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Michael Soares

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https://www.readbyqxmd.com/read/29789377/polyamine-modulation-of-anticonvulsant-drug-response-a-potential-mechanism-contributing-to-pharmacoresistance-in-chronic-epilepsy
#1
Niklas Michael Beckonert, Thoralf Opitz, Julika Pitsch, Patrício Soares da Silva, Heinz Beck
Despite the development of numerous novel anticonvulsant drugs, approximately 30% of epilepsy patients remain refractory to antiepileptic drugs (AEDs). Many established and novel AEDs reduce hyperexcitability via voltage- and use-dependent inhibition of voltage-gated Na+ channels. For the widely-used anticonvulsant carbamazepine (CBZ), use-dependent block of Na+ channels is significantly reduced both in experimental and human epilepsy. However, the molecular underpinnings of this potential cellular mechanism for pharmacoresistance have remained enigmatic...
May 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29730999/skin-picking-disorder-prevalence-correlates-and-associations-with-quality-of-life-in-a-large-sample
#2
Myrela O Machado, Cristiano A Köhler, Brendon Stubbs, Paulo R Nunes-Neto, Ai Koyanagi, João Quevedo, Jair C Soares, Thomas N Hyphantis, Donatella Marazziti, Michael Maes, Dan J Stein, André F Carvalho
OBJECTIVE: Evidence suggests that skin picking disorder (SPD) could be a prevalent condition associated with comorbidity and psychosocial dysfunction. However, just a few studies have assessed the prevalence and correlates of SPD in samples from low- and middle-income countries. In addition, the impact of SPD on quality of life (QoL) dimension after multivariable adjustment to potential confounders remains unclear. METHODS: Data were obtained from a Brazilian anonymous Web-based research platform...
May 7, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29720955/environmental-strategies-of-affect-regulation-and-their-associations-with-subjective-well-being
#3
Kalevi M Korpela, Tytti Pasanen, Veera Repo, Terry Hartig, Henk Staats, Michael Mason, Susana Alves, Ferdinando Fornara, Tony Marks, Sunil Saini, Massimiliano Scopelliti, Ana L Soares, Ulrika K Stigsdotter, Catharine Ward Thompson
Environmental strategies of affect regulation refer to the use of natural and urban socio-physical settings in the service of regulation. We investigated the perceived use and efficacy of environmental strategies for regulation of general affect and sadness, considering them in relation to other affect regulation strategies and to subjective well-being. Participants from Australia, Finland, Germany, Great Britain, Italy, India, the Netherlands, Portugal, and Sweden ( N = 507) evaluated the frequency of use and perceived efficacy of affect regulation strategies using a modified version of the Measure of Affect Regulation Styles (MARS)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29702159/quinolinic-acid-and-glutamatergic-neurodegeneration-in-caenorhabditis-elegans
#4
Tássia Limana da Silveira, Daniele Coradine Zamberlan, Leticia Priscilla Arantes, Marina Lopes Machado, Thayanara Cruz da Silva, Daniela de Freitas Câmara, Abel Santamaría, Michael Aschner, Felix Alexandre Antunes Soares
Quinolinic acid (QUIN) is an endogenous neurotoxin that acts as an N-methyl-D-aspartate receptor (NMDAR) agonist generating a toxic cascade, which can lead to neurodegeneration. The action of QUIN in Caenorhabditis elegans and the neurotoxins that allow the study of glutamatergic system disorders have not been carefully addressed. The effects of QUIN on toxicological and behavioral parameters in VM487 and VC2623 transgenic, as well as wild-type (WT) animals were performed to evaluate whether QUIN could be used as a neurotoxin in C...
April 24, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29673961/metabolic-effects-of-manganese-in-the-nematode-caenorhabditis-elegans-through-daergic-pathway-and-transcription-factors-activation
#5
Priscila Gubert, Bruna Puntel, Tassia Lehmen, Joshua P Fessel, Pan Cheng, Julia Bornhorst, Lucas Siqueira Trindade, Daiana S Avila, Michael Aschner, Felix A A Soares
Manganese (Mn) is an essential trace element for physiological functions since it acts as an enzymatic co-factor. Nevertheless, overexposure to Mn has been associated with a pathologic condition called manganism. Furthermore, Mn has been reported to affect lipid metabolism by mechanisms which have yet to be established. Herein, we used the nematode Caenorhabditis elegans to examine Mn's effects on the dopaminergic (DAergic) system and determine which transcription factors that regulate with lipid metabolism are affected by it...
April 16, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29582210/in-hospital-and-day-120-survival-of-critically-ill-solid-cancer-patients-after-discharge-of-the-intensive-care-units-results-of-a-retrospective-multicenter-study-a-groupe-de-recherche-respiratoire-en-r%C3%A3-animation-en-onco-h%C3%A3-matologie-grrr-oh-study
#6
François Vincent, Marcio Soares, Djamel Mokart, Virginie Lemiale, Fabrice Bruneel, Marouane Boubaya, Frédéric Gonzalez, Yves Cohen, Elie Azoulay, Michaël Darmon
OBJECTIVES: To assess outcomes at hospital discharge and day-120 after intensive care unit (ICU) discharge among patients with solid cancer admitted to ICU and to identify characteristics associated with in-hospital and day-120 after ICU discharge mortalities. DESIGN: International, multicenter, retrospective study. SETTING: Five ICUs in France and Brazil, two located in cancer centers, two in university affiliated and one in general hospitals...
March 27, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29483506/a-dual-mechanism-promotes-switching-of-the-stormorken-stim1-r304w-mutant-into-the-activated-state
#7
Marc Fahrner, Michael Stadlbauer, Martin Muik, Petr Rathner, Peter Stathopulos, Mitsu Ikura, Norbert Müller, Christoph Romanin
STIM1 and Orai1 are key components of the Ca2+ -release activated Ca2+ (CRAC) current. Orai1, which represents the subunit forming the CRAC channel complex, is activated by the ER resident Ca2+ sensor STIM1. The genetically inherited Stormorken syndrome disease has been associated with the STIM1 single point R304W mutant. The resulting constitutive activation of Orai1 mainly involves the CRAC-activating domain CAD/SOAR of STIM1, the exposure of which is regulated by the molecular interplay between three cytosolic STIM1 coiled-coil (CC) domains...
February 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29481584/hemochorial-placentation-development-function-and-adaptations
#8
Michael J Soares, Kaela Varberg, Khursheed Iqbal
Placentation is a reproductive adaptation that permits fetal growth and development within the protected confines of the female reproductive tract. Through this important role, the placenta also determines postnatal health and susceptibility to disease. The hemochorial placenta is prominent feature in primate and rodent development. This review offers an overview of the basics of hemochorial placental development and function, provides perspective on major discoveries that have shaped placental research, and thoughts on strategies for future investigation...
February 22, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29432457/the-spectrum-of-neurological-disease-associated-with-zika-and-chikungunya-viruses-in-adults-in-rio-de-janeiro-brazil-a-case-series
#9
Ravi Mehta, Cristiane Nascimento Soares, Raquel Medialdea-Carrera, Mark Ellul, Marcus Tulius Texeira da Silva, Anna Rosala-Hallas, Marcia Rodrigues Jardim, Girvan Burnside, Luciana Pamplona, Maneesh Bhojak, Radhika Manohar, Gabriel Amorelli Medeiros da Silva, Marcus Vinicius Adriano, Patricia Brasil, Rita Maria Ribeiro Nogueira, Carolina Cardoso Dos Santos, Lance Turtle, Patricia Carvalho de Sequeira, David W Brown, Michael J Griffiths, Ana Maria Bispo de Filippis, Tom Solomon
BACKGROUND: During 2015-16 Brazil experienced the largest epidemic of Zika virus ever reported. This arthropod-borne virus (arbovirus) has been linked to Guillain-Barré syndrome (GBS) in adults but other neurological associations are uncertain. Chikungunya virus has caused outbreaks in Brazil since 2014 but associated neurological disease has rarely been reported here. We investigated adults with acute neurological disorders for Zika, chikungunya and dengue, another arbovirus circulating in Brazil...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29428874/a-novel-hepatitis-b-virus-species-discovered-in-capuchin-monkeys-sheds-new-light-on-the-evolution-of-primate-hepadnaviruses
#10
Breno Frederico de Carvalho Dominguez Souza, Alexander König, Andrea Rasche, Ianei de Oliveira Carneiro, Nora Stephan, Victor Max Corman, Pia Luise Roppert, Nora Goldmann, Ramona Kepper, Simon Franz Müller, Christof Völker, Alex Junior Souza de Souza, Michele Soares Gomes-Gouvêa, Andrés Moreira-Soto, Andreas Stöcker, Michael Nassal, Carlos Roberto Franke, João Renato Rebello Pinho, Manoel do Carmo Pereira Soares, Joachim Geyer, Philippe Lemey, Christian Drosten, Eduardo Martins Netto, Dieter Glebe, Jan Felix Drexler
BACKGROUND & AIMS: All known hepatitis B virus (HBV) genotypes occur in humans and hominoid Old World non-human primates (NHPs). The divergent woolly monkey HBV (WMHBV) forms another orthohepadnavirus species. The evolutionary origins of HBV are unclear. METHODS: We analysed sera from 124 Brazilian monkeys collected during 2012-2016 for hepadnaviruses using molecular and serological tools, and conducted evolutionary analyses. RESULTS: We identified a novel orthohepadnavirus species in capuchin monkeys (capuchin monkey hepatitis B virus [CMHBV])...
February 8, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29415256/an-unbiased-genome-wide-view-of-the-mutation-rate-and-spectrum-of-the-endosymbiotic-bacterium-teredinibacter-turnerae
#11
Marcus V X Senra, Way Sung, Matthew Ackerman, Samuel F Miller, Michael Lynch, Carlos Augusto G Soares
Mutations contribute to genetic variation in all living systems. Thus, precise estimates of mutation rates and spectra across a diversity of organisms are required for a full comprehension of evolution. Here, a mutation-accumulation (MA) assay was carried out on the endosymbiotic bacterium Teredinibacter turnerae. After ∼3,025 generations, base-pair substitutions (BPSs) and insertion-deletion (indel) events were characterized by whole-genome sequencing analysis of 47 independent MA lines, yielding a BPS rate of 1...
March 1, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29367940/ex-vivo-trophoblast-specific-genetic-manipulation-using-lentiviral-delivery
#12
Damayanti Chakraborty, Masanaga Muto, Michael J Soares
In this protocol report, we describe a lentiviral gene delivery technique for genetic modification of the rat trophoblast cell lineage. Lentiviral packaged gene constructs can be efficiently and specifically delivered to the trophoblast cell lineage of the blastocyst. The consequences of 'gain-of-function' and 'loss-of-function' blastocyst manipulations can be evaluated with in vitro outgrowth assays or following transfer to pseudopregnant rats.
December 20, 2017: Bio-protocol
https://www.readbyqxmd.com/read/29366672/resuscitation-highlights-in-2017
#13
EDITORIAL
J P Nolan, J P Ornato, M J A Parr, G D Perkins, J Soar
No abstract text is available yet for this article.
March 2018: Resuscitation
https://www.readbyqxmd.com/read/29356769/enteroaggregative-escherichia-coli-subclinical-infection-and-coinfections-and-impaired-child-growth-in-the-mal-ed-cohort-study
#14
Aldo A M Lima, Alberto M Soares, José Q S Filho, Alexandre Havt, Ila F N Lima, Noélia L Lima, Cláudia B Abreu, Francisco S Junior, Rosa M S Mota, William K-Y Pan, Christopher Troeger, Pedro H Q S Medeiros, Herlice N Veras, Mara A Prata, Ben J J McCormick, Monica McGrath, Elizabeth T Rogawski, Eric R Houpt, James A Platts-Mills, Jean Gratz, Amidou Samie, Pascal Bessong, Sudhir Babji, Gangadeep Kang, Shahida Qureshi, Sadia Shakoor, Zulfigar A Bhutta, Rashidul Haque, Tahmeed Ahmed, Estomih R Mduma, Erling Svensen, Margaret Kosek, Pablo P Yori, Ladaporn Bodhidatta, Shrestha Jasmin, Carl J Mason, Dennis Lang, Michael Gottlieb, Richard L Guerrant
OBJECTIVE: We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first 6 months of life on child growth. METHODS: Nondiarrheal samples from 1684 children across 8 Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; more than 90% of children were followed-up twice weekly for the first 6 months of life...
February 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29330799/hypoxia-signaling-and-placental-adaptations
#15
Damayanti Chakraborty, Regan L Scott, Michael J Soares
Oxygen is an essential nutrient for cells. Oxygen is delivered to tissues via red blood cells through the vasculature. Molecular mechanisms mediating cellular responses to low oxygen tension have been identified. Hypoxia-inducible factors (HIFs) are activated by low oxygen and promote transcriptional regulation of downstream effector genes, which lead to cellular adaptations. Controlled hypoxia exposure is utilized as an experimental tool to investigate biological processes, regulating cellular adaptations...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29193635/inactivation-of-ammecr1-is-associated-with-growth-bone-and-heart-alterations
#16
Mariana Moysés-Oliveira, Giuliana Giannuzzi, Richard J Fish, Jill A Rosenfeld, Florence Petit, Maria de Fatima Soares, Leslie Domenici Kulikowski, Adriana Di-Battista, Malú Zamariolli, Fan Xia, Thomas Liehr, Nadezda Kosyakova, Gianna Carvalheira, Michael Parker, Eleanor G Seaby, Sarah Ennis, Rodney D Gilbert, R Tanner Hagelstrom, Maria L Cremona, Wenhui L Li, Alka Malhotra, Anjana Chandrasekhar, Denise L Perry, Ryan J Taft, Julie McCarrier, Donald G Basel, Joris Andrieux, Taiza Stumpp, Fernanda Antunes, Gustavo José Pereira, Marguerite Neerman-Arbez, Vera Ayres Meloni, Margaret Drummond-Borg, Maria Isabel Melaragno, Alexandre Reymond
We report five individuals with loss-of-function of the X-linked AMMECR1: a girl with a balanced X-autosome translocation and inactivation of the normal X-chromosome; two boys with maternally inherited and de novo nonsense variants; and two half-brothers with maternally inherited microdeletion variants. They present with short stature, cardiac and skeletal abnormalities, and hearing loss. Variants of unknown significance in AMMECR1 in four male patients from two families with partially overlapping phenotypes were previously reported...
February 2018: Human Mutation
https://www.readbyqxmd.com/read/29158425/improving-metabolic-health-through-precision-dietetics-in-mice
#17
William T Barrington, Phillip Wulfridge, Ann E Wells, Carolina Mantilla Rojas, Selene Y F Howe, Amie Perry, Kunjie Hua, Michael A Pellizzon, Kasper D Hansen, Brynn H Voy, Brian J Bennett, Daniel Pomp, Andrew P Feinberg, David W Threadgill
The incidence of diet-induced metabolic disease has soared over the last half-century, despite national efforts to improve health through universal dietary recommendations. Studies comparing dietary patterns of populations with health outcomes have historically provided the basis for healthy diet recommendations. However, evidence that population-level diet responses are reliable indicators of responses across individuals is lacking. This study investigated how genetic differences influence health responses to several popular diets in mice, which are similar to humans in genetic composition and the propensity to develop metabolic disease, but enable precise genetic and environmental control...
January 2018: Genetics
https://www.readbyqxmd.com/read/29105383/hypoxia-and-placental-development
#18
REVIEW
Michael J Soares, Khursheed Iqbal, Keisuke Kozai
Hemochorial placentation is orchestrated through highly regulated temporal and spatial decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell acquisition of specializations facilitating invasion and uterine spiral artery remodeling is a labile process, sensitive to the environment, and represents a process that is vulnerable to dysmorphogenesis in pathologic states. Hypoxia is a signal guiding placental development, and molecular mechanisms directing cellular adaptations to low oxygen tension are integral to trophoblast cell differentiation and placentation...
October 16, 2017: Birth Defects Research
https://www.readbyqxmd.com/read/29099391/different-growth-regimes-in-inp-nanowire-growth-mediated-by-ag-nanoparticles
#19
Douglas Soares Oliveira, Mariana Zavarize, Luiz H G Tizei, Michael Walls, Carlos Ospina, Fernando Iikawa, Daniel Ugarte, Monica A Cotta
We report on the existence of two different regimes in one-step Ag-seeded InP nanowire growth. The vapor-liquid-solid- mechanism is present at larger In precursor flows and temperatures, ~500°C, yielding high aspect ratio and pure wurtzite InP nanowires with a semi-spherical metal particle at the thin apex. Periodic diameter oscillations can be achieved under extreme In supersaturations at this temperature range, showing the presence of a liquid catalyst. However, under lower temperatures and In precursor flows, large diameter InP nanowires with mixed wurtzite/zincblende segments are obtained, similarly to In-assisted growth...
November 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29079468/addition-of-vitamin-d-reverses-the-decline-in-gfr-following-treatment-with-ace-inhibitors-angiotensin-receptor-blockers-in-patients-with-chronic-kidney-disease
#20
Abel Esteves Soares, Michael Maes, Paula Godeny, Andressa Keiko Matsumoto, Décio Sabbatini Barbosa, Taysa Antonia F da Silva, Flávio Henrique M O Souza, Vinicius Daher Alvares Delfino
AIMS: Vitamin D has anti-inflammatory, anti-fibrotic effect, and may block the intrarenal renin-angiotensin system. Adequate vitamin D levels in conjunction with the use of Angiotensin-converting Enzyme Inhibitors/Angiotensin Receptor Blockers may help to slow down chronic kidney disease progression. MAIN METHODS: To study a possible beneficial effect of vitamin D supplementation in chronic kidney disease patients using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers on chronic kidney disease progression we performed a clinical study involving vitamin D supplementation in patients with deficiency of this vitamin...
December 15, 2017: Life Sciences
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