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https://www.readbyqxmd.com/read/28938487/regulation-of-endogenous-male-rodent-glp-1-secretion-and-human-islet-insulin-secretion-by-antagonism-of-somatostatin-receptor-5
#1
Thomas B Farb, Marta Adeva, Thomas J Beauchamp, Over Cabrera, David A Coates, Tamika DeShea Meredith, Brian A Droz, Alexander Efanov, James V Ficorilli, Susan L Gackenheimer, Maria A Martinez-Grau, Victoriano Molero, Gema Ruano, Michael A Statnick, Todd M Suter, Samreen K Syed, Miguel A Toledo, Francis S Willard, Xin Zhou, Krister B Bokvist, David G Barrett
Incretin and insulin responses to nutrient loads are suppressed in persons with diabetes, resulting in decreased glycemic control. Whereas agents including sulfonylureas and Dipeptidyl peptidase-4 inhibitors (DPP4i) partially reverse these effects and provide therapeutic benefit, their modes of action limit efficacy. Because somatostatin (SST) has been shown to suppress both insulin and GLP-1 secretion through the Gi-coupled SST receptor 5 (SSTR5) isoform in vitro, antagonism of SSTR5 may improve glycemic control via intervention in both pathways...
September 11, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938392/segmental-bone-loss-reconstruction-using-ring-fixation
#2
Stephen M Quinnan
Ring fixation is a powerful tool in the treatment of bone defects. The ability to create high-quality, biologically normal new bone of even massive proportions using distraction osteogenesis is a major reason for its success. In addition, ring fixation provides the ability to limit the risk of deep infection, improves flexibility in limb length control and alignment, and increases soft tissue coverage options. The drawbacks of ring fixation include long frame times, pin problems, risk of joint contractures, and difficult usage in areas with a large soft tissue envelope such as the thigh...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28938214/dermal-transfer-and-environmental-release-of-ceo2-nanoparticles-used-as-uv-inhibitors-on-outdoor-surfaces-implications-for-human-and-environmental-health
#3
Justin G Clar, William E Platten, Eric J Baumann, Andrew Remsen, Steve M Harmon, Christina L Bennett-Stamper, Treye A Thomas, Todd P Luxton
A major area of growth for "nano-enabled" consumer products have been surface coatings, including paints stains and sealants. Ceria (CeO2) nanoparticles (NPs) are of interest as they have been used as additives in these these products to increase UV resistance. Currently, there is a lack of detailed information on the potential release, and speciation (i.e., ion vs. particle) of CeO2 NPs used in consumer-available surface coatings during intended use scenarios. In this study, both Micronized-Copper Azole pressure-treated lumber (MCA), and a commercially available composite decking were coated with CeO2 NPs dispersed in Milli-Q water or wood stain...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938209/interactions-between-biogenic-selenium-nanoparticles-and-goethite-colloids-and-consequence-for-remediation-of-elemental-mercury-contaminated-groundwater
#4
Xiaonan Wang, Daoyong Zhang, Haifeng Qian, Yan Liang, Xiangliang Pan, Geoffrey Michael Gadd
Ubiquitous colloidal minerals such as goethite can have a significant impact on the performance of nanoparticles-based groundwater remediation due to aggregation. Heteroaggregation and retention of Se nanoparticles (SeNPs) by goethite in groundwater, and its impact on Hg(0) remediation by SeNPs were investigated in this study. In order to mitigate the adverse effects of aggregation, the effects of bacterial extracellular polymeric substances (EPS) on the stability of SeNPs and Hg(0) sequestration using SeNPs were also evaluated...
September 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28938141/amendment-damages-the-function-of-continuous-flooding-in-decreasing-cd-and-pb-uptake-by-rice-in-acid-paddy-soil
#5
Xinxin Ye, Hongying Li, Ligan Zhang, Rushan Chai, Renfeng Tu, Hongjian Gao
Combinations of remediation technologies are needed to solve the problem of soil contamination in paddy rice, due to multiple potential toxic elements (PTEs). Two potential mitigation methods, water management and in-situ remediation by soil amendment, have been widely used in treatment of PTE-polluted paddy soil. However, the interactive relationship between soil amendment and water management, and its influence on the accumulation of PTEs in rice are poorly understood. Greenhouse pot experiments were conducted to examine the effects of phosphate amendment on Cd and Pb availability in soil and their influence on Cd and Pb uptake into rice, on Fe and P availability in soil, and on the alteration of Fe amount and compartment on root surface among different water management strategies...
September 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28938140/encapsulating-fe3o4-into-calcium-alginate-coated-chitosan-hydrochloride-hydrogel-beads-for-removal-of-cu-ii-and-u-vi-from-aqueous-solutions
#6
Xiaofeng Yi, Jiarui He, Yingyuan Guo, Zhenhua Han, Meixia Yang, Jiali Jin, Junjie Gu, Minrui Ou, Xiaoping Xu
The aim of this work was to study the removal of Cu (II) and U (VI) ions from aqueous solutions by encapsulating magnetic Fe3O4 nanoparticles into calcium alginate coated chitosan hydrochloride (CCM) hydrogel beads. ATR-FTIR and XRD analysis data indicated that the CCM composites were successfully prepared. SEM images and EDX spectra showed that Cu(2+) and UO2(2+) ions were adhered onto sorbents. Adsorption properties for removal of both copper and uranium ions under various experimental conditions were investigated...
September 19, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28938076/fabrication-of-robust-reference-tips-and-reference-electrodes-for-kelvin-probe-applications-in-changing-atmospheres
#7
Matthias Uebel, Ashokanand Vimalanandan, Abdelaziz Laaboudi, Stefan Evers, Martin Stratmann, Detlef Diesing, Michael Rohwerder
The scanning Kelvin probe (SKP) is a versatile method for the measurement of the Volta potential difference between a sample and the SKP tip (Δψsample, SKP-tip). Based on suitable calibration, this technique is highly suited for the application in corrosion science due to its ability to serve as a very sensitive non-contact and non-destructive method for determining the electrode potential, even at buried interfaces beneath coatings or on surfaces covered by ultra-thin electrolyte layers, which are not accessible by standard reference electrodes...
September 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28938019/fabrication-of-3-methoxyphenol-sensor-based-on-fe3o4-decorated-carbon-nanotube-nanocomposites-for-environmental-safety-real-sample-analyses
#8
Mohammed M Rahman, Mohammad Musarraf Hussain, Abdullah M Asiri
Iron oxide ornamented carbon nanotube nanocomposites (Fe3O4.CNT NCs) were prepared by a wet-chemical process in basic means. The optical, morphological, and structural characterizations of Fe3O4.CNT NCs were performed using FTIR, UV/Vis., FESEM, TEM; XEDS, XPS, and XRD respectively. Flat GCE had been fabricated with a thin-layer of NCs using a coating binding agent. It was performed for the chemical sensor development by a dependable I-V technique. Among all interfering analytes, 3-methoxyphenol (3-MP) was selective towards the fabricated sensor...
2017: PloS One
https://www.readbyqxmd.com/read/28937740/ab-initio-study-of-the-atomic-level-structure-of-the-rutile-tio2-110-titanium-nitride-tin-interface
#9
Jose Julio Gutierrez Moreno, Michael Nolan
Titanium nitride (TiN) is widely used in industry as a protective coating due to its hardness and resistance to corrosion and can spontaneously form a thin oxide layer when it is exposed to air, which could modify the properties of the coating. With limited understanding of the TiO2 - TiN interfacial system at present, this work aims to describe the structural and electronic properties of oxidized TiN based on a density functional theory (DFT) study of the rutile TiO2 (110) - TiN (100) interface model system, also including Hubbard +U correction on Ti 3d states...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937738/mussel-inspired-coating-and-adhesion-for-rechargeable-batteries-a-review
#10
You Kyeong Jeong, Sung Hyeon Park, Jang Wook Choi
A significant effort is currently being invested to improve the electrochemical performance of classical lithium-ion batteries (LIBs) or to accelerate the advent of new chemistry-based post-LIBs. Regardless of governing chemistry associated with charge storage, stable electrode-electrolyte interface and wet-adhesion among the electrode particles are universally desired for rechargeable batteries adopting liquid electrolytes. In this regard, recent studies have witnessed the usefulness of mussel-inspired polydopamine or catechol functional group in modifying the key battery components, such as active material, separator, and binder...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937731/two-dimensional-porous-sandwich-like-c-si-graphene-si-c-nanosheets-for-superior-lithium-storage
#11
Weiqi Yao, Jie Chen, Liang Zhan, Yanli Wang, Shubin Yang
A novel two-dimensional porous sandwich-like Si/carbon nanosheets are designed and successfully fabricated as anode for superior lithium storage, where porous Si nanofilm grows on the two sides of reduced grahene oxide (rGO) and then coated with a carbon layer (denoted as C/Si-rGO-Si/C). The coexistence of micropores and mesopores in C/Si-rGO-Si/C nanosheets offer a rapid Li+ diffusion rate, and the porous Si provides a short pathway for electric transportation. Meanwhile, the coated carbon layer not only can promote to form stable SEI layer, but also can improve the electric conductivity of nanoscale Si coupled with rGO...
September 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28937313/shed-blood-separation-and-cell-saver-an-integral-part-of-miecc-shed-blood-separation-and-its-influence-on-the-perioperative-inflammatory-response-during-coronary-revascularization-with-minimal-invasive-extracorporeal-circulation-systems-a-randomized-controlled
#12
Adrian Bauer, Harald Hausmann, Jan Schaarschmidt, Martin Scharpenberg, Dirk Troitzsch, Peter Johansen, Hans Nygaard, Thomas Eberle, J Michael Hasenkam
OBJECTIVE: The postoperative systemic inflammatory response after cardiopulmonary bypass (CPB) is still an undesirable side-effect after cardiac surgery. It is most likely caused by blood contact with foreign surfaces and by the surgical trauma itself. However, the recirculation of activated shed mediastinal blood is another main cause of blood cell activation and cytokine release. Minimal invasive extracorporeal circulation (MiECC) comprises a completely closed circuit, coated surfaces and the separation of suction blood...
September 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28937165/a-facile-solvent-mediated-self-assembly-silver-nanoparticle-mirror-substrate-for-quantitatively-improved-surface-enhanced-raman-scattering
#13
Yanqi Qu, Chen Tan, Zhiyun Zhang, Lili He
Herein, a facile solvent mediated silver nanoparticle (AgNP) mirror was introduced as a reproducible and sensitive surface-enhanced Raman scattering (SERS) substrate. The AgNP mirror was fabricated based on commercially available citrate coated AgNPs via a facile and unique water-solvent interface assembly method without using any electrical equipment. By adding 0.2 mg ml(-1) citrate coated AgNPs dropwise into a mediating solvent, self-assembled AgNP mirrors were formed instantly and gradually settled down at the bottom...
September 22, 2017: Analyst
https://www.readbyqxmd.com/read/28937069/oral-health-in-diabetic-and-nondiabetic-patients-with-chronic-kidney-disease
#14
Lingam Amara Swapna, Pradeep Koppolu, Jyothi Prince
The objective of our study is to assess the subjective and objective oral manifestations and salivary pH in diabetic and nondiabetic uremic patients at a nephrology clinic. A total of 194 diabetic and nondiabetic patients with chronic kidney disease (CKD), who were divided into four groups, Group A, B, C, D, and who were attending a nephrology clinic were included in the study. Predialytic unstimulated whole salivary pH was recorded using pH- measuring strips. Subjective and objective findings were evaluated and recorded in the specially designed pro forma...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28936659/transmission-electron-microscopy-tem-to-study-histology-of-pollen-and-pollen-tubes
#15
Peng-Fei Jia, Hong-Ju Li, Wei-Cai Yang
Here, we describe methods of transmission electron microscopy (TEM) based on conventional chemical fixation and high-pressure freezing (HPF) and freeze-substitution (FS) to examine the ultrastructure of Arabidopsis pollen grains and pollen tubes. Compared to other plant samples, such as root or leaf, pollen grains have thick pollen coat and cell wall which limit the permeation of fixative. Thus, it is difficult to obtain high-quality ultrastructural images of pollen. Moreover, pollen tube is very soft and the traditional procedure is too harsh to get an intact pollen tube sample...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28936513/solar-cells-with-pbs-quantum-dot-sensitized-tio2-multiwalled-carbon-nanotube-composites-sulfide-titania-gel-and-tin-sulfide-coated-c-fabric
#16
Ramesh K Kokal, Melepurath Deepa, Ankarao Kalluri, Shrishti Singh, Isaac Macwan, Prabir K Patra, Jeff Gilarde
Novel approaches to boost quantum dot solar cell (QDSC) efficiencies are in demand. Herein, three strategies are used: (i) a hydrothermally synthesized TiO2-multiwalled carbon nanotube (MWCNT) composite instead of conventional TiO2, (ii) a counter electrode (CE) that has not been applied to QDSCs until now, namely, tin sulfide (SnS) nanoparticles (NPs) coated over a conductive carbon (C)-fabric, and (iii) a quasi-solid-state gel electrolyte composed of S(2-), an inert polymer and TiO2 nanoparticles as opposed to a polysulfide solution based hole transport layer...
September 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28936479/surface-coating-of-nanoparticles-reduces-background-inflammatory-activity-while-increasing-particle-uptake-and-delivery
#17
Brittany A Moser, Rachel C Steinhardt, Aaron P Esser-Kahn
In the study of host-pathogen interactions, vaccines and drug delivery, particulate delivery system are widely used to mimic pathogen size, pattern recognition receptor agonist presentation, and target cells or organs. However, some of the polymeric systems used in particulate delivery have inherent inflammatory properties that are variable and nonspecific. These properties enhance their adjuvant activity, but confound the analysis of signaling mechanisms. Here, we present a method for particle coating with minimal background immune activation via passivation of the surface with silica-silane...
February 13, 2017: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28936060/endophthalmitis-due-to-proteus-vulgaris-after-pars-plana-vitrectomy-with-devastating-outcome
#18
Abdullah S Al-Kharashi, Abdulmajeed S Al-Kharshi, Yasser H Al-Faky
Postoperative infectious endophthalmitis is rare, yet devastating loss of vision or loss of the eye can occur due to a highly purulent microorganism or uncontrolled endophthalmitis that may spread to all coats of the eye. We report, herewith, a case of rapidly progressive postoperative endophthalmitis after pars plana vitrectomy which ended up with enucleation. The isolated microorganism was Proteus vulgaris which has not been reported as causative bacteria of postoperative infections following pars plana vitrectomy...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28935639/isolation-and-characterization-of-endothelial-to-mesenchymal-transition-cells-in-pulmonary-arterial-hypertension
#19
Toshio Suzuki, Erica J Carrier, Megha A Talati, Anandharajan Rathinasabapathy, Xinping Chen, Rintaro Nishimura, Yuji Tada, Koichiro Tatsumi, James D West
Endothelial-to-mesenchymal transition (EndMT) is a process in which endothelial cells lose polarity and cell-to-cell contacts, and undergo a dramatic remodeling of the cytoskeleton. It has been implicated in initiation and progression of pulmonary arterial hypertension (PAH). However, the characteristics of cells which have undergone EndMT-cells in vivo have not been reported and so remain unclear. To study this, sugen5416 and hypoxia (SuHx)-induced PAH was established in Cdh5-Cre / Gt(ROSA)26Sor(tm4(ACTB-tdTomato,-EGFP)Luo)/J double-transgenic mice, in which GFP was stably expressed in pan-endothelial cells...
September 21, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28935443/complex-formation-with-protamine-prolongs-the-thrombin-inhibiting-effect-of-dna-aptamer-in-vivo
#20
V A Spiridonova, T M Novikova, D M Nikulina, T A Shishkina, E V Golubkina, O S Dyukareva, N N Trizno
Antithrombin DNA aptamersRE31 are single-chain oligonucleotides that fold into three-dimensional forms allowing them to bind the enzyme with high affinity and inhibit its activity in vivo. They are rapidly degraded by a nonspecific nuclease, and, to prolong the lifetime of the aptamer DNA in the bloodstream, it is necessary to coat it with a polymer envelope. A new approach to solving this problem based on preparation of DNA-polyelectrolyte complexes with a minimal particle size that can circulate with blood flow...
September 18, 2017: Biochimie
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