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https://www.readbyqxmd.com/read/27233245/in-vivo-neurochemical-characterization-of-developing-guinea-pigs-and-the-effect-of-chronic-fetal-hypoxia
#1
Wen-Tung Wang, Phil Lee, Yafeng Dong, Hung-Wen Yeh, Jieun Kim, Carl P Weiner, William M Brooks, In-Young Choi
The guinea pig is a frequently used animal model for human pregnancy complications, such as oxygen deprivation or hypoxia, which result in altered brain development. To investigate the impact of in utero chronic hypoxia on brain development, pregnant guinea pigs underwent either normoxic or hypoxic conditions at about 70 % of 65-day term gestation. After delivery, neurochemical profiles consisting of 19 metabolites and macromolecules were obtained from the neonatal cortex, hippocampus, and striatum from birth to 12 weeks postpartum using in vivo (1)H MR spectroscopy at 9...
July 2016: Neurochemical Research
https://www.readbyqxmd.com/read/26972897/placental-origins-of-adverse-pregnancy-outcomes-potential-molecular-targets-an-executive-workshop-summary-of-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development
#2
REVIEW
John V Ilekis, Ekaterini Tsilou, Susan Fisher, Vikki M Abrahams, Michael J Soares, James C Cross, Stacy Zamudio, Nicholas P Illsley, Leslie Myatt, Christine Colvis, Maged M Costantine, David M Haas, Yoel Sadovsky, Carl Weiner, Erik Rytting, Gene Bidwell
Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related disorders, a significant gap exists in the utilization of this information for the development of new drug therapies to improve pregnancy outcome. On March 5-6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap...
July 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26254842/myths-and-realities-of-training-in-obstetric-emergencies
#3
REVIEW
Timothy J Draycott, Katherine J Collins, Joanna F Crofts, Dimitrios Siassakos, Cathy Winter, Carl P Weiner, Fiona Donald
Training for intrapartum emergencies is a promising strategy to reduce preventable harm during birth; however, not all training is clinically effective. Many myths have developed around such training. These principally derive from misinformed beliefs that all training must be effective, cheap, independent of context and sustainable. The current evidence base for effective training supports local, unit-based and multi-professional training, with appropriate mannequins, and practice-based tools to support the best care...
November 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/26135785/is-an-isolated-ventricular-septal-defect-detected-before-24-weeks-on-ultrasound-associated-with-fetal-aneuploidy
#4
Gene Lee, Susie X Fong, Maitreyi Salpekar, Catherine L Satterwhite, Carl Weiner
OBJECTIVE: Whether the isolated VSD (i-VSD) is associated with aneuploidy to the same degree as a more severe heart anomaly is unclear. Our objective was to determine the likelihood of aneuploidy in pregnancies at a tertiary referral center when an i-VSD is detected before 24 weeks. METHODS: A retrospective chart review of all detailed anatomy ultrasounds before 24 weeks performed at the University of Kansas Medical Center from 08/23/2006 to 06/07/2012 was conducted...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/25504885/chronic-fetal-hypoxia-affects-axonal-maturation-in-guinea-pigs-during-development-a-longitudinal-diffusion-tensor-imaging-and-t2-mapping-study
#5
Jieun Kim, In-Young Choi, Yafeng Dong, Wen-Tung Wang, William M Brooks, Carl P Weiner, Phil Lee
PURPOSE: To investigate the impact of chronic hypoxia on neonatal brains, and follow developmental alterations and adaptations noninvasively in a guinea pig model. Chronic hypoxemia is the prime cause of fetal brain injury and long-term sequelae such as neurodevelopmental compromise, seizures, and cerebral palsy. MATERIALS AND METHODS: Thirty guinea pigs underwent either normoxic and hypoxemic conditions during the critical stage of brain development (0.7 gestation) and studied prenatally (n = 16) or perinatally (n = 14)...
September 2015: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/25465168/altered-inflammatory-activity-associated-with-reduced-hippocampal-volume-and-more-severe-posttraumatic-stress-symptoms-in-gulf-war-veterans
#6
Aoife O'Donovan, Linda L Chao, Jennifer Paulson, Kristin W Samuelson, Judy K Shigenaga, Carl Grunfeld, Mike W Weiner, Thomas C Neylan
BACKGROUND: Inflammation may reduce hippocampal volume by blocking neurogenesis and promoting neurodegeneration. Posttraumatic stress disorder (PTSD) has been linked with both elevated inflammation and reduced hippocampal volume. However, few studies have examined associations between inflammatory markers and hippocampal volume, and none have examined these associations in the context of PTSD. METHODS: We measured levels of the inflammatory markers interleukin-6 (IL-6) and soluble receptor II for tumor necrosis factor (sTNF-RII) as well as hippocampal volume in 246 Gulf War veterans with and without current and past PTSD as assessed with the Clinician Administered PTSD Scale (CAPS)...
January 2015: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/25261564/effect-of-prostaglandin-e2-on-multidrug-resistance-transporters-in-human-placental-cells
#7
Clifford W Mason, Gene T Lee, Yafeng Dong, Helen Zhou, Lily He, Carl P Weiner
Prostaglandin (PG) E2, a major product of cyclooxygenase (COX)-2, acts as an immunomodulator at the maternal-fetal interface during pregnancy. It exerts biologic function through interaction with E-prostanoid (EP) receptors localized to the placenta. The activation of the COX-2/PGE2/EP signal pathway can alter the expression of the ATP-binding cassette (ABC) transporters, multidrug resistance protein 1 [P-glycoprotein (Pgp); gene: ABCB1], and breast cancer resistance protein (BCRP; gene: ABCG2), which function to extrude drugs and xenobiotics from cells...
December 2014: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/25035154/widespread-white-matter-degeneration-preceding-the-onset-of-dementia
#8
Klaus H Maier-Hein, Carl-Fredrik Westin, Martha E Shenton, Michael W Weiner, Ashish Raj, Philipp Thomann, Ron Kikinis, Bram Stieltjes, Ofer Pasternak
BACKGROUND: Brain atrophy in subjects with mild cognitive impairment (MCI) introduces partial volume effects, limiting the sensitivity of diffusion tensor imaging to white matter microstructural degeneration. Appropriate correction isolates microstructural effects in MCI that might be precursors of Alzheimer's disease (AD). METHODS: Forty-eight participants (18 MCI, 15 AD, and 15 healthy controls) had magnetic resonance imaging scans and clinical evaluations at baseline and follow-up after 36 months...
May 2015: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/24996693/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#9
REVIEW
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
August 2014: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/24835557/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#10
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
August 2014: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/24835439/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#11
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
October 7, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/24828236/scai-aats-acc-sts-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-ii-mitral-valve
#12
EDITORIAL
Carl L Tommaso, David A Fullerton, Ted Feldman, Larry S Dean, Ziyad M Hijazi, Eric Horlick, Bonnie H Weiner, Evan Zahn, Joaquin E Cigarroa, Carlos E Ruiz, Joseph Bavaria, Michael J Mack, Duke E Cameron, R Morton Bolman, D Craig Miller, Marc R Moon, Debabrata Mukherjee, Alfredo Trento, Gabriel S Aldea, Emile A Bacha
No abstract text is available yet for this article.
October 1, 2014: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/24814494/peripartum-cardiomyopathy-predictors-of-recovery-and-current-state-of-implantable-cardioverter-defibrillator-use
#13
MULTICENTER STUDY
Jayasree Pillarisetti, Ashok Kondur, Anas Alani, Madhu Reddy, Madhuri Reddy, James Vacek, Carl P Weiner, Edward Ellerbeck, Theodore Schreiber, Dhanunjaya Lakkireddy
OBJECTIVES: The purpose of this study was to identify the predictors of left ventricular (LV) recovery in patients with peripartum cardiomyopathy (PPCM) and to record rates of implantable cardioverter-defibrillator (ICD) use. BACKGROUND: PPCM is a rare, life-threatening disease. The use of ICDs has not been clearly understood in this patient group. Identification of the predictors of persistent LV dysfunction can help select patients at risk for sudden cardiac death...
July 1, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/24399358/the-enigma-consortium-large-scale-collaborative-analyses-of-neuroimaging-and-genetic-data
#14
REVIEW
Paul M Thompson, Jason L Stein, Sarah E Medland, Derrek P Hibar, Alejandro Arias Vasquez, Miguel E Renteria, Roberto Toro, Neda Jahanshad, Gunter Schumann, Barbara Franke, Margaret J Wright, Nicholas G Martin, Ingrid Agartz, Martin Alda, Saud Alhusaini, Laura Almasy, Jorge Almeida, Kathryn Alpert, Nancy C Andreasen, Ole A Andreassen, Liana G Apostolova, Katja Appel, Nicola J Armstrong, Benjamin Aribisala, Mark E Bastin, Michael Bauer, Carrie E Bearden, Orjan Bergmann, Elisabeth B Binder, John Blangero, Henry J Bockholt, Erlend Bøen, Catherine Bois, Dorret I Boomsma, Tom Booth, Ian J Bowman, Janita Bralten, Rachel M Brouwer, Han G Brunner, David G Brohawn, Randy L Buckner, Jan Buitelaar, Kazima Bulayeva, Juan R Bustillo, Vince D Calhoun, Dara M Cannon, Rita M Cantor, Melanie A Carless, Xavier Caseras, Gianpiero L Cavalleri, M Mallar Chakravarty, Kiki D Chang, Christopher R K Ching, Andrea Christoforou, Sven Cichon, Vincent P Clark, Patricia Conrod, Giovanni Coppola, Benedicto Crespo-Facorro, Joanne E Curran, Michael Czisch, Ian J Deary, Eco J C de Geus, Anouk den Braber, Giuseppe Delvecchio, Chantal Depondt, Lieuwe de Haan, Greig I de Zubicaray, Danai Dima, Rali Dimitrova, Srdjan Djurovic, Hongwei Dong, Gary Donohoe, Ravindranath Duggirala, Thomas D Dyer, Stefan Ehrlich, Carl Johan Ekman, Torbjørn Elvsåshagen, Louise Emsell, Susanne Erk, Thomas Espeseth, Jesen Fagerness, Scott Fears, Iryna Fedko, Guillén Fernández, Simon E Fisher, Tatiana Foroud, Peter T Fox, Clyde Francks, Sophia Frangou, Eva Maria Frey, Thomas Frodl, Vincent Frouin, Hugh Garavan, Sudheer Giddaluru, David C Glahn, Beata Godlewska, Rita Z Goldstein, Randy L Gollub, Hans J Grabe, Oliver Grimm, Oliver Gruber, Tulio Guadalupe, Raquel E Gur, Ruben C Gur, Harald H H Göring, Saskia Hagenaars, Tomas Hajek, Geoffrey B Hall, Jeremy Hall, John Hardy, Catharina A Hartman, Johanna Hass, Sean N Hatton, Unn K Haukvik, Katrin Hegenscheid, Andreas Heinz, Ian B Hickie, Beng-Choon Ho, David Hoehn, Pieter J Hoekstra, Marisa Hollinshead, Avram J Holmes, Georg Homuth, Martine Hoogman, L Elliot Hong, Norbert Hosten, Jouke-Jan Hottenga, Hilleke E Hulshoff Pol, Kristy S Hwang, Clifford R Jack, Mark Jenkinson, Caroline Johnston, Erik G Jönsson, René S Kahn, Dalia Kasperaviciute, Sinead Kelly, Sungeun Kim, Peter Kochunov, Laura Koenders, Bernd Krämer, John B J Kwok, Jim Lagopoulos, Gonzalo Laje, Mikael Landen, Bennett A Landman, John Lauriello, Stephen M Lawrie, Phil H Lee, Stephanie Le Hellard, Herve Lemaître, Cassandra D Leonardo, Chiang-Shan Li, Benny Liberg, David C Liewald, Xinmin Liu, Lorna M Lopez, Eva Loth, Anbarasu Lourdusamy, Michelle Luciano, Fabio Macciardi, Marise W J Machielsen, Glenda M Macqueen, Ulrik F Malt, René Mandl, Dara S Manoach, Jean-Luc Martinot, Mar Matarin, Karen A Mather, Manuel Mattheisen, Morten Mattingsdal, Andreas Meyer-Lindenberg, Colm McDonald, Andrew M McIntosh, Francis J McMahon, Katie L McMahon, Eva Meisenzahl, Ingrid Melle, Yuri Milaneschi, Sebastian Mohnke, Grant W Montgomery, Derek W Morris, Eric K Moses, Bryon A Mueller, Susana Muñoz Maniega, Thomas W Mühleisen, Bertram Müller-Myhsok, Benson Mwangi, Matthias Nauck, Kwangsik Nho, Thomas E Nichols, Lars-Göran Nilsson, Allison C Nugent, Lars Nyberg, Rene L Olvera, Jaap Oosterlaan, Roel A Ophoff, Massimo Pandolfo, Melina Papalampropoulou-Tsiridou, Martina Papmeyer, Tomas Paus, Zdenka Pausova, Godfrey D Pearlson, Brenda W Penninx, Charles P Peterson, Andrea Pfennig, Mary Phillips, G Bruce Pike, Jean-Baptiste Poline, Steven G Potkin, Benno Pütz, Adaikalavan Ramasamy, Jerod Rasmussen, Marcella Rietschel, Mark Rijpkema, Shannon L Risacher, Joshua L Roffman, Roberto Roiz-Santiañez, Nina Romanczuk-Seiferth, Emma J Rose, Natalie A Royle, Dan Rujescu, Mina Ryten, Perminder S Sachdev, Alireza Salami, Theodore D Satterthwaite, Jonathan Savitz, Andrew J Saykin, Cathy Scanlon, Lianne Schmaal, Hugo G Schnack, Andrew J Schork, S Charles Schulz, Remmelt Schür, Larry Seidman, Li Shen, Jody M Shoemaker, Andrew Simmons, Sanjay M Sisodiya, Colin Smith, Jordan W Smoller, Jair C Soares, Scott R Sponheim, Emma Sprooten, John M Starr, Vidar M Steen, Stephen Strakowski, Lachlan Strike, Jessika Sussmann, Philipp G Sämann, Alexander Teumer, Arthur W Toga, Diana Tordesillas-Gutierrez, Daniah Trabzuni, Sarah Trost, Jessica Turner, Martijn Van den Heuvel, Nic J van der Wee, Kristel van Eijk, Theo G M van Erp, Neeltje E M van Haren, Dennis van 't Ent, Marie-Jose van Tol, Maria C Valdés Hernández, Dick J Veltman, Amelia Versace, Henry Völzke, Robert Walker, Henrik Walter, Lei Wang, Joanna M Wardlaw, Michael E Weale, Michael W Weiner, Wei Wen, Lars T Westlye, Heather C Whalley, Christopher D Whelan, Tonya White, Anderson M Winkler, Katharina Wittfeld, Girma Woldehawariat, Christiane Wolf, David Zilles, Marcel P Zwiers, Anbupalam Thalamuthu, Peter R Schofield, Nelson B Freimer, Natalia S Lawrence, Wayne Drevets
The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects...
June 2014: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/23404738/conversation-in-cardiology-should-ffr-and-ivus-be-counted-as-pci
#15
EDITORIAL
Morton Kern, Robert Applegate, Richard G Bach, Steven R Bailey, Thomas M Bashore, Theodore A Bass, Malcolm Bell, Bernard de Bruyne, Kirk N Garratt, Allen Jeremias, Dean J Kereiakes, Lloyd W Klein, Mitchell W Krucoff, Gary S Mintz, Douglas Morrison, E Magnus Ohman, Augusto Pichard, Kenneth Rosenfield, Habib Samady, Gregg W Stone, Carl Tommaso, Zoltan G Turi, Barry Uretsky, George Vetrovec, Bonnie H Weiner, Frederick Welt, Alan C Yeung
No abstract text is available yet for this article.
July 1, 2013: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/23280393/new-tools-for-an-old-quest
#16
EDITORIAL
Carl P Weiner
No abstract text is available yet for this article.
May 2013: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/22782295/development-and-assessment-of-a-composite-score-for-memory-in-the-alzheimer-s-disease-neuroimaging-initiative-adni
#17
Paul K Crane, Adam Carle, Laura E Gibbons, Philip Insel, R Scott Mackin, Alden Gross, Richard N Jones, Shubhabrata Mukherjee, S McKay Curtis, Danielle Harvey, Michael Weiner, Dan Mungas
We sought to develop and evaluate a composite memory score from the neuropsychological battery used in the Alzheimer's Disease (AD) Neuroimaging Initiative (ADNI). We used modern psychometric approaches to analyze longitudinal Rey Auditory Verbal Learning Test (RAVLT, 2 versions), AD Assessment Schedule - Cognition (ADAS-Cog, 3 versions), Mini-Mental State Examination (MMSE), and Logical Memory data to develop ADNI-Mem, a composite memory score. We compared RAVLT and ADAS-Cog versions, and compared ADNI-Mem to RAVLT recall sum scores, four ADAS-Cog-derived scores, the MMSE, and the Clinical Dementia Rating Sum of Boxes...
December 2012: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/22595626/multisociety-aats-accf-scai-and-sts-expert-consensus-statement-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-1-transcatheter-aortic-valve-replacement
#18
Carl L Tommaso, R Morton Bolman, Ted Feldman, Joseph Bavaria, Michael A Acker, Gabriel Aldea, Duke E Cameron, Larry S Dean, Dave Fullerton, Ziyad M Hijazi, Eric Horlick, D Craig Miller, Marc R Moon, Richard Ringel, Carlos E Ruiz, Alfredo Trento, Bonnie H Weiner, Evan M Zahn, , , et al.
No abstract text is available yet for this article.
June 2012: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/22564839/population-pharmacokinetics-and-pharmacodynamics-of-ofloxacin-in-south-african-patients-with-multidrug-resistant-tuberculosis
#19
RANDOMIZED CONTROLLED TRIAL
Emmanuel Chigutsa, Sandra Meredith, Lubbe Wiesner, Nesri Padayatchi, Joe Harding, Prashini Moodley, William R Mac Kenzie, Marc Weiner, Helen McIlleron, Carl M J Kirkpatrick
Despite the important role of fluoroquinolones and the predominant use of ofloxacin for treating multidrug-resistant tuberculosis in South Africa, there are limited data on ofloxacin pharmacokinetics in patients with multidrug-resistant tuberculosis, no ofloxacin pharmacokinetic data from South African patients, and no direct assessment of the relationship between ofloxacin pharmacokinetics and the MIC of ofloxacin of patient isolates. Our objectives are to describe ofloxacin pharmacokinetics in South African patients being treated for multidrug-resistant tuberculosis and assess the adequacy of ofloxacin drug exposure with respect to the probability of pharmacodynamic target attainment (area under the time curve/MIC ratio of at least 100)...
July 2012: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/22387052/multisociety-aats-accf-scai-and-sts-expert-consensus-statement-operator-and-institutional-requirements-for-transcatheter-valve-repair-and-replacement-part-1-transcatheter-aortic-valve-replacement
#20
Carl L Tommaso, R Morton Bolman, Ted Feldman, Joseph Bavaria, Michael A Acker, Gabriel Aldea, Duke E Cameron, Larry S Dean, Dave Fullerton, Ziyad M Hijazi, Eric Horlick, D Craig Miller, Marc R Moon, Richard Ringel, Carlos E Ruiz, Alfredo Trento, Bonnie H Weiner, Evan M Zahn
No abstract text is available yet for this article.
May 29, 2012: Journal of the American College of Cardiology
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