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Carl weiner

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https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#1
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29220353/research-on-hiv-cure-mapping-the-ethics-landscape
#2
Karine Dubé, Laurie Sylla, Lynda Dee, Jeff Taylor, David Evans, Carl Dean Bruton, Adam Gilberston, Lisa Gralinski, Brandon Brown, Asheley Skinner, Bryan J Weiner, Sandra B Greene, Amy Corneli, Adaora A Adimora, Joseph D Tucker, Stuart Rennie
In an essay, Karine Dubé and coauthors discuss the ethics of preclinical and clinical studies relevant to achieving an HIV cure.
December 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29112664/placental-alpha-microglobulin-1-compared-with-fetal-fibronectin-to-predict-preterm-delivery-in-symptomatic-women
#3
Deborah A Wing, Sina Haeri, Angela C Silber, Cheryl K Roth, Carl P Weiner, Nelson C Echebiri, Albert Franco, Lanissa M Pappas, John D Yeast, Angelle A Brebnor, J Gerald Quirk, Aisling M Murphy, Louise C Laurent, Nancy T Field, Mary E Norton
OBJECTIVE: To compare the rapid bedside test for placental α microglobulin-1 with the instrumented fetal fibronectin test for prediction of imminent spontaneous preterm delivery among women with symptoms of preterm labor. METHODS: We conducted a prospective observational study on pregnant women with signs or symptoms suggestive of preterm labor between 24 and 35 weeks of gestation with intact membranes and cervical dilatation less than 3 cm. Participants were prospectively enrolled at 15 U...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28571031/perimortem-demonstration-and-treatment-of-recipient-to-donor-transfusion-in-monochorionic-diamniotic-twin-gestation
#4
Jessica Parrott, Tricia Schwartz, Tracy Cowles, Marium Holland, Carl P Weiner
Twin-twin transfusion syndrome is a complication of monochorionic-diamniotic placentation. Should one twin die, ≈30% of co-twins will also die, and if they survive, ≈30% experience severe morbidity rates, each believed secondary to hemorrhage of the co-twin into the deceased twin. We report apparently the first ultrasound-documented case of perimortem hemorrhage in twin-twin transfusion syndrome and its treatment by emergent ultrasound-guided percutaneous cord occlusion followed by percutaneous fetal intravascular transfusion...
2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28476165/microrna-205-promotes-cell-invasion-by-repressing-tcf21-in-human-ovarian-cancer
#5
Jun Wei, Lahong Zhang, Jennifer Li, Shuguang Zhu, Minghui Tai, Clifford W Mason, Julia A Chapman, Evelyn A Reynolds, Carl P Weiner, Helen H Zhou
BACKGROUND: Ovarian cancer is the leading lethal, gynecological malignancy in the United States. No doubt, the continued morbidity and mortality of ovarian cancer reflects a poor understanding of invasive mechanisms. Recent studies reveal that ovarian cancers express aberrant microRNAs (miRNAs or miRs), some of which have oncogenic or tumor suppressor properties. Several studies suggested that miR-205 is involved in tumorigenesis. Presently, we investigate the molecular mechanisms and target of miR-205 in ovarian cancer...
May 5, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28344359/privacy-and-security-in-mobile-health-a-research-agenda
#6
David Kotz, Carl A Gunter, Santosh Kumar, Jonathan P Weiner
Mobile health technology has great potential to increase healthcare quality, expand access to services, reduce costs, and improve personal wellness and public health. However, mHealth also raises significant privacy and security challenges.
June 2016: Computer
https://www.readbyqxmd.com/read/28193189/assessment-of-dha-on-reducing-early-preterm-birth-the-adore-randomized-controlled-trial-protocol
#7
RANDOMIZED CONTROLLED TRIAL
Susan E Carlson, Byron J Gajewski, Christina J Valentine, Lynette K Rogers, Carl P Weiner, Emily A DeFranco, Catalin S Buhimschi
BACKGROUND: Preterm birth contributes to 0.5 million deliveries in the United States (one of eight pregnancies) and poses a huge burden on public health with costs in the billions. Of particular concern is that the rate of earliest preterm birth (<34 weeks) (ePTB), which has decreased little since 1990 and has the greatest impact on the overall infant mortality, resulting in the greatest cost to society. Docosahexaenoic acid (DHA) supplementation provides a potential high yield, low risk strategy to reduce early preterm delivery in the US by up to 75%...
February 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27233245/in-vivo-neurochemical-characterization-of-developing-guinea-pigs-and-the-effect-of-chronic-fetal-hypoxia
#8
Wen-Tung Wang, Phil Lee, Yafeng Dong, Hung-Wen Yeh, Jieun Kim, Carl P Weiner, William M Brooks, In-Young Choi
The guinea pig is a frequently used animal model for human pregnancy complications, such as oxygen deprivation or hypoxia, which result in altered brain development. To investigate the impact of in utero chronic hypoxia on brain development, pregnant guinea pigs underwent either normoxic or hypoxic conditions at about 70 % of 65-day term gestation. After delivery, neurochemical profiles consisting of 19 metabolites and macromolecules were obtained from the neonatal cortex, hippocampus, and striatum from birth to 12 weeks postpartum using in vivo (1)H MR spectroscopy at 9...
July 2016: Neurochemical Research
https://www.readbyqxmd.com/read/26972897/placental-origins-of-adverse-pregnancy-outcomes-potential-molecular-targets-an-executive-workshop-summary-of-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development
#9
John V Ilekis, Ekaterini Tsilou, Susan Fisher, Vikki M Abrahams, Michael J Soares, James C Cross, Stacy Zamudio, Nicholas P Illsley, Leslie Myatt, Christine Colvis, Maged M Costantine, David M Haas, Yoel Sadovsky, Carl Weiner, Erik Rytting, Gene Bidwell
Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related disorders, a significant gap exists in the utilization of this information for the development of new drug therapies to improve pregnancy outcome. On March 5-6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap...
July 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26254842/myths-and-realities-of-training-in-obstetric-emergencies
#10
REVIEW
Timothy J Draycott, Katherine J Collins, Joanna F Crofts, Dimitrios Siassakos, Cathy Winter, Carl P Weiner, Fiona Donald
Training for intrapartum emergencies is a promising strategy to reduce preventable harm during birth; however, not all training is clinically effective. Many myths have developed around such training. These principally derive from misinformed beliefs that all training must be effective, cheap, independent of context and sustainable. The current evidence base for effective training supports local, unit-based and multi-professional training, with appropriate mannequins, and practice-based tools to support the best care...
November 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/26135785/is-an-isolated-ventricular-septal-defect-detected-before-24-weeks-on-ultrasound-associated-with-fetal-aneuploidy
#11
Gene Lee, Susie X Fong, Maitreyi Salpekar, Catherine L Satterwhite, Carl Weiner
OBJECTIVE: Whether the isolated VSD (i-VSD) is associated with aneuploidy to the same degree as a more severe heart anomaly is unclear. Our objective was to determine the likelihood of aneuploidy in pregnancies at a tertiary referral center when an i-VSD is detected before 24 weeks. METHODS: A retrospective chart review of all detailed anatomy ultrasounds before 24 weeks performed at the University of Kansas Medical Center from 08/23/2006 to 06/07/2012 was conducted...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25504885/chronic-fetal-hypoxia-affects-axonal-maturation-in-guinea-pigs-during-development-a-longitudinal-diffusion-tensor-imaging-and-t2-mapping-study
#12
Jieun Kim, In-Young Choi, Yafeng Dong, Wen-Tung Wang, William M Brooks, Carl P Weiner, Phil Lee
PURPOSE: To investigate the impact of chronic hypoxia on neonatal brains, and follow developmental alterations and adaptations noninvasively in a guinea pig model. Chronic hypoxemia is the prime cause of fetal brain injury and long-term sequelae such as neurodevelopmental compromise, seizures, and cerebral palsy. MATERIALS AND METHODS: Thirty guinea pigs underwent either normoxic and hypoxemic conditions during the critical stage of brain development (0.7 gestation) and studied prenatally (n = 16) or perinatally (n = 14)...
September 2015: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/25465168/altered-inflammatory-activity-associated-with-reduced-hippocampal-volume-and-more-severe-posttraumatic-stress-symptoms-in-gulf-war-veterans
#13
Aoife O'Donovan, Linda L Chao, Jennifer Paulson, Kristin W Samuelson, Judy K Shigenaga, Carl Grunfeld, Mike W Weiner, Thomas C Neylan
BACKGROUND: Inflammation may reduce hippocampal volume by blocking neurogenesis and promoting neurodegeneration. Posttraumatic stress disorder (PTSD) has been linked with both elevated inflammation and reduced hippocampal volume. However, few studies have examined associations between inflammatory markers and hippocampal volume, and none have examined these associations in the context of PTSD. METHODS: We measured levels of the inflammatory markers interleukin-6 (IL-6) and soluble receptor II for tumor necrosis factor (sTNF-RII) as well as hippocampal volume in 246 Gulf War veterans with and without current and past PTSD as assessed with the Clinician Administered PTSD Scale (CAPS)...
January 2015: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/25261564/effect-of-prostaglandin-e2-on-multidrug-resistance-transporters-in-human-placental-cells
#14
Clifford W Mason, Gene T Lee, Yafeng Dong, Helen Zhou, Lily He, Carl P Weiner
Prostaglandin (PG) E2, a major product of cyclooxygenase (COX)-2, acts as an immunomodulator at the maternal-fetal interface during pregnancy. It exerts biologic function through interaction with E-prostanoid (EP) receptors localized to the placenta. The activation of the COX-2/PGE2/EP signal pathway can alter the expression of the ATP-binding cassette (ABC) transporters, multidrug resistance protein 1 [P-glycoprotein (Pgp); gene: ABCB1], and breast cancer resistance protein (BCRP; gene: ABCG2), which function to extrude drugs and xenobiotics from cells...
December 2014: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/25035154/widespread-white-matter-degeneration-preceding-the-onset-of-dementia
#15
Klaus H Maier-Hein, Carl-Fredrik Westin, Martha E Shenton, Michael W Weiner, Ashish Raj, Philipp Thomann, Ron Kikinis, Bram Stieltjes, Ofer Pasternak
BACKGROUND: Brain atrophy in subjects with mild cognitive impairment (MCI) introduces partial volume effects, limiting the sensitivity of diffusion tensor imaging to white matter microstructural degeneration. Appropriate correction isolates microstructural effects in MCI that might be precursors of Alzheimer's disease (AD). METHODS: Forty-eight participants (18 MCI, 15 AD, and 15 healthy controls) had magnetic resonance imaging scans and clinical evaluations at baseline and follow-up after 36 months...
May 2015: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/24996693/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#16
REVIEW
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
August 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24835557/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#17
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
August 2014: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/24835439/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#18
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
October 7, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/24828236/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#19
EDITORIAL
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
October 1, 2014: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/24814494/peripartum-cardiomyopathy-predictors-of-recovery-and-current-state-of-implantable-cardioverter-defibrillator-use
#20
MULTICENTER STUDY
Jayasree Pillarisetti, Ashok Kondur, Anas Alani, Madhu Reddy, Madhuri Reddy, James Vacek, Carl P Weiner, Edward Ellerbeck, Theodore Schreiber, Dhanunjaya Lakkireddy
OBJECTIVES: The purpose of this study was to identify the predictors of left ventricular (LV) recovery in patients with peripartum cardiomyopathy (PPCM) and to record rates of implantable cardioverter-defibrillator (ICD) use. BACKGROUND: PPCM is a rare, life-threatening disease. The use of ICDs has not been clearly understood in this patient group. Identification of the predictors of persistent LV dysfunction can help select patients at risk for sudden cardiac death...
July 1, 2014: Journal of the American College of Cardiology
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