental measurements to interpret EFM signals in front of nanocomposites with the aim of detecting and characterizing interphases...
2017: Scanning
Amanda M Goodman, Oara Neumann, Kamilla Nørregaard, Luke Henderson, Mi-Ran Choi, Susan E Clare, Naomi J Halas
Remotely controlled, localized drug delivery is highly desirable for potentially minimizing the systemic toxicity induced by the administration of typically hydrophobic chemotherapy drugs by conventional means. Nanoparticle-based drug delivery systems provide a highly promising approach for localized drug delivery, and are an emerging field of interest in cancer treatment. Here, we demonstrate near-IR light-triggered release of two drug molecules from both DNA-based and protein-based hosts that have been conjugated to near-infrared-absorbing Au nanoshells (SiO2 core, Au shell), each forming a light-responsive drug delivery complex...
November 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
Yu Zhang, Cai-Feng Wan, Jing Du, Qi Dong, Yuan-Yuan Wang, Hong Yang, Feng-Hua Li
Antibody-mediated targeting therapy has been successful in treating patients with breast cancer by improving the specificity and clinical efficacy. In this study, we constructed the human epidermal growth factor receptor-2 (Her2) antibody-conjugated ultrasound contrast agent with lactic-co-glycolic acid (PLGA) as film forming and perfluorocty bromide (PFOB) as internal material, which was coated by gold nanoshell (Her2-PFOB@PLGA@Au), to realize the integration of diagnosis and treatment. The contrast agent was spherical, with the diameter was 256...
November 4, 2017: Journal of Biomaterials Science. Polymer Edition
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