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Michael Soares

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https://www.readbyqxmd.com/read/29105383/hypoxia-and-placental-development
#1
REVIEW
Michael J Soares, Khursheed Iqbal, Keisuke Kozai
Hemochorial placentation is orchestrated through highly regulated temporal and spatial decisions governing the fate of trophoblast stem/progenitor cells. Trophoblast cell acquisition of specializations facilitating invasion and uterine spiral artery remodeling is a labile process, sensitive to the environment, and represents a process that is vulnerable to dysmorphogenesis in pathologic states. Hypoxia is a signal guiding placental development, and molecular mechanisms directing cellular adaptations to low oxygen tension are integral to trophoblast cell differentiation and placentation...
October 16, 2017: Birth defects research
https://www.readbyqxmd.com/read/29099391/different-growth-regimes-in-inp-nanowire-growth-mediated-by-ag-nanoparticles
#2
Douglas Soares Oliveira, Mariana Zavarize, Luiz H G Tizei, Michael Walls, Carlos Ospina, Fernando Iikawa, Daniel Ugarte, Monica A Cotta
We report on the existence of two different regimes in one-step Ag-seeded InP nanowire growth. The vapor-liquid-solid- mechanism is present at larger In precursor flows and temperatures, ~500°C, yielding high aspect ratio and pure wurtzite InP nanowires with a semi-spherical metal particle at the thin apex. Periodic diameter oscillations can be achieved under extreme In supersaturations at this temperature range, showing the presence of a liquid catalyst. However, under lower temperatures and In precursor flows, large diameter InP nanowires with mixed wurtzite/zincblende segments are obtained, similarly to In-assisted growth...
November 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29079468/addition-of-vitamin-d-reverses-the-decline-in-gfr-following-treatment-with-ace-inhibitors-angiotensin-receptor-blockers-in-patients-with-chronic-kidney-disease
#3
Abel Esteves Soares, Michael Maes, Paula Godeny, Andressa Keiko Matsumoto, Décio Sabbatini Barbosa, Taysa Antonia F da Silva, Flávio Henrique M O Souza, Vinicius Daher Alvares Delfino
AIMS: Vitamin D has anti-inflammatory, anti-fibrotic effect, and may block the intrarenal renin-angiotensin system. Adequate vitamin D levels in conjunction with the use of Angiotensin-converting Enzyme Inhibitors/Angiotensin Receptor Blockers may help to slow down chronic kidney disease progression. MAIN METHODS: To study a possible beneficial effect of vitamin D supplementation in chronic kidney disease patients using angiotensin-converting enzyme inhibitors/angiotensin receptor blockers on chronic kidney disease progression we performed a clinical study involving vitamin D supplementation in patients with deficiency of this vitamin...
October 30, 2017: Life Sciences
https://www.readbyqxmd.com/read/28978747/optimal-dynamic-soaring-consists-of-successive-shallow-arcs
#4
Gabriel D Bousquet, Michael S Triantafyllou, Jean-Jacques E Slotine
Albatrosses can travel a thousand kilometres daily over the oceans. They extract their propulsive energy from horizontal wind shears with a flight strategy called dynamic soaring. While thermal soaring, exploited by birds of prey and sports gliders, consists of simply remaining in updrafts, extracting energy from horizontal winds necessitates redistributing momentum across the wind shear layer, by means of an intricate and dynamic flight manoeuvre. Dynamic soaring has been described as a sequence of half-turns connecting upwind climbs and downwind dives through the surface shear layer...
October 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28916652/lsd1-mediated-epigenetic-reprogramming-drives-cenpe-expression-and-prostate-cancer-progression
#5
Yi Liang, Musaddeque Ahmed, Haiyang Guo, Fraser Soares, Junjie T Hua, Shuai Gao, Catherine Lu, Christine Poon, Wanting Han, Jens Langstein, Muhammad B Ekram, Brian Li, Elai Davicioni, Mandeep Takhar, Nicholas Erho, R Jeffrey Karnes, Dianne Chadwick, Theodorus van der Kwast, Paul C Boutros, Cheryl H Arrowsmith, Felix Y Feng, Anthony M Joshua, Amina Zoubeidi, Changmeng Cai, Housheng H He
Androgen receptor (AR) signaling is a key driver of prostate cancer, and androgen-deprivation therapy (ADT) is a standard treatment for patients with advanced and metastatic disease. However, patients receiving ADT eventually develop incurable castration-resistant prostate cancer (CRPC). Here, we report that the chromatin modifier LSD1, an important regulator of AR transcriptional activity, undergoes epigenetic reprogramming in CRPC. LSD1 reprogramming in this setting activated a subset of cell-cycle genes, including CENPE, a centromere binding protein and mitotic kinesin...
October 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28906319/enteroaggregative-e-coli-subclinical-infection-and-co-infections-and-impaired-child-growth-in-the-mal-ed-cohort-study
#6
Aldo A M Lima, Alberto M Soares, José Q S Filho, Alexandre Havt, Ila F N Lima, Noélia L Lima, Cláudia B Abreu, Francisco S Junior, Rosa M S Mota, William K-Y Pan, Christopher Troeger, Pedro H Q S Medeiros, Herlice N Vera, Mara M G Prata, Ben McCormick, Monica McGrath, Elizabeth Rogawski, Eric Houpt, James Platts-Mills, Jean Gratz, Amidou Samie, Pascal Bessong, Sudhir Babji, Gangadeep Kang, Qureshi Shahida, Sadia Shakoor, Zulfiqar Bhutta, Rashidul Haque, Tahmeed Ahmed, Estomih Mduma, Erling Svensen, Margaret Kosek, Pablo Penataro Yori, Ladaporn Bodhidatta, Shrestha Jasmin, Carl Mason, Dennis Lang, Michael Gottlieb, Richard L Guerrant
OBJECTIVE: We evaluated the impact of subclinical enteroaggregative Escherichia coli (EAEC) infection alone and in combination with other pathogens in the first six months of life on child growth. METHODS: Non-diarrheal samples from 1,684 children across eight Multisite Birth Cohort Study, Malnutrition and Enteric Diseases (MAL-ED) sites in Asia, Africa, and Latin America were tested monthly; over 90% of children were followed-up twice weekly for the first six months of life...
September 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28861630/an-integrated-inverse-model-experimental-approach-to-determine-soft-tissue-three-dimensional-constitutive-parameters-application-to-post-infarcted-myocardium
#7
Reza Avazmohammadi, David S Li, Thomas Leahy, Elizabeth Shih, João S Soares, Joseph H Gorman, Robert C Gorman, Michael S Sacks
Knowledge of the complete three-dimensional (3D) mechanical behavior of soft tissues is essential in understanding their pathophysiology and in developing novel therapies. Despite significant progress made in experimentation and modeling, a complete approach for the full characterization of soft tissue 3D behavior remains elusive. A major challenge is the complex architecture of soft tissues, such as myocardium, which endows them with strongly anisotropic and heterogeneous mechanical properties. Available experimental approaches for quantifying the 3D mechanical behavior of myocardium are limited to preselected planar biaxial and 3D cuboidal shear tests...
August 31, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28840459/pancreatogastrostomy-vs-pancreatojejunostomy-a-risk-stratified-analysis-of-5316-pancreatoduodenectomies
#8
Brett L Ecker, Matthew T McMillan, Laura Maggino, Valentina Allegrini, Horacio J Asbun, Chad G Ball, Claudio Bassi, Joal D Beane, Stephen W Behrman, Adam C Berger, Mark Bloomston, Mark P Callery, John D Christein, Euan Dickson, Elijah Dixon, Jeffrey A Drebin, Carlos Fernandez-Del Castillo, William E Fisher, Zhi Ven Fong, Ericka Haverick, Robert H Hollis, Michael G House, Steven J Hughes, Nigel B Jamieson, Tara S Kent, Stacy J Kowalsky, John W Kunstman, Giuseppe Malleo, Ronald R Salem, Kevin C Soares, Vicente Valero, Ammara A Watkins, Christopher L Wolfgang, Amer H Zureikat, Charles M Vollmer
No abstract text is available yet for this article.
August 24, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28822104/comparison-of-the-toxic-effects-of-quinolinic-acid-and-3-nitropropionic-acid-in-c-elegans-involvement-of-the-skn-1-pathway
#9
Ilan Kotlar, Aline Colonnello, María Fernanda Aguilera-González, Daiana Silva Avila, María Eduarda de Lima, Rodolfo García-Contreras, Alma Ortíz-Plata, Félix Alexandre Antunes Soares, Michael Aschner, Abel Santamaría
The tryptophan metabolite, quinolinic acid (QUIN), and the mitochondrial toxin 3-nitropropionic acid (3-NP) are two important tools for toxicological research commonly used in neurotoxic models of excitotoxicity, oxidative stress, energy depletion, and neuronal cell death in mammals. However, their toxic properties have yet to be explored in the nematode Caenorhabditis elegans (C. elegans) for the establishment of novel, simpler, complementary, alternative, and predictive neurotoxic model of mammalian neurotoxicity...
August 18, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28755142/erratum-to-white-matter-measures-are-near-normal-in-controlled-hiv-infection-except-in-those-with-cognitive-impairment-and-longer-hiv-duration
#10
Lucette A Cysique, James R Soares, Guangqiang Geng, Maia Scarpetta, Kirsten Moffat, Michael Green, Bruce J Brew, Roland G Henry, Caroline Rae
No abstract text is available yet for this article.
August 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28725926/the-intensive-care-medicine-research-agenda-on-critically-ill-oncology-and-hematology-patients
#11
REVIEW
Elie Azoulay, Peter Schellongowski, Michael Darmon, Philippe R Bauer, Dominique Benoit, Pieter Depuydt, Jigeeshu V Divatia, Virginie Lemiale, Maarten van Vliet, Anne-Pascale Meert, Djamel Mokart, Stephen M Pastores, Anders Perner, Frédéric Pène, Peter Pickkers, Kathryn A Puxty, Francois Vincent, Jorge Salluh, Ayman O Soubani, Massimo Antonelli, Thomas Staudinger, Michael von Bergwelt-Baildon, Marcio Soares
Over the coming years, accelerating progress against cancer will be associated with an increased number of patients who require life-sustaining therapies for infectious or toxic chemotherapy-related events. Major changes include increased number of cancer patients admitted to the ICU with full-code status or for time-limited trials, increased survival and quality of life in ICU survivors, changing prognostic factors, early ICU admission for optimal monitoring, and use of noninvasive diagnostic and therapeutic strategies...
July 19, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28710952/indices-of-insulin-resistance-and-glucotoxicity-are-not-associated-with-bipolar-disorder-or-major-depressive-disorder-but-are-differently-associated-with-inflammatory-oxidative-and-nitrosative-biomarkers
#12
Kamila Landucci Bonifácio, Décio Sabbatini Barbosa, Estefânia Gastaldello Moreira, Carine Coneglian de Farias, Luciana Higachi, Alissana Ester Iakmiu Camargo, Janaina Favaro Soares, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Michael Berk, Seetal Dodd, Michael Maes
BACKGROUND: Insulin resistance (IR) is a key factor in diabetes mellitus, metabolic syndrome (MetS) and obesity and may occur in mood disorders and tobacco use disorder (TUD), where disturbances of immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways are important shared pathophysiological pathways. METHODS: This study aimed to a) examine IR and β-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and β cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or without MetS and TUD, versus 46 healthy controls, and b) whether IR is associated with IO&NS biomarkers, including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), plasma advanced oxidation protein products (AOPP), C-reactive protein (CRP), haptoglobin (Hp) and uric acid...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28622511/metabolic-adaptation-establishes-disease-tolerance-to-sepsis
#13
Sebastian Weis, Ana Rita Carlos, Maria Raquel Moita, Sumnima Singh, Birte Blankenhaus, Silvia Cardoso, Rasmus Larsen, Sofia Rebelo, Sascha Schäuble, Laura Del Barrio, Gilles Mithieux, Fabienne Rajas, Sandro Lindig, Michael Bauer, Miguel P Soares
Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance is a defense strategy against infection that preserves host homeostasis without exerting a direct negative impact on pathogens. Here, we demonstrate that induction of the iron-sequestering ferritin H chain (FTH) in response to polymicrobial infections is critical to establish disease tolerance to sepsis. The protective effect of FTH is exerted via a mechanism that counters iron-driven oxidative inhibition of the liver glucose-6-phosphatase (G6Pase), and in doing so, sustains endogenous glucose production via liver gluconeogenesis...
June 15, 2017: Cell
https://www.readbyqxmd.com/read/28603584/acute-calculous-cholecystitis-review-of-current-best-practices
#14
REVIEW
Carlos Augusto Gomes, Cleber Soares Junior, Salomone Di Saverio, Massimo Sartelli, Michael Denis Kelly, Camila Couto Gomes, Felipe Couto Gomes, Lívia Dornellas Corrêa, Camila Brandão Alves, Samuel de Fádel Guimarães
Acute calculous cholecystitis (ACC) is the most frequent complication of cholelithiasis and represents one-third of all surgical emergency hospital admissions, many aspects of the disease are still a matter of debate. Knowledge of the current evidence may allow the surgical team to develop practical bedside decision-making strategies, aiming at a less demanding procedure and lower frequency of complications. In this regard, recommendations on the diagnosis supported by specific criteria and severity scores are being implemented, to prioritize patients eligible for urgency surgery...
May 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28594741/characterization-and-optimal-management-of-high-risk-pancreatic-anastomoses-during-pancreatoduodenectomy
#15
Brett L Ecker, Matthew T McMillan, Horacio J Asbun, Chad G Ball, Claudio Bassi, Joal D Beane, Stephen W Behrman, Adam C Berger, Euan J Dickson, Mark Bloomston, Mark P Callery, John D Christein, Elijah Dixon, Jeffrey A Drebin, Carlos Fernandez-Del Castillo, William E Fisher, Zhi Ven Fong, Ericka Haverick, Robert H Hollis, Michael G House, Steven J Hughes, Nigel B Jamieson, Ammar A Javed, Tara S Kent, Stacy J Kowalsky, John W Kunstman, Giuseppe Malleo, Katherine E Poruk, Ronald R Salem, Carl R Schmidt, Kevin Soares, John A Stauffer, Vicente Valero, Lavanniya K P Velu, Amarra A Watkins, Christopher L Wolfgang, Amer H Zureikat, Charles M Vollmer
OBJECTIVE: The aim of this study was to identify the optimal fistula mitigation strategy following pancreaticoduodenectomy. BACKGROUND: The utility of technical strategies to prevent clinically relevant postoperative pancreatic fistula (CR-POPF) following pancreatoduodenectomy (PD) may vary by the circumstances of the anastomosis. The Fistula Risk Score (FRS) identifies a distinct high-risk cohort (FRS 7 to 10) that demonstrates substantially worse clinical outcomes...
June 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28576872/origin-of-a-rapidly-evolving-homeostatic-control-system-programming-testis-function
#16
Pengli Bu, Shintaro Yagi, Kunio Shiota, S M Khorshed Alam, Jay L Vivian, Michael W Wolfe, M A Karim Rumi, Damayanti Chakraborty, Kaiyu Kubota, Pramod Dhakal, Michael J Soares
Mammals share common strategies for regulating reproduction, including a conserved hypothalamic-pituitary-gonadal axis; yet, individual species exhibit differences in reproductive performance. In this report, we describe the discovery of a species-restricted homeostatic control system programming testis growth and function. Prl3c1 is a member of the prolactin gene family and its protein product (PLP-J) was discovered as a uterine cytokine contributing to the establishment of pregnancy. We utilized mouse mutagenesis of Prl3c1 and revealed its involvement in the regulation of the male reproductive axis...
August 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28576389/healthcare-utilization-in-adults-with-opioid-dependence-receiving-extended-release-naltrexone-compared-to-treatment-as-usual
#17
William E Soares, Donna Wilson, Niels Rathlev, Joshua D Lee, Michael Gordon, Edward V Nunes, Charles P O'Brien, Peter D Friedmann
BACKGROUND: Opioid use disorders have reached epidemic proportions, with overdose now the leading cause of accidental death in the United States. Extended release naltrexone (XR-NTX) has emerged as a medication treatment that reduces opioid use and craving. However, the effect of XR-NTX therapy on acute healthcare utilization, including emergency department visits and inpatient hospitalizations, remains uncertain. The objective of the current study is to evaluate hospital-based healthcare resource utilization in adults involved in the criminal justice system with a history of opioid use disorder randomized to XR-NTX therapy compared with treatment as usual (TAU) during a 6-month treatment phase and 12months post-treatment follow up...
May 12, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28566537/corrigendum-mutations-in-genes-encoding-condensins-cause-microcephaly-through-decatenation-failure-at-mitosis
#18
Carol-Anne Martin, Jennie E Murray, Paula Carroll, Andrea Leitch, Karen J MacKenzie, Mihail Halachev, Ahmed E Fetit, Charlotte Keith, Louise S Bicknell, Adeline Fluteau, Philippe Gautier, Emma A Hall, Shelagh Joss, Gabriela Soares, João Silva, Michael B Bober, Angela Duker, Carol A Wise, Alan J Quigley, Shubha R Phadke, Andrew J Wood, Paola Vagnarelli, Andrew P Jackson
No abstract text is available yet for this article.
May 1, 2017: Genes & Development
https://www.readbyqxmd.com/read/28550365/a-longitudinal-study-of-neurotrophic-oxidative-and-inflammatory-markers-in-first-onset-depression-in-midlife-women
#19
Matheus A Pasquali, Bernard L Harlow, Claudio N Soares, Michael W Otto, Lee S Cohen, Luciano Minuzzi, Daniel P Gelain, Jose Claudio F Moreira, Benicio N Frey
Prospective studies have shown during the years preceding and following menopause, also known as "menopause transition", that midlife women are at higher risk for developing first-onset major depressive disorder (MDD). The biological factors associated with risk and resilience in this population are, however, largely unknown. Considering the growing body of evidence suggesting that inflammation, oxidative stress, and brain-derived neurotrophic factor (BDNF) are associated with the pathophysiology of MDD, we investigated serum levels of protein carbonyl, lipid peroxidation (thiobarbituric acid reactive substances-TBARS), thiol group content, BDNF, 3-nitrotyrosine, and heat shock protein 70 (HSP70) in a longitudinal cohort of first-onset MDD...
May 26, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28544903/estrogen-receptor-%C3%AE-deficiency-impairs-bdnf-5-ht2a-signaling-in-the-hippocampus-of-female-brain-a-possible-mechanism-for-menopausal-depression
#20
Anindit Chhibber, Sarah K Woody, M A Karim Rumi, Michael J Soares, Liqin Zhao
Depression currently affects 350 million people worldwide and 19 million Americans each year. Women are 2.5 times more likely to experience major depression than men, with some women appearing to be at a heightened risk during the menopausal transition. Estrogen signaling has been implicated in the pathophysiology of mood disorders including depression; however, the underlying mechanisms are poorly understood. In this study, the role of estrogen receptor (ER) subtypes, ERα and ERβ, in the regulation of brain-derived neurotrophic factor (BDNF) and serotonin (5-HT) signaling was investigated; two pathways that have been hypothesized to be interrelated in the etiology of depression...
August 2017: Psychoneuroendocrinology
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