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Susan Fisher

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https://www.readbyqxmd.com/read/28645013/per-and-polyfluoroalkyl-substances-in-human-serum-and-urine-samples-from-a-residentially-exposed-community
#1
Rachel Rogers Worley, Susan McAfee Moore, Bruce C Tierney, Xiaoyun Ye, Antonia M Calafat, Sean Campbell, Million B Woudneh, Jeffrey Fisher
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are considered chemicals of emerging concern, in part due to their environmental and biological persistence and the potential for widespread human exposure. In 2007, a PFAS manufacturer near Decatur, Alabama notified the United States Environmental Protection Agency (EPA) it had discharged PFAS into a wastewater treatment plant, resulting in environmental contamination and potential exposures to the local community. OBJECTIVES: To characterize PFAS exposure over time, the Agency for Toxic Substances and Disease Registry (ATSDR) collected blood and urine samples from local residents...
June 20, 2017: Environment International
https://www.readbyqxmd.com/read/28640154/vaginal-microbiota-and-genitourinary-menopausal-symptoms-a-cross-sectional-analysis
#2
Caroline M Mitchell, Sujatha Srinivasan, Xiang Zhan, Michael C Wu, Susan D Reed, Katherine A Guthrie, Andrea Z LaCroix, Tina Fiedler, Matthew Munch, Congzhou Liu, Noah G Hoffman, Ian A Blair, Katherine Newton, Ellen W Freeman, Hadine Joffe, Lee Cohen, David N Fredricks
OBJECTIVE: To examine associations between the composition of the vaginal microbiota and genitourinary menopausal symptoms, serum estrogen, and vaginal glycogen. METHODS: For this cross-sectional study, 88 women aged 40 to 62 years, enrolled in a hot flash treatment trial, provided vaginal swabs and a blood sample at enrollment. Bacterial communities were characterized using 16S rRNA PCR and deep sequencing targeting the V3-V4 region. Quantities of Lactobacillus crispatus and Lactobacillus iners were measured using qPCR...
June 19, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28632531/a-descriptive-survey-of-anesthesiology-residency-simulation-programs-how-are-programs-preparing-residents-for-the-new-american-board-of-anesthesiology-applied-certification-examination
#3
Robert S Isaak, Fei Chen, Harendra Arora, Susan M Martinelli, David A Zvara, Marjorie P Stiegler
BACKGROUND: Anesthesiology residency programs may need new simulation-based programs to prepare residents for the new Objective Structured Clinical Examination (OSCE) component of the American Board of Anesthesiology (ABA) Primary Certification process. The design of such programs may require significant resources, including faculty time, expertise, and funding, as are currently needed for structured oral examination (SOE) preparation. This survey analyzed the current state of US-based anesthesiology residency programs regarding simulation-based educational programming for SOE and OSCE preparation...
June 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28546090/safety-and-tolerability-of-long-acting-cabotegravir-injections-in-hiv-uninfected-men-eclair-a-multicentre-double-blind-randomised-placebo-controlled-phase-2a-trial
#4
Martin Markowitz, Ian Frank, Robert M Grant, Kenneth H Mayer, Richard Elion, Deborah Goldstein, Chester Fisher, Magdalena E Sobieszczyk, Joel E Gallant, Hong Van Tieu, Winkler Weinberg, David A Margolis, Krischan J Hudson, Britt S Stancil, Susan L Ford, Parul Patel, Elizabeth Gould, Alex R Rinehart, Kimberly Y Smith, William R Spreen
BACKGROUND: Cabotegravir (GSK1265744) is an HIV-1 integrase strand transfer inhibitor with potent antiviral activity and a long half-life when administered by injection that prevented simian-HIV infection upon repeat intrarectal challenge in male macaques. We aimed to assess the safety, tolerability, and pharmacokinetics of long-acting cabotegravir injections in healthy men not at high risk of HIV-1 infection. METHODS: We did this multicentre, double-blind, randomised, placebo-controlled, phase 2a trial at ten sites in the USA...
May 22, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28494786/compositionally-and-functionally-distinct-sinus-microbiota-in-chronic-rhinosinusitis-patients-have-immunological-and-clinically-divergent-consequences
#5
Emily K Cope, Andrew N Goldberg, Steven D Pletcher, Susan V Lynch
BACKGROUND: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sinus microbiome dysbiosis. The basis of this heterogeneity is poorly understood. We sought to address the hypothesis that a limited number of compositionally distinct pathogenic bacterial microbiota exist in CRS patients and invoke discrete immune responses and clinical phenotypes in CRS patients. RESULTS: Sinus brushings from patients with CRS (n = 59) and healthy individuals (n = 10) collected during endoscopic sinus surgery were analyzed using 16S rRNA gene sequencing, predicted metagenomics, and RNA profiling of the mucosal immune response...
May 12, 2017: Microbiome
https://www.readbyqxmd.com/read/28478740/improving-autopsy-report-turnaround-times-by-implementing-lean-management-principles
#6
Susan Cromwell, David A Chiasson, Debra Cassidy, Gino R Somers
The autopsy is an integral part of the service of a large academic pathology department. Timely reporting is central to providing good service and is beneficial for many stakeholders, including the families, the clinical team, the hospital, and the wider community. The current study aimed to improve hospital-consented autopsy reporting times (turnaround time, TAT) by using lean principles modified for a healthcare setting, with an aim of signing out 90% of autopsies in 90 days. An audit of current and historical TATs was performed, and a working group incorporating administrative, technical, and professional staff constructed a value stream map documenting the steps involved in constructing an autopsy report...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28449033/response-assessment-in-medulloblastoma-and-leptomeningeal-seeding-tumors-recommendations-from-the-response-assessment-in-pediatric-neuro-oncology-committee
#7
Katherine E Warren, Gilbert Vezina, Tina Y Poussaint, Monika Warmuth-Metz, Marc C Chamberlain, Roger J Packer, Alba A Brandes, Moshe Reiss, Stewart Goldman, Michael J Fisher, Ian F Pollack, Michael D Prados, Patrick Y Wen, Susan M Chang, Christelle Dufour, David Zurakowski, Rolf D Kortmann, Mark W Kieran
Lack of standard response criteria in clinical trials for medulloblastoma and other seeding tumors complicates assessment of therapeutic efficacy and comparisons across studies. An international working group was established to develop consensus recommendations for response assessment. The aim is that these recommendations be prospectively evaluated in clinical trials, with the goal of achieving more reliable risk stratification and uniformity across clinical trials. Current practices and literature review were performed to identify major confounding issues and justify subsequently developed recommendations; in areas lacking scientific investigations, recommendations were based on experience of committee members and consensus was reached after discussion...
April 25, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28419515/incivility-in-the-online-classroom-a-guide-for-policy-development
#8
Emily E Hopkins, Kathleen C Spadaro, Lora Walter, Jennifer J Wasco, MaryDee Fisher, Susan E Sterrett
The growth of online education has created a learning environment that permits nontraditional students the opportunity for degree completion without the burden of relocation. Given the shortage of nurses at all educational levels, many institutions of higher learning have created online programs to meet the needs of both the student and the profession as a whole. Although convenient for the student and beneficial for the nursing profession, the online learning environment can present numerous challenges. Among these challenges are acts of student incivility-creating a difficult work environment for faculty and, at times, negatively affecting other students...
April 17, 2017: Nursing Forum
https://www.readbyqxmd.com/read/28395890/frequency-of-nonalcoholic-fatty-liver-disease-and-subclinical-atherosclerosis-among-young-mexican-americans
#9
Clarence Gill, Kristina P Vatcheva, Jen-Jung Pan, Beverly Smulevitz, David D McPherson, Michael Fallon, Joseph B McCormick, Susan P Fisher-Hoch, Susan T Laing
Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of the metabolic syndrome, whose criteria are risk factors for atherosclerotic cardiovascular disease. We aimed to evaluate the prevalence of NAFLD, its association with subclinical atherosclerosis, and factors that may account for this association in Mexican Americans. In a population-based cross-sectional sample drawn from the Cameron County Hispanic Cohort in Texas, carotid intima media thickness (cIMT), an indicator of subclinical atherosclerosis, was measured...
June 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28392908/shared-genetic-influences-between-dimensional-asd-and-adhd-symptoms-during-child-and-adolescent-development
#10
Evie Stergiakouli, George Davey Smith, Joanna Martin, David H Skuse, Wolfgang Viechtbauer, Susan M Ring, Angelica Ronald, David E Evans, Simon E Fisher, Anita Thapar, Beate St Pourcain
BACKGROUND: Shared genetic influences between attention-deficit/hyperactivity disorder (ADHD) symptoms and autism spectrum disorder (ASD) symptoms have been reported. Cross-trait genetic relationships are, however, subject to dynamic changes during development. We investigated the continuity of genetic overlap between ASD and ADHD symptoms in a general population sample during childhood and adolescence. We also studied uni- and cross-dimensional trait-disorder links with respect to genetic ADHD and ASD risk...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28389324/comparing-the-incidence-of-bone-tumors-in-rats-chronically-exposed%C3%A2-to-the-selective-pth-type-1-receptor-agonist-abaloparatide%C3%A2-or%C3%A2-pth-1-34
#11
Jacquelin Jolette, Bassem Attalla, Aurore Varela, Gerald G Long, Nacera Mellal, Sabile Trimm, Susan Y Smith, Michael S Ominsky, Gary Hattersley
Prolonged treatment with human parathyroid hormone (hPTH) in rats results in development of bone tumors, though this finding has not been supported by clinical experience. The PTH type 1 receptor agonist abaloparatide, selected for its bone anabolic activity, is under clinical development to treat postmenopausal women with osteoporosis. To determine the carcinogenic potential of abaloparatide, Fischer (F344) rats were administered SC daily abaloparatide at doses of 0, 10, 25, and 50 μg/kg or 30 μg/kg hPTH(1-34) as a positive control for up to 2 years...
April 4, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28388838/trauma-exposure-among-women-in-the-pacific-rim
#12
Elizabeth Reeves, Pilar Bernal de, Susan G Silva, Diva Jaramillo, Tulia Uribe, Agnes Tiwari, Gladys Eugenia Canaval, Maria Eugenia Mendoza Flores, Ruth Ann Belknap, Janice C Humphreys
PURPOSE: Healthcare professionals who provide services in the immediate or long-term aftermath of traumatic events need to understand the nature and frequency of traumatic events in the lives of women. However, research on trauma exposure in women has only recently begun to assess events other than intimate partner and sexual violence and has not supported direct statistical comparison of cross-national and cross-cultural data. The purpose of this descriptive, correlational study was to describe and compare trauma exposure prevalence and type in community-based samples of women in the United States, Colombia, and Hong Kong...
May 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28386042/mexican-americans-receive-less-intensive-stroke-rehabilitation-than-non-hispanic-whites
#13
Lewis B Morgenstern, Emma Sais, Michael Fuentes, Nneka L Ifejika, Xiaqing Jiang, Susan D Horn, Erin Case, Lynda D Lisabeth
BACKGROUND AND PURPOSE: Mexican Americans (MAs) have worse neurological, functional, and cognitive outcomes after stroke. Stroke rehabilitation is important for good outcome. In a population-based study, we sought to determine whether allocation of stroke rehabilitation services differed by ethnicity. METHODS: Patients with stroke were identified as part of the Brain Attack Surveillance in Corpus Christi (BASIC) project, TX, USA. Cases were validated by physicians using source documentation...
June 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28385427/percent-predicted-lung-volume-changes-on-fetal-magnetic-resonance-imaging-throughout-gestation-in-congenital-diaphragmatic-hernia
#14
Hester F Shieh, Carol E Barnewolt, Jay M Wilson, David Zurakowski, Susan A Connolly, Judy A Estroff, Jill Zalieckas, C Jason Smithers, Terry L Buchmiller
PURPOSE: Percent predicted lung volume (PPLV)<15% on fetal MRI predicts high-risk CDH. Potential changes in PPLV throughout gestation and impact on risk stratification are unknown. We reviewed CDH patients with serial fetal MRIs to follow PPLV and determine correlation with postnatal outcomes. METHODS: CDH patients with serial fetal MRIs from 2005 to 2015 were included. We recorded prenatal MRI gestational age (GA) and PPLV, postnatal ECMO use, and survival. Data were analyzed by logistic regression and Fisher's exact test...
June 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28383813/mibg-avidity-correlates-with-clinical-features-tumor-biology-and-outcomes-in-neuroblastoma-a-report-from-the-children-s-oncology-group
#15
Steven G DuBois, Rajen Mody, Arlene Naranjo, Collin Van Ryn, Douglas Russ, Derek Oldridge, Susan Kreissman, David L Baker, Marguerite Parisi, Barry L Shulkin, Harrison Bai, Sharon J Diskin, Vandana Batra, John M Maris, Julie R Park, Katherine K Matthay, Gregory Yanik
BACKGROUND: Prior studies suggest that neuroblastomas that do not accumulate metaiodobenzylguanidine (MIBG) on diagnostic imaging (MIBG non-avid) may have more favorable features compared with MIBG avid tumors. We compared clinical features, biologic features, and clinical outcomes between patients with MIBG nonavid and MIBG avid neuroblastoma. PROCEDURE: Patients had metastatic high- or intermediate-risk neuroblastoma and were treated on Children's Oncology Group protocols A3973 or A3961...
April 6, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28381130/pilot-trial-of-intravenous-autologous-culture-expanded-mesenchymal-stem-cell-transplantation-in-multiple-sclerosis
#16
Jeffrey A Cohen, Peter B Imrey, Sarah M Planchon, Robert A Bermel, Elizabeth Fisher, Robert J Fox, Amit Bar-Or, Susan L Sharp, Thomai T Skaramagas, Patricia Jagodnik, Matt Karafa, Shannon Morrison, Jane Reese Koc, Stanton L Gerson, Hillard M Lazarus
BACKGROUND: Mesenchymal stem cells (MSCs) exhibit immunomodulatory, tissue-protective, and repair-promoting properties in vitro and in animals. Clinical trials in several human conditions support the safety and efficacy of MSC transplantation. Published experience in multiple sclerosis (MS) is modest. OBJECTIVE: To assess feasibility, safety, and tolerability and explore efficacy of autologous MSC transplantation in MS. METHODS: Participants with relapsing-remitting multiple sclerosis (RRMS) or secondary progressive multiple sclerosis (SPMS), Expanded Disability Status Scale score 3...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28369857/increased-public-reimbursement-for-prophylactic-visits-with-dentists-associated-with-increased-receipt-of-preventive-dental-services-in-children
#17
Susan A Fisher-Owens, Louis Amendola, John D B Featherstone, Ronald E Inge, Valerie J Flaherman
OBJECTIVE: To determine whether higher reimbursement for children's preventive dentistry correlates with greater utilization of preventive dental care. METHODS: A cross-sectional analysis of National Survey of Children's Health 2011/2012 was conducted, combined with state Medicaid reimbursement rates for preventive dentistry. Analyses included prevalence, unadjusted odds ratios, and multivariable logistic regression for receipt of preventive dental services. RESULTS: Of all surveyed American children 1-17 years, almost 20 percent had not received preventive dental care in prior year; this percentage is even higher in those with public insurance...
March 30, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/28347715/preeclampsia-novel-insights-from-global-rna-profiling-of%C3%A2-trophoblast-subpopulations
#18
Matthew Gormley, Katherine Ona, Mirhan Kapidzic, Tamara Garrido-Gomez, Tamara Zdravkovic, Susan J Fisher
BACKGROUND: The maternal signs of preeclampsia, which include the new onset of high blood pressure, can occur because of faulty placentation. We theorized that transcriptomic analyses of trophoblast subpopulations in situ would lend new insights into the role of these cells in preeclampsia pathogenesis. OBJECTIVE: Our goal was to enrich syncytiotrophoblasts, invasive cytotrophoblasts, or endovascular cytotrophoblasts from the placentas of severe preeclampsia cases...
March 24, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28337575/a-novel-modeling-approach-for-estimating-patterns-of-migration-into-and-out-of-san-francisco-by-hiv-status-and-race-among-men-who-have-sex-with-men
#19
Alison J Hughes, Yea-Hung Chen, Susan Scheer, H Fisher Raymond
In the early 1980s, men who have sex with men (MSM) in San Francisco were one of the first populations to be affected by the human immunodeficiency virus (HIV) epidemic, and they continue to bear a heavy HIV burden. Once a rapidly fatal disease, survival with HIV improved drastically following the introduction of combination antiretroviral therapy in 1996. As a result, the ability of HIV-positive persons to move into and out of San Francisco has increased due to lengthened survival. Although there is a high level of migration among the general US population and among HIV-positive persons in San Francisco, in- and out-migration patterns of MSM in San Francisco have, to our knowledge, never been described...
March 23, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28328120/a-qualitative-study-of-adolescents-understanding-of-biobanks-and-their-attitudes-toward-participation-re-contact-and-data-sharing
#20
Andrea M Murad, Melanie F Myers, Susan D Thompson, Rachel Fisher, Armand H Matheny Antommaria
While biobanks have become more prevalent, little is known about adolescents' views of key governance issues. We conducted semi-structured interviews with adolescents between 15 and 17 years old to solicit their views. All interviews were audiotaped and transcribed. Two investigators coded the transcripts and resolved any discrepancies through consensus. We conducted 18 interviews before reaching data saturation. Four participants (22%) had previously heard of a biobank. Many participants had misunderstandings about biobanks, some of which persisted after education...
April 2017: American Journal of Medical Genetics. Part A
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