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https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#1
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
September 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28921675/altered-cav1-2-function-in-the-timothy-syndrome-mouse-model-produces-ascending-serotonergic-abnormalities
#2
Daniel G Ehlinger, Kathryn G Commons
Polymorphism in the gene CACNA1C, encoding the pore-forming subunit of Cav1.2 L-type calcium channels, has one of the strongest genetic linkages to schizophrenia, bipolar disorder, and major depressive disorder: psychopathologies in which serotonin signaling has been implicated. Additionally, a gain-of-function mutation in CACNA1C is responsible for the neurodevelopmental disorder Timothy Syndrome that presents with prominent behavioral features on the autism spectrum. Given an emerging role for serotonin in the etiology of autism spectrum disorders, we investigate the relationship between Cav1...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921532/the-morphological-characterization-of-orientation-biased-displaced-large-field-ganglion-cells-in-the-central-part-of-goldfish-retina
#3
Hideo Hoshi, Fumi Sato
The vertebrate retina has about 30 subtypes of ganglion cells. Each ganglion cell receives synaptic inputs from specific types of bipolar and amacrine cells ramifying at the same depth of the inner plexiform layer (IPL), each of which is thought to process a specific aspect of visual information. Here, we identified one type of displaced ganglion cell in the goldfish retina which had a large and elongated dendritic field. As a population, all of these ganglion cells were oriented in the horizontal axis and perpendicular to the dorsal-ventral axis of the goldfish eye in the central part of retina...
September 18, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28920921/increased-intracellular-proteolysis-reduces-disease-severity-in-an-er-stress-associated-dwarfism
#4
Lorna A Mullan, Ewa J Mularczyk, Louise H Kung, Mitra Forouhan, Jordan Ma Wragg, Royston Goodacre, John F Bateman, Eileithyia Swanton, Michael D Briggs, Raymond P Boot-Handford
The short-limbed dwarfism metaphyseal chondrodysplasia type Schmid (MCDS) is linked to mutations in type X collagen, which increase ER stress by inducing misfolding of the mutant protein and subsequently disrupting hypertrophic chondrocyte differentiation. Here, we show that carbamazepine (CBZ), an autophagy-stimulating drug that is clinically approved for the treatment of seizures and bipolar disease, reduced the ER stress induced by 4 different MCDS-causing mutant forms of collagen X in human cell culture...
September 18, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28918859/a-preliminary-study-of-bipolar-disorder-type-i-by-mass-spectrometry-based-serum-lipidomics
#5
Henrique C Ribeiro, Aline Klassen, Mariana Pedrini, Michelle S Carvalho, Lucas B Rizzo, Mariane N Noto, Maiara Zeni-Graiff, Sumit Sethi, Francisco A H Fonseca, Ljubica Tasic, Mirian A F Hayashi, Quirino Cordeiro, Elisa Brietzke, Alessandra Sussulini
The present study aimed at investigating possible alterations in the serum lipid profile of euthymic patients with bipolar disorder type I (BD) compared to healthy controls (HC). Thirty-five individuals from both genders were recruited, with 14 diagnosed and treated as BD patients (BD group) and 21 healthy subjects (HC group). Clinical assessment was based on the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Young Mania Rating Scale (YMRS), and 17-items of Hamilton Depression Rating Scale (HDRS-17) data, which were used to confirm diagnosis, to verify psychiatric comorbidities, and to estimate the severity of manic and depressive symptoms...
August 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28917190/posttraumatic-stress-symptoms-and-dissociation-between-childhood-trauma-and-two-different-types-of-psychosis-like-experience
#6
Ji Young Choi
This study examined the roles of posttraumatic stress (PTS) symptoms and dissociation in the relationship between childhood trauma and two different types of psychosis-like experience, including persecutory ideation and aberrant experience, in non-psychotic psychiatric patients. From August 2015 to August 2016, among psychiatric out patients seeking treatment at the Department of Psychiatry at a major teaching medical hospital in Seoul, Korea, 169 patients who had never been diagnosed with a psychotic disorder, including schizophrenia spectrum disorder, bipolar disorder, and/or depressive disorder with psychotic features, completed the Korean Childhood Trauma Questionnaire, the Korean version of the Impact of Event Scale-Revised, the modified Korean version of the Peritraumatic Dissociation Experiences Questionnaire, and the Korean Minnesota Multiphasic Personality Inventory-2 (MMPI-2)...
September 13, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28914726/pro-inflammatory-cytokines-mood-and-sleep-in-interepisode-bipolar-disorder-and-insomnia-a-pilot-study-with-implications-for-psychosocial-interventions
#7
Michael R Dolsen, Adriane M Soehner, Allison G Harvey
OBJECTIVE: Pro-inflammatory cytokines are associated with bipolar disorder (BD), but less is known about how cytokines function during the interepisode period. This study examined cytokines, mood symptoms, and sleep in individuals with interepisode BD with complaints of insomnia. We also investigated the effects of a BD-specific modification of cognitive behavior therapy for insomnia (CBTI-BP) on cytokine levels. METHODS: The 22 adults with interepisode BD Type I and insomnia were drawn from a subset of an NIMH-funded study...
September 13, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28912043/abnormal-segments-of-right-uncinate-fasciculus-and-left-anterior-thalamic-radiation-in-major-and-bipolar-depression
#8
Feng Deng, Ying Wang, Huiyuan Huang, Meiqi Niu, Shuming Zhong, Ling Zhao, Zhangzhang Qi, Xiaoyan Wu, Yao Sun, Chen Niu, Yuan He, Li Huang, Ruiwang Huang
Differential brain structural abnormalities between bipolar disorder (BD) and major depressive disorder (MDD) may reflect different pathological mechanisms underlying these two brain disorders. However, few studies have directly compared the brain structural properties, especially in white matter (WM) tracts, between BD and MDD. Using automated fiber-tract quantification (AFQ), we utilized diffusion tensor images (DTI) from 67 unmedicated depressed patients, including 31 BD and 36 MDD, and 45 healthy controls (HC) to create fractional anisotropy (FA) tract profiles along 20 major WM tracts...
September 11, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28904603/mindfulness-based-treatment-for-bipolar-disorder-a-systematic-review-of-the-literature
#9
REVIEW
Sanja Bojic, Rodrigo Becerra
Despite the increasing number of studies examining the effects of mindfulness interventions on symptoms associated with Bipolar Disorder (BD), the effectiveness of this type of interventions remains unclear. The aim of the present systematic review was to (i) critically review all available evidence on Mindfulness Based Cognitive Therapy (MBCT) as a form of intervention for BD; (ii) discuss clinical implications of MBCT in treating patients with BD; and (iii) provide a direction for future research. The review presents findings from 13 studies (N = 429) that fulfilled the following selection criteria: (i) included BD patients; (ii) presented results separately for BD patients and control groups (where a control group was available); (iii) implemented MBCT intervention; (iv) were published in English; (v) were published in a peer reviewed journal; and (vi) reported results for adult participants...
August 2017: Europe's journal of psychology
https://www.readbyqxmd.com/read/28900737/the-benefit-of-the-systematic-revision-of-the-acetabular-implant-in-favor-of-a-dual-mobility-articulation-during-the-treatment-of-periprosthetic-fractures-of-the-femur-a-49-cases-prospective-comparative-study
#10
A Perrin, M Saab, S Putman, K Benad, E Drumez, C Chantelot
INTRODUCTION: The SOFCOT symposium (2005) on periprosthetic fractures of the femur (PFFs) highlighted a high rate of dislocation (15.6% at 6 months) after change of prosthesis. So far, no study has ever proved the benefit of dual-mobility articulation during PFFs revisions. We conducted a comparative study on two prospective cohorts in order to (1) assess the influence of systematic acetabular revision in favor of a double mobility on dislocation rate (2) and in order to evaluate the rate of morbidity associated with this extra surgical procedure...
September 12, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28884713/-mental-disorders-in-patients-with-breast-cancer-a-differentiated-approach-to-the-study-of-nozogeny
#11
O V Shushpanova
AIM: To study mental disorders in patients with breast cancer (BC) at different stages of the disease taking into account premorbid characteristics and psychosomatic correlations in their development. MATERIAL AND METHODS: The study included 82 patients with histologically confirmed BC. The first group consisted of 30 patients (mean age 49.7±11.1 years) with the first established diagnosis of BC and mental disorders caused by somatic disease (ICD-10 F40-F48, stress-related neurotic and somatoform disorders)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28882405/efficacy-of-quetiapine-xr-vs-placebo-as-concomitant-treatment-to-mood-stabilizers-in-the-control-of-subthreshold-symptoms-of-bipolar-disorder-results-from-a-pilot-randomized-controlled-trial
#12
Marina Garriga, Eva Solé, Ana González-Pinto, Gabriel Selva-Vera, Belén Arranz, Benedikt L Amann, Jerónimo Saiz-Ruiz, Josefina Pérez-Blanco, Eduard Vieta
Patients with bipolar disorder (BD) do not always achieve full remission between episodes. Subthreshold symptoms (depressive, manic or mixed) represent a major cause of relapse and disability in these patients. Immediate release (IR) and extended release (XR) formulations of quetiapine are both indicated for short and long-term treatment of BD. The aim of this study was to evaluate the efficacy of quetiapine XR vs placebo in subthreshold symptomatology when added to previous mood stabilizer treatment. A pilot phase IIIB, multicentre, prospective, placebo controlled, randomized, double blinded study of 12 weeks follow-up was performed (NCT01197846)...
September 4, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28879470/childhood-maltreatment-and-the-medical-morbidity-in-bipolar-disorder-a-case-control-study
#13
Georgina M Hosang, Helen L Fisher, Rudolf Uher, Sarah Cohen-Woods, Barbara Maughan, Peter McGuffin, Anne E Farmer
BACKGROUND: Childhood maltreatment (abuse and neglect) can have long-term deleterious consequences, including increased risk for medical and psychiatric illnesses, such as bipolar disorder in adulthood. Emerging evidence suggests that a history of childhood maltreatment is linked to the comorbidity between medical illnesses and mood disorders. However, existing studies on bipolar disorder have not yet explored the specific influence of child neglect and have not included comparisons with individuals without mood disorders (controls)...
September 7, 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28878002/combat-a-combined-association-test-for-genes-using-summary-statistics
#14
Minghui Wang, Jianfei Huang, Yiyuan Liu, Li Ma, James B Potash, Shizhong Han
Genome-wide association studies (GWAS) have been widely used for identifying common variants associated with complex diseases. Traditional analysis of GWAS typically examines one marker at a time, usually single nucleotide polymorphisms (SNPs), to identify individual variants associated with a disease. However, due to the small effect sizes of common variants, the power to detect individual risk variants is generally low. As a complementary approach to SNP-level analysis, a variety of gene-based association tests have been proposed...
September 6, 2017: Genetics
https://www.readbyqxmd.com/read/28874522/efficient-stimulus-secretion-coupling-at-ribbon-synapses-requires-rim-binding-protein-tethering-of-l-type-ca-2-channels
#15
Fujun Luo, Xinran Liu, Thomas C Südhof, Claudio Acuna
Fast neurotransmitter release from ribbon synapses via Ca(2+)-triggered exocytosis requires tight coupling of L-type Ca(2+) channels to release-ready synaptic vesicles at the presynaptic active zone, which is localized at the base of the ribbon. Here, we used genetic, electrophysiological, and ultrastructural analyses to probe the architecture of ribbon synapses by perturbing the function of RIM-binding proteins (RBPs) as central active-zone scaffolding molecules. We found that genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release, and rendered evoked and spontaneous neurotransmitter release sensitive to the slow Ca(2+) buffer EGTA...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28873468/neuropsychological-functioning-age-and-medication-adherence-in-bipolar-disorder
#16
Nadia Corréard, Julia-Lou Consoloni, Aurélie Raust, Bruno Etain, Romain Guillot, Sophie Job, Joséphine Loftus, Isabelle Médecin, Thierry Bougerol, Mircea Polosan, Benjamin Fredembach, Sébastien Gard, Katia M'Bailara, Jean-Pierre Kahn, Paul Roux, Anne-Sophie Homassel, Mathilde Carminati, Lucile Matos, Emilie Olié, Frank Bellivier, Philippe Courtet, Chantal Henry, Marion Leboyer, Jean-Michel Azorin, Raoul Belzeaux
OBJECTIVES: Poor adherence to medication is frequent in bipolar disorder (BD) and has been associated with several factors. To date, the relationship between low adherence and neuropsychological functioning in BD is still unclear. As age and neuropsychological functioning might have opposing influences on adherence, our aim was to investigate this link with a particular focus on the effect of age. METHODS: In a cross-sectional study, we included 353 patients divided into two age-groups (16-46; 47-71) from a French cohort diagnosed with BD (type I, II, NOS) and strictly euthymic...
2017: PloS One
https://www.readbyqxmd.com/read/28872643/tropism-of-engineered-and-evolved-recombinant-aav-serotypes-in-the-rd1-mouse-and-ex-vivo-primate-retina
#17
D G Hickey, T L Edwards, A R Barnard, M S Singh, S R de Silva, M E McClements, J G Flannery, M W Hankins, R E MacLaren
There is much debate on the adeno-associated virus (AAV) serotype that best targets specific retinal cell types and the route of surgical delivery-intravitreal or subretinal. This study compared three of the most efficacious AAV vectors known to date in a mouse model of retinal degeneration (rd1 mouse) and macaque and human retinal explants. GFP driven by a ubiquitous promoter was packaged into three AAV capsids: AAV2/8(Y733F), AAV2/2(quad Y-F) and AAV2/2(7m8). Overall AAV2/2(7m8) transduced the largest area of retina and resulted in the highest level of GFP expression, followed by AAV2/2(quad Y-F) and AAV2/8(Y733F)...
September 5, 2017: Gene Therapy
https://www.readbyqxmd.com/read/28871844/management-of-bleeding-in-exclusive-endoscopic-ear-surgery-pilot-clinical-experience
#18
Lukas Anschuetz, Marco Bonali, Pierre Guarino, Filippo B Fabbri, Matteo Alicandri-Ciufelli, Domenico Villari, Marco Caversaccio, Livio Presutti
Objective Transcanal exclusive endoscopic ear surgery requires the management of the endoscope and the surgical instruments in the external auditory canal. Bleeding in this narrow space is one of the most challenging issues, especially for novice endoscopic ear surgeons. We aim to assess the severity and occurrence of bleeding and describe strategies to control the bleeding during endoscopic ear surgery. We hypothesize that bleeding is reasonably controllable in endoscopic ear surgery. Study Design Case series with chart review...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28869584/an-xqtl-map-integrates-the-genetic-architecture-of-the-human-brain-s-transcriptome-and-epigenome
#19
Bernard Ng, Charles C White, Hans-Ulrich Klein, Solveig K Sieberts, Cristin McCabe, Ellis Patrick, Jishu Xu, Lei Yu, Chris Gaiteri, David A Bennett, Sara Mostafavi, Philip L De Jager
We report a multi-omic resource generated by applying quantitative trait locus (xQTL) analyses to RNA sequence, DNA methylation and histone acetylation data from the dorsolateral prefrontal cortex of 411 older adults who have all three data types. We identify SNPs significantly associated with gene expression, DNA methylation and histone modification levels. Many of these SNPs influence multiple molecular features, and we demonstrate that SNP effects on RNA expression are fully mediated by epigenetic features in 9% of these loci...
September 4, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28869511/analysis-of-multi-level-simultaneous-driving-technique-for-capacitive-touch-sensors
#20
Jong Kang Park, Chang-Ju Lee, Jong Tae Kim
The signal-to-noise ratio (SNR) and driving levels of capacitive touch sensors determine the applicability of these sensors to thinner displays and sensor-integrated modules. The simultaneous driving technique has been widely applied to capacitive touch sensors to cope with various types of environmental noise. A Hadamard matrix has been used to determine the driving code and multiplex capacitive signals required to increase the SNR and responsivity of touch sensors. Using multi-level Hadamard matrices, a new driving technique for sensing concurrent capacitive elements across multiple rows of a touch panel was developed...
September 2, 2017: Sensors
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