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John Ilekis

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https://www.readbyqxmd.com/read/26972897/placental-origins-of-adverse-pregnancy-outcomes-potential-molecular-targets-an-executive-workshop-summary-of-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development
#1
REVIEW
John V Ilekis, Ekaterini Tsilou, Susan Fisher, Vikki M Abrahams, Michael J Soares, James C Cross, Stacy Zamudio, Nicholas P Illsley, Leslie Myatt, Christine Colvis, Maged M Costantine, David M Haas, Yoel Sadovsky, Carl Weiner, Erik Rytting, Gene Bidwell
Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related disorders, a significant gap exists in the utilization of this information for the development of new drug therapies to improve pregnancy outcome. On March 5-6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap...
July 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26692181/predictors-of-response-to-17-alpha-hydroxyprogesterone-caproate-for-prevention-of-recurrent-spontaneous-preterm-birth
#2
MULTICENTER STUDY
Tracy A Manuck, M Sean Esplin, Joseph Biggio, Radek Bukowski, Samuel Parry, Heping Zhang, Hao Huang, Michael W Varner, William Andrews, George Saade, Yoel Sadovsky, Uma M Reddy, John Ilekis
BACKGROUND: Prematurity is the leading cause of neonatal morbidity and death among nonanomalous neonates in the United States. Intramuscular 17-alpha hydroxyprogesterone caproate injections reduce the risk of recurrent prematurity by approximately one third. Unfortunately, prophylactic 17-alpha hydroxyprogesterone caproate is not always effective, and one-third of high-risk women will have a recurrent preterm birth, despite 17-alpha hydroxyprogesterone caproate therapy. The reasons for this variability in response are unknown...
March 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26070700/cluster-analysis-of-spontaneous-preterm-birth-phenotypes-identifies-potential-associations-among-preterm-birth-mechanisms
#3
MULTICENTER STUDY
M Sean Esplin, Tracy A Manuck, Michael W Varner, Bryce Christensen, Joseph Biggio, Radek Bukowski, Samuel Parry, Heping Zhang, Hao Huang, William Andrews, George Saade, Yoel Sadovsky, Uma M Reddy, John Ilekis
OBJECTIVE: We sought to use an innovative tool that is based on common biologic pathways to identify specific phenotypes among women with spontaneous preterm birth (SPTB) to enhance investigators' ability to identify and to highlight common mechanisms and underlying genetic factors that are responsible for SPTB. STUDY DESIGN: We performed a secondary analysis of a prospective case-control multicenter study of SPTB. All cases delivered a preterm singleton at SPTB ≤34...
September 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25687564/the-phenotype-of-spontaneous-preterm-birth-application-of-a-clinical-phenotyping-tool
#4
MULTICENTER STUDY
Tracy A Manuck, M Sean Esplin, Joseph Biggio, Radek Bukowski, Samuel Parry, Heping Zhang, Hao Huang, Michael W Varner, William Andrews, George Saade, Yoel Sadovsky, Uma M Reddy, John Ilekis
OBJECTIVE: Spontaneous preterm birth (SPTB) is a complex condition that is likely a final common pathway with multiple possible causes. We hypothesized that a comprehensive classification system appropriately could group women with similar STPB causes and could provide an explanation, at least in part, for the disparities in SPTB that are associated with race and gestational age at delivery. STUDY DESIGN: This was a planned analysis of a multicenter, prospective study of singleton SPTBs...
April 2015: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/25599974/a-genome-wide-association-study-of-early-spontaneous-preterm-delivery
#5
COMPARATIVE STUDY
Heping Zhang, Don A Baldwin, Radek K Bukowski, Samuel Parry, Yaji Xu, Chi Song, William W Andrews, George R Saade, M Sean Esplin, Yoel Sadovsky, Uma M Reddy, John Ilekis, Michael Varner, Joseph R Biggio
Preterm birth is the leading cause of infant morbidity and mortality. Despite extensive research, the genetic contributions to spontaneous preterm birth (SPTB) are not well understood. Term controls were matched with cases by race/ethnicity, maternal age, and parity prior to recruitment. Genotyping was performed using Affymetrix SNP Array 6.0 assays. Statistical analyses utilized PLINK to compare allele occurrence rates between case and control groups, and incorporated quality control and multiple-testing adjustments...
March 2015: Genetic Epidemiology
https://www.readbyqxmd.com/read/24954659/maternal-serum-serpin-b7-is-associated-with-early-spontaneous-preterm-birth
#6
Samuel Parry, Heping Zhang, Joseph Biggio, Radek Bukowski, Michael Varner, Yaji Xu, William W Andrews, George R Saade, M Sean Esplin, Rita Leite, John Ilekis, Uma M Reddy, Yoel Sadovsky, Ian A Blair
OBJECTIVE: We sought to identify serum biomarkers of early spontaneous preterm birth (SPTB) using semiquantitative proteomic analyses. STUDY DESIGN: This was a nested case-control study of pregnant women with previous SPTB. Maternal serum was collected at 19-24 and 28-32 weeks' gestation, and analyzed by liquid chromatography-multiple reaction monitoring/mass spectrometry. Targeted and shotgun proteomics identified 31 candidate proteins that were differentially expressed in pooled serum samples from spontaneous preterm (cases [<34 weeks]) and term (controls) deliveries...
December 2014: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/17959880/preeclampsia-a-pressing-problem-an-executive-summary-of-a-national-institute-of-child-health-and-human-development-workshop
#7
John V Ilekis, Uma M Reddy, James M Roberts
On September 21 and 22, 2006, the National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled "Preeclampsia--A Pressing Problem." The purpose of the workshop was to bring together leaders in the field to present and discuss their diverse research areas, which ranged from basic science to clinical trials and management, and to identify scientific gaps. This article is a summary of the proceedings of that workshop. Although much progress is being made in understanding the underpinnings of preeclampsia, a number of research gaps are identified that, if filled, would hasten progress in the field...
September 2007: Reproductive Sciences
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