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Susan Fisher

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https://www.readbyqxmd.com/read/29122066/oral-and-dental-aspects-of-child-abuse-and-neglect
#1
Susan A Fisher-Owens, James L Lukefahr, Anupama Rao Tate
In all 50 states, health care providers (including dentists) are mandated to report suspected cases of abuse and neglect to social service or law enforcement agencies. The purpose of this report is to review the oral and dental aspects of physical and sexual abuse and dental neglect in children and the role of pediatric care providers and dental providers in evaluating such conditions. This report addresses the evaluation of bite marks as well as perioral and intraoral injuries, infections, and diseases that may raise suspicion for child abuse or neglect...
July 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/29120328/neuropathological-and-transcriptomic-characteristics-of-the-aged-brain
#2
Jeremy A Miller, Angela Guillozet-Bongaarts, Laura E Gibbons, Nadia Postupna, Anne Renz, Allison E Beller, Susan M Sunkin, Lydia Ng, Shannon E Rose, Kimberly A Smith, Aaron Szafer, Chris Barber, Darren Bertagnolli, Kristopher Bickley, Krissy Brouner, Shiella Caldejon, Mike Chapin, Mindy L Chua, Natalie M Coleman, Eiron Cudaback, Christine Cuhaciyan, Rachel A Dalley, Nick Dee, Tsega Desta, Tim A Dolbeare, Nadezhda I Dotson, Michael Fisher, Nathalie Gaudreault, Garrett Gee, Terri L Gilbert, Jeff Goldy, Fiona Griffin, Caroline Habel, Zeb Haradon, Nika Hejazinia, Leanne L Hellstern, Steve Horvath, Kim Howard, Robert Howard, Justin Johal, Nikolas L Jorstad, Samuel R Josephsen, Chihchau L Kuan, Florence Lai, Eric Lee, Felix Lee, Tracy Lemon, Xianwu Li, Desiree A Marshall, Jose Melchor, Shubhabrata Mukherjee, Julie Nyhus, Julie Pendergraft, Lydia Potekhina, Elizabeth Y Rha, Samantha Rice, David Rosen, Abharika Sapru, Aimee Schantz, Elaine Shen, Emily Sherfield, Shu Shi, Andy J Sodt, Nivretta Thatra, Michael Tieu, Angela M Wilson, Thomas J Montine, Eric B Larson, Amy Bernard, Paul K Crane, Richard G Ellenbogen, C Dirk Keene, Ed Lein
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer's disease (AD) have not led to effective treatments, and there is increasing evidence of a disconnect between traditional pathology and cognitive abilities with advancing age, indicative of individual variation in resilience to pathology. Here, we generated a comprehensive neuropathological, molecular, and transcriptomic characterization of hippocampus and two regions cortex in 107 aged donors (median = 90) from the Adult Changes in Thought (ACT) study as a freely-available resource (http://aging...
November 9, 2017: ELife
https://www.readbyqxmd.com/read/29117032/a-preliminary-observational-study-of-anovulatory-uterine-bleeding-after-aneurysmal-subarachnoid-hemorrhage
#3
Suzanne M Brown, Susan W Fifield, Michael A Pizzi, David Alejos, Alexa N Richie, Tri A Dinh, William P Cheshire, Shon E Meek, William D Freeman
INTRODUCTION: It was observed that women with aneurysmal subarachnoid hemorrhage (aSAH) tended to have earlier menses than a typical 21- to 28-day cycle. The goal was to determine whether there is an association between aSAH and early onset of menses. METHODS: All cases of aSAH in women aged 18 to 55 years who were admitted to our facility's neuroscience intensive care unit from June 1, 2011, to June 30, 2012, were reviewed. The electronic healthcare record for each of these patients was examined for documentation of menses onset, computed tomography of the head, brain aneurysm characteristics, modified Fisher score and Glasgow Coma Scale on admission, presence/absence of vasospasm, medical/surgical history, and use of medications that affect the menstrual cycle...
December 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/29102923/a-traumatic-tale-of-two-cities-does-ems-level-of-care-and-transportation-model-affect-survival-in-patients-with-trauma-at-level-1-trauma-centres-in-two-neighbouring-canadian-provinces
#4
Colin Rouse, Jefferson Hayre, James French, Jacqueline Fraser, Ian Watson, Susan Benjamin, Allison Chisholm, Beth Sealy, Mete Erdogan, Robert S Green, George Stoica, Paul Atkinson
BACKGROUND: Two distinct Emergency Medical Services (EMS) systems exist in Atlantic Canada. Nova Scotia operates an Advanced Emergency Medical System (AEMS) and New Brunswick operates a Basic Emergency Medical System (BEMS). We sought to determine if survival rates differed between the two systems. METHODS: This study examined patients with trauma who were transported directly to a level 1 trauma centre in New Brunswick or Nova Scotia between 1 April 2011 and 31 March 2013...
November 4, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29100628/developmental-changes-within-the-genetic-architecture-of-social-communication-behavior-a-multivariate-study-of-genetic-variance-in-unrelated-individuals
#5
Beate St Pourcain, Lindon J Eaves, Susan M Ring, Simon E Fisher, Sarah Medland, David M Evans, George Davey Smith
BACKGROUND: Recent analyses of trait-disorder overlap suggest that psychiatric dimensions may relate to distinct sets of genes that exert maximum influence during different periods of development. This includes analyses of social communication difficulties that share, depending on their developmental stage, stronger genetic links with either autism spectrum disorder or schizophrenia. We developed a multivariate analysis framework in unrelated individuals to model directly the developmental profile of genetic influences contributing to complex traits, such as social communication difficulties, during an approximately 10-year period spanning childhood and adolescence...
September 28, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29089331/prevalence-of-aflatoxin-associated-tp53r249s-mutation-in-hepatocellular-carcinoma-in-hispanics-in-south-texas
#6
Jingjing Jiao, Weibo Niu, Ying Wang, Keith A Baggerly, Yuanqing Ye, Xifeng Wu, Dewitt Davenport, Jose Luis Almeda, Monica M Betancourt-Garcia, R Armour Forse, Heather L Stevenson, Gordon P Watt, Joseph B McCormick, Susan P Fisher-Hoch, Laura Beretta
We aimed to determine whether aflatoxin dietary exposure plays a role in the high incidence of hepatocellular carcinoma (HCC) observed among Hispanics in South Texas.We measured TP53R249S somatic mutation, hallmark of aflatoxin etiology in HCC, using droplet digital PCR and restriction fragment length polymorphism. TP53R249S mutation was detected in 3 out of 41 HCC tumors from Hispanics in South Texas (7.3%). We also measured TP53R249S mutation in plasma cell free DNA (cfDNA) from 218 HCC patients and 96 Hispanic subjects with advanced fibrosis or cirrhosis, from South Texas...
October 31, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29078768/men-s-perceptions-of-prostate-cancer-diagnosis-and-care-insights-from-qualitative-interviews-in-victoria-australia
#7
Maggie Kirkman, Kate Young, Susan Evans, Jeremy Millar, Jane Fisher, Danielle Mazza, Rasa Ruseckaite
BACKGROUND: The Victorian Prostate Cancer Registry (Australia) revealed poorer rates of survival for men diagnosed with prostate cancer in one Victorian regional area than for men in metropolitan Melbourne. We sought to explore the perceptions and experiences of prostate cancer diagnosis, treatment, and care of men diagnosed with prostate cancer who lived in regional or metropolitan areas and of men who had not been so diagnosed. Our goal was to contribute to the evidence from which can be built continuing improvements in prostate health care...
October 27, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29070965/validity-and-reliability-of-four-clinical-gait-measures-in-patients-with-multiple-sclerosis
#8
Susan E Bennett, Lacey E Bromley, Nadine M Fisher, Machiko R Tomita, Paulette Niewczyk
BACKGROUND: The gold standards for assessing ambulation are the Expanded Disability Status Scale (EDSS) and the Timed 25-Foot Walk (T25FW) test. In relation with these measures, we assessed the reliability and validity of four clinical gait measures: the Timed Up and Go (TUG) test, the Dynamic Gait Index (DGI), the 2-Minute Walk Test (2MWT), and the 6-Minute Walk Test (6MWT). Patient self-report of gait was also assessed using the 12-item Multiple Sclerosis Walking Scale (MSWS-12). METHODS: Individuals 20 years or older with a diagnosis of multiple sclerosis (MS) and an EDSS score of 2...
September 2017: International Journal of MS Care
https://www.readbyqxmd.com/read/29038234/patient-reported-symptom-control-of-diarrhea-and-flushing-in-patients-with-neuroendocrine-tumors-treated-with-lanreotide-depot-autogel-results-from-a-randomized-placebo-controlled-double-blind-and-32-week-open-label-study
#9
George A Fisher, Edward M Wolin, Nilani Liyanage, Susan Pitman Lowenthal, Beloo Mirakhur, Rodney F Pommier, Montaser Shaheen, Aaron Vinik
BACKGROUND: In the double-blind (DB) ELECT study, lanreotide depot/autogel significantly reduced versus placebo the need for short-acting octreotide for symptomatic carcinoid syndrome (CS) control in neuroendocrine tumor (NET) patients. Here we present patient-reported symptom data during DB and initial open-label (IOL) treatment. MATERIALS AND METHODS: Adults with NETs and CS history, with/without prior somatostatin analog use, were randomized to 16 weeks' DB lanreotide 120 mg subcutaneous or placebo every 4 weeks, followed by 32 weeks' IOL lanreotide...
October 16, 2017: Oncologist
https://www.readbyqxmd.com/read/29020308/management-of-latent-tuberculosis-infection-among-healthcare-workers-10-year-experience-at-a-single-center
#10
Esther Arguello Perez, Susan K Seo, William J Schneider, Cynthia Eisenstein, Arthur E Brown
Background: The risk of infection with Mycobacterium tuberculosis among healthcare workers (HCWs) is estimated to be higher than the general population. However, HCW acceptance and compliance with available latent tuberculosis infection (LTBI) treatment regimens has been problematic. Recently, regimens have become available that might improve HCW acceptance and compliance with LTBI treatment. Methods: A retrospective single-center review of Employee Health &Wellness Services records of all HCWs diagnosed with LTBI was conducted...
August 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28962523/metabolic-disruption-early-in-life-is-associated-with-latent-carcinogenic-activity-of-dichloroacetic-acid-in-mice
#11
Leah C Wehmas, Anthony B DeAngelo, Susan D Hester, Brian N Chorley, Gleta Carswell, Greg R Olson, Michael H George, Julia H Carter, Sandra R Eldridge, Anna Fisher, Beena Vallanat, Charles E Wood
Early-life environmental factors can influence later-life susceptibility to cancer. Recent evidence suggests that metabolic pathways may mediate this type of latency effect. Previously, we reported that short-term exposure to dichloroacetic acid (DCA) increased liver cancer in mice 84 weeks after exposure was stopped. Here, we evaluated time course dynamics for key events related to this effect. This study followed a stop-exposure design in which 28-day-old male B6C3F1 mice were given the following treatments in drinking water for up to 93 weeks: deionized water (dH2O, control); 3...
October 1, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28952369/current-caregiver-perspectives-and-effects-of-demographics-on-family-centered-rounds
#12
Ayesha Ahmed, Dorothy Chu, Susan Wang
The 2010 Pediatric Research in Inpatient Settings survey stated that 44% of pediatric hospitals practiced family-centered rounds (FCRs). We aimed to study caregivers' opinions of FCRs and determine if there are demographic associations with these opinions. A cross-sectional survey of caregivers who attended FCRs was conducted at a tertiary-care general pediatrics unit. The survey contained Likert-type scale and qualitative questions. Fisher's exact test was used to test demographic associations. Only English proficient caregivers were included...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28951466/emergency-department-blood-gas-utilization-and-changes-in-ventilator-settings
#13
Haitham S Al Ashry, Jeremy B Richards, Daniel F Fisher, Jeffrey Sankoff, Todd A Seigel, Lauren B Angotti, Susan R Wilcox
BACKGROUND: Mechanically ventilated patients increasingly spend hours in emergency department beds before ICU admission. This study evaluated the performance of blood gases in mechanically ventilated subjects in the emergency department and subsequent changes to mechanical ventilation settings. METHODS: This was a multi-center, prospective, observational study of subjects ventilated in the emergency department, conducted at 3 academic emergency departments from July 2011 to March 2013...
September 26, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28925048/the-association-between-insulin-resistance-metabolic-variables-and-depressive-symptoms-in-mexican-american-elderly-a-population-based-study
#14
Breno S Diniz, Susan Fisher-Hoch, Joseph McCormick
OBJECTIVE: Depressive symptoms are common among older adults with obesity and diabetes. Nonetheless, the mechanisms for this association are not clear but may involve changes in the insulin cascade signaling. We aimed to investigate the association, and potential mediators, between obesity, insulin resistance, and depressive symptoms among older adults from a homogenous cohort of Mexican-Americans. METHODS: We included a total of 500 Mexican-American older adults assessed in the Cameron County Health Study...
September 18, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28923940/defective-decidualization-during-and-after-severe-preeclampsia-reveals-a-possible-maternal-contribution-to-the-etiology
#15
Tamara Garrido-Gomez, Francisco Dominguez, Alicia Quiñonero, Patricia Diaz-Gimeno, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Pablo Padilla-Iserte, Michael McMaster, Olga Genbacev, Alfredo Perales, Susan J Fisher, Carlos Simón
In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by severe PE (sPE). Compared with control cells, they failed to decidualize in vitro as demonstrated by morphological criteria and the analysis of stage-specific antigens (i...
October 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28885494/prevalence-and-predictors-of-patient-reported-long-term-mental-and-physical-health-after-donation-in-the-adult-to-adult-living-donor-liver-transplantation-cohort-study-a2all
#16
Mary Amanda Dew, Zeeshan Butt, Qian Liu, Mary Ann Simpson, Jarcy Zee, Daniela P Ladner, Susan Holtzman, Abigail R Smith, Elizabeth A Pomfret, Robert M Merion, Brenda W Gillespie, Averell H Sherker, Robert A Fisher, Kim M Olthoff, James R Burton, Norah A Terrault, Alyson N Fox, Andrea F DiMartini
BACKGROUND: Prospective and longitudinal studies have examined liver donors' medical outcomes beyond the first 1-2 years postdonation. There is no analogous longitudinal evidence on long-term psychosocial outcomes, including patient-reported clinically significant mental health problems and perceptions of physical well-being. We examined prevalence, descriptive characteristics, and predictors of diagnosable mental health conditions and self-reported physical health problems, including fatigue and pain, in the long-term years after liver donation...
September 6, 2017: Transplantation
https://www.readbyqxmd.com/read/28881294/sleep-disturbance-may-impact-treatment-outcome-in-bipolar-disorder-a-preliminary-investigation-in-the-context-of-a-large-comparative-effectiveness-trial
#17
Louisa G Sylvia, Weilynn C Chang, Masoud Kamali, Mauricio Tohen, Gustavo Kinrys, Thilo Deckersbach, Joseph R Calabrese, Michael E Thase, Noreen Reilly-Harrington, William V Bobo, James H Kocsis, Melvin G McInnis, Charles L Bowden, Terence A Ketter, Edward S Friedman, Richard C Shelton, Susan L McElroy, Keming Gao, Dustin J Rabideau, Andrew A Nierenberg
BACKGROUND: Bipolar patients experience sleep disturbances during and between mood episodes. Yet the impact of sleep on treatment with different medications has not been fully explored. The purpose of this paper is to explore the potential impact of poor sleep at baseline on outcomes in a randomized effectiveness trial of quetiapine and lithium. METHODS: The Bipolar CHOICE study was a 6-month, parallel group, multisite randomized controlled trial. Participants with bipolar disorder (N = 482; 59% female and age 18-70 years) received quetiapine or lithium...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28874952/duration-of-mechanical-ventilation-in-the-emergency-department
#18
Lauren B Angotti, Jeremy B Richards, Daniel F Fisher, Jeffrey D Sankoff, Todd A Seigel, Haitham S Al Ashry, Susan R Wilcox
INTRODUCTION: Due to hospital crowding, mechanically ventilated patients are increasingly spending hours boarding in emergency departments (ED) before intensive care unit (ICU) admission. This study aims to evaluate the association between time ventilated in the ED and in-hospital mortality, duration of mechanical ventilation, ICU and hospital length of stay (LOS). METHODS: This was a multi-center, prospective, observational study of patients ventilated in the ED, conducted at three academic Level I Trauma Centers from July 2011 to March 2013...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28872529/in-hospital-complications-following-ankle-arthrodesis-versus-ankle-arthroplasty-a-matched-cohort-study
#19
COMPARATIVE STUDY
Susan M Odum, Bryce A Van Doren, Robert B Anderson, W Hodges Davis
BACKGROUND: Ankle arthrodesis has been the traditional surgical treatment for end-stage hindfoot arthritis. However, utilization of total ankle arthroplasty (TAA) is increasing as surgical techniques and implants have substantially improved. The purpose of this study was to compare the U.S. national rates of perioperative (in-hospital) complications between a statistically matched cohort of patients who underwent either an ankle arthrodesis or a TAA. METHODS: Data from the 2002 to 2013 Nationwide Inpatient Sample releases were analyzed...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28866750/relationship-between-laryngeal-sensory-deficits-aspiration-and-pneumonia-in-patients-with-dysphagia
#20
Asako Kaneoka, Jessica M Pisegna, Haruhi Inokuchi, Rumi Ueha, Takao Goto, Takaharu Nito, Cara E Stepp, Michael P LaValley, Nobuhiko Haga, Susan E Langmore
The laryngeal adductor reflex (LAR) is an airway protective reflex that manifests as a brief vocal fold closure in response to laryngeal stimulation. This study examined if the absence of the LAR in response to touch delivered by a laryngoscope is associated with penetration/aspiration or pneumonia in patients with dysphagia. Inpatients at a teaching hospital with clinical symptoms of dysphagia were recruited upon referral to the otolaryngology clinic for a swallowing evaluation. Otolaryngologists observed the status of secretions and touched each arytenoid with the tip of the laryngoscope...
September 2, 2017: Dysphagia
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