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https://www.readbyqxmd.com/read/29343245/an-unusual-case-of-symptomatic-deep-vein-thrombosis-and-pulmonary-embolism-after-arthroscopic-meniscus-surgery
#1
Chao-Hua Fang, Hua Liu, Jun-Hui Zhang, Shi-Gui Yan
BACKGROUND: Although thrombosis complication is rare after arthroscopic meniscus surgery, deep vein thrombosis and pulmonary embolism can be fatal. The associated risk factors and whether anticoagulant prevention after arthroscopic knee surgery is necessary have not reach consensus. Here we present a case of deep vein thrombosis and pulmonary embolism after a common arthroscopic meniscectomy. CASE PRESENTATION: The patient had no risk factors except ipsilateral leg varicose veins...
January 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29341680/ultimate-stable-underwater-superhydrophobic-state
#2
Yaolei Xiang, Shenglin Huang, Pengyu Lv, Yahui Xue, Qiang Su, Huiling Duan
Underwater metastability hinders the durable application of superhydrophobic surfaces. In this work, through thermodynamic analysis, we theoretically demonstrate the existence of an ultimate stable state on underwater superhydrophobic surfaces. Such a state is achieved by the synergy of mechanical balance and chemical diffusion equilibrium across the entrapped liquid-air interfaces. By using confocal microscopy, we in situ examine the ultimate stable states on structured hydrophobic surfaces patterned with cylindrical micropores in different pressure and flow conditions...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29340746/similar-clinical-outcomes-following-collagen-or-polyurethane-meniscal-scaffold-implantation-a-systematic-review
#3
REVIEW
Darby A Houck, Matthew J Kraeutler, John W Belk, Eric C McCarty, Jonathan T Bravman
PURPOSE: The purpose of this systematic review is to evaluate the current literature in an effort to assess specific clinical outcomes following meniscal scaffold implantation using the two available scaffolds: Collagen Meniscal Implant (CMI) and the Actifit polyurethane meniscal scaffold. METHODS: A systematic review was performed by searching PubMed, Embase, and Cochrane Library to find studies evaluating clinical outcomes of patients undergoing meniscal scaffold implantation...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29340652/pain-sensitivity-associated-with-the-length-of-the-maximum-interblink-period
#4
Wing Li, Meng C Lin
Purpose: Pain sensitivity has been identified as a factor that affects how individuals answer dry eye questionnaires, but it is unknown how it affects ocular discomfort. This study used the time that individuals could refrain from blinking as an indicator of ocular discomfort and set out to determine whether it was related to pain sensitivity, while adjusting for ocular surface conditions. Methods: Subjects first completed the Pain Sensitivity Questionnaire to quantify pain sensitivity levels...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29334180/nitric-oxide-dependent-degradation-of-polyethylene-glycol-modified-single-walled-carbon-nanotubes-implications-for-intra-articular-delivery
#5
Kunal Bhattacharya, Cristiano Sacchetti, Pedro M Costa, Jens Sommertune, Birgit D Brandner, Andrea Magrini, Nicola Rosato, Nunzio Bottini, Massimo Bottini, Bengt Fadeel
Polyethylene glycol (PEG)-modified carbon nanotubes have been successfully employed for intra-articular delivery in mice without systemic or local toxicity. However, the fate of the delivery system itself remains to be understood. In this study 2 kDa PEG-modified single-walled carbon nanotubes (PNTs) are synthesized, and trafficking and degradation following intra-articular injection into the knee-joint of healthy mice are studied. Using confocal Raman microspectroscopy, PNTs can be imaged in the knee-joint and are found to either egress from the synovial cavity or undergo biodegradation over a period of 3 weeks...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334080/effects-of-microarchitecture-and-mechanical-properties-of-3d-microporous-plla-plga-scaffolds-on-fibrochondrocyte-and-l929-fibroblast-behavior
#6
Gokhan Bahcecioglu, Nesrin Hasırcı, Vasif Hasirci
There are several reports studying cell behavior on surfaces in 2D or in hydrogels in 3D. However, cell behavior in 3D microporous scaffolds has not been investigated extensively. In this study, poly(L-lactic acid)/poly(lactic acid-co-glycolic acid) (PLLA/PLGA)-based microporous scaffolds were used to study the effects of scaffold microarchitecture and mechanical properties on the behavior of two different cell types, human meniscal fibrochondrocytes and L929 mouse fibroblasts. In general, cell attachment, spreading and proliferation rate were mainly regulated by the strut stiffness...
January 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29333332/next-generation-tissue-engineering-of-orthopedic-soft-tissue-to-bone-interfaces
#7
Alexander J Boys, Mary Clare McCorry, Scott Rodeo, Lawrence J Bonassar, Lara A Estroff
Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues...
September 2017: MRS Communications
https://www.readbyqxmd.com/read/29333118/the-relationship-between-chondromalacia-patella-medial-meniscal-tear-and-medial-periarticular-bursitis-in-patients-with-osteoarthritis
#8
Mustafa Resorlu, Davut Doner, Ozan Karatag, Canan Akgun Toprak
Background: This study investigated the presence of bursitis in the medial compartment of the knee (pes anserine, semimembranosus-tibial collateral ligament, and medial collateral ligament bursa) in osteoarthritis, chondromalacia patella and medial meniscal tears. Patients and methods: Radiological findings of 100 patients undergoing magnetic resonance imaging with a preliminary diagnosis of knee pain were retrospectively evaluated by two radiologists. The first radiologist assessed all patients in terms of osteoarthritis, chondromalacia patella and medial meniscal tear...
December 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/29331994/acl-and-meniscal-injuries-increase-the-risk-of-primary-total-knee-replacement-for-osteoarthritis-a-matched-case-control-study-using-the-clinical-practice-research-datalink-cprd
#9
Tanvir Khan, Abtin Alvand, Daniel Prieto-Alhambra, David J Culliford, Andrew Judge, William F Jackson, Brigitte E Scammell, Nigel K Arden, Andrew James Price
OBJECTIVES: The aim of this study was to investigate whether ACL injury (ACLi) or meniscal injury increases the risk of end-stage osteoarthritis (OA) resulting in total knee replacement (TKR). METHODS: A matched case-control study of all TKRs performed in the UK between January 1990 and July 2011 and recorded in the Clinical Practice Research Datalink (CPRD) was undertaken. The CPRD contains longitudinal data on approximately 3.6 million patients. Two controls were selected for each case of TKR, matched on age, sex and general practitioner location as a proxy for socioeconomic status...
January 13, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29330740/3d-reconstruction-of-dynamic-liquid-film-shape-by-optical-grid-deflection-method
#10
L Fourgeaud, E Ercolani, J Duplat, P Gully, V S Nikolayev
In this paper, we describe the optical grid deflection method used to reconstruct the 3D profile of liquid films deposited by a receding liquid meniscus. This technique uses the refractive properties of the film surface and is suitable for liquid thickness from several microns to millimeter. This method works well for strong interface slopes and changing in time film shape; it applies when the substrate and fluid media are transparent. The refraction is assumed to be locally unidirectional. The method is particularly appropriate to follow the evolution of parameters such as dynamic contact angle, triple liquid-gas-solid contact line velocity or dewetting ridge thickness...
January 15, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29329496/positive-feedback-regulation-of-subchondral-h-type-vessel-formation-by-chondrocyte-promotes-osteoarthritis-development-in-mice
#11
Jiansen Lu, Haiyan Zhang, Daozhang Cai, Chun Zeng, Pinglin Lai, Yan Shao, Hang Fang, Delong Li, Jiayao Ouyang, Chang Zhao, Denghui Xie, Bin Huang, Jian Yang, Yu Jiang, Xiaochun Bai
Vascular-invasion-mediated interactions between activated articular chondrocytes and subchondral bone are essential for osteoarthritis (OA) development. Here, we determined the role of nutrient sensing mechanistic target of rapamycin complex 1 (mTORC1) signaling in the crosstalk across the bone cartilage interface and its regulatory mechanisms. Then mice with chondrocyte-specific mTORC1 activation (Tsc1 CKO and Tsc1 CKOER ) or inhibition (Raptor CKOER ) and their littermate controls were subjected to OA induced by destabilization of the medial meniscus (DMM) or not...
January 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29329471/diagnosing-meniscal-pathology-and-understanding-how-to-evaluate-a-postoperative-meniscus-based-on-the-operative-procedure
#12
Monica Tafur, Linda Probyn, Jaskarndip Chahal, Lawrence M White
Magnetic resonance imaging (MRI) represents the preferred noninvasive imaging technique to diagnose meniscal pathology in the pre- and postoperative setting. Furthermore, characterization of meniscal tissue MR properties has been possible by the development of advanced MRI techniques. Suspected meniscal tears are a frequent indication for MRI and the International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS) classification system has been developed to facilitate accurate and uniform reporting of such meniscal tears...
January 12, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29323710/blocking-pi3k-akt-signaling-inhibits-bone-sclerosis-in-subchondral-bone-and-attenuates-post-traumatic-osteoarthritis
#13
Chuangxin Lin, Yan Shao, Chun Zeng, Chang Zhao, Hang Fang, Liping Wang, Jianying Pan, Liangliang Liu, Weizhong Qi, Xiaofeng Feng, Hong Qiu, Haiyang Zhang, Yuhui Chen, Hong Wang, Daozhang Cai, Cory J Xian
PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA). However, its potential modulatory role in early OA progression has not been investigated yet. Here, a mouse destabilization OA model in the tibia was used to investigate roles of PI3K/AKT signaling in the early subchondral bone changes and OA pathological process. We revealed a significant increase in PI3K/AKT signaling activation which was associated with aberrant bone formation in tibial subchondral bone following destabilizing the medial meniscus (DMM), which was effectively prevented by treatment with PI3K/AKT signaling inhibitor LY294002...
January 11, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29322332/evaluation-of-age-dependent-morphometrics-of-the-meniscofemoral-ligaments-in-reference-to-the-posterior-cruciate-ligament-in-routine-mri
#14
Sebastian Röhrich, Franz Kainberger, Lena Hirtler
OBJECTIVES: To quantify the morphological correlation between the posterior cruciate ligament (PCL) and the meniscofemoral ligaments (MFLs), to propose normal ranges for different age populations, and to define guidelines for correct identification and differentiation of MFLs in routine MRI. METHODS: Three hundred forty-two subjects were included retrospectively and subdivided into five age groups. Morphometrics of the PCL and the MFLs were measured on standard MRI in the sagittal, coronal, and axial planes...
January 10, 2018: European Radiology
https://www.readbyqxmd.com/read/29317848/traumatic-osteoarthritis-induced-persistent-mechanical-hyperalgesia-in-a-rat-model-of-anterior-cruciate-ligament-transection-plus-a-medial-meniscectomy
#15
Hsiao-Chien Tsai, Ta-Liang Chen, Yu-Pin Chen, Ruei-Ming Chen
Background: Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage degeneration, subchondral bone changes, osteophyte formation, and synovitis. A major symptom is pain that is triggered by peripheral and central changes within the pain pathways. Some surgery-induced joint instability rat models of OA were described to mimic traumatic OA. Several behavioral tests were developed to access OA-induced pain. However, follow-up in most studies usually only occurred for about 4 weeks...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29315440/femtosecond-laser-assisted-stromal-lenticule-addition-keratoplasty-for-the-treatment-of-advanced-keratoconus-a-preliminary-study
#16
Leonardo Mastropasqua, Mario Nubile, Niccolò Salgari, Rodolfo Mastropasqua
PURPOSE: To investigate the in vivo effect of a novel femtosecond laser-assisted procedure termed stromal lenticule addition keratoplasty for advanced keratoconus. METHODS: Ten patients with stage III and IV stable keratoconus were included. Negative meniscus-shaped stromal lenticules were produced from corneoscleral eye bank buttons with a refractive lenticule extraction procedure with a 500-kHz VisuMax femtosecond laser (Carl Zeiss Meditec, Jena, Germany). Recipient corneas underwent a modified femtosecond laser flap-cut procedure to produce an intrastromal pocket and lenticules were implanted...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29314864/outcomes-of-osteochondral-allograft-transplantation-with-and-without-concomitant-meniscus-allograft-transplantation-a-comparative-matched-group-analysis
#17
Rachel M Frank, Simon Lee, Eric J Cotter, Charles P Hannon, Timothy Leroux, Brian J Cole
BACKGROUND: Osteochondral allograft transplantation (OCA) is often performed with concomitant meniscus allograft transplantation (MAT) as a strategy for knee joint preservation, although to date, the effect of concomitant MAT on outcomes and failure rates after OCA has not been assessed. PURPOSE: To determine clinical outcomes for patients undergoing OCA with MAT as compared with a matched cohort of patients undergoing isolated OCA. STUDY DESIGN: Control study; Level of evidence, 3...
January 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29314205/cdc42-is-essential-for-both-articular-cartilage-degeneration-and-subchondral-bone-deterioration-in-experimental-osteoarthritis
#18
Xinhua Hu, Xing Ji, Mengting Yang, Shihao Fan, Jirong Wang, Meiping Lu, Wei Shi, Liu Mei, Chengyun Xu, Xueying Fan, Musaddique Hussain, Jingyu Du, Junsong Wu, Ximei Wu
Cdc42, a member of Rho family small GTPases, is critical for cartilage development. We investigated the roles of Cdc42 in osteoarthritis and explored the potential mechanism underlying Cdc42-mediated articular cartilage degeneration and subchondral bone deterioration. Cdc42 is highly expressed in both articular cartilage and subchondral bone in a mouse osteoarthritis model with surgical destabilisation of the medial meniscus (DMM) in the knee joints. Specifically, genetic disruption of Cdc42, knockdown of Cdc42 expression, or inhibition of Cdc42 activity robustly attenuates the DMM-induced destruction, hypertrophy, high expression of matrix metallopeptidase-13 and collagen X, and activation of Stat3 in articular cartilages...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29311146/impact-of-broad-regulatory-regions-on-gdf5-expression-and-function-in-knee-development-and-susceptibility-to-osteoarthritis
#19
Steve K Pregizer, Ata M Kiapour, Mariel Young, Hao Chen, Michael Schoor, Zun Liu, Jiaxue Cao, Vicki Rosen, Terence D Capellini
OBJECTIVES: Given the role of growth and differentiation factor 5 (GDF5) in knee development and osteoarthritis risk, we sought to characterise knee defects resulting from Gdf5 loss of function and how its regulatory regions control knee formation and morphology. METHODS: The brachypodism (bp) mouse line, which harbours an inactivating mutation in Gdf5, was used to survey how Gdf5 loss of function impacts knee morphology, while two transgenic Gdf5 reporter bacterial artificial chromosome mouse lines were used to assess the spatiotemporal activity and function of Gdf5 regulatory sequences in the context of clinically relevant knee anatomical features...
January 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29305617/decline-in-clinical-scores-at-long-term-follow-up-of-arthroscopically-treated-discoid-lateral-meniscus-in-children
#20
Jonathan D Haskel, Tyler J Uppstrom, David M Dare, Scott A Rodeo, Daniel W Green
PURPOSE: The purpose of this study was to examine the long-term clinical outcomes of arthroscopic partial meniscectomy for the treatment of discoid lateral meniscus in children. METHODS: A previous study identified 34 consecutive patients that underwent arthroscopic meniscal saucerization by one of the two surgeons between 1997 and 2002. Patients were asked to complete several outcomes questionnaires and were given the opportunity to receive a knee exam performed by their treating surgeon...
January 5, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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