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Klaus Häfelein, Andrea Preuße-Prange, Peter Behrendt, Bodo Kurz
Meniscal integrity is a prerequisite for sustained knee joint health and prevention of meniscal degeneration is a main research goal. Cartilage-protective effects of selenium have been described, but little is known about the impact on the meniscus. We therefore investigated the influence of sodium selenite on meniscal explants under tumor necrosis factor-alpha (TNFα)-stimulated proinflammatory conditions. Meniscal explant disks (3 mm diameter × 1 mm thickness) were isolated from 2-year-old cattle and incubated with TNFα (10 ng/ml) and sodium selenite (low dose, LoD 6...
October 25, 2016: Biological Trace Element Research
Hugh Sherman, Anh V Nguyen, Warren Bruckard
Atomic force microscopy makes it possible to measure the interacting forces between individual colloidal particles and air bubbles, which can provide a measure of the particle hydrophobicity. To indicate the level of hydrophobicity of the particle the contact angle can be calculated, assuming that no interfacial deformation occurs with the bubble retaining a spherical profile. Our experimental results obtained using a modified sphere tensiometry apparatus to detach sub-millimeter spherical particles show that deformation of the bubble interface does occur during particle detachment...
October 25, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Hangfei Gao, Jiancao Gui, Liming Wang, Yan Xu, Yiqiu Jiang, Mingyue Xiong, Yongguang Cui
Aquaporins (AQPs) have been found to be associated with a number of diseases. However, the role of AQP‑1 in the pathogenesis of osteoarthritis remains unclear. We previously found that AQP‑1 expression was upregulated in osteoarthritic cartilage and strongly correlated with caspase‑3 expression and activity. The aim of this study was to further investigate the association of AQP‑1 expression with chondrocyte apoptosis in a rat model of osteoarthritis, using RNA interference to knock down AQP‑1. For this purspose, 72 male Sprague‑Dawley rats were randomly assigned to 3 groups as follows: the control group not treated surgically (n=24), the sham‑operated group (n=24), and the osteoarthritis group (n=24)...
October 24, 2016: International Journal of Molecular Medicine
Marcelo Novelino Simão, Emily N Vinson, Charles E Spritzer
OBJECTIVE: The objective of this study was to determine the incidence of a "meniscoid" superior labrum. MATERIALS AND METHODS: This was a retrospective analysis of 582 magnetic resonance imaging examinations of shoulders. Of those 582 examinations, 110 were excluded, for a variety of reasons, and the final analysis therefore included 472 cases. Consensus readings were performed by three musculoskeletal radiologists using specific criteria to diagnose meniscoid labra...
July 2016: Radiologia Brasileira
Andrew S Wilmot, Alexander T Ruutiainen, Prashant T Bakhru, Mark E Schweitzer, Nogah Shabshin
OBJECTIVE: Primary: to describe the presence and pattern of soft tissue edema in subchondral insufficiency fractures of the knee (SIFK). Secondary: to investigate the gender distribution and identify factors associated with disease progression. METHODS: MR images of 74 SIFKs in 74 patients were retrospectively reviewed for soft tissue edema presence and location, meniscal tears and extrusion and synovitis. The clinical records were reviewed for age, gender, and BMI...
November 2016: European Journal of Radiology
Jun Suganuma, Tadashi Sugiki, Yutaka Inoue
We report a case of bilateral, permanent subluxation of the lateral meniscus. To our knowledge, the present case is the first reported description of bilateral irreducible anterior dislocation of the posterior segment of the lateral meniscus. This disorder is characterized by a flipped meniscus sign of the lateral meniscus on sagittal magnetic resonance images of the knee joint, with no history of trauma or locking symptoms. A detailed examination of serial magnetic resonance images of the lateral meniscus can help differentiate this condition from malformation of the lateral meniscus, that is, a double-layered meniscus...
2016: Case Reports in Orthopedics
Jongju Lee, Alex Nikolov, Darsh Wasan
Liquid films formed from a surfactant micellar solution thin in a stepwise fashion (stratify): the film thickness decreases layer-by-layer and dark spots appear (areas of the film with one micellar layer less than their surroundings). In a recent paper [Langmuir2016, 32, 4837-4847], we presented a two-dimensional diffusion model to explain the expansion of the dark spots inside the foam film formed from a nonionic surfactant micellar solution. Here, we apply the model to explain the dark spot expansion in the foam film formed from an anionic surfactant micellar solution of sodium dodecyl sulfate...
October 19, 2016: Journal of Colloid and Interface Science
Marco Galli, Emanuele Marzetti
OBJECTIVES: To determine the overall diagnostic accuracy of the McMurray and Joint Line Tenderness (JLT) tests for the detection of meniscal lesions. DESIGN: Secondary analysis of a prospective observational study. SETTING: Orthopedics outpatient clinic, university hospital. PARTICIPANTS: Patients (n=56) with suspected non-acute meniscal lesions who underwent knee arthroscopy. INTERVENTIONS: Not applicable...
October 19, 2016: Archives of Physical Medicine and Rehabilitation
Vishal Mehta, Timothy Petsche, Ashish M Rawal
PURPOSE: To determine the inter- and intrarater reliability of the clock-face grading system as used by 3 fellowship-trained sports medicine surgeons. METHODS: Arthroscopic video was taken of the femoral tunnel placement during 20 consecutive anterior cruciate ligament (ACL) reconstructions performed by 2 surgeons. All femoral tunnels were created using a medial portal technique. The video was taken using a 30° arthroscope placed in the lateral portal and showed the femoral tunnel as well as the remainder of the femoral notch, the posterior cruciate ligament, and the menisci for orientation...
October 19, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
Ingrid Eitzen, Hege Grindem, Agnethe Nilstad, Håvard Moksnes, May Arna Risberg
BACKGROUND: Reduced quadriceps strength influences knee function and increases the risk of knee osteoarthritis. Thus, it is of significant clinical relevance to precisely quantify strength deficits in patients with knee injuries. PURPOSE: To evaluate isokinetic concentric quadriceps muscle strength torque values, assessed both from peak torque and at specific knee flexion joint angles, in patients with anterior cruciate ligament (ACL) injury, focal cartilage lesions, and degenerative meniscus tears...
October 2016: Orthopaedic Journal of Sports Medicine
Donghee Shin, Kanwoo Youn, Eunja Lee, Myeongjun Lee, Hweemin Chung, Deokweon Kim
BACKGROUND: This study was designed to investigate the prevalence of the menisci lesions in national park workers and work factors affecting this prevalence. METHODS: The study subjects were 698 workers who worked in 20 Korean national parks in 2014. An orthopedist visited each national park and performed physical examinations. Knee MRI was performed if the McMurray test or Apley test was positive and there was a complaint of pain in knee area. An orthopedist and a radiologist respectively read these images of the menisci using a grading system based on the MRI signals...
2016: Annals of Occupational and Environmental Medicine
Aaron J Krych, Patrick J Reardon, Nick R Johnson, Rohith Mohan, Logan Peter, Bruce A Levy, Michael J Stuart
PURPOSE: Medial meniscus posterior root tears (MMPRTs) are a significant source of pain and dysfunction, but little is known about the natural history and outcome and for non-operative management of these lesions. The purpose of this study was to evaluate (1) the mid-term clinical and radiographic outcomes of non-operative treatment of MMPRTs and (2) risk factors for worse outcomes. METHODS: A retrospective review was performed for patients with symptomatic, unrepaired MMPRTs and a minimum 2-year follow-up for IKDC and Tegner outcome scores...
October 19, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
A Przeworski, Z Adamiak, J Głodek
The most common cause of hindlimb lameness in dogs is cranial cruciate ligament rupture. In 48-77.3% of the population this trauma leads to secondary damage of the meniscus. Depending on the magnetic strength of the used device, different diagnostic accuracy can be achieved. The examination sensitivity of magnetic resonance imaging is affected by many factors which are independent of diagnostic strength, such as correct positioning of the patient, size of the stifle joint examined, or selection of the right protocol of sequences...
September 1, 2016: Polish Journal of Veterinary Sciences
Laura Mecozzi, Oriella Gennari, Romina Rega, Luigi Battista, Pietro Ferraro, Simonetta Grilli
A simple and rapid process for multiscale printing of bioinks with dot widths ranging from hundreds of microns down to 0.5 μm is presented. The process makes use of spontaneous surface charges generated pyroelectrically that are able to draw little daughter droplets directly from the free meniscus of a mother drop through jetting ("p-jet"), thus avoiding time-consuming and expensive fabrication of microstructured nozzles. Multiscale can be easily achieved by modulating the parameters of the p-jet process. Here, it is shown that the p-jet allows us to print well-defined adhesion islands where NIH-3T3 fibroblasts are constrained to live into cluster configurations ranging from 20 down to single cell level...
October 19, 2016: Macromolecular Bioscience
Yue Zhang, Richard Potter, William Zhang, Zahra Fakhraai
Recent studies have shown that diffusion on the surface of organic glasses can be many orders of magnitude faster than bulk diffusion. Developing new probes that can readily measure surface diffusion can help study the effect of parameters such as chemical structure, intermolecular interaction, molecules' shape and size on the enhanced surface diffusion. In this study, we develop a novel probe that significantly simplifies these types of studies. Tobacco mosaic virus (TMV) is used as probe particle to measure surface diffusion coefficient of molecular glass N,N'-bis(3-methylphenyl)-N,N'-diphenylbenzidine (TPD)...
October 19, 2016: Soft Matter
Elizabeth M Meier, Bin Wu, Aamir Siddiqui, Donna G Tepper, Michael T Longaker, Mai T Lam
: Efforts have been made to engineer knee meniscus tissue for injury repair, yet most attempts have been unsuccessful. Creating a cell source that resembles the complex, heterogeneous phenotype of the meniscus cell remains difficult. Stem cell differentiation has been investigated, mainly using bone marrow mesenchymal cells and biochemical means for differentiation, resulting in no solution. Mechanical stimulation has been investigated to an extent with no conclusion. Here, we explore the potential for and effectiveness of mechanical stimulation to induce the meniscal phenotype in adipose-derived stromal cells...
September 2016: Plastic and Reconstructive Surgery. Global Open
Kristine M Fischenich, Hannah M Pauly, Keith D Button, Ryan S Fajardo, Charles E DeCamp, Roger C Haut, Tammy L Haut Donahue
OBJECTIVE: The objective of this study was to monitor the progression of joint damage in two animal models of knee joint trauma using two non-invasive, clinically available imaging modalities. METHODS: A 3-T clinical magnet and micro-computed tomography was used to document changes immediately following injury (acute) and post injury (chronic) at time points of 4, 8, or 12 weeks. Joint damage was recorded at dissection and compared to the chronic MRI record. Fifteen Flemish Giant rabbits were subjected to a single tibiofemoral compressive impact (ACLF), and 18 underwent a combination of ACL and meniscal transection (mACLT)...
October 15, 2016: Osteoarthritis and Cartilage
Axel Marx, Alexander Beier, Pouria Taheri, Martin Röpke, Thomas Kalinski, Andreas M Halder
BACKGROUND: Avascular necrosis after arthroscopic surgery of the knee has already been published. The purpose of this article is to report on the frequently misdiagnosed entity of osteonecrosis of the medial tibial plateau. CASE PRESENTATION: Charts and radiographs of a consecutive series with isolated medial tibial plateau osteonecrosis were analyzed. The criterion for inclusion was the absence of trauma. Six caucasian female patients with an average age of 76...
October 19, 2016: Journal of Medical Case Reports
Brad Meulenkamp, C Ryan Martin, Nicholas Desy, Paul Duffy, Rob Korley, Shannon Puloski, Richard Buckley
OBJECTIVES: To define the incidence, risk factors and anatomic location of articular malreductions in operatively treated lateral tibial plateau fractures DESIGN:: Prospective Cohort Study SETTING:: Academic Level 1 Trauma CentrePatients/Participants: Study subjects were patients entered into a prospective cohort study of tibial plateau fractures. INTERVENTIONS: Surgical Fixation of tibial plateau fractures and post-operative computed tomography (CT) scans. MAIN OUTCOME MEASURES: The primary outcome was incidence of articular malreduction...
October 7, 2016: Journal of Orthopaedic Trauma
Guangpu Zhu, Jun Yao, Lei Zhang, Hai Sun, Aifen Li
A large amount of residual oil, which exists as isolated oil slugs, remains trapped in reservoirs after water flooding. Numerous numerical studies are performed to investigate the fundamental flow mechanism of oil slugs to improve flooding efficiency. Dynamic contact angle models are usually introduced to simulate an accurate contact angle and meniscus displacement of oil slug under a high capillary number. Nevertheless, in the oil slug flow simulation process, it is unnecessary to introduce the dynamic contact angle model due to a negligible change of meniscus displacement after using the dynamic contact angle model when the capillary number is small...
October 18, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
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