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https://www.readbyqxmd.com/read/29660369/evaluation-of-an-epigenetic-assay-for-predicting-repeat-prostate-biopsy-outcome-in-african-american-men
#1
Robert L Waterhouse, Leander Van Neste, Kelvin A Moses, Carlton Barnswell, Jonathan L Silberstein, Mark Jalkut, Ronald Tutrone, James Sylora, Ronald Anglade, Myron Murdock, Zvi Shiffman, Todd Vandenberg, Nikhil Shah, Michael Carter, Manuel Krispin, Jack Groskopf, Wim Van Criekinge
OBJECTIVES: To evaluate an epigenetic assay performed on tissue from negative prostate biopsies in a group of African American (AA) men undergoing repeat biopsy, and to compare accuracy for predicting repeat biopsy outcome to prior studies conducted in predominantly Caucasian populations. METHODS: The study population consisted of 211 AA men from seven urology centers across the U.S., all of whom were undergoing 12-core trans-rectal ultrasound guided repeat biopsy within 30 months from a negative index biopsy...
April 13, 2018: Urology
https://www.readbyqxmd.com/read/29656064/a-prospective-study-of-patient-reported-pain-after-bulbar-urethroplasty
#2
Patrick Evans, Sorena Keihani, Benjamin N Breyer, Bradley A Erickson, James M Hotaling, Sara M Lenherr, Jeremy B Myers
PURPOSE: To understand the prevalence of chronic perineal pain, activity limitations, and patient satisfaction after urethroplasty. METHODS: From 2014-2016, we prospectively enrolled men undergoing urethroplasty for bulbar urethral strictures. Patients, before and after surgery, completed questions from the Core Lower Urinary Tract Symptom Score (CLSS) assessing pain frequency in the bladder and penis/urethra, as well as non-validated questions assessing perineal pain...
April 12, 2018: Urology
https://www.readbyqxmd.com/read/29569320/primary-mri-us-fusion-guided-biopsy-of-the-prostate
#3
Andreas Maxeiner, Beatrice Kittner, Carsten Stephan, Thomas Fischer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Florian Fuller, Kurt Miller, Hannes Cash
OBJECTIVE: To examine the performance of a primary MRI/ultrasound fusion guided targeted biopsy (TB) and in combination with an added systematic biopsy (SB). PATIENTS AND METHODS: Analysis of 318 consecutive biopsy naïve men with suspicious mpMRI (PI-RADS score ≥3) undergoing transrectal TB and 10-core systematic biopsy (SB) between January 2012 and December 2016. The indication for performing a mpMRI was based on clinical parameters and decided by the treating urologist prior to admittance...
March 22, 2018: BJU International
https://www.readbyqxmd.com/read/29552975/mri-targeted-or-standard-biopsy-for-prostate-cancer-diagnosis
#4
Veeru Kasivisvanathan, Antti S Rannikko, Marcelo Borghi, Valeria Panebianco, Lance A Mynderse, Markku H Vaarala, Alberto Briganti, Lars Budäus, Giles Hellawell, Richard G Hindley, Monique J Roobol, Scott Eggener, Maneesh Ghei, Arnauld Villers, Franck Bladou, Geert M Villeirs, Jaspal Virdi, Silvan Boxler, Grégoire Robert, Paras B Singh, Wulphert Venderink, Boris A Hadaschik, Alain Ruffion, Jim C Hu, Daniel Margolis, Sébastien Crouzet, Laurence Klotz, Samir S Taneja, Peter Pinto, Inderbir Gill, Clare Allen, Francesco Giganti, Alex Freeman, Stephen Morris, Shonit Punwani, Norman R Williams, Chris Brew-Graves, Jonathan Deeks, Yemisi Takwoingi, Mark Emberton, Caroline M Moore
Background Multiparametric magnetic resonance imaging (MRI), with or without targeted biopsy, is an alternative to standard transrectal ultrasonography-guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who have not undergone biopsy. However, comparative evidence is limited. Methods In a multicenter, randomized, noninferiority trial, we assigned men with a clinical suspicion of prostate cancer who had not undergone biopsy previously to undergo MRI, with or without targeted biopsy, or standard transrectal ultrasonography-guided biopsy...
March 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29408568/role-of-mri-targeted-biopsy-in-detection-of-prostate-cancer-harbouring-adverse-pathological-features-of-intraductal-carcinoma-and-invasive-cribriform-carcinoma
#5
Susan Prendeville, Mark Gertner, Manjula Maganti, Melania Pintilie, Nathan Perlis, Ants Toi, Andrew J Evans, Antonio Finelli, Theodorus H van der Kwast, Sangeet Ghai
PURPOSE: The aim of this study was to compare biopsy detection of intraductal (IDC) and cribriform (CR) pattern invasive prostate carcinoma (PCa) in mpMRI positive and negative regions of the prostate. MATERIAL AND METHODS: A prospectively maintained single institution database was queried to identify patients who underwent mpMRI/US fusion targeted biopsy (MRI-TBx) and concurrent systematic sextant biopsy of MRI negative regions (SMN-Bx) between January 2013 and May 2016...
January 31, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29368286/why-laparoscopists-may-opt-for-three-dimensional-view-a-summary-of-the-full-hta-report-on-3d-versus-2d-laparoscopy-by-s-i-c-e-societ%C3%A3-italiana-di-chirurgia-endoscopica-e-nuove-tecnologie
#6
Nereo Vettoretto, Emanuela Foglia, Lucrezia Ferrario, Alberto Arezzo, Roberto Cirocchi, Gianfranco Cocorullo, Giuseppe Currò, Domenico Marchi, Giuseppe Portale, Chiara Gerardi, Umberto Nocco, Michele Tringali, Gabriele Anania, Micaela Piccoli, Gianfranco Silecchia, Mario Morino, Andrea Valeri, Emauele Lettieri
BACKGROUND: Three-dimensional view in laparoscopic general, gynaecologic and urologic surgery is an efficient, safe and sustainable innovation. The present paper is an extract taken from a full health technology assessment report on three-dimensional vision technology compared with standard two-dimensional laparoscopic systems. METHODS: A health technology assessment approach was implemented in order to investigate all the economic, social, ethical and organisational implications related to the adoption of the innovative three-dimensional view...
January 24, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29297487/prostate-cancer-grading-a-decade-after-the-2005-modified-system
#7
Jonathan I Epstein
This review article will cover the evolution of grading of prostate cancer from the original Gleason system in the 1960-1970s to a more patient-centric grading system proposed in 2013 from a group at Johns Hopkins Hospital, validated in 2014 by a large multi-institutional study, and subsequently accepted by the World Health Organization (WHO), College of American Pathology (CAP), and the AJCC TNM system. Covered topics include: (1) historical background; (2) 2005 and 2014 International Society of Urological Pathology Grading Conferences; (3) Description of Gleason patterns; (4) new approaches to display Gleason grades; (5) grading variants and variations of acinar adenocarcinoma; (6) reporting rules for Gleason grading reporting secondary patterns of higher grade when present to a limited extent; (7) reporting secondary patterns of lower grade when present to a limited extent; (8) reporting percentage pattern 4; (9) general applications of the Gleason grading system; (10) needle biopsy with different cores showing different grades; (11) radical prostatectomy specimens with separate tumor nodules; and (12) a new grading system for prostate cancer...
January 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29279591/transperineal-template-guided-prostate-saturation-biopsies-in-men-with-suspicion-of-prostate-cancer-a-pilot-study-from-pakistan
#8
K Mehmood, M Mubarak, M Dhar, M Rafi, J Kinsella
Traditionally, transrectal ultrasound (TRUS)-guided biopsies are done for the diagnosis of prostate cancer (PCa) in Pakistan. The transperineal template-guided saturation biopsy (TTSB) approach has been recently introduced in Pakistan and we share diagnostic yields and pathological findings of specimens taken for PCa diagnosis in men with elevated serum total prostate specific antigen (PSA) and negative TRUS-guided prostate biopsies. In all, 16 patients investigated at the Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), underwent TTSB...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29162327/e-learning-teaches-attendings-how-to-objectively-assess-pediatric-urology-trainees-surgery-skills-for-orchiopexy
#9
Nicolas Fernandez, Max Maizels, Walid Farhat, Edwin Smith, Dennis Liu, Michael Chua, Yasin Bhanji
INTRODUCTION: Established methods to train pediatric urology surgery by residency training programs require updating in response to administrative changes such as new, reduced trainee duty hours. Therefore, new objective methods must be developed to teach trainees. We approached this need by creating e-learning to teach attendings objective assessment of trainee skills using the Zwisch scale, an established assessment tool. The aim of this study was to identify whether or not e-learning is an appropriate platform for effective teaching of this assessment tool, by assessing inter-rater correlation of assessments made by the attendings after participation in the e-learning...
November 9, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29154932/correlation-of-virtual-reality-simulation-and-dry-lab-robotic-technical-skills
#10
Laura K Newcomb, Megan S Bradley, Tracy Truong, Michelle Tang, Bryan Comstock, Yi-Ju Li, Anthony G Visco, Nazema Y Siddiqui
STUDY OBJECTIVE: To examine whether a set of virtual reality (VR) surgical simulation drills have correlative validity when compared with the validated Robotic Objective Structured Assessment of Technical Skills (R-OSATS) dry lab drills. DESIGN: A prospective methods comparison study (Canadian Task Force classification II-2). SETTING: A teaching hospital. PARTICIPANTS: Thirty current residents, fellows, and faculty from the Departments of Obstetrics and Gynecology, Urology, and General Surgery...
November 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29051978/symptom-prevalence-bother-and-treatment-satisfaction-in-men-with-lower-urinary-tract-symptoms-in-southeast-asia-a-multinational-cross-sectional-survey
#11
Lap-Yin Ho, Peggy Sau-Kwan Chu, David Terrence Consigliere, Zulkifli Md Zainuddin, David Bolong, Chi-Kwok Chan, Molly Eng, Dac Nhat Huynh, Wachira Kochakarn, Marie Carmela M Lapitan, Dinh Khanh Le, Quang Dung Le, Frank Lee, Bannakij Lojanapiwat, Bao-Ngoc Nguyen, Teng-Aik Ong, Buenaventura Jose Reyes, Apirak Santingamkun, Woon-Chau Tsang, Paul Abrams
PURPOSE: The overall objective of the survey was to systematically examine patients' perspectives on lower urinary tract symptoms (LUTS) and their treatment in Southeast Asia. METHODS: A multinational cross-sectional survey involving adult men seeking consultation at urology outpatient clinics because of LUTS in Southeast Asia was conducted using convenience sampling. Self-reported prevalence, bother, treatment and treatment satisfaction of selected LUTS including urgency, nocturia, slow stream, and post-micturition dribble were evaluated...
January 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29016402/disability-and-health-consequences-of-traumatic-brain-injury-national-prevalence
#12
Claire Jourdan, Philippe Azouvi, François Genêt, Nicolas Selly, Loic Josseran, Alexis Schnitzler
OBJECTIVE: To measure the prevalence of traumatic brain injury-related disability and health status in the general population. DESIGN: The French National Survey, conducted in households and institutions, assessed 33,896 adults. Data included sequelae from traumatic brain injury, impairments, current health conditions and uses of health services. Analyses, adjusted for age and gender, compared subjects who declared sequelae from traumatic brain injury (n=479) to the remaining survey population (n=33,287)...
October 7, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28969413/the-eternal-enigma-in-prostatic-biopsy-access-route
#13
Andrea Fabiani, Emanuele Principi, Alessandra Filosa, Lucilla Servi
Dear Editors,We read with interest the article by Di Franco and co-workers (1). The introduction of prostatic magnetic resonance and the relative fusion-biopsy have not yet allowed the expected improvements in prostate biopsy. To our knowledge, there are no works that demonstrate the superiority of fusion techniques on the remaining ultrasound guided prostate biopsies that are still the widely used in the diagnosis of prostate cancer. Furthemore, these technologies are expensive exams and they are not yet available in all centers, especially in those minors...
October 3, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28933973/magnetic-resonance-imaging-in-the-early-detection-of-prostate-cancer-and-review-of-the-literature-on-magnetic-resonance-imaging-stratified-clinical-pathways
#14
REVIEW
Taimur Tariq Shah, Wilson King Lim To, Hashim Uddin Ahmed
With level 1 evidence now available on the diagnostic accuracy of multiparametric magnetic resonance imaging (MRI) we must now utilise this data in developing an MRI-stratified diagnostic pathway for the early detection of prostate cancer. Areas covered: A literature review was conducted and identified seven randomised control trials (RCT's) assessing the diagnostic accuracy of such a pathway against the previously accepted systematic/random trans-rectal ultrasound guided (TRUS) biopsy pathway. The studies were heterogeneous in their design...
December 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28826701/outcomes-of-men-on-active-surveillance-for-low-risk-prostate-cancer-at-a-safety-net-hospital
#15
E Charles Osterberg, Nynikka R A Palmer, Catherine R Harris, Gregory P Murphy, Sarah D Blaschko, Carissa Chu, Isabel E Allen, Matthew R Cooperberg, Peter R Carroll, Benjamin N Breyer
PURPOSE: To characterize demographic, disease, and cancer outcomes of men on active surveillance (AS) at a safety-net hospital and characterize those who were lost to follow-up (LTFU). METHODS: From January 2004 to November 2014, 104 men with low-risk prostate cancer (PCa) were followed with AS at Zuckerberg San Francisco General Hospital (ZSFG). Criteria for AS have evolved over time; however, patients with diagnostic prostate-specific antigen (PSA) 10ng/mL or less, clinical stage T1/2, biopsy Gleason score 3 + 3 or 3 + 4, 33% or fewer positive cores, and 50% or less tumor in any single core were potentially eligible for AS...
November 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28807644/predictors-of-infectious-complications-after-targeted-prophylaxis-for-prostate-needle-biopsy
#16
Dimitri Papagiannopoulos, Michael Abern, Nathaniel Wilson, Nicholas O'Block, Lester Raff, Christopher Coogan, Kalyan C Latchamsetty
PURPOSE: The incidence of infectious complications after transrectal ultrasound guided prostate needle biopsy is rising. We sought to identify the incidence and predictors of infection in a large cohort of men undergoing biopsy who receive targeted prophylaxis. MATERIALS AND METHODS: We retrospectively reviewed the records of 5,214 consecutive patients who underwent transrectal ultrasound guided prostate needle biopsy from January 2013 to December 2014 at UroPartners, a large urology group comprising 28 clinics in metropolitan Chicago...
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/28796919/evaluation-of-a-needle-disinfectant-technique-to-reduce-infection-related-hospitalisation-after-transrectal-prostate-biopsy
#17
Gregory B Auffenberg, Ji Qi, Yuqing Gao, David C Miller, Zaojun Ye, Andrew Brachulis, Susan Linsell, Tejal N Gandhi, David Kraklau, James E Montie, Khurshid R Ghani
OBJECTIVES: To determine whether a needle disinfectant step during transrectal ultrasonography (TRUS)-guided prostate biopsy is associated with lower rates of infection-related hospitalisation. PATIENTS AND METHODS: We conducted a retrospective analysis of all TRUS-guided prostate biopsies taken across the Michigan Urological Surgery Improvement Collaborative (MUSIC) from January 2012 to March 2015. Natural variation in technique allowed us to evaluate for differences in infection-related hospitalisations based on whether or not a needle disinfectant technique was used...
February 2018: BJU International
https://www.readbyqxmd.com/read/28751165/predictors-of-a-successful-urology-resident-using-medical-student-application-materials
#18
R Houston Thompson, Christine M Lohse, Douglas A Husmann, Bradley C Leibovich, Matthew T Gettman
OBJECTIVE: To evaluate features from the medical student application record that predict for a high-quality urology resident because there are currently sparse data on factors that are associated with a successful urology residency. MATERIALS AND METHODS: We reviewed the Mayo Clinic experience with 53 urology residents who matriculated between 2000 and 2011. Residents were independently scored 1-10 based on overall quality by the Program Director and Associate Program Director...
July 24, 2017: Urology
https://www.readbyqxmd.com/read/28741141/detonation-nanodiamonds-are-promising-nontoxic-delivery-system-for-urothelial-cells
#19
Daša Zupančič, Mateja Erdani Kreft, Maja Grdadolnik, Dimitar Mitev, Aleš Iglič, Peter Veranič
Detonation nanodiamonds (DNDs) are carbon-based nanomaterials that are among the most promising nanoparticles available for biomedical applications so far. This is due to their biocompatibility, which could be contributed to their inert core and conformable surface nature. However, DNDs cytotoxicity for urothelial cells and the routes of their internalization remains an open question in the aspect of nanodiamond surface. We therefore analyzed four types of DNDs for cytotoxicity and internalization with normal urothelial cells and two types of cancer urothelial cell lines in vitro...
January 2018: Protoplasma
https://www.readbyqxmd.com/read/28693386/development-methodology-of-the-novel-endoscopic-stone-treatment-step-1-est-s1-training-assessment-curriculum
#20
Domenico Veneziano, Kamran Ahmed, Ben S E P Van Cleynenbreugel, Ali Serdar Gözen, Joan Palou, Kemal Sarica, Evangelos N Liatsikos, Francesco Sanguedolce, Patrick Honeck, Mario Alvarez-Maestro, Athanasios Papatsoris, Panagiotis Kallidonis, Francesco Greco, Alberto Breda, Bhaskar Somani
Background Simulation based technical-skill assessment is a core topic of debate, especially in high-risk environments. After the introduction of the E-BLUS exam for basic laparoscopy, no more technical training/assessment urological protocols have been developed in Europe. Objective We describe the methodology used in the development of the novel Endoscopic Stone Treatment step 1 (EST s1) assessment curriculum. Materials and Methods The "full life cycle curriculum development" template was followed for curriculum development...
July 10, 2017: Journal of Endourology
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