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JOURNAL ARTICLE
Anand Prasad, Audrey C Choh, Nelson D Gonzalez, Marlene Garcia, Miryoung Lee, Gordon Watt, Liliana Maria Vasquez, Susan Laing, Shenghui Wu, Joseph B McCormick, Susan Fisher-Hoch
Ethnic differences exist in the United States in the interrelated problems of diabetes (DM), peripheral arterial disease (PAD), and leg amputations. The purpose of this study was to determine the prevalence and risk factor associations for subclinical PAD in a population sample of Mexican Americans using the ankle brachial (ABI) index. The ABI-High (higher of the two ankle pressures/highest brachial pressure) and ABI-Low (lower of the two ankle pressures/highest brachial pressure) were calculated to define PAD...
February 2024: Preventive Medicine Reports
#22
Andrew S Perry, Niran Hadad, Emeli Chatterjee, Maria Jimenez Ramos, Eric Farber-Eger, Rashedeh Roshani, Lindsay K Stolze, Shilin Zhao, Liesbet Martens, Timothy J Kendall, Tinne Thone, Kaushik Amancherla, Samuel Bailin, Curtis L Gabriel, John Koethe, J Jeffrey Carr, James Greg Terry, Jane Freedman, Kahraman Tanriverdi, Eric Alsop, Kendall Van Keuren-Jensen, John F K Sauld, Gautam Mahajan, Sadiya Khan, Laura Colangelo, Matthew Nayor, Susan Fisher-Hoch, Joseph McCormick, Kari E North, Jennifer Below, Quinn Wells, Dale Abel, Ravi Kalhan, Charlotte Scott, Martin Guilliams, Jonathan A Fallowfield, Nicholas E Banovich, Saumya Das, Ravi Shah
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing in parallel with an obesity pandemic, calling for novel strategies for prevention and treatment. We defined a circulating proteome of human MASLD across ≈7000 proteins in ≈5000 individuals from diverse, at-risk populations across the metabolic health spectrum, demonstrating reproducible diagnostic performance and specifying both known and novel metabolic pathways relevant to MASLD (central carbon and amino acid metabolism, hepatocyte regeneration, inflammation, fibrosis, insulin sensitivity)...
January 29, 2024: medRxiv
#23
JOURNAL ARTICLE
Sudhir B Malla, Ryan M Byrne, Maxime W Lafarge, Shania M Corry, Natalie C Fisher, Petros K Tsantoulis, Megan L Mills, Rachel A Ridgway, Tamsin R M Lannagan, Arafath K Najumudeen, Kathryn L Gilroy, Raheleh Amirkhah, Sarah L Maguire, Eoghan J Mulholland, Hayley L Belnoue-Davis, Elena Grassi, Marco Viviani, Emily Rogan, Keara L Redmond, Svetlana Sakhnevych, Aoife J McCooey, Courtney Bull, Emily Hoey, Nicoleta Sinevici, Holly Hall, Baharak Ahmaderaghi, Enric Domingo, Andrew Blake, Susan D Richman, Claudio Isella, Crispin Miller, Andrea Bertotti, Livio Trusolino, Maurice B Loughrey, Emma M Kerr, Sabine Tejpar, Timothy S Maughan, Mark Lawler, Andrew D Campbell, Simon J Leedham, Viktor H Koelzer, Owen J Sansom, Philip D Dunne
Molecular stratification using gene-level transcriptional data has identified subtypes with distinctive genotypic and phenotypic traits, as exemplified by the consensus molecular subtypes (CMS) in colorectal cancer (CRC). Here, rather than gene-level data, we make use of gene ontology and biological activation state information for initial molecular class discovery. In doing so, we defined three pathway-derived subtypes (PDS) in CRC: PDS1 tumors, which are canonical/LGR5+ stem-rich, highly proliferative and display good prognosis; PDS2 tumors, which are regenerative/ANXA1+ stem-rich, with elevated stromal and immune tumor microenvironmental lineages; and PDS3 tumors, which represent a previously overlooked slow-cycling subset of tumors within CMS2 with reduced stem populations and increased differentiated lineages, particularly enterocytes and enteroendocrine cells, yet display the worst prognosis in locally advanced disease...
February 13, 2024: Nature Genetics
#24
JOURNAL ARTICLE
Rakhshan Kamran, Liam Jackman, Cynthia Chan, Ann C Lee, Aleeza Kamran, Jenna Alli, Chloë Jacklin, Eve Deck, Yujin Suk, Victoria Jackman, Micon Garvilles, Susan Cheng Shelmerdine, Andrea Schwarz Doria
BACKGROUND: Gender inequalities in academic medicine persist despite progress over the past decade. Evidence-based targeted interventions are needed to reduce gender inequalities. OBJECTIVE: This systematic review aimed to investigate the impact of COVID-19 on gender trends in authorship of paediatric radiology research worldwide. MATERIALS AND METHODS: This prospectively registered, PRISMA-compliant systematic review searched the following databases: PubMed, MEDLINE, Web of Science, and Scopus from January 1, 2018, to May 29, 2023, with no restrictions on country of origin...
February 13, 2024: Pediatric Radiology
#25
RANDOMIZED CONTROLLED TRIAL
Robert Sykes, Damien Collison, Bela Merkely, Klaus F Kofoed, Patrick Donnelly, José Rodríguez-Palomares, Andrejs Erglis, Josef Veselka, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Jonathan D Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Pál Maurovich-Horvat, Andreas D Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Martin Horváth, Antanas Jankauskas, Filip Ađić, Michael Woinke, Stephen Keane, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandra Zivanic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Michele Porcu, Michael Fisher, Tamás Bárány, Charlotte Sørum, Rosca Aurelian, Stephanie Kelly, Bruno Garcia Del Blanco, Ainhoa Rubio, Bálint Szilveszter, Jawdat Abdulla, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, Milán Vecsey-Nagy, Birgit Jurlander, Roxana Hodas, Sarah Feger, Mahmoud Mohamed, Lina M Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Maros Ferencik, Melanie Estrella, Maria Bosserdt, Peter Martus, Theodora Benedek, Marc Dewey
Background Recent trials support the role of cardiac CT in the evaluation of symptomatic patients suspected of having coronary artery disease (CAD); however, body mass index (BMI) has been reported to negatively impact CT image quality. Purpose To compare initial use of CT versus invasive coronary angiography (ICA) on clinical outcomes in patients with stable chest pain stratified by BMI category. Materials and Methods This prospective study represents a prespecified BMI subgroup analysis of the multicenter Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial conducted between October 2015 and April 2019...
February 2024: Radiology
#26
JOURNAL ARTICLE
Jolyn S Taylor, Bryan M Fellman, Sally Raty, Javier Lasala, Maria D Iniesta, Katherine E Cain, Allison A Horner, Morgan Bruno, Justin P Folloder, Susan L Knippel, Vu Khanh, Shannon Popovich, Matthew H G Katz, Conor Best, Sonali Thosani
INTRODUCTION: To improve the detection and management of perioperative hyperglycemia at our tertiary cancer center, we implemented a glycemic control quality improvement initiative. The primary goal was to decrease the percentage of diabetic patients with median postoperative glucose levels > 180 mg/dL during hospitalization by 15% within 2 years. METHODS: A multidisciplinary team standardized preoperative screening, preoperative, intraoperative, and postoperative hyperglycemia management...
February 12, 2024: Annals of Surgical Oncology
#27
JOURNAL ARTICLE
Rachael A Gordon, Yann Nguyen, Nathan Foulquier, Maxime Beydon, Tamer A Gheita, Raouf Hajji, Ilfita Sahbudin, Alberta Hoi, Wan-Fai Ng, Jose Alexandre Mendonça, Daniel J Wallace, Beverley Shea, George Aw Bruyn, Susan M Goodman, Benjamin A Fisher, Chiara Baldini, Karina D Torralba, Hendrika Bootsma, Esen K Akpek, Sezen Karakus, Alan N Baer, Soumya D Chakravarty, Lene Terslev, Maria-Antonietta D'Agostino, Xavier Mariette, Dana DiRenzo, Astrid Rasmussen, Athena Papas, Cristina Montoya, Suzanne Arends, Md Yuzaiful Md Yusof, Ionut Pintilie, Blake M Warner, Katherine M Hammitt, Vibeke Strand, Coralie Bouillot, Peter Tugwell, Nevsun Inanc, José Luis Andreu, Marie Wahren-Herlenius, Valerie Devauchelle-Pensec, Caroline H Shiboski, Anas Benyoussef, Sharmila Masli, Adrian Y S Lee, Divi Cornec, Simon Bowman, Maureen Rischmueller, Sara S McCoy, Raphaele Seror
Sjögren's disease (SjD) is a systemic autoimmune exocrinopathy with key features of dryness, pain, and fatigue. SjD can affect any organ system with a variety of presentations across individuals. This heterogeneity is one of the major barriers for developing effective disease modifying treatments. Defining core disease domains comprising both specific clinical features and incorporating the patient experience is a critical first step to define this complex disease. The OMERACT SjD Working Group held its first international collaborative hybrid meeting in 2023, applying the OMERACT 2...
January 23, 2024: Seminars in Arthritis and Rheumatism
#28
Michelle Kudron, Louis Gevirtzman, Alec Victorsen, Bridget C Lear, Jiahao Gao, Jinrui Xu, Swapna Samanta, Emily Frink, Adri Tran-Pearson, Chau Huynh, Dionne Vafeados, Ann Hammonds, William Fisher, Martha Wall, Greg Wesseling, Vanessa Hernandez, Zhichun Lin, Mary Kasparian, Kevin White, Ravi Allada, Mark Gerstein, LaDeana Hillier, Susan E Celniker, Valerie Reinke, Robert H Waterston
A catalog of transcription factor (TF) binding sites in the genome is critical for deciphering regulatory relationships. Here we present the culmination of the modERN (model organism Encyclopedia of Regulatory Networks) consortium that systematically assayed TF binding events in vivo in two major model organisms, Drosophila melanogaster (fly) and Caenorhabditis elegans (worm). We describe key features of these datasets, comprising 604 TFs identifying 3.6M sites in the fly and 350 TFs identifying 0.9 M sites in the worm...
January 20, 2024: bioRxiv
#29
JOURNAL ARTICLE
L Lee Dupuis, Brian T Fisher, A J Sugalski, Allison Caren Grimes, Michelle Nuño, S Ramakrishnan, M P Beauchemin, Paula D Robinson, Nancy Santesso, Alexandra Walsh, A R Wrightson, Lolie Yu, Susan K Parsons, Lillian Sung
BACKGROUND: The primary objective was to measure the proportion of episodes where care delivery was inconsistent with selected recommendations of a clinical practice guideline (CPG) on fever and neutropenia (FN) management. The influence of site size on CPG-inconsistent care delivery, and association between patient outcomes and CPG-inconsistent care were described. METHODS: This retrospective, multicenter study included patients less than 21 years old with cancer who were at high risk of poor FN outcomes and were previously enrolled to a Children's Oncology Group (COG) study at participating National Cancer Institute Community Oncology Research Program (NCORP) institutions from January 2014 through December 2015...
January 30, 2024: Pediatric Blood & Cancer
#30
JOURNAL ARTICLE
Jacqueline Bangma, Kitrina M Barry, Christine M Fisher, Susan Genualdi, Theresa C Guillette, Carin A Huset, James McCord, Brian Ng, Benjamin J Place, Jessica L Reiner, Anna Robuck, Alix E Rodowa
With increasing public awareness of PFAS, and their presence in biological and environmental media across the globe, comes a matching increase in the number of PFAS monitoring studies. As more matrices and sample cohorts are examined, there are more opportunities for matrix interferents to appear as PFAS where there are none (i.e., "seeing ghosts"), impacting subsequent reports. Addressing these ghosts is vital for the research community, as proper analytical measurements are necessary for decision-makers to understand the presence, levels, and potential risks associated with PFAS and protect human and environmental health...
January 27, 2024: Analytical and Bioanalytical Chemistry
#31
Justin A Bosch, Nathan Keith, Felipe Escobedo, William W Fisher, James Thai LaGraff, Jorden Rabasco, Kenneth H Wan, Richard Weiszmann, Yulun Wu, Yanhui Hu, Shu Kondo, James B Brown, Norbert Perrimon, Susan E Celniker
No abstract text is available yet for this article.
January 23, 2024: Cell Reports
#32
Alexander Grabner, Michaela Fuchs, Emily Burke, Nejla Latic, Susan Murray, Hanjun Li, Matthew Sparks, Dennis Abraham, Hengtao Zhang, Paul Rosenberg, Sonja Hänzelmann, Fabian Hausmann, Tobias Huber, Reinhold Erben, Kelsey Fisher-Wellman, Nenad Bursac, Myles Wolf
Chronic kidney disease (CKD) is a global health epidemic that significantly increases mortality due to cardiovascular disease. Left ventricular hypertrophy (LVH) is an important mechanism of cardiac injury in CKD. High serum levels of fibroblast growth factor (FGF) 23 in patients with CKD may contribute mechanistically to the pathogenesis of LVH by activating FGF receptor (FGFR) 4 signaling in cardiac myocytes. Mitochondrial dysfunction and cardiac metabolic remodeling are early features of cardiac injury that predate development of hypertrophy, but these mechanisms of disease have been insufficiently studied in models of CKD...
December 23, 2023: Research Square
#33
JOURNAL ARTICLE
Joe Gryskiewicz, Blaire V Slavin, Benjamin R Slavin, Vasudev Vivekanand Nayak, Randall G Pierrot, Susan M Taghioff, Khaled O Alameddine, Devinder Singh, Karan Chopra, Paulo G Coelho
Federal government research grants provide limited funding to plastic surgeon-scientists, with reconstructive research taking precedence over aesthetic research. The Aesthetic Surgery Education and Research Foundation (ASERF) is a nonprofit, 501(c)(3) organization that seeks to support innovative, diverse research endeavors within aesthetic surgery. A total of 130 ASERF-funded studies and 32 non-funded applications 1992-2022 were reviewed. Kruskal Wallis, Fisher's Exact, and Chi-Squared tests were used to assess the potential relationship between self-identified gender, practice setting, geographical location, and study type with individual grant amounts and grant funding decision...
January 9, 2024: Aesthetic Surgery Journal
#34
JOURNAL ARTICLE
Nicolle Fernandez Dyess, Cara Beth Carr, Stephanie Mavis, Catherine Grace Caruso, Susan Izatt, Heather French, Rita Dadiz, Elizabeth M Bonachea, Megan Gray
Objective To characterize implicit bias (IB) and health disparities (HD) education in neonatal-perinatal medicine (NPM), including current educational opportunities, resources, and barriers. Study Design A national web-based survey was sent to NPM fellows, neonatologists, and front-line providers after iterative review by education experts from the National Neonatology Curriculum Committee. Quantitative data were analyzed with chi-square and Fisher exact tests. Qualitative data were evaluated using thematic analysis...
January 8, 2024: American Journal of Perinatology
#35
JOURNAL ARTICLE
Gillian Kasper, Mahsa Momen, Kristen A Sorice, Kiara N Mayhand, Elizabeth A Handorf, Evelyn T Gonzalez, Amie Devlin, Kirsten Brownstein, Nestor Esnaola, Susan G Fisher, Shannon M Lynch
BACKGROUND: Although mammography can significantly reduce breast cancer mortality, many women do not receive their annual breast cancer screening. Differences in screening adherence exist by race/ethnicity, socioeconomic status (SES), and insurance status. However, more detailed investigations into the impact of neighborhood disadvantage and access to resources on screening adherence are lacking. METHODS: We comprehensively examined the effect of individual social, economic, and demographic factors (n = 34 variables), as well as neighborhood level SES (nSES) indicators (n = 10 variables) on breast cancer screening adherence across a multi-ethnic population (n = 472)...
January 2, 2024: BMC Public Health
#36
JOURNAL ARTICLE
Kelly M Elleson, Katherine Englander, Julia Gallagher, Neha Chintapally, Weihong Sun, Junmin Whiting, Melissa Mallory, John Kiluk, Susan Hoover, Nazanin Khakpour, Brian Czerniecki, Christine Laronga, Marie Catherine Lee
BACKGROUND: Axillary node status is an important prognostic factor in breast cancer. The primary aim was to evaluate tumor size and other characteristics relative to axillary disease. MATERIALS AND METHODS: Single institution retrospective chart review of stage I-III breast cancer patients collected demographic and clinical/pathologic data from 1998-2019. Student's t -test, Chi-squared test (or Fisher exact test if applicable), and logistic regression models were used for testing the association of pN+ to predictive variables...
December 6, 2023: Current Oncology
#37
JOURNAL ARTICLE
Lila Gutstein, Mariana Arevalo, Richard R Reich, Wenyi Fan, Susan T Vadaparampil, Cathy D Meade, Rania Abdulla, Elizabeth Lawrence, Richard G Roetzheim, Diana Lopez, Aaron Collier, Emalyn Deak, Aldenise P Ewing, Clement K Gwede, Shannon M Christy
BACKGROUND: Colorectal cancer (CRC) and liver cancer are two of the leading causes of cancer death in the United States and persistent disparities in CRC and liver cancer incidence and outcomes exist. Chronic hepatitis C virus (HCV) infection is one of the main contributors to liver cancer. Effective screening for both CRC and HCV exist and are recommended for individuals based upon age, regardless of gender or sex assigned at birth. Recommendations for both screening behaviors have been recently updated...
December 21, 2023: Journal of Behavioral Medicine
#38
JOURNAL ARTICLE
Isela De La Cerda, Cici X Bauer, Kehe Zhang, Miryoung Lee, Michelle Jones, Arturo Rodriguez, Joseph B McCormick, Susan P Fisher-Hoch
BACKGROUND: Cameron County, a low-income south Texas-Mexico border county marked by severe health disparities, was consistently among the top counties with the highest COVID-19 mortality in Texas at the onset of the pandemic. The disparity in COVID-19 burden within Texas counties revealed the need for effective interventions to address the specific needs of local health departments and their communities. Publicly available COVID-19 surveillance data were not sufficiently timely or granular to deliver such targeted interventions...
December 20, 2023: JMIR Public Health and Surveillance
#39
JOURNAL ARTICLE
Jennifer Yang, Lucy Yang, Susan Zheng, Eiichi A Miyasaka
INTRODUCTION: Postoperative (postop) management of pediatric perforated appendicitis varies significantly, and postop intra-abdominal abscesses (IAA) remain a significant issue. Between 2019 and 2020, our standardized protocol included routine postop labs after an appendectomy for perforated appendicitis. However, given the lack of predictive utility of these routine labs, we discontinued this practice in 2021. We hypothesize that discontinuing routine postop labs will not be associated with an increase in complication rates after an appendectomy for pediatric perforated appendicitis...
December 15, 2023: Journal of Surgical Research
#40
JOURNAL ARTICLE
Anto I Bagić, Stephanie M Ahrens, Kevin E Chapman, Shasha Bai, Dave F Clarke, Mariah Eisner, Nathan B Fountain, Jay R Gavvala, Kyle C Rossi, Susan T Herman, Adam P Ostendorf
OBJECTIVE: An epilepsy monitoring unit (EMU) is a specialized unit designed for capturing and characterizing seizures and other paroxysmal events with continuous video electroencephalography (vEEG). Nearly 260 epilepsy centers in the United States are accredited by the National Association of Epilepsy Centers (NAEC) based on adherence to specific clinical standards to improve epilepsy care, safety, and quality. This study examines EMU staffing, safety practices, and reported outcomes...
December 8, 2023: Epilepsy & Behavior: E&B
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