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https://www.readbyqxmd.com/read/28550744/evaluation-of-a-multi-site-program-designed-to-strengthen-relational-bonds-for-siblings-separated-by-foster-care
#1
Jeffrey Waid, Armeda Stevenson Wojciak
Sibling relationships in foster care settings have received increased attention in recent years. Despite growing evidence regarding the protective potential of sibling relationships for youth in care, some sibling groups continue to experience foster care related separation, and few programs exist to address the needs of these youth. This study describes and evaluates Camp To Belong, a multi-site program designed to provide short-term reunification to separated sibling groups through a week-long summer camp experience...
May 13, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28549648/characterization-of-long-term-gait-deficits-in-mouse-dmcao-using-the-catwalk-system
#2
E Caballero-Garrido, J C Pena-Philippides, Z Galochkina, E Erhardt, T Roitbak
Evaluation of functional outcome is widely used across species to assess the recovery process following various pathological conditions, including spinal cord injury, musculo-skeletal injury, mithochondrial disease, neuropathic cancer, Huntington's disease, chronic pain, cortical lesion, and olivocerebellar degeneration among others. The Stroke Therapy Academic Industry Roundtable (STAIR) recommends multiple endpoints for behavioral studies in pre-clinical stroke research, to demonstrate their clinical relevance...
May 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28549452/in-hospital-prognosis-and-long-term-mortality-of-stemi-in-a-reperfusion-network-head-to-head-analisys-invasive-reperfusion-vs-optimal-medical-therapy
#3
C García-García, N Ribas, L L Recasens, O Meroño, I Subirana, A Fernández, A Pérez, F Miranda, H Tizón-Marcos, J Martí-Almor, J Bruguera, R Elosua
BACKGROUND: ST Segment Elevation Acute myocardial infarction (STEMI) preferred treatment is culprit artery reperfusion with primary percutaneous coronary intervention (PPCI). We ought to analyze the benefit of early reperfusion vs. optimal medical therapy in STEMI before and after the set-up of a regional STEMI network that prioritizes PPCI. METHODS: Between January 2002 and December 2013, 1268 STEMI patients were consecutively admitted in a University Hospital...
May 26, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28549427/developing-an-australian-first-recovery-model-for-parents-in-victorian-mental-health-and-family-services-a-study-protocol-for-a-randomised-controlled-trial
#4
Darryl Maybery, Melinda Goodyear, Andrea Reupert, Jade Sheen, Warren Cann, Kim Dalziel, Phillip Tchernagovski, Brendan O'Hanlon, Henry von Doussa
BACKGROUND: A considerable number of people with a mental illness are parents caring for dependent children. For those with a mental illness, parenting can provide a sense of competence, belonging, identity and hope and hence is well aligned to the concept of personal recovery. However, little research has focused on the recovery journey of those who are parents and have a mental illness. This randomised controlled trial aims to (i) evaluate the effectiveness of an intervention model of recovery for parents (Let's Talk about Children) in three different mental health service sectors and (ii) examine the economic value of a larger roll out (longer term) of the parent recovery model...
May 26, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28549170/are-multidimensional-pain-inventory-coping-strategy-profiles-associated-with-long-term-spinal-cord-stimulation-effectiveness
#5
Mery Paroli, Olivia Bernini, Giuliano De Carolis, Lara Tollapi, Franca Bondi, Antonella Martini, Alessandro Dario, Adriana Paolicchi
Introduction.:  It is acknowledged that the way patients cope with pain may influence treatment outcome. In particular, psychological factors are deemed important when considering patients for suitability for spinal cord stimulation (SCS). Objective.:  The aim of the study is to observe how pre-implantation psychological characteristics impact the effectiveness of SCS for chronic pain. Methods.:  The analysis comprised data from 137 patients who underwent an SCS implant...
May 26, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28548626/correlates-of-protection-for-inactivated-enterovirus-71-vaccine-the-analysis-of-immunological-surrogate-endpoints
#6
Wenbo Zhu, Pengfei Jin, Jing-Xin Li, Feng-Cai Zhu, Pei Liu
BACKGROUND: Inactivated Enterovirus 71 (EV71) vaccines showed significant efficacy against the diseases associated with EV71 and a neutralizing antibody (NTAb) titer of 1:16-1:32 was suggested as the correlates of the vaccine protection. This paper aims to further estimate the immunological surrogate endpoints for the protection of inactivated EV71 vaccines and the effect factors. METHOD: Pre-vaccination NTAb against EV71 at baseline (day 0), post-vaccination NTAb against EV71 at day 56, and the occurrence of laboratory-confirmed EV71-associated diseases during a 24-months follow-up period were collected from a phase 3 efficacy trial of an inactivated EV71 vaccine...
May 26, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28548599/an-extent-of-resection-threshold-for-seizure-freedom-in-patients-with-low-grade-gliomas
#7
David S Xu, Al-Wala Awad, Chad Mehalechko, Jeffrey R Wilson, Lynn S Ashby, Stephen W Coons, Nader Sanai
OBJECTIVE Seizures are the most common presenting symptom of newly diagnosed WHO Grade II gliomas (low-grade glioma [LGG]) and significantly impair quality of life. Although gross-total resection of LGG is associated with better seizure control, it remains unclear whether an extent of resection (EOR) "threshold" exists for long-term seizure control. Specifically, what proportion of FLAIR-positive tissue in patients with newly diagnosed LGG must be removed to achieve Engel Class I seizure freedom? To clarify the EOR threshold for long-term seizure control, the authors analyzed data from a consecutive series of patients with newly diagnosed LGG who presented with seizures and subsequently underwent microsurgical resection...
May 26, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28547098/obstetrical-and-perinatal-morbidity-and-mortality-among-in-vitro-fertilization-pregnancies-a-population-based-study
#8
Hussein Sabban, Andrew Zakhari, Valerie Patenaude, Togas Tulandi, Haim A Abenhaim
PURPOSE: To compare patient characteristics and obstetrical/neonatal outcomes of in-vitro fertilization (IVF) and spontaneously conceived pregnancies. METHODS: Using the Nationwide Inpatient Sample, we conducted a retrospective cohort study from 2008 to 2011 comparing IVF conceptions to spontaneous ones. Patient characteristics were descriptively compared, and after adjusting for baseline characteristics with logistic regression, obstetrical/neonatal outcomes were also compared...
May 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28546678/effect-of-selected-yogic-practices-on-pain-and-disability-in-patients-with-lumbar-spondylitis
#9
Rajesh Kumar Manik, Ashok Kumar Mahapatra, Rajendra Gartia, Sumit Bansal, Ashis Patnaik
AIM: The study was designed to find the effect of selected yogic practices on lumbar spondylitis. MATERIALS AND METHODS: This was a prospective, randomized study without a control trial. A total of 172 participants with lumbar spondylitis (age 21-79 years) from the outpatient department (OPD) of neurosurgery, AIIMS, Bhubaneswar, were randomly assigned to receive yoga therapy. The module of selected yogic practices consisted of pawanamuktasana series 1 (loosening and strengthening), asana, pranayama, and relaxation techniques Yoga Nidra...
May 2017: International Journal of Yoga
https://www.readbyqxmd.com/read/28546543/metabolic-profiling-of-polycystic-ovary-syndrome-reveals-interactions-with-abdominal-obesity
#10
Alexessander Couto Alves, Beatriz Valcarcel, Ville-Petteri Mäkinen, Laure Morin-Papunen, Sylvain Sebert, Antti J Kangas, Pasi Soininen, Shikta Das, Maria De Iorio, Lachlan Coin, Mika Ala-Korpela, Marjo-Riitta Järvelin, Stephen Franks
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance, and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels. DESIGN AND METHODS: We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3,127)...
May 26, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28546325/reciprocal-interaction-of-24-hour-blood-pressure-variability-and-systolic-blood-pressure-on-outcome-in-stroke-thrombolysis
#11
Lars Kellert, Christian Hametner, Niaz Ahmed, Geraldine Rauch, Mary J MacLeod, Francesco Perini, Kennedy R Lees, Peter A Ringleb
BACKGROUND AND PURPOSE: Significance and management of blood pressure (BP) changes in acute stroke care are unclear. Here, we aimed to investigate the impact of 24-hour BP variability (BPV) on outcome in patients with acute ischemic stroke treated with intravenous thrombolysis. METHODS: From the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis registry, 28 976 patients with documented pre-treatment systolic BP at 2 and 24 hours were analyzed...
May 25, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28545678/rapid-synaptogenesis-in-the-nucleus-accumbens-is-induced-by-a-single-cocaine-administration-and-stabilized-by-mitogen-activated-protein-kinase-interacting-kinase-1-activity
#12
Marc Dos Santos, Marine Salery, Benoit Forget, Maria Alexandra Garcia Perez, Sandrine Betuing, Thomas Boudier, Peter Vanhoutte, Jocelyne Caboche, Nicolas Heck
BACKGROUND: Repeated cocaine exposure produces new spine formation in striatal projection neurons (SPNs) of the nucleus accumbens. However, an acute exposure to cocaine can trigger long-lasting synaptic plasticity in SPNs leading to behavioral alterations. This raises the intriguing question as to whether a single administration of cocaine could enduringly modify striatal connectivity. METHODS: A three-dimensional morphometric analysis of presynaptic glutamatergic boutons and dendritic spines was performed on SPNs 1 hour and 1 week after a single cocaine administration...
March 29, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28545501/pregnancy-induced-gene-expression-changes-in-vivo-among-women-with-rheumatoid-arthritis-a-pilot-study
#13
Dana E Goin, Mette Kiel Smed, Lior Pachter, Elizabeth Purdom, J Lee Nelson, Hanne Kjærgaard, Jørn Olsen, Merete Lund Hetland, Vibeke Zoffmann, Bent Ottesen, Damini Jawaheer
BACKGROUND: Little is known about gene expression changes induced by pregnancy in women with rheumatoid arthritis (RA) and healthy women because the few studies previously conducted did not have pre-pregnancy samples available as baseline. We have established a cohort of women with RA and healthy women followed prospectively from a pre-pregnancy baseline. In this study, we tested the hypothesis that pregnancy-induced changes in gene expression among women with RA who improve during pregnancy (pregDASimproved) overlap substantially with changes observed among healthy women and differ from changes observed among women with RA who worsen during pregnancy (pregDASworse)...
May 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28545461/interventions-to-reduce-inequalities-in-health-and-early-child-development-in-europe-from-a-qualitative-perspective
#14
Joana Morrison, Hynek Pikhart, Peter Goldblatt
BACKGROUND: Early childhood is a critical stage of development. Inequalities in experiences affect children's wellbeing and determine their development. Early years interventions focusing on children and their parents may help address inequalities during this critical period. Understanding the experiences and perceptions of parents receiving early years programmes and staff providing these may help service development and delivery. The objective of this study was to describe staff and parents' accounts of how early childhood programmes in different European country contexts improved child development...
May 25, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28545403/long-lasting-effect-of-obesity-on-skeletal-muscle-transcriptome
#15
Ilhem Messaoudi, Mithila Handu, Maham Rais, Suhas Sureshchandra, Byung S Park, Suzanne S Fei, Hollis Wright, Ashley E White, Ruhee Jain, Judy L Cameron, Kerri M Winters-Stone, Oleg Varlamov
BACKGROUND: Reduced physical activity and increased intake of calorically-dense diets are the main risk factors for obesity, glucose intolerance, and type 2 diabetes. Chronic overnutrition and hyperglycemia can alter gene expression, contributing to long-term obesity complications. While caloric restriction can reduce obesity and glucose intolerance, it is currently unknown whether it can effectively reprogram transcriptome to a pre-obesity level. The present study addressed this question by the preliminary examination of the transcriptional dynamics in skeletal muscle after exposure to overnutrition and following caloric restriction...
May 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28545161/classic-galactosemia-study-on-the-late-prenatal-development-of-galt-specific-activity-in-a-sheep-model
#16
Ana I Coelho, Jörgen Bierau, Martijn Lindhout, Jelle Achten, Boris W Kramer, M Estela Rubio-Gozalbo
BACKGROUND: Classic galactosemia results from deficient activity of galactose-1-phosphate uridylyltransferase (GALT), a key enzyme of galactose metabolism. Despite early diagnosis and early postnatal therapeutic intervention, patients still develop neurologic and fertility impairments. Prenatal developmental toxicity has been hypothesized as a determinant factor of disease. In order to shed light on the importance of prenatal GALT activity, several studies have examined GALT activity throughout development...
May 25, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28544997/exposure-to-ultrafine-particles-in-different-transport-modes-in-the-city-of-rome
#17
Mario Grana, Nicola Toschi, Laura Vicentini, Antonio Pietroiusti, Andrea Magrini
There is evidence of adverse health impacts from human exposure to particulate air pollution, including increased rates of respiratory and cardiovascular illness, hospitalizations, and pre-mature mortality. Most recent hypotheses assign an important role to ultrafine particles (UFP) (<0.1 μm) and to associated transition metals (in particular Fe). In a large city like Rome, where many active people spend more than one hour per day in private or public transportation, it may be important to evaluate the level of exposure to harmful pollutants which occurs during urban travelling...
May 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28544980/what-we-authors-reviewers-and-editors-of-scientific-work-can-learn-from-the-analytical-history-of-biological-3-nitrotyrosine
#18
REVIEW
Dimitrios Tsikas
Tyrosine and tyrosine residues in proteins are attacked by the reactive oxygen and nitrogen species peroxynitrite (O=N-OO(-)) to generate 3-nitrotyrosine (3-NT) and 3-nitrotyrosine-proteins (3-NTProt), respectively. 3-NT and 3-NTProt are widely accepted as biomarkers of nitr(os)ative stress. Over the years many different analytical methods have been reported for 3-NT and 3-NTProt. Reported concentrations often differ by more than three orders of magnitude, indicative of serious analytical problems. Strategies to overcome pre-analytical and analytical shortcomings and pitfalls have been proposed...
May 13, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28544223/long-term-outcomes-of-metacognitive-narrative-psychotherapy-for-people-diagnosed-with-schizophrenia
#19
Robert D Schweitzer, Melissa Greben, Rebecca Bargenquast
OBJECTIVES: This study investigated long-term outcomes of Metacognitive Narrative Psychotherapy. Previous studies have shown the approach to be effective in enhancing recovery and metacognition in people with a diagnosis of schizophrenia. DESIGN: A 2-year longitudinal follow-up case study design. METHODS: Eight people with a diagnosis of schizophrenia received an average of 52 sessions over 13-26 months. Follow-up interviews were conducted and self-report measures administered at approximately 2 years (22-30 months) post-completion of therapy...
May 24, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28543781/fracture-prospectively-recorded-from-pre-puberty-to-young-adulthood-are-they-markers-of-peak-bone-mass-and-strength-in-males
#20
Chevalley T, J-P Bonjour, M-C Audet, F Merminod, B van Rietbergen, R Rizzoli, S Ferrari
Fractures are common in otherwise healthy children and adolescents. They result from trauma of varying severity. Some reflect a greater skeletal fragility. A long-term implication of these fractures is their potentiality to predict adult bone fragility and increased risk of osteoporosis in later life. Using DXA, HR-pQCT and µFEA measurements, we previously found in 124 healthy females followed from the age of 7.9 to 20.4 years, substantial deficits in both structural and strength components of the radius in the 42 girls who sustained a fracture during skeletal development...
May 24, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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