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https://www.readbyqxmd.com/read/28943457/clinical-staging-of-fibrodysplasia-ossificans-progressiva-fop
#1
Robert J Pignolo, Frederick S Kaplan
Fibrodyplasia ossificans progressiva (FOP) is an ultra-rare genetic condition of heterotopic ossification (HO) that results in progressive loss of joint function, ultimately rendering movement impossible. Death is most commonly the result of thoracic insufficiency syndrome, or complications related to recurrent respiratory infections. There are no current treatments for FOP, but early and emerging clinical trials offer hope for this devastating disease. With the recent reporting of a comprehensive global natural history study, scales to assess joint dysfunction, and a more accurate prediction of joint survival, it is now possible to construct a conceptual framework for the clinical staging of FOP...
September 21, 2017: Bone
https://www.readbyqxmd.com/read/28942667/depression-and-anxiety-correlate-with-disease-related-characteristics-and-quality-of-life-in-chinese-patients-with-gout-a-case-control-study
#2
Ting Fu, Haixia Cao, Rulan Yin, Lijuan Zhang, Qiuxiang Zhang, Liren Li, Xingmei Feng, Zhifeng Gu
This study aims to evaluate the prevalence of depression and anxiety and investigate the potential risk factors for depression and anxiety in Chinese gout patients. A self-report survey was administered to 226 gout patients and 232 age- and gender-matched healthy individuals. Patients were asked to complete a set of standardized self-report questionnaires. Univariate and mutiple regression were used to analyze the data. We found 15.0% of gout patients had depression, and 5.3% had anxiety. After adjusted demographic variables, the prevalence of depression was significantly higher than the healthy controls (6...
September 23, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/28941137/incidence-determinants-and-outcomes-of-pregnancy-associated-hepatitis-b-flares-a-regional-hospital-based-cohort-study
#3
Tatyana Kushner, Pamela A Shaw, Ankush Kalra, Lora Magaldi, Pooja Monpara, Gurneet Bedi, Karen Krok, Sierra Centkowski, Katherine Dalldorf, Julia D'souza, Dina Halegoua-De Marzio, David S Goldberg, Stacey Trooskin, Lisa D Levine, Sindhu K Srinivas, James D Lewis, Kimberly A Forde, Vincent Lo Re
BACKGROUND & AIMS: There is limited knowledge about hepatitis B virus (HBV) flare among pregnant women. We evaluated the incidence, determinants, and outcomes of HBV flare in a multicultural cohort of pregnant HBV-infected women in the United States. METHODS: We performed a retrospective cohort study of pregnant hepatitis B surface antigen-positive women cared for at hospital-based clinics of four medical centers in Southeastern Pennsylvania from 2006-2015. The main outcome was incident HBV flare (alanine aminotransferase [ALT] ≥2 times upper limit of normal) during pregnancy or within 6 months after delivery...
September 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28940780/prolonged-azathioprine-treatment-reduces-the-need-for-surgery-in-early-crohn-s-disease
#4
Yun Qiu, Bai-Li Chen, Rui Feng, Sheng-Hong Zhang, Yao He, Zhi-Rong Zeng, Shomron Ben-Horin, Laurent Peyrin-Biroulet, Ren Mao, Min-Hu Chen
BACKGROUND AND AIM: Whether an early use of azathioprine (AZA) can alter the natural history of Crohn's disease (CD) remains debated. To evaluate the impact of AZA on disease progression in a cohort of patients with early CD. METHODS: This longitudinal cohort study examined patients with early CD defined as disease duration ≤18 months and no previous use of disease-modifying agents according to Paris definition. The primary outcome was the proportion of CD-related intestinal surgery...
September 22, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28940487/when-should-the-diagnosis-contact-urticaria-be-used
#5
Kristiina Aalto-Korte
In the dermatological literature, the term 'contact urticaria syndrome' is often used with patients presenting no symptoms of contact urticaria, but symptoms of adjacent mucous membranes evolving to a systemic allergic reaction. Contact urticaria refers to a wheal and flare reaction following external contact with a causative substance. Its use should be restricted to skin: a skin reaction after direct skin contact.
September 21, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28935637/biological-tapering-and-sonographic-flare-in-rheumatoid-arthritis
#6
Chi-Hua Ko, Jia-Feng Chen, Tien-Tsai Cheng, Han-Ming Lai, Ying-Chou Chen
This study aimed to evaluate the risk of ultrasound-detected synovitis after antitumor necrosis factor (TNF) tapering in patients with rheumatoid arthritis. We recruited patients with rheumatoid arthritis who accepted TNF tapering. Gray-scale synovitis and power Doppler score in bilateral wrists at the dorsal radiolunate joint were evaluated. We defined a sum of bilateral wrist scores of ≥2 as sonographic inflammation. Logistical regression analysis was used to adjust for confounding factors. One hundred and twenty-two patients who received a tapered dose of anti-TNF were enrolled, of whom 96 (78%) had ultrasound-detected synovitis and 26 had no inflammation...
September 20, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28933339/incidence-and-outcome-of-lupus-nephritis-in-french-polynesia%C3%A2
#7
Antoine Delarche, Catherine Lumbroso, Alain Fournier, Ronan Delaval, Jacques Pourrat, Pascale Testevuide, Sylvie Leou, Christophe Cordonnier, Dominique Chauveau, Stanislas Faguer
OBJECTIVE: Outcomes of systemic lupus erythematosus (SLE) and lupus nephritis (LN) are highly heterogeneous among some populations because of interactions between genetic, epigenetic, environmental, and socioeconomic factors. A better characterization of social and ethnic disparities in mixed populations may thus help to develop individualized treatment regimens. MATERIALS AND METHODS: Retrospective observational study including all patients with LN diagnosed between January 1993 and January 2014 in the only Nephrology Department of French Polynesia...
September 21, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28932753/effect-of-iop-based-infusion-system-with-and-without-balanced-phaco-tip-on-cumulative-dissipated-energy-and-estimated-fluid-usage-in-comparison-to-gravity-fed-infusion-in-torsional-phacoemulsification
#8
Praveen K Malik, Taru Dewan, Arun Kr Patidar, Ekta Sain
BACKGROUND: To evaluate the effect of three different combinations of tip designs and infusion systems in torsional phacoemulsification (INFINITI and CENTURION) in patients with cataract. According to the manufacturer, two unique improvements in the Centurion are: active fluid dynamic management system and use of an intrepid balanced tip. The study specifically aimed to evaluate the beneficial effects, if any, of change in tip design and infusion system individually and in combination on both per-operative parameters as well as endothelial health over 6 months...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28929279/effectiveness-and-safety-of-combined-cataract-surgery-and-microhook-ab-interno-trabeculotomy-in-japanese-eyes-with-glaucoma-report-of-an-initial-case-series
#9
Masaki Tanito, Yoshifumi Ikeda, Etsuko Fujihara
PURPOSE: To report the early postoperative results and safety profile of ab interno microhook trabeculotomy (μLOT) combined with cataract surgery. PATIENTS AND METHODS: This retrospective observational case series included 68 consecutive glaucomatous eyes of 23 Japanese men and 25 Japanese women [mean (SD) age, 76.0 ± 8.5 years] who underwent μLOT for intraocular pressure (IOP) and visually relevant cataracts. The LOT site/extent, perioperative complications, and complication treatments were collected from the medical and surgical records...
September 19, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28929239/flares-in-chinese-systemic-lupus-erythematosus-patients-a-6-year-follow-up-study
#10
Liying Peng, Ziqian Wang, Mengtao Li, Yanhong Wang, Dong Xu, Qian Wang, Shangzhu Zhang, Jiuliang Zhao, Xinping Tian, Xiaofeng Zeng
This study determined the flare status of SLE patients in a single-center Chinese cohort and identified the predictors of flare in this underreported Asian population. The patients were recruited from April 2009 to February 2010 at the Peking Union Medical College Hospital (PUMCH), and then followed up regularly at our clinic until December 2015. Flare was defined as an increase in SLEDAI-2K to ≥ 4 points from the previous visit, or appearing of a new SLE manifestation or worsening of a preexisting clinical or hematological manifestation (not included in SLEDAI-2K) that results in restarting or increasing corticosteroids or immunosuppressant...
September 19, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28927891/vitiligo-skin-is-imprinted-with-resident-memory-cd8-t-cells-expressing-cxcr3
#11
Katia Boniface, Clément Jacquemin, Anne-Sophie Darrigade, Benoît Dessarthe, Christina Martins, Nesrine Boukhedouni, Charlotte Vernisse, Alexis Grasseau, Denis Thiolat, Jérôme Rambert, Fabienne Lucchese, Antoine Bertolotti, Khaled Ezzedine, Alain Taieb, Julien Seneschal
Vitiligo is a chronic auto-immune depigmenting skin disorder that results from a loss of melanocytes. Multiple combinatorial factors have been involved in disease development, with a prominent role of the immune system, in particular T cells. After repigmentation, vitiligo frequently recurs in the same area, suggesting that vitiligo could involve the presence of resident memory T cells (TRM). We sought to perform a thorough characterization of the phenotype and function of skin memory T cells in vitiligo. We show that stable and active vitiligo perilesional skin is enriched with a population of CD8 TRM expressing both CD69 and CD103 compared to psoriasis and control unaffected skin...
September 16, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28927109/disease-progression-patterns-of-bevacizumab-responders-with-recurrent-malignant-gliomas
#12
Ju-Hwi Kim, Tae-Young Jung, Eu Chang Hwang, Sung-Hoon Jung, Shin Jung, In-Young Kim, Woo-Youl Jang, Kyung-Sub Moon, Kyung-Hwa Lee, Seul-Kee Kim
Tumor progression in patients with recurrent malignant glioma who respond to bevacizumab (BEV) is difficult to assess. The current study reviewed the clinical and radiological results of patients following a BEV-based chemotherapy regimen, and evaluated disease progression patterns in patients who responded to BEV therapy. From August 2011 to November 2015, 24 patients (18 glioblastoma cases and 6 anaplastic astrocytoma cases) were treated with BEV-based chemotherapy. In total, 6 patients were treated with BEV alone and 18 patients were treated with BEV combined with irinotecan...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925027/a-prospective-international-study-on-adherence-to-treatment-in-305-patients-with-flaring-sle-assessment-by-drug-levels-and-by-self-administered-questionnaires
#13
Nathalie Costedoat-Chalumeau, Frédéric Houssiau, Peter Izmirly, Véronique Le Guern, Sandra Navarra, Meenakshi Jolly, Guillermo Ruiz-Irastorza, Gabriel Baron, Eric Hachulla, Nancy Agmon-Levin, Yehuda Shoenfeld, Francesca Dall'Ara, Jill Buyon, Christophe Deligny, Ricard Cervera, Estibaliz Lazaro, Holy Bezanahary, Gaëlle Leroux, Nathalie Morel, Jean-François Viallard, Christian Pineau, Lionel Galicier, Ronald Van Vollenhoven, Angela Tincani, Hanh Nguyen, Guillaume Gondran, Noel Zahr, Jacques Pouchot, Jean-Charles Piette, Michelle Petri, David Isenberg
Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half-life and can be quantified by HPLC. This international study evaluated nonadherence in 305 lupus patients with flares using drug levels (HCQ<200ng/ml or undetectable desethylchloroquine), and self-administered questionnaires (MASRI<80% or MMAS-8<6). Drug levels defined 18.4% of the patients as severely nonadherent. In multivariate analyses, younger age, non-use of steroids, higher BMI and unemployment were associated with nonadherence by drug level...
September 19, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28924415/stalagmite-like-preretinal-inflammatory-deposits-in-vitrectomized-eyes-with-posterior-uveitis
#14
Yoshihiro Yonekawa, Ashkan M Abbey, Lily van Laere, Ankoor R Shah, Benjamin J Thomas, Alan J Ruby, Lisa J Faia
We report a new clinical sign of vitreous inflammation in patients with posterior uveitis: spectral-domain optical coherence tomography identified stalagmite-like, discrete, diffusely distributed, hyperreflective, preretinal deposits in previously vitrectomized eyes of 2 patients during flares of posterior uveitis. The extent of the deposits correlated with disease activity. The underlying primary diseases encountered were necrotizing retinochoroiditis secondary to toxoplasmosis and primary central nervous system lymphoma...
2017: Digital Journal of Ophthalmology: DJO
https://www.readbyqxmd.com/read/28921906/outcomes-of-severe-uveitic-glaucoma-treated-with-baerveldt-implant-can-blindness-be-prevented
#15
Annelie N Tan, Michiel F Cornelissen, Carroll A B Webers, Roel J Erckens, Tos T J M Berendschot, Henny J M Beckers
PURPOSE: To evaluate long-term outcomes on efficacy and safety of severe uveitic glaucoma treated with a Baerveldt glaucoma implant (BGI). METHODS: A retrospective study of 47 eyes of 47 patients with uveitic glaucoma treated by a BGI between September 2002 and September 2015. Main outcome measures were intraocular pressure (IOP), number of glaucoma medications, course of the uveitis, visual acuity (VA) and complications. RESULTS: Mean IOP dropped from 30...
September 18, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28918181/flared-sign-of-flail-mandible-on-computed-tomography-an-unstable-fracture-associated-with-a-compromised-airway
#16
I Papadiochos, L Goutzanis, K-I Karydi, E Kalfarentzos, N Papadogeorgakis
A mandibular fracture alone rarely causes a life-threatening injury. The aim of this paper was to emphasise the importance of prompt identification of the radiological signs of a flail mandible in a patient with maxillofacial trauma who eventually needed definitive management of her airway.
September 13, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28917574/-apparent-worsening-of-psoriasis-lesions-revealing-methotrexate-overdosage
#17
R Haber, B Baroudjian, M Battistella, M Bagot, A Petit
BACKGROUND: Methotrexate (MTX) is an antimetabolite drug used in the treatment of cancers and autoimmune diseases and frequently in dermatology for cutaneous and/or arthritic psoriasis. Toxicities due to MTX overdosage are mainly cutaneous, hepatic and hematologic. Herein, we report a case of MTX overdosage presenting as an erosive and an inflammatory flare of preexisting psoriatic plaques and with new palmar lesions. PATIENTS AND METHODS: A 51-year-old male with a 6-year history of plaque psoriasis resistant to topical corticosteroids was started for the first time on MTX 20mg weekly...
September 13, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28915838/gout-and-comorbidity-a-nominal-group-study-of-people-with-gout
#18
Jasvinder A Singh
BACKGROUND: Comorbidities are common in patients with gout, yet qualitative research is lacking. The study objective was to examine the impact of gout on comorbidities. METHODS: Nine nominal groups were conducted. Patients with gout discussed and rank-ordered their concerns in response to the question, "How does gout or its treatment affect your other conditions and their treatment?" RESULTS: Nine nominal groups had 45 gout patients, with mean age 61 years (standard deviation (SD) 10...
September 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28913596/-perioperative-management-of-immunosuppressive-treatment-in-patients-undergoing-joint-surgery
#19
K Krüger
The perioperative management of patients on immunosuppressive drugs is uncertain due to a lack of controlled studies. Continuation of medication without a pause may increase the risk of postoperative infections and wound healing disorders and when the pause is too long this can induce a flare of the underlying rheumatic disease. Additional factors, such as rheumatic disease activity, comorbidities, previous infections and the type of surgical procedure also modulate the risk. The highest risk of infection is associated with corticosteroids depending on the dose, so that a dosage as low as possible but stable in the perioperative period is recommended...
September 14, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28906316/secondary-loss-of-response-to-infliximab-in-pediatric-crohn-s-disease-does-it-matter-how-and-when-we-start
#20
Rishi Bolia, Jeremy Rosenbaum, Vered Schildkraut, Winita Hardikar, Mark Oliver, Donald Cameron, George Alex
OBJECTIVES: A significant proportion of children with Crohn's disease develop a secondary loss of response (LOR) to infliximab. Our aim was to study the impact of initial treatment strategies on secondary LOR. METHODS: We reviewed the medical records of children with Crohn's disease who received scheduled maintenance infliximab therapy for at least 12 months. We compared children who developed LOR with those who did not; with regards to their clinical and laboratory parameters, disease phenotype and treatment strategy before developing LOR...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
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