Victoria J M Reid, Wesley K X McLoughlin, Kalyani Pandya, Holly Stott, Monika Iškauskienė, Algirdas Šačkus, Judit A Marti, Dominic Kurian, Thomas M Wishart, Christophe Lucatelli, Dan Peters, Gillian A Gray, Andrew H Baker, David E Newby, Patrick W F Hadoke, Adriana A S Tavares, Mark G MacAskill
BACKGROUND: Cardiac repair and remodeling following myocardial infarction (MI) is a multifactorial process involving pro-reparative inflammation, angiogenesis and fibrosis. Noninvasive imaging using a radiotracer targeting these processes could be used to elucidate cardiac wound healing mechanisms. The alpha7 nicotinic acetylcholine receptor (ɑ7nAChR) stimulates pro-reparative macrophage activity and angiogenesis, making it a potential imaging biomarker in this context. We investigated this by assessing in vitro cellular expression of ɑ7nAChR, and by using a tritiated version of the PET radiotracer [18 F]NS14490 in tissue autoradiography studies...
January 11, 2024: EJNMMI Research