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https://www.readbyqxmd.com/read/29778418/correlation-between-translational-and-rotational-kinematic-abnormalities-and-osteoarthritis-like-damage-in-two-in-vivo-sheep-injury-models
#1
Mehdi Shekarforoush, Jillian E Beveridge, David A Hart, Cyril B Frank, Nigel G Shrive
The relations between kinematic abnormalities and post traumatic osteoarthritis have not yet been clearly elucidated. This study was conducted to determine the finite helical axes parameters and the tibiofemoral translation vector in the knee joints of two surgically induced injury sheep models: anterior cruciate ligament and medial collateral ligament transection (ACL/MCL Tx) (n = 5) and lateral meniscectomy (n = 5). We hypothesized that morphological damage in the experimental joints would be correlated to alterations in these kinematic variables...
May 16, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29776813/unicompartmental-knee-arthroplasty-for-spontaneous-osteonecrosis-of-the-medial-tibial-plateau
#2
Tomoyuki Kamenaga, Takafumi Hiranaka, Yuichi Hida, Takaaki Fujishiro, Koji Okamoto
BACKGROUND: There have been very few reports on isolated medial tibial plateau osteonecrosis, and the condition has not been clearly described. Unicompartmental knee arthroplasty (UKA) may be an appropriate treatment method for this condition. The aims of this study were to report our experience of using mobile-bearing knee implants for osteonecrosis of the medial tibial plateau and to discuss the etiology and treatment of this type of osteonecrosis. METHODS: This study included six consecutive patients with isolated medial tibial plateau osteonecrosis treated with an Oxford mobile-bearing knee implant...
May 16, 2018: Knee
https://www.readbyqxmd.com/read/29774599/deep-convolutional-neural-network-for-segmentation-of-knee-joint-anatomy
#3
Zhaoye Zhou, Gengyan Zhao, Richard Kijowski, Fang Liu
PURPOSE: To describe and evaluate a new segmentation method using deep convolutional neural network (CNN), 3D fully connected conditional random field (CRF), and 3D simplex deformable modeling to improve the efficiency and accuracy of knee joint tissue segmentation. METHODS: A segmentation pipeline was built by combining a semantic segmentation CNN, 3D fully connected CRF, and 3D simplex deformable modeling. A convolutional encoder-decoder network was designed as the core of the segmentation method to perform high resolution pixel-wise multi-class tissue classification for 12 different joint structures...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29772990/the-effects-of-meniscal-geometry-on-susceptibility-for-meniscal-and-acl-injury-in-non-arthritic-knees-a-retrospective-case-control-study
#4
Alexander Tejani, Qais Naziri, Preston W Grieco, Robert Pivec, Damon Greene, Bhaveen V Kapadia, Dipal Chatterjee, William P Urban
Prior studies have not found significant differences in meniscal parameters between patients with meniscal and ligamentous injury and those without. The purpose of this study was to determine whether such relationships exist. Clinical records and magnetic resonance images of three subject groups were reviewed. Group 1 solely had meniscal tears (medial/lateral), Group 2 had meniscal tears with concurrent ACL tears, and Group 3 had healthy knees. The mean age of subjects included was 35.9 years (range 8.2-72...
2018: Journal of Long-term Effects of Medical Implants
https://www.readbyqxmd.com/read/29772846/analysis-of-the-content-of-chromium-in-certain-parts-of-the-human-knee-joint
#5
Wojciech Roczniak, Barbara Brodziak-Dopierała, Elżbieta Cipora, Agata Jakóbik-Kolon, Magdalena Konieczny, Magdalena Babuśka-Roczniak
Chromium is an essential microelement in the human body. It exerts an effect on bones by modulating their biochemical parameters: alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP). With considerable accumulation of chromium in the skeleton, the activity of alkaline phosphatase was found to decrease, which affected bone formation rate. The study objective was to analyze chromium content in the knee tissues. Tissues for analysis were obtained during endoprosthesoplasty of the knee joint and included tibia, femur, and meniscus tissues...
May 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29772338/hyaluronic-acid-an-efficient-biomacromolecule-for-treatment-of-inflammatory-skin-and-joint-diseases-a-review-of-recent-developments-and-critical-appraisal-of-preclinical-and-clinical-investigations
#6
REVIEW
Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29770844/effect-of-arthroscopic-resection-for-discoid-lateral-meniscus-on-the-axial-alignment-of-the-lower-limb
#7
Puyan Zhang, Qichun Zhao, Xifu Shang, Yingming Wang
PURPOSE: This study was designed to investigate the changes in the lower limb axial alignment and knee joint function after arthroscopic resection of discoid lateral menisci. METHODS: Pre-operative and post-operative full-length weight-bearing radiographs of the lower limb were obtained from 60 patients with discoid lateral menisci from August 2015 to August 2016. Twenty-four patients were treated with meniscectomy and 36 cases were treated with meniscoplasty. The axial alignment of the lower limb was measured, and changes in the lower limb axial alignment before and after surgery were analyzed...
May 16, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29770517/validity-and-generalizability-of-findings-of-randomized-controlled-trials-on-arthroscopic-partial-meniscectomy-of-the-knee
#8
REVIEW
Antti Malmivaara
BACKGROUND: The validity and generalizability of evidence from trials on arthroscopic partial meniscectomy (APM) for a ruptured meniscus of the knee has been debated in scientific journals. OBJECTIVE: To assess the validity and generalizability of evidence for trials on effectiveness of APM by a novel Benchmarking method; and to compare this assessment with established assessment methods; and to make an overall assessment of the current evidence on validity and generalizability of findings...
May 16, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29770342/fibular-collateral-ligament-varus-stress-radiographic-analysis-using-3-different-clinical-techniques
#9
Patrick W Kane, Mark E Cinque, Gilbert Moatshe, Jorge Chahla, Nicholas N DePhillipo, Matthew T Provencher, Robert F LaPrade
Background: Fibular collateral ligament (FCL) tears are challenging to diagnose. Left untreated, FCL tears lead to residual ligament instability and increased joint loading on the medial compartment of the knee. Additionally, when a concomitant anterior cruciate ligament (ACL) reconstruction is performed, increased forces on reconstruction grafts occur, which may lead to premature graft failure. Stress radiographs constitute a reliable and validated technique for the objective assessment of a complete grade III FCL tear...
May 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29770332/incidence-and-extent-of-graft-extrusion-following-meniscus-allograft-transplantation
#10
REVIEW
Dae-Hee Lee
Background: The incidence and extent of graft extrusion after meniscus allograft transplantation (MAT) may differ in patients undergoing medial and lateral meniscus transplantation due to the use of different surgical techniques. This meta-analysis was therefore designed to quantify the extent and incidence of graft extrusion after meniscus allograft transplantation. Methods: Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, all studies reporting absolute extrusion, relative percentage of extrusion (RPE), or frequency of major extrusions (>3 mm) on magnetic resonance imaging in patients undergoing medial or lateral MAT were included...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29769537/a-co-culture-system-of-rat-synovial-stem-cells-and-meniscus-cells-promotes-cell-proliferation-and-differentiation-as-compared-to-mono-culture
#11
Xing Xie, Jingxian Zhu, Xiaoqing Hu, Linghui Dai, Xin Fu, Jiying Zhang, Xiaoning Duan, Yingfang Ao
A meniscus tear often happens during active sports. It needs to be repaired or replaced surgically to avoid further damage to the articular cartilage. To address the shortage of autologous meniscal cells, we designed a co-culture system of synovial stem cells (SMSCs) and meniscal cells (MCs) to produce a large cell number and to maintain characteristics of MCs. Different ratios of SMSCs and MCs at 3:1, 1:1, and 1:3 were tested. Mono-culture of SMSCs or MCs served as control groups. Proliferation and differentiation abilities were compared...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29762116/incidence-and-risk-factors-for-reoperation-following-meniscal-repair-in-a-military-population
#12
Alaina M Brelin, Michael A Donohue, George C Balazs, Lance E LeClere, John-Paul H Rue, Jonathan F Dickens
The purpose of this study is to determine the reoperation rate following meniscal repair and the associated risk factors. The Military Health System Data Repository was queried for active duty patients between January 2009 and December 2012 undergoing meniscal repair by Current Procedural Terminology code (29882, 29883, and 27403). This cohort was then screened for subsequent procedures following the index procedure. Risk factors for reoperation were calculated using a Cox proportional hazard analysis. A total of 3259 primary meniscal repairs were identified over the study period, of which 1423 (43...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29758646/contact-angle-hysteresis-on-doubly-periodic-smooth-rough-surfaces-in-wenzel-s-regime-the-role-of-the-contact-line-depinning-mechanism
#13
Stanimir Iliev, Nina Pesheva, Pavel Iliev
We report here on the contact angle hysteresis, appearing when a liquid meniscus is in contact with doubly sinusoidal wavelike patterned surfaces in Wenzel's wetting regime. Using the full capillary model we obtain numerically the contact angle hysteresis as a function of the surface roughness factor and the equilibrium contact angle for a block case and a kink case contact line depinning mechanism. We find that the dependencies of the contact angle hysteresis on the surface roughness factor are different for the different contact line depinning mechanisms...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29755817/comparison-of-electrocoagulation-and-conventional-medical-drops-for-treatment-of-conjunctivochalasis-short-term-results
#14
Mehtap Çağlayan, Pınar Kösekahya, Canan Gürdal, Özge Saraç
Objectives: To compare the effectiveness of electrocoagulation and conventional medical drops for treatment of conjunctivochalasis using anterior segment-optical coherence tomography (AS-OCT). Materials and Methods: Forty eyes of 20 patients with bilateral conjunctivochalasis were included in this prospective study. Twenty eyes of 10 patients were assigned to Group 1 and underwent electrocoagulation. The other 20 eyes of 10 patients were assigned to Group 2 and received conventional medical treatment consisting of non-steroidal antiinflammatory drop (topical 0...
April 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29754495/evaluation-of-anterior-intermeniscal-ligament-in-discoid-lateral-meniscus-cases-and-presenting-the-accompanying-meniscal-pathologies-with-mri
#15
Ali Koç, Turgut Tursem Tokmak, Özgür Karabıyık, Gamze Türk
Background Although several studies were conducted to put forth the biomechanical function of anterior intermeniscal ligament (AIML) on the stability of meniscal structures, there are few data on the etiology of the early degeneration of discoid type compared to the normal shaped ones. Purpose To determine the AIML subtypes and accompanying meniscal pathologies in discoid lateral menisci (DLM) on knee MRI exams. Material and Methods Knee MRI exams of 171 individuals with DLM were reviewed. DLMs and AIMLs were typed according to Watanabe's classification and Nelson-Laprade classification, respectively...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29752501/it-is-safe-and-effective-to-use-all-inside-meniscal-repair-devices-for-posteromedial-meniscal-ramp-lesions
#16
Giles Heilpern, Jo Stephen, Simon Ball, Andrew Amis, Andy Williams
PURPOSE: Recently, it has been recognized that meniscocapsular ('ramp') lesions of the posterior one-third of the medial meniscus frequently occur during injuries causing ACL rupture, and that these lesions are easily missed at arthroscopy. Furthermore, it is clear that these lesions are biomechanically significant, adding to the deficits caused by ACL rupture, and that their repair can reverse this. The efficacy of an all inside repair technique has been questioned by some authors and by those who advocate a suture shuttle technique via an accessory posteromedial portal...
May 12, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29752059/risk-factors-for-abnormal-anteroposterior-knee-laxity-after-primary-anterior-cruciate-ligament-reconstruction
#17
Riccardo Cristiani, Magnus Forssblad, Björn Engström, Gunnar Edman, Anders Stålman
PURPOSE: To identify preoperative and intraoperative factors associated with abnormal anterior knee laxity after primary anterior cruciate ligament (ACL) reconstruction. METHODS: A total of 5,462 patients who underwent primary ACL reconstruction at our institution from January 2000 to October 2015, with no associated ligament injuries, were included. Demographic data, information regarding graft used, concomitant meniscal surgery, and instrumented laxity were reviewed...
May 8, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29752053/anterior-laxity-lateral-tibial-slope-and-in-situ-acl-force-differentiate-knees-exhibiting-distinct-patterns-of-motion-during-a-pivoting-event-a-human-cadaveric-study
#18
Robert N Kent, Mark J Amirtharaj, Brendan M Hardy, Andrew D Pearle, Thomas L Wickiewicz, Carl W Imhauser
Knee instability following anterior cruciate ligament (ACL) rupture compromises function and increases risk of injury to the cartilage and menisci. To understand the biomechanical function of the ACL, previous studies have primarily reported the net change in tibial position in response to multiplanar torques, which generate knee instability. In contrast, we retrospectively analyzed a cohort of 13 consecutively tested cadaveric knees and found distinct motion patterns, defined as the motion of the tibia as it translates and rotates from its unloaded, initial position to its loaded, final position...
April 11, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29750304/intraperitoneal-injection-of-thalidomide-alleviates-early-osteoarthritis-development-by-suppressing-vascular-endothelial-growth-factor-expression-in-mice
#19
Jia Lin Song, De Long Li, Hang Fang, Dao Zhang Cai
Vascular endothelial growth factor (VEGF) is expressed in articular cartilage and increases in expression levels have been associated with the progression of osteoarthritis (OA). Thalidomide is a drug that has been reported to inhibit angiogenesis and reduce VEGF production by downregulating VEGF expression. The objective of the present study was to determine whether intraperitoneal administration of thalidomide may attenuate early OA development in mice. Male C57BL/6 mice (10‑weeks‑old) were randomly assigned into the destabilization of the medial meniscus (Dmm) with thalidomide treatment (Dmm+Th), Dmm and Sham groups equally...
May 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29748855/multi-speed-sedimentation-velocity-simulations-with-ultrascan-iii
#20
Tayler L Williams, Gary E Gorbet, Borries Demeler
Recent developments in the UltraScan-III software make it possible to model multi-speed analytical ultracentrifugation sedimentation velocity experiments using finite-element solutions of the Lamm equation. Using simulated data, we demonstrate here how these innovations can be used to enhance the resolution of sedimentation velocity experiments when compared to single-speed experiments. Using heterogeneous systems covering as much as five orders of magnitude in molar mass and fivefold in anisotropy, we compare results from runs performed at multiple speeds to those obtained from single-speed experiments, fitted individually and analyzed globally over multiple speeds, and quantify resolution for sample heterogeneous in size and anisotropy...
May 10, 2018: European Biophysics Journal: EBJ
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