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https://www.readbyqxmd.com/read/29777617/simulation-in-urology-to-train-non-technical-skills-in-ward-rounds
#1
K Somasundram, H Spence, A J Colquhoun, C Mcilhenny, C S Biyani, S Jain
OBJECTIVE: We have designed an exercise to train newly appointed Urology trainees in non-technical skills on ward rounds as a part of a simulation 'boot camp'. This paper reports our experience, including a qualitative analysis of participant feedback on the utility of this method of training. PATIENTS AND METHODS: The simulations took place in a high-fidelity simulated ward bay. Forty-eight doctors with formal Urology training ranging between 2-60 months (mean 19...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29776870/historical-bibliometric-analysis-of-the-top-cited-articles-on-vesicoureteral-reflux-1950-2016-and-incorporation-of-a-novel-impact-index
#2
N Fernandez, A Puerto, A Azuero, F O'Kelly, J Hannick, M Rickard, A Kirsch, A Caldamone, M Koyle
INTRODUCTION AND OBJECTIVES: Vesicoureteral reflux (VUR) has been one of the defining conditions unique to pediatric urology since its inception. The clinical implications of this disease process depend on intrinsic patient factors such as age, genetics, epigenetics, voiding habits, anatomic anomalies, and extrinsic factors such as the pathogenicity of infectious agents. Knowledge about its natural history, the implications of conservative and surgical management, and their associated outcomes have evolved dramatically over time...
April 24, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29772103/how-can-we-expand-active-surveillance-criteria-in-patients-with-low-and-intermediate-risk-prostate-cancer-without-increasing-the-risk-of-misclassification-development-of-a-novel-risk-calculator
#3
Giorgio Gandaglia, Roderick C N van den Bergh, Derya Tilki, Nicola Fossati, Piet Ost, Christian I Surcel, Prasanna Sooriakumaran, Igor Tsaur, Massimo Valerio, Alexander Kretschmer, Emanuele Zaffuto, Laurent Salomon, Francesco Montorsi, Markus Graefen, Henk van der Poel, Alexandre de la Taille, Alberto Briganti, Guillaume Ploussard
OBJECTIVE: To develop a novel tool to increase the number of prostate cancer (PCa) patients eligible for active surveillance (AS) without increasing the risk of unfavourable pathologic features (i.e., misclassification) at radical prostatectomy (RP). MATERIALS AND METHODS: Overall, 16,049 patients with low- or intermediate risk PCa treated with RP were identified. Misclassification was defined as non-organ confined or grade group ≥3 disease at RP. The coefficients of a logistic regression model predicting misclassification were used to develop a risk score...
May 17, 2018: BJU International
https://www.readbyqxmd.com/read/29739919/identification-of-core-genes-and-key-pathways-via-integrated-analysis-of-gene-expression-and-dna-methylation-profiles-in-bladder-cancer
#4
Yongzhen Zhang, Liang Fang, Yuanwei Zang, Zhonghua Xu
BACKGROUND Bladder cancer (BC) is the most common urological malignant tumor. In BC, aberrant DNA methylation is believed to be associated with carcinogenesis. Therefore, the identification of key genes and pathways could help determine the potential molecular mechanisms of BC development. MATERIAL AND METHODS Microarray data on gene expression and gene methylation were downloaded from the Gene Expression Omnibus (GEO) database. Abnormal methylated/expressed genes were analyzed by GEO2R and statistical software R...
May 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29733838/validation-of-pi-rads-version-2-for-the-detection-of-prostate-cancer
#5
Sebastian L Hofbauer, Beatrice Kittner, Andreas Maxeiner, Robin Heckmann, Maximillian Reimann, Laura Wiemer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Carsten Stephan, Frank Friedersdorff, Florian Fuller, Kurt Miller, Hannes Cash
PURPOSE: The second version of the Prostate Imaging Reporting and Data System (PI-RADSv2) was introduced in 2015 to standardize the interpretation and reporting of multiparametric prostate magnetic resonance imaging (mpMRI). Recently, low cancer detection rates (CDR) for PI-RADSv2 category 4 lesions were reported. Therefore the aim of the study was to evaluate the CDR of PI-RADSv2 in a large prospective cohort. METHODS: The study included 704 consecutive men with primary or prior negative biopsies who underwent MRI/ultrasound fusion-guided targeted biopsy (TB) and 10-core systematic prostate biopsy (SB) between September 2015 and May 2017...
May 4, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29720406/contemporary-prostate-biopsy-reporting-insights-from-a-survey-of-clinicians-use-of-pathology-data
#6
Murali Varma, Krishna Narahari, Malcolm Mason, Jon D Oxley, Daniel M Berney
AIM: To determine how clinicians use data in contemporary prostate biopsy reports. METHODS: A survey was circulated to members of the British Association of Urological Surgeons and the British Uro-oncology Group. RESULTS: Responses were received from 114 respondents (88 urologists, 26 oncologists). Ninety-seven (94%) use the number of positive cores from each side and 43 (42%) use the % number of positive cores. When determining the number and percentage of positive cores, 72 (71%) would not differentiate between targeted and non-targeted samples...
May 2, 2018: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29660369/evaluation-of-an-epigenetic-assay-for-predicting-repeat-prostate-biopsy-outcome-in-african-american-men
#7
Robert L Waterhouse, Leander Van Neste, Kelvin A Moses, Carlton Barnswell, Jonathan L Silberstein, Mark Jalkut, Ronald Tutrone, James Sylora, Ronald Anglade, Myron Murdock, Zvi Shiffman, Todd Vandenberg, Nikhil Shah, Michael Carter, Manuel Krispin, Jack Groskopf, Wim Van Criekinge
OBJECTIVES: To evaluate an epigenetic assay performed on tissue from negative prostate biopsies in a group of African American (AA) men undergoing repeat biopsy, and to compare accuracy for predicting repeat biopsy outcome to prior studies conducted in predominantly Caucasian populations. METHODS: The study population consisted of 211 AA men from seven urology centers across the U.S., all of whom were undergoing 12-core trans-rectal ultrasound guided repeat biopsy within 30 months from a negative index biopsy...
April 13, 2018: Urology
https://www.readbyqxmd.com/read/29656064/a-prospective-study-of-patient-reported-pain-after-bulbar-urethroplasty
#8
Patrick Evans, Sorena Keihani, Benjamin N Breyer, Bradley A Erickson, James M Hotaling, Sara M Lenherr, Jeremy B Myers
OBJECTIVE: To understand the prevalence of chronic perineal pain, activity limitations, and patient satisfaction after urethroplasty. METHODS: From 2014 to 2016, we prospectively enrolled men undergoing urethroplasty for bulbar urethral strictures. Patients, before and after surgery, completed questions from the Core Lower Urinary Tract Symptom Score assessing pain frequency in the bladder and penis or urethra, as well as nonvalidated questions assessing perineal pain...
April 12, 2018: Urology
https://www.readbyqxmd.com/read/29569320/primary-magnetic-resonance-imaging-ultrasonography-fusion-guided-biopsy-of-the-prostate
#9
Andreas Maxeiner, Beatrice Kittner, Conrad Blobel, Laura Wiemer, Sebastian L Hofbauer, Thomas Fischer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Florian Fuller, Kurt Miller, Hannes Cash
OBJECTIVE: To examine the performance of a primary magnetic resonance imaging (MRI)/ultrasonography (US) fusion-guided targeted biopsy (TB), and in combination with an added systematic biopsy (SB). PATIENTS AND METHODS: Analysis of 318 consecutive biopsy-naïve men with suspicious multiparametric MRI (mpMRI; Prostate Imaging Reporting and Data System [PI-RADS] score ≥3) undergoing transrectal TB and 10-core SB between January 2012 and December 2016. The indication for performing mpMRI was based on clinical parameters and decided by the treating urologist before admission...
March 22, 2018: BJU International
https://www.readbyqxmd.com/read/29552975/mri-targeted-or-standard-biopsy-for-prostate-cancer-diagnosis
#10
RANDOMIZED CONTROLLED TRIAL
Veeru Kasivisvanathan, Antti S Rannikko, Marcelo Borghi, Valeria Panebianco, Lance A Mynderse, Markku H Vaarala, Alberto Briganti, Lars Budäus, Giles Hellawell, Richard G Hindley, Monique J Roobol, Scott Eggener, Maneesh Ghei, Arnauld Villers, Franck Bladou, Geert M Villeirs, Jaspal Virdi, Silvan Boxler, Grégoire Robert, Paras B Singh, Wulphert Venderink, Boris A Hadaschik, Alain Ruffion, Jim C Hu, Daniel Margolis, Sébastien Crouzet, Laurence Klotz, Samir S Taneja, Peter Pinto, Inderbir Gill, Clare Allen, Francesco Giganti, Alex Freeman, Stephen Morris, Shonit Punwani, Norman R Williams, Chris Brew-Graves, Jonathan Deeks, Yemisi Takwoingi, Mark Emberton, Caroline M Moore
BACKGROUND: Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence is limited. METHODS: In a multicenter, randomized, noninferiority trial, we assigned men with a clinical suspicion of prostate cancer who had not undergone biopsy previously to undergo MRI, with or without targeted biopsy, or standard transrectal ultrasonography-guided biopsy...
May 10, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29408568/role-of-magnetic-resonance-imaging-targeted-biopsy-in-detection-of-prostate-cancer-harboring-adverse-pathological-features-of-intraductal-carcinoma-and-invasive-cribriform-carcinoma
#11
Susan Prendeville, Mark Gertner, Manjula Maganti, Melania Pintilie, Nathan Perlis, Ants Toi, Andrew J Evans, Antonio Finelli, Theodorus H van der Kwast, Sangeet Ghai
PURPOSE: The aim of this study was to compare biopsy detection of intraductal and cribriform pattern invasive prostate carcinoma in multiparametric magnetic resonance imaging positive and negative regions of the prostate. MATERIALS AND METHODS: We queried a prospectively maintained, single institution database to identify patients who underwent multiparametric magnetic resonance imaging/ultrasound fusion targeted biopsy and concurrent systematic sextant biopsy of magnetic resonance imaging negative regions between January 2013 and May 2016...
February 2, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29368286/why-laparoscopists-may-opt-for-three-dimensional-view-a-summary-of-the-full-hta-report-on-3d-versus-2d-laparoscopy-by-s-i-c-e-societ%C3%A3-italiana-di-chirurgia-endoscopica-e-nuove-tecnologie
#12
Nereo Vettoretto, Emanuela Foglia, Lucrezia Ferrario, Alberto Arezzo, Roberto Cirocchi, Gianfranco Cocorullo, Giuseppe Currò, Domenico Marchi, Giuseppe Portale, Chiara Gerardi, Umberto Nocco, Michele Tringali, Gabriele Anania, Micaela Piccoli, Gianfranco Silecchia, Mario Morino, Andrea Valeri, Emauele Lettieri
BACKGROUND: Three-dimensional view in laparoscopic general, gynaecologic and urologic surgery is an efficient, safe and sustainable innovation. The present paper is an extract taken from a full health technology assessment report on three-dimensional vision technology compared with standard two-dimensional laparoscopic systems. METHODS: A health technology assessment approach was implemented in order to investigate all the economic, social, ethical and organisational implications related to the adoption of the innovative three-dimensional view...
January 24, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29297487/prostate-cancer-grading-a-decade-after-the-2005-modified-system
#13
Jonathan I Epstein
This review article will cover the evolution of grading of prostate cancer from the original Gleason system in the 1960-1970s to a more patient-centric grading system proposed in 2013 from a group at Johns Hopkins Hospital, validated in 2014 by a large multi-institutional study, and subsequently accepted by the World Health Organization (WHO), College of American Pathology (CAP), and the AJCC TNM system. Covered topics include: (1) historical background; (2) 2005 and 2014 International Society of Urological Pathology Grading Conferences; (3) Description of Gleason patterns; (4) new approaches to display Gleason grades; (5) grading variants and variations of acinar adenocarcinoma; (6) reporting rules for Gleason grading reporting secondary patterns of higher grade when present to a limited extent; (7) reporting secondary patterns of lower grade when present to a limited extent; (8) reporting percentage pattern 4; (9) general applications of the Gleason grading system; (10) needle biopsy with different cores showing different grades; (11) radical prostatectomy specimens with separate tumor nodules; and (12) a new grading system for prostate cancer...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29279591/transperineal-template-guided-prostate-saturation-biopsies-in-men-with-suspicion-of-prostate-cancer-a-pilot-study-from-pakistan
#14
K Mehmood, M Mubarak, M Dhar, M Rafi, J Kinsella
Traditionally, transrectal ultrasound (TRUS)-guided biopsies are done for the diagnosis of prostate cancer (PCa) in Pakistan. The transperineal template-guided saturation biopsy (TTSB) approach has been recently introduced in Pakistan and we share diagnostic yields and pathological findings of specimens taken for PCa diagnosis in men with elevated serum total prostate specific antigen (PSA) and negative TRUS-guided prostate biopsies. In all, 16 patients investigated at the Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), underwent TTSB...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29162327/e-learning-teaches-attendings-how-to-objectively-assess-pediatric-urology-trainees-surgery-skills-for-orchiopexy
#15
Nicolas Fernandez, Max Maizels, Walid Farhat, Edwin Smith, Dennis Liu, Michael Chua, Yasin Bhanji
INTRODUCTION: Established methods to train pediatric urology surgery by residency training programs require updating in response to administrative changes such as new, reduced trainee duty hours. Therefore, new objective methods must be developed to teach trainees. We approached this need by creating e-learning to teach attendings objective assessment of trainee skills using the Zwisch scale, an established assessment tool. The aim of this study was to identify whether or not e-learning is an appropriate platform for effective teaching of this assessment tool, by assessing inter-rater correlation of assessments made by the attendings after participation in the e-learning...
April 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29154932/correlation-of-virtual-reality-simulation-and-dry-lab-robotic-technical-skills
#16
Laura K Newcomb, Megan S Bradley, Tracy Truong, Michelle Tang, Bryan Comstock, Yi-Ju Li, Anthony G Visco, Nazema Y Siddiqui
STUDY OBJECTIVE: To examine whether a set of virtual reality (VR) surgical simulation drills have correlative validity when compared with the validated Robotic Objective Structured Assessment of Technical Skills (R-OSATS) dry lab drills. DESIGN: A prospective methods comparison study (Canadian Task Force classification II-2). SETTING: A teaching hospital. PARTICIPANTS: Thirty current residents, fellows, and faculty from the Departments of Obstetrics and Gynecology, Urology, and General Surgery...
November 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29051978/symptom-prevalence-bother-and-treatment-satisfaction-in-men-with-lower-urinary-tract-symptoms-in-southeast-asia-a-multinational-cross-sectional-survey
#17
Lap-Yin Ho, Peggy Sau-Kwan Chu, David Terrence Consigliere, Zulkifli Md Zainuddin, David Bolong, Chi-Kwok Chan, Molly Eng, Dac Nhat Huynh, Wachira Kochakarn, Marie Carmela M Lapitan, Dinh Khanh Le, Quang Dung Le, Frank Lee, Bannakij Lojanapiwat, Bao-Ngoc Nguyen, Teng-Aik Ong, Buenaventura Jose Reyes, Apirak Santingamkun, Woon-Chau Tsang, Paul Abrams
PURPOSE: The overall objective of the survey was to systematically examine patients' perspectives on lower urinary tract symptoms (LUTS) and their treatment in Southeast Asia. METHODS: A multinational cross-sectional survey involving adult men seeking consultation at urology outpatient clinics because of LUTS in Southeast Asia was conducted using convenience sampling. Self-reported prevalence, bother, treatment and treatment satisfaction of selected LUTS including urgency, nocturia, slow stream, and post-micturition dribble were evaluated...
January 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29016402/disability-and-health-consequences-of-traumatic-brain-injury-national-prevalence
#18
Claire Jourdan, Philippe Azouvi, François Genêt, Nicolas Selly, Loic Josseran, Alexis Schnitzler
OBJECTIVE: The aim of the study was to measure the prevalence of traumatic brain injury (TBI)-related disability and health status in the general population. DESIGN: The French National Survey, conducted in households and institutions, assessed 33,896 adults. Data included sequelae from TBI, impairments, current health conditions, and uses of health services. Analyses, adjusted for age and sex, compared subjects who declared sequelae from TBI (n = 479) with the remaining survey population (n = 33,287)...
May 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28969413/the-eternal-enigma-in-prostatic-biopsy-access-route
#19
Andrea Fabiani, Emanuele Principi, Alessandra Filosa, Lucilla Servi
Dear Editors,We read with interest the article by Di Franco and co-workers (1). The introduction of prostatic magnetic resonance and the relative fusion-biopsy have not yet allowed the expected improvements in prostate biopsy. To our knowledge, there are no works that demonstrate the superiority of fusion techniques on the remaining ultrasound guided prostate biopsies that are still the widely used in the diagnosis of prostate cancer. Furthemore, these technologies are expensive exams and they are not yet available in all centers, especially in those minors...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28933973/magnetic-resonance-imaging-in-the-early-detection-of-prostate-cancer-and-review-of-the-literature-on-magnetic-resonance-imaging-stratified-clinical-pathways
#20
REVIEW
Taimur Tariq Shah, Wilson King Lim To, Hashim Uddin Ahmed
With level 1 evidence now available on the diagnostic accuracy of multiparametric magnetic resonance imaging (MRI) we must now utilise this data in developing an MRI-stratified diagnostic pathway for the early detection of prostate cancer. Areas covered: A literature review was conducted and identified seven randomised control trials (RCT's) assessing the diagnostic accuracy of such a pathway against the previously accepted systematic/random trans-rectal ultrasound guided (TRUS) biopsy pathway. The studies were heterogeneous in their design...
December 2017: Expert Review of Anticancer Therapy
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