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https://www.readbyqxmd.com/read/29026068/hollow-mno2-as-a-tumor-microenvironment-responsive-biodegradable-nano-platform-for-combination-therapy-favoring-antitumor-immune-responses
#1
Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu
Herein, an intelligent biodegradable hollow manganese dioxide (H-MnO2) nano-platform is developed for not only tumor microenvironment (TME)-specific imaging and on-demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti-tumor immune responses. With hollow structures, H-MnO2 nanoshells post modification with polyethylene glycol (PEG) could be co-loaded with a photodynamic agent chlorine e6 (Ce6), and a chemotherapy drug doxorubicin (DOX)...
October 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29023105/specific-detection-of-carcinoembryonic-antigen-based-on-fluorescence-quenching-of-hollow-porous-gold-nanoshells-with-roughened-surface
#2
Ting-Yang Xing, Jing Zhao, Guo-Jun Weng, Jian Zhu, Jian-Jun Li, Jun-Wu Zhao
The detection of tumor biomarkers in the early stage is highly desirable for the therapy of cancer. However, rapid, low-cost, sensitive, and selective detection of biomarkers remains a challenge owing to the sequence homology, short length, and low abundance. This Research Article describes the synthesis of a novel carcinoembryonic antigen (CEA) probe using hollow porous gold nanoparticles (HPGNPs) with roughened surface based on fluorescence quenching. For specific detection of CEA, the surface of HPGNP is modified by carboxyl modification, carboxyl activation, and antibody conjugation...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28993825/a-transparent-cds-tio2-nanotextile-photoanode-with-boosted-photoelectrocatalytic-efficiency-and-stability
#3
Long Liu, Huilin Hou, Lin Wang, Rui Xu, Yong Lei, Shaohua Shen, Dongjiang Yang, Weiyou Yang
In the present work, we report the exploration of a transparent CdS@TiO2 nanotextile photoanode with boosted photoelectrocatalytic (PEC) efficiency and stability, by the controllable coating of an amorphous TiO2 ultrathin layer via the atomic layer deposition (ALD) technique. The optimal CdS@TiO2 nanotextile photoanode with a 3.5 nm TiO2 ultrathin layer exhibits a photocurrent density of 1.8 mA cm(-2) at 0 V vs. RHE, which is 11 times higher than that of the pristine CdS counterpart. The photocatalytic H2 evolution rate of CdS@TiO2 ranges up to 47...
October 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28917152/pegylated-thermosensitive-lipid-coated-hollow-gold-nanoshells-for-effective-combinational-chemo-photothermal-therapy-of-pancreatic-cancer
#4
Bijay Kumar Poudel, Biki Gupta, Thiruganesh Ramasamy, Raj Kumar Thapa, Shiva Pathak, Kyung Taek Oh, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Pancreatic cancer has extremely poor prognosis with an 85% mortality rate that results from aggressive and asymptomatic growth, high metastatic potential, and rapid development of resistance to already ineffective chemotherapy. In this study, plasmonic hollow gold nanoshells (GNS) coated with PEGylated thermosensitive lipids were prepared as an efficient platform to ratiometrically co-deliver two drugs, bortezomib and gemcitabine (GNS-L/GB), for combinational chemotherapy and photothermal therapy of pancreatic cancer...
September 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28914612/bnc-nanoshells-a-novel-structure-for-atomic-storage
#5
Francisco Wellery Nunes Silva, Eduardo Cruz-Silva, Mauricio Terrones, Humberto Terrones, E B Barros
Quantum molecular dynamics (QMD) and density functional theory (DFT) are employed in this work in order to study the structural and electronics properties of carbon, Boron Nitride or hybrid BNC nanoshells (BNCNSs). The studied nanoshells can be formed by stacking two zigzag graphene nanoribbons (zGNRs), two zigzag Boron Nitride nanoribbons (zBNNRs) or one zigzag graphene nanoribbon on a Boron Nitride nanoribbon. In all cases only one of the edges of the ribbon is passivated, while the other one is left unpassivated...
September 15, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28903086/an-efficient-size-dependent-shear-deformable-shell-model-and-molecular-dynamics-simulation-for-axial-instability-analysis-of-silicon-nanoshells
#6
S Sahmani, M M Aghdam, M Bahrami
Understanding the size-dependent behavior of structures at nanoscale is essential in order to have an effective design of nanosystems. In the current investigation, the surface elasticity theory is extended to study the nonlinear buckling and postbuckling response of axially loaded silicon cylindrical naoshells. Thereby, an efficient size-dependent shear deformable shell model is developed including the size effect of surface free energy. A boundary layer theory of shell buckling in conjunction with a perturbation-based solution methodology is employed to predict the size dependency in the buckling loads and postbuckling behavior of silicon nanoshells having various thicknesses...
August 24, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28886507/sers-study-of-surface-plasmon-resonance-induced-carrier-movement-in-au-cu2o-core-shell-nanoparticles
#7
Lei Chen, Fan Zhang, Xin-Yu Deng, Xiangxin Xue, Li Wang, Yantao Sun, Jing-Dong Feng, Yongjun Zhang, Yaxin Wang, Young Mee Jung
A plasmon induced carrier movement enhanced mechanism of surface-enhanced Raman scattering (SERS) was investigated using a charge-transfer (CT) enhancement mechanism. Here, we designed a strategy to study SERS in Au@Cu2O nanoshell nanoparticles with different shell thicknesses. Among the plasmonically coupled nanostructures, Au spheres with Cu2O shells have been of special interest due to their ultrastrong electromagnetic fields and controllable carrier transfer properties, which are useful for SERS. Au@Cu2O nanoshell nanoparticles (NPs) with shell thicknesses of 48-56nm are synthesized that exhibit high SERS activity...
September 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28883606/photothermal-enhancement-of-chemotherapy-in-breast-cancer-by-visible-irradiation-of-gold-nanoparticles
#8
Rita Mendes, Pedro Pedrosa, João C Lima, Alexandra R Fernandes, Pedro V Baptista
Photothermal Therapy (PTT) impact in cancer therapy has been increasing due to the enhanced photothermal capabilities of a new generation of nanoscale photothermal agents. Among these nanoscale agents, gold nanoshells and nanorods have demonstrated optimal properties for translation of near infra-red radiation into heat at the site of interest. However, smaller spherical gold nanoparticles (AuNPs) are easier to produce, less toxic and show improved photoconversion capability that may profit from the irradiation in the visible via standard surgical green lasers...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882036/micropatternable-double-faced-zno-nanoflowers-for-flexible-gas-sensor
#9
Jong-Woo Kim, Yoann Porte, Kyung Yong Ko, Hyungjun Kim, Jae-Min Myoung
Micropatternable double-faced (DF) zinc oxide (ZnO) nanoflowers (NFs) for flexible gas sensors have been successfully fabricated on a polyimide (PI) substrate with single-walled carbon nanotubes (SWCNTs) as electrode. The fabricated sensor comprises ZnO nanoshells laid out on a PI substrate at regular intervals, on which ZnO nanorods (NRs) were grown in- and outside the shells to maximize the surface area and form a connected network. This three-dimensional network structure possesses multiple gas diffusion channels and the micropatterned island structure allows the stability of the flexible devices to be enhanced by dispersing the strain into the empty spaces of the substrate...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28881282/enlarge-the-biologic-coating-induced-absorbance-enhancement-of-au-ag-bimetallic-nanoshells-by-tuning-the-metal-composition
#10
Jian Zhu, Xin Li, Jian-Jun Li, Jun-Wu Zhao
Surface plasmon resonance (SPR) absorption properties of biologic layer-coated Au-Ag core-shell nanoparticle have been studied theoretically. By comparing with pure Au and Ag nanoparticles, the absorption peak intensity of Au-Ag bimetallic nanoparticle is more dependent on the dielectric coating, and the longer wavelength peak corresponding to the Au-Ag interface is more sensitive to the coating thickness. As the Au-Ag composition ratio is increased, the dielectric coating-dependent peak intensity change is always non-monotonous, and the critical Au-Ag composition ratio corresponding to the greatest peak intensity increase could be further tuned by changing the dielectric constant of the coated dielectric layer...
September 1, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28875848/polymeric-nanocarriers-a-new-horizon-for-the-effective-management-of-breast-cancer
#11
Iliyas Khan, Hitesh Kumar, Gaurav Mishra, Avinash Gothwal, Prashant Kesharwani, Umesh Gupta
BACKGROUND: Delivery of chemotherapeutic drugs for the diagnosis and treatment of cancer is becoming advanced day by day. However, the challenge of the effective delivery system still does exist. In various types of cancers, breast cancer is the most commonly diagnosed cancer among women. Breast cancer is a combination of different diseases. It cannot be considered as only one entity because there are many specific patient factors, which are involved in the development of this disease...
August 29, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28858662/surface-engineering-of-organic-nanoparticles-for-highly-improved-bioimaging
#12
Yanqiu Liu, Xiujuan Zhang, Mengjiao Zhou, Xianfeng Chen, Xiaohong Zhang
Surface properties of nanoparticles (NPs) have a huge influence on their biological activities. In this work, we report to use mesoporous silica nanoshell surface to regulate the cellular internalization rate and intracellular fate of fluorescent organic NPs for highly improved cellular imaging. We systematically studied the internalization of the NPs into cells, the intracellular transport pathways, the excretion from cells, and very importantly, compared the results with those from various NPs with different surface properties...
July 30, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28841005/confined-nucleation-and-growth-of-pdo-nanocrystals-in-a-seed-free-solution-inside-hollow-nanoreactor
#13
Daun Kim, Jung Kyu Choi, Soo Min Kim, Ilha Hwang, Jaehyoung Koo, Seoyoung Choi, Seung Hwan Cho, Kimoon Kim, In Su Lee
This paper reports a novel and adaptable hollow nanoreactor system containing a solution of cucurbituril (CB) inside a silica nanoparticle (CB@h-SiO2) which enables the nucleation and formation of nanocrystals (NCs) to be confined at the seed-free interior solution inside the cavity. The above nanospace confinement strategy restricted the volume of medium available for NC formation to the solution inside the cavity to a few tens of nanometers in size and allowed homogeneous NC nucleation to be examined. Harboring of CB@h-SiO2 in a Pd(2+) complex solution confined the nucleation and formation of PdO NCs to the well-isolated nanosized cavity protected by the silica nanoshell, allowing the convoluted formation of clustered PdO NCs to be thoroughly examined...
August 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28830262/nanocarriers-in-advanced-drug-targeting-setting-novel-paradigm-in-cancer-therapeutics
#14
Md Habban Akhter, Md Rizwanullah, Javed Ahmad, Mohamed Jawed Ahsan, Md Ali Mujtaba, Saima Amin
Cancer has been growing nowadays consequently high number of death ascertained worldwide. The medical intervention involves chemotherapy, radiation therapy and surgical removal. This conventional technique lacking targeting potential and harm the normal cells. In drug treatment regimen, the combination therapy is preferred than single drug treatment module due to higher internalization of chemotherapeutics in the cancer cells both by enhance permeation retention effect and by direct cell apoptosis. The cancer therapeutics involves different methodologies of delivering active moiety to the target site...
August 22, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28829313/a-novel-nanoparticle-mediated-selective-inner-retinal-photocoagulation-sirep-for-diseases-of-the-inner-retina
#15
Rupesh Singh, Srinivas Rajaraman, Madhusudhanan Balasubramanian
PURPOSE: A novel nanoparticle mediated methodology for laser photocoagulation of the inner retina to achieve tissue selective treatment is presented. METHODS: Transport of 527 nm, 577 nm, and 810 nm laser, heat deposition and eventual thermal damage in vitreous, retina, RPE, choroid and sclera were modelled using Bouguer-Beer-Lambert law of absorption and solved numerically using the finite volume method. Nanoparticles were designed using Mie theory of scattering...
August 18, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28820223/a-dual-modal-silver-bumpy-nanoprobe-for-photoacoustic-imaging-and-sers-multiplexed-identification-of-in-vivo-lymph-nodes
#16
Myeong Geun Cha, Seunghyun Lee, Sungjo Park, Homan Kang, Sung Gun Lee, Cheolhwan Jeong, Yoon-Sik Lee, Chulhong Kim, Dae Hong Jeong
Multimodal imaging can provide complementary biomedical information which has huge potential in pre-clinical and clinical imaging and sensing. In this study, we introduce dual modal NIR silver bumpy nanoprobes for in vivo imaging and multiplexed detection of biomolecules by both photoacoustic imaging (PAI) and surface-enhanced Raman scattering (SERS) techniques. For this study, we used silica-coated silver bumpy nanoshell probes (AgNS@SiO2). AgNS@SiO2 have strong NIR-absorption and scattering properties compared with other nanostructures, and therefore, can be a good candidate for photoacoustic (PA) and SERS multimodal imaging...
August 31, 2017: Nanoscale
https://www.readbyqxmd.com/read/28811657/colorimetric-fingerprints-of-gold-nanorods-for-discriminating-catecholamine-neurotransmitters-in-urine-samples
#17
Somayeh Jafarinejad, Mahmoud Ghazi-Khansari, Forough Ghasemi, Pezhman Sasanpour, M Reza Hormozi-Nezhad
Catecholamine neurotransmitters, generally including dopamine (DA), epinephrine (EP) and norepinephrine (NE) are known as substantial indicators of various neurological diseases. Simultaneous detection of these compounds and their metabolites is highly recommended in early clinical diagnosis. To this aim, in the present contribution, a high performance colorimetric sensor array has been proposed for the detection and discrimination of catecholamines based on their reducing ability to deposit silver on the surface of gold nanorods (AuNRs)...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28790311/plasmonic-silver-nanoshells-for-drug-and-metabolite-detection
#18
Lin Huang, Jingjing Wan, Xiang Wei, Yu Liu, Jingyi Huang, Xuming Sun, Ru Zhang, Deepanjali D Gurav, Vadanasundari Vedarethinam, Yan Li, Ruoping Chen, Kun Qian
In-vitro metabolite and drug detection rely on designed materials-based analytical platforms, which are universally used in biomedical research and clinical practice. However, metabolic analysis in bio-samples needs tedious sample preparation, due to the sample complexity and low molecular abundance. A further challenge is to construct diagnostic tools. Herein, we developed a platform using silver nanoshells. We synthesized SiO2@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28783216/sensitive-quantitative-naked-eye-biodetection-with-polyhedral-cu-nanoshells
#19
Jae-Ho Kim, Jeong-Eun Park, Mouhong Lin, Sungi Kim, Gyeong-Hwan Kim, SungJun Park, GwangPyo Ko, Jwa-Min Nam
One of the most heavily used methods in chemical and biological labeling, detection, and imaging is based on silver shell-based enhancement on Au nanoparticles (AuNPs) that is useful for amplifying Rayleigh scattering, colorimetric signal, surface-enhanced Raman scattering, and electrical signal, but poor structural controllability and nonspecific growth of silver shells have limited its applications, especially with respect to signal reproducibility and quantification. Here, a highly specific, well-defined Cu nanopolyhedral shell overgrowth chemistry is developed with the aid of polyethyleneimine (PEI) on AuNPs, and the use of this PEI-mediated Cu polyhedral nanoshell (CuP) chemistry is shown as a means of light-scattering signal enhancement for the development of naked-eye-based highly sensitive and quantitative detections of DNA and viruses...
August 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28774579/afm-nanoindentation-of-protein-shells-expanding-the-approach-beyond-viruses
#20
REVIEW
Wouter H Roos
The archetypical protein nanoshell is the capsid that surrounds viral genomes. These capsids protect the viral RNA or DNA and function as transport vehicle for their nucleic acid. The material properties of a variety of viral capsids have been probed by Atomic Force Microscopy. In particular nanoindentation measurements revealed the complex mechanics of these shells and the intricate interplay of the capsid with its genomic content. Furthermore, effects of capsid protein mutations, capsid maturation and the effect of environmental changes have been probed...
July 31, 2017: Seminars in Cell & Developmental Biology
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