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Core urology

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https://www.readbyqxmd.com/read/28094072/survey-on-graduate-education-in-the-confederaci%C3%A3-n-americana-de-urolog%C3%A3-a-opinions-and-reality
#1
J C Angulo, H Dávila, R Vela
OBJECTIVE: Quality graduate medical training is a concern of Confederación Americana de Urología (CAU), the third largest urological society worldwide. It is important to analyse the diversity in the state training programmes and the feasibility and implications of conducting a common CAU programme. MATERIAL AND METHODS: A 20-item questionnaire was distributed to the directors of national societies who are members of the CAU concerning the graduate urological training in their institutions...
January 13, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/27987030/improved-decision-making-in-intermediate-risk-prostate-cancer-a-multicenter-study-on-pathologic-and-oncologic-outcomes-after-radical-prostatectomy
#2
Jean Baptiste Beauval, Guillaume Ploussard, Bastien Cabarrou, Mathieu Roumiguié, Adil Ouzzane, Jérome Gas, Annabelle Goujon, Gautier Marcq, Romain Mathieu, Sébastien Vincendeau, Xavier Cathelineau, Pierre Mongiat-Artus, Laurent Salomon, Michel Soulié, Arnaud Méjean, Alexandre de La Taille, Morgan Rouprêt, François Rozet
BACKGROUND: Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS: Between 2000 and 2011, 4038 patients who underwent RP for intermediate-risk PCa in seven French academic centers were included. Unfavorable intermediate-risk (UIR) PCa was defined as having a primary Gleason score of 4, ≥50% positive biopsy cores (PPBC), or more than one D'Amico intermediate-risk factor (i...
December 16, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27939865/pitx2-dna-methylation-as-biomarker-for-individualized-risk-assessment-of-prostate-cancer-in-core-biopsies
#3
Barbara Uhl, Heidrun Gevensleben, Yuri Tolkach, Verena Sailer, Michael Majores, Maria Jung, Sebastian Meller, Johannes Stein, Jörg Ellinger, Dimo Dietrich, Glen Kristiansen
Hypermethylation of the paired-like homeodomain transcription factor 2 (PITX2) gene is a strong predictor of the risk of biochemical recurrence in patients with prostate cancer (PCa) after radical prostatectomy. We investigate whether PITX2 methylation is feasible for individualized risk assessment in prostate core biopsies before surgery. A quantitative, methylation-specific real-time PCR was used to measure PITX2 in three cohorts: i) matched samples of neoplastic and nonneoplastic tissue from 24 patients with PCa, ii) a well-characterized cohort of 300 patients with PCa after radical prostatectomy, and iii) core biopsy specimens from 32 patients with PCa and 31 patients with benign prostatic disease...
January 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/27924198/comparison-of-effect-of-electroacupuncture-and-nefopam-for-prevention-of-postanesthetic-shivering-in-patients-undergoing-urologic-operation-under-spinal-anesthesia
#4
Jun-Ho Hong, Su-Jin Kim, Min-Sub Hwang
BACKGROUND: Shivering during spinal anesthesia is a frequent complication and is induced by the core-to-peripheral redistribution of heat. Nefopam has minimal side effects and prevents shivering by reducing the shivering threshold. Electroacupuncture is known to prevent shivering by preserving the core body temperature. We compared the efficacies of electroacupuncture and nefopam for the prevention of shivering during spinal anesthesia. METHODS: Ninety patients scheduled for elective urological surgery under spinal anesthesia were enrolled in the study...
December 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27720531/focal-high-intensity-focused-ultrasound-of-unilateral-localized-prostate-cancer-a-prospective-multicentric-hemiablation-study-of-111-patients
#5
Pascal Rischmann, Albert Gelet, Benjamin Riche, Arnauld Villers, Gilles Pasticier, Pierre Bondil, Jean-Luc Jung, Hubert Bugel, Jacques Petit, Harry Toledano, Stéphane Mallick, Olivier Rouvière, Muriel Rabilloud, Hélène Tonoli-Catez, Sebastien Crouzet
BACKGROUND: Up to a third of patients with localized prostate cancer have unilateral disease that may be suitable for partial treatment with hemiablation. OBJECTIVE: To evaluate the ability of high intensity focused ultrasound (HIFU) to achieve local control of the tumor in patients with unilateral localized prostate cancer. DESIGN, SETTING, AND PARTICIPANTS: The French Urological Association initiated a prospective IDEAL multi-institutional study (2009-2015), to evaluate HIFU-hemiablation as a primary treatment...
February 2017: European Urology
https://www.readbyqxmd.com/read/27713790/mapping-a-competency-based-surgical-curriculum-in-urology-agreement-and-discrepancies-in-the-canadian-national-opinion
#6
Keith Francis Rourke, Andrew E MacNeily
INTRODUCTION: Urology residency training in Canada is quickly evolving from a time-based to a competency-based model. We aim to better define core surgical competencies that would comprise a surgical curriculum and assess any discrepancies in opinion nationally. METHODS: A web-based survey was validated and sent to the 536 practicing members of the Canadian Urological Association (CUA) in August and October 2014. The survey consisted of questions regarding practice demographics, fellowship training, and evaluated the 76 most common urological procedures (using a five-point Likert scale) in the context of the question, "After completion of residency training in Canada a urologist should be proficient in…" A core procedure was defined as one for which there was ≥75% agreement...
May 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27711086/fournier-s-gangrene-a-clinical-review
#7
REVIEW
Ariana Singh, Kamran Ahmed, Abdullatif Aydin, Muhammad Shamim Khan, Prokar Dasgupta
INTRODUCTION AND HYPOTHESIS: Fournier's gangrene is a rare, necrotising fasciitis of the external genitalia, perineal or perianal regions. The disease has a higher incidence in males and risk factors for development include diabetes, HIV, alcoholism and other immune-compromised states. The aggressive disease process is associated with a high mortality rate of 20-30%. In addition, the increasing age and prevalence of diabetes in the population, begs the need for increased clinical awareness of Fournier's gangrene with emphasis on early diagnosis and management...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27687359/a-comparison-of-prophylactic-use-of-meperidine-meperidine-plus-dexamethasone-and-ketamine-plus-midazolam-for-preventing-of-shivering-during-spinal-anesthesia-a-randomized-double-blind-placebo-controlled-study
#8
Ali Solhpour, Alireza Jafari, Masoud Hashemi, Behnam Hosseini, Sajad Razavi, Gholamreza Mohseni, Maryam Vosoughian, Faranak Behnaz, Reza Amin Nejad, Mohamad Amin Pourhoseingholi, Fereshteh Soltani
STUDY OBJECTIVES: The aim of this study is to compare the efficacy of combination of meperidine and dexamethasone with that of placebo, meperidine alone, and the combination of ketamine and midazolam in preventing shivering during spinal anesthesia. DESIGN: This is a prospective, placebo-controlled study. SETTING: The setting is at an operating room of a university-based teaching hospital. PATIENTS: Two hundred American Society of Anesthesiologists I and II patients undergoing orthopedic and urologic surgery under spinal anesthesia were included...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27574875/higher-prostate-cancer-grade-groups-are-detected-in-patients-undergoing-multiparametric-mri-targeted-biopsy-compared-with-standard-biopsy
#9
Jennifer B Gordetsky, John V Thomas, Jeffrey W Nix, Soroush Rais-Bahrami
Recent studies have suggested that multiparametric magnetic resonance imaging (MRI)/ultrasound (US) fusion-guided prostate biopsy can detect more clinically significant prostate cancers, which could impact patient management. As many of the studies evaluating MRI/US fusion-guided prostate biopsy were conducted in specialized quaternary care centers, the question remains whether this technology is transferable to general practice. Our study assesses the diagnostic ability of MRI/US fusion-guided prostate biopsy compared with standard biopsy in the new era of prostate cancer Grade Grouping...
January 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27522247/prostate-cancer-outcomes-of-men-with-biopsy-gleason-score-6-and-7-without-cribriform-or-intraductal-carcinoma
#10
Charlotte F Kweldam, Intan P Kümmerlin, Daan Nieboer, Esther I Verhoef, Ewout W Steyerberg, Luca Incrocci, Chris H Bangma, Theodorus H van der Kwast, Monique J Roobol, Geert J van Leenders
AIM OF THE STUDY: Gleason score (GS) 3 + 4 = 7 prostate cancer patients with presence of cribriform or intraductal carcinoma (7(+)) have a worse disease-specific survival than those without. The aim of this study was to compare the clinicopathologic characteristics and patient outcomes of men with biopsy GS 3 + 4 = 7 without cribriform or intraductal carcinoma (7(-)) to those with GS 3 + 3 = 6. MATERIALS AND METHODS: We included all patients from the first screening round of the European Randomized Study of Screening for Prostate Cancer (1993-2000) with a revised GS ≤ 3 + 4 = 7 (n = 796) following the 2014 International Society of Urological Pathology criteria...
October 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27487740/interobserver-reproducibility-of-percent-gleason-pattern-4-in-prostatic-adenocarcinoma-on-prostate-biopsies
#11
Evita T Sadimin, Francesca Khani, Mairo Diolombi, Abdelrazak Meliti, Jonathan I Epstein
In the WHO Classification of Tumours of the Urinary System and Male Genital Organs published in 2016, it was officially recommended that the percent of Gleason pattern 4 (GP4) be reported on pathology reports to better reflect the extent in Gleason score 7 tumors. In this study we assessed the reproducibility of reporting GP4 on prostate biopsies. We analyzed prospectively 422 cores containing GP4 from our consult cases over a period of 2.5 months. The percent pattern 4 was assigned to all the cases in 10% increments from 0% to 100% (with the addition of 5%) by 1 of 4 fellows in urological pathology and by the expert urological pathologist...
December 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27457972/active-surveillance-is-suitable-for-intermediate-term-follow-up-of-renal-oncocytoma-diagnosed-by-percutaneous-core-biopsy
#12
Shuo Liu, Stephen Lee, Prem Rashid, Haider Bangash, Akhlil Hamid, Jason Lau, Ronald Cohen
OBJECTIVES: To evaluate the intermediate outcome of conservative management in patients with biopsy-proven oncocytoma. PATIENTS AND METHODS: Patients with oncocytoma diagnosed on percutaneous core biopsy between January 2000 to December 2014 were identified from the renal biopsy database of a large specialist urologic pathology laboratory. After review of patient clinical records, the study cohort comprised only of patients enrolled in active surveillance. Clinicopathological and follow-up details were reviewed for each case, in particular: type and interval of surveillance imaging, tumour growth, definitive intervention and reason for intervention...
October 2016: BJU International
https://www.readbyqxmd.com/read/27416104/interobserver-variability-in-gleason-histological-grading-of-prostate-cancer
#13
Tayyar A Ozkan, Ahmet T Eruyar, Oguz O Cebeci, Omur Memik, Levent Ozcan, Ibrahim Kuskonmaz
OBJECTIVE: The aims of this study were to evaluate the reproducibility of the Gleason grading system and to compare its interobserver variability with the novel Gleason grade grouping proposal using a large sample volume. MATERIALS AND METHODS: In total, 407 pathology slides of prostate needle biopsies from 34 consecutive patients with prostate cancer were re-evaluated. The International Society of Urological Pathology 2005 modified Gleason grading system with Epstein's modification was used...
December 2016: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/27376330/botulinum-toxin-a-for-bladder-pain-syndrome-interstitial-cystitis
#14
REVIEW
Bin Chiu, Huai-Ching Tai, Shiu-Dong Chung, Lori A Birder
Botulinum neurotoxin A (BoNT-A), derived from Clostridium botulinum, has been used clinically for several diseases or syndrome including chronic migraine, spasticity, focal dystonia and other neuropathic pain. Chronic pelvic or bladder pain is the one of the core symptoms of bladder pain syndrome/interstitial cystitis (BPS/IC). However, in the field of urology, chronic bladder or pelvic pain is often difficult to eradicate by oral medications or bladder instillation therapy. We are looking for new treatment modality to improve bladder pain or associated urinary symptoms such as frequency and urgency for patients with BPS/IC...
2016: Toxins
https://www.readbyqxmd.com/read/27364520/the-rationale-and-the-role-of-lymph-node-dissection-in-renal-cell-carcinoma
#15
Umberto Capitanio, Bradley C Leibovich
PURPOSE: Although the role of lymph node dissection (LND) is well defined in many urological settings, uncertainty regarding need for LND still exists for patients with renal cell carcinoma (RCC). The aim of the current review is to highlight the rationale for performing or omitting LND at the time of renal surgery. METHODS: Data were identified through a search of PubMed and Web of Science, including studies published in the last 20 years in core clinical journals...
June 30, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27320841/prostate-magnetic-resonance-imaging-and-magnetic-resonance-imaging-targeted-biopsy-in-patients-with-a-prior-negative-biopsy-a-consensus-statement-by-aua-and-sar
#16
Andrew B Rosenkrantz, Sadhna Verma, Peter Choyke, Steven C Eberhardt, Scott E Eggener, Krishnanath Gaitonde, Masoom A Haider, Daniel J Margolis, Leonard S Marks, Peter Pinto, Geoffrey A Sonn, Samir S Taneja
PURPOSE: After an initial negative biopsy there is an ongoing need for strategies to improve patient selection for repeat biopsy as well as the diagnostic yield from repeat biopsies. MATERIALS AND METHODS: As a collaborative initiative of the AUA (American Urological Association) and SAR (Society of Abdominal Radiology) Prostate Cancer Disease Focused Panel, an expert panel of urologists and radiologists conducted a literature review and formed consensus statements regarding the role of prostate magnetic resonance imaging and magnetic resonance imaging targeted biopsy in patients with a negative biopsy, which are summarized in this review...
June 16, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27256190/is-there-any-association-between-national-institute-of-health-category-iv-prostatitis-and-prostate-specific-antigen-levels-in-patients-with-low-risk-localized-prostate-cancer
#17
Omer Gokhan Doluoglu, Cavit Ceylan, Fatih Kilinc, Eymen Gazel, Berkan Resorlu, Oner Odabas
PURPOSE: We investigated the association between National Institute of Health category IV prostatitis and prostate-specific antigen levels in patients with low-risk localized prostate cancer. MATERIALS AND METHODS: The data of 440 patients who had undergone prostate biopsies due to high PSA levels and suspicious digital rectal examination findings were reviewed retrospectively. The patients were divided into two groups based on the presence of accompanying NIH IV prostatitis...
March 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/27160113/effect-of-perioperative-inadvertent-hypothermia-on-the-ecg-parameters-in-patients-undergoing-transurethral-resection
#18
H Bayir, I Yildiz, F Erdem, U Y Tekelioglu, M E Ozyalvacli, M Bilgi, H Kocoglu
OBJECTIVE: Perioperative inadvertent hypothermia (PIH) (core body temperature to < 36 °C) is a common event during surgery. PIH may result from multiple factors. Elderly urology patients are at greater risk than other patients for hypothermia. PIH may cause adverse postoperative cardiac clinical manifestations. Our study aimed to determine the effects of postoperative alteration of core body temperature on the ECG parameters in patients undergoing transurethral resection. PATIENTS AND METHODS: Fifty-nine patients, 40-83 years of age, who were scheduled for elective Transurethral Resection Prostate and/or Bladder (TUR-P and/or TUR-B) were enrolled in the study...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27028241/renal-splenosis-renal-mass-biopsy-diagnosis-of-a-tumor-clinically-mimicking-renal-cell-carcinoma
#19
Sean R Williamson
Renal mass biopsy is increasingly used to guide conservative tumor management, placing increasing importance on pathologists' ability to diagnose small tumor samples. A 66-year-old man with a history of prior splenectomy for trauma presented for urologic evaluation after identification of a left 5.8 cm renal mass. Partial envelopment of the mass by renal parenchyma and equivocal enhancement on computed tomography raised concern for renal cell carcinoma. Needle-core biopsy revealed blood, subtle vasculature, few aggregates of lymphocytes, and rare renal tubules...
March 29, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27006875/tissue-damage-by-laser-radiation-an-in-vitro-comparison-between-tm-yag-and-ho-yag-laser-on-a-porcine-kidney-model
#20
Stephan Huusmann, Mathias Wolters, Mario W Kramer, Thorsten Bach, Heinrich-Otto Teichmann, Andreas Eing, Sebastian Bardosi, Thomas R W Herrmann
The understanding of tissue damage by laser radiation is very important for the safety in the application of surgical lasers. The objective of this study is to evaluate cutting, vaporization and coagulation properties of the 2 µm Tm:YAG laser (LISA Laser Products OHG, GER) in comparison to the 2.1 µm Ho:YAG laser (Coherent Medical Group, USA) at different laser power settings in an in vitro model of freshly harvested porcine kidneys. Laser radiation of both laser generators was delivered by using a laser fiber with an optical core diameter of 550 µm (RigiFib, LISA Laser GER)...
2016: SpringerPlus
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