keyword
https://read.qxmd.com/read/38447149/cognitive-functioning-of-adolescents-using-methamphetamine-the-impact-of-inflammatory-and-oxidative-processes
#21
JOURNAL ARTICLE
Burak Çakır, Aylin Deniz Uzun Çakır, Şermin Yalın Sapmaz, Öznur Bilaç, Fatma Taneli, Hasan Kandemir
BACKGROUND: Methamphetamine is a substance that causes neurotoxicity and its use is increasing in recent years. Literature highlights cognitive impairment resulting from Methamphetamine use. The aim of the present study is to evaluate the relationship between cognitive impairment and inflammatory processes in adolescents with Methamphetamine use disorder. METHODS: The study included 69 adolescents aged 15-19 years, comprising 37 participants with Methamphetamine Use Disorder and 32 healthy controls...
March 6, 2024: Applied Neuropsychology. Child
https://read.qxmd.com/read/38440414/endovascular-management-of-acute-and-subacute-venous-thoracic-outlet-syndrome
#22
REVIEW
Mark G Davies, Joseph P Hart
Approximately 3% of all patients presenting with Thoracic Outlet Syndrome have a venous etiology (vTOS), which is considered "effort thrombosis". These patients will present with symptomatic deep venous thrombosis or focal subclavian vein (SCV) stenosis. Endovascular management of vTOS occurs in several phases: diagnostic, preoperative therapeutic intervention before decompression, postoperative interventions after decompression, and delayed interventions in the follow-up after decompression. In the diagnostic phase, dynamic SCV venography can establish functional vTOS...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38440253/safety-evaluation-of-the-food-enzyme-%C3%AE-galactosidase-from-the-genetically-modified-saccharomyces-cerevisiae-strain-cbs-615-94
#23
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Yrjö Roos, Jaime Aguilera, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Yi Liu, Eleonora Marini, Andrew Chesson
The food enzyme α-galactosidase (α-d-galactoside galactohydrolase; EC 3.2.1.22) is produced with the genetically modified Saccharomyces cerevisiae strain CBS 615.94 by Kerry Ingredients & Flavours Ltd. The production strain of the food enzyme contains multiple copies of a known antimicrobial resistance gene. However, based on the absence of viable cells and DNA from the production organism in the food enzyme, this is not considered to be a risk. As no other concerns arising from the genetically modified microbial source or from the manufacturing process have been identified, the Panel considered that toxicological tests were not needed for the assessment of this food enzyme...
March 2024: EFSA journal
https://read.qxmd.com/read/38439686/diazoxide-attenuates-dox-induced-cardiotoxicity-in-cultured-rat-myocytes
#24
JOURNAL ARTICLE
Celal Guven, Eylem Taskin, Özgül Aydın, Salih Tunç Kaya, Yusuf Sevgiler
Doxorubicin (DOX)-induced cardiotoxicity is a well known clinical problem, and many investigations have been made of its possible amelioration. We have investigated whether diazoxide (DIA), an agonist at mitochondrial ATP-sensitive potassium channels (mitoKATP ), could reverse DOX-induced apoptotic myocardial cell loss, in cultured rat cardiomyocytes. The role of certain proteins in this pathway was also studied. The rat cardiomyocyte cell line (H9c2) was treated with DOX, and also co-treated with DOX and DIA, for 24 h...
March 5, 2024: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://read.qxmd.com/read/38432970/three-dimensional-visualization-of-the-brachial-plexus
#25
JOURNAL ARTICLE
Taku Suzuki, Katsuhiko Hayakawa, Takuji Iwamoto
No abstract text is available yet for this article.
March 4, 2024: Internal Medicine
https://read.qxmd.com/read/38432516/fingertip-injuries-and-their-reconstruction-focusing-on-nails
#26
REVIEW
Pierluigi Tos, Alessandro Crosio, Roberto Adani
The fingertip is a complex anatomical structure that is frequently injured, especially in manual workers. Different classifications have been reported, considering injury orientation, level and geometry. To optimize treatment planning, the area of soft-tissue defect should be considered. Treatment aims to conserve as long a finger as possible, restore sensation (S3 + or more) and ensure a pleasant esthetic appearance. When amputation occurs, the best treatment is replantation when conditions allow. When this is not possible, the fingertip should be used as a composite graft or the nail complex can be grafted and soft tissue reconstructed, according to the preferred method...
March 1, 2024: Hand Surgery and Rehabilitation
https://read.qxmd.com/read/38428008/pediatric-thoracic-outlet-syndrome-a-systematic-review-and-meta-analysis
#27
JOURNAL ARTICLE
Anthony Price, Nathan Fredricks, Nina Truong, Robert Y North
OBJECTIVE: Thoracic outlet syndrome (TOS) is a complex disorder affecting the neurovascular structures of the upper extremity as they traverse from the neck and thorax to the upper extremity. This systematic review and meta-analysis focuses on pediatric TOS, offering insights into its clinical presentation, etiology, treatment modalities, and outcomes in contrast to those reported in adult TOS. METHODS: A comprehensive search for pediatric TOS in the PubMed database using PRISMA guidelines identified 6 relevant studies published between 2008 and 2022...
March 1, 2024: Journal of Neurosurgery. Pediatrics
https://read.qxmd.com/read/38419047/the-influence-of-nrf2-gene-promoter-methylation-on-gene-expression-and-oxidative-stress-parameters-in-preeclampsia
#28
JOURNAL ARTICLE
Saba Zakeri, Zohreh Rahimi, Nayebali Rezvani, Asad Vaisi-Raygani, Reza Alibakhshi, Sahel Zakeri, Kheirolah Yari
BACKGROUND AND AIMS: Preeclampsia (PE) is a serious medical condition that usually causes high blood pressure and affects multiple organs. Considering the adverse effect of oxidative stress on the process of PE in pregnant women and regarding the role of the Nrf2 gene in placental oxidative pathways, this study was conducted to investigate the DNA methylation status of Nrf2 in PE and healthy pregnant women. MATERIALS AND METHODS: The present case-control study consisted of 70 PE and 70 healthy pregnant women...
February 28, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38417895/videothoracoscopic-first-rib-resection-for-neurogenic-thoracic-outlet-syndrome-results-of-13-patients
#29
JOURNAL ARTICLE
Onur Derdiyok, Ugˇur Temel
PURPOSE: To present the clinical experience in video-assisted thoracic surgery (VATS) of first rib resection for patients with neurogenic thoracic outlet syndrome (NTOS). METHODS: The files of 13 patients (10 males, 3 females) having unilateral NTOS undergoing first rib resection via VATS were retrospectively investigated. The symptoms, operative times, durations of chest tube and hospital stay, complications, and postoperative courses were analyzed. All patients underwent VATS using a camera port and 3-5 cm utility incision...
2024: Annals of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38415018/safety-evaluation-of-the-food-enzyme-%C3%AE-fructofuranosidase-from-the-non-genetically-modified-saccharomyces-cerevisiae-strain-ncyc-r693
#30
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu, Eleonora Marini, Francesco Pesce, Giulio di Piazza, Andrew Chesson
The food enzyme β-fructofuranosidase (β-d-fructofuranoside fructohydrolase; EC 3.2.1.26) is produced with the non-genetically modified Saccharomyces cerevisiae strain NCYC R693 by Kerry Ingredients & Flavours Ltd. The production strain meets the requirements for the qualified presumption of safety (QPS) approach. The food enzyme is intended to be used in four food manufacturing processes. The dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 2.485 mg TOS/kg body weight per day in European populations...
February 2024: EFSA journal
https://read.qxmd.com/read/38410788/anticancer-action-of-silver-nanoparticles-in-skbr3-breast-cancer-cells-through-promotion-of-oxidative-stress-and-apoptosis
#31
JOURNAL ARTICLE
Mohammad Vahabirad, Sajedeh Daei, Roghayeh Abbasalipourkabir, Nasrin Ziamajidi
Silver nanoparticles (AgNPs) are known as one of the highly utilized NPs owing to their unique characteristics in the field of cancer research. The goal of this research was to explore the oxidative stress, apoptosis, and angiogenesis in SKBR3 breast cancer cells after exposure to AgNPs. The survival rate of SKBR3 cancer cells and MCF-10A normal breast cells was assessed under the effects of different concentrations (0, 32, 64, 128, and 250  μ g/ml) by MTT method. The oxidative condition was assessed by measuring reactive oxygen species (ROS) production, total oxidant status (TOS), total antioxidant capacity (TAC), malondialdehyde (MDA), and antioxidant enzyme activity (CAT, GPx, and CAT) using colorimetric-based kits...
2024: BioMed Research International
https://read.qxmd.com/read/38410150/safety-evaluation-of-the-food-enzyme-mucorpepsin-from-the-non-genetically-modified-rhizomucor-miehei-strain-m19-21
#32
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Yrjö Roos, Magdalena Andryszkiewicz, Cristina Fernàndez-Fraguas, Natalia Kovalkovicova, Yi Liu, Silvia Peluso, Andrew Chesson
The food enzyme mucorpepsin (EC 3.4.23.23) is produced with the non-genetically modified Rhizomucor miehei strain M19-21 by Meito Sangyo Co., Ltd. The enzyme is chemically modified to produce a thermolabile form. The food enzyme was considered free from viable cells of the production organism. It is intended to be used in the processing of dairy products for the production of cheese and fermented dairy products. Based on the maximum use levels, dietary exposure was estimated to be up to 0.108 mg TOS/kg body weight (bw) per day in European populations...
February 2024: EFSA journal
https://read.qxmd.com/read/38410147/safety-evaluation-of-the-food-enzyme-bacillolysin-from-the-non-genetically-modified-bacillus-amyloliquefaciens-strain-dp-cyb74
#33
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Magdalena Andryszkiewicz, Kyriaki Apergi, Natália Kovalkovičová, Yi Liu, Simone Lunardi, Giulio di Piazza, Andrew Chesson
The food enzyme bacillolysin (EC 3.4.24.28) is produced with the non-genetically modified Bacillus amyloliquefaciens strain DP-Cyb74 by Genencor International B.V. The production strain met all requirements for the qualified presumption of safety (QPS) approach to safety assessment. The food enzyme is intended to be used in six food manufacturing processes. Dietary exposure to the food enzyme total organic solids (TOS) was estimated to be up to 1.536 mg TOS/kg body weight per day in European populations. As the production strain qualifies for the QPS approach and no issue of concern arose from the production process of the food enzyme, the Panel considered that no toxicological studies other than the assessment of allergenicity were necessary...
February 2024: EFSA journal
https://read.qxmd.com/read/38410144/safety-evaluation-of-the-food-enzyme-thermolysin-from-the-non-genetically-modified-anoxybacillus-caldiproteolyticus-strain-ae-tp
#34
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Magdalena Andryszkiewicz, Yi Liu, Simone Lunardi, Elsa Nielsen, Karin Nørby, Andrew Chesson
The food enzyme thermolysin (EC. 3.4.24.27) is produced with the non-genetically modified Anoxybacillus caldiproteolyticus strain AE-TP by Amano Enzyme Inc. The food enzyme is free from viable cells of the production organism. It is intended to be used in eight food manufacturing processes. Dietary exposure was estimated to be up to 0.973 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats...
February 2024: EFSA journal
https://read.qxmd.com/read/38408527/ameliorative-effects-of-thymoquinone-on-the-caspase-3-kidney-function-and-oxidative-stress-tartrazine-induced-nephrotoxicity
#35
JOURNAL ARTICLE
Zeynep Erdemli, Mehmet Gul, Nurcan Gokturk, Elif Kayhan, Nursena Demircigil, Eda Nur Ozsoy, Harika Gozukara Bag, Mehmet Erman Erdemli
First in the literature this study aimed to investigate the effects of Tartrazine, a common industrial food dye, on kidney and whether Thymoquinone has a protective effect in tartrazine-induced nephrotoxicity. The study conducted on the rats bred at İnönü University Experimental Animals Production and Research Center. Wistar albino rats were randomly divided into 4 groups, where each group included 8 rats: control, Tartrazine, Thymoquinone, and Tartrazine + Thymoquinone groups. The experiments continued for 3 weeks and then, kidney tissues and blood samples were collected from the rats under anesthesia...
February 24, 2024: Toxicon: Official Journal of the International Society on Toxinology
https://read.qxmd.com/read/38405112/safety-evaluation-of-the-food-enzyme-microbial-collagenase-from-the-genetically-modified-streptomyces-violaceoruber-strain-pcol
#36
JOURNAL ARTICLE
Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Cristina Fernàndez-Fraguas, Silvia Peluso, Elsa Nielsen, Karin Nørby, Giulio di Piazza, Laura Sanmartín Cabo, Yi Liu, Andrew Chesson
The food enzyme microbial collagenase (EC 3.4.24.3) is produced with the genetically modified Streptomyces violaceoruber strain pCol by Nagase (Europa) GmbH. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in two food manufacturing processes: the production of modified meat and fish products and the production of protein hydrolysates from meat and fish proteins. The dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 1...
February 2024: EFSA journal
https://read.qxmd.com/read/38405110/safety-evaluation-of-the-food-enzyme-glutaminase-from-the-non-genetically-modified-bacillus-amyloliquefaciens-strain-ae-gt
#37
JOURNAL ARTICLE
Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Claude Lambré, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger-Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu, Simone Lunardi, Elsa Nielsen, Karin Norby, Giulio di Piazza, Yrjö Roos, Andrew Chesson
The food enzyme glutaminase (l-glutamine amidohydrolase; EC 3.5.1.2) is produced with the non-genetically modified Bacillus amyloliquefaciens strain AE-GT by Amano Enzyme Inc. The production strain met the requirements for the qualified presumption of safety (QPS) approach. The food enzyme is intended to be used in five food manufacturing processes. Dietary exposure to the food enzyme-total organic solids (TOS) was estimated to be up to 0.462 mg TOS/kg body weight per day in European populations. Given the QPS status of the production strain and the absence of concerns resulting from the food enzyme's manufacturing process, toxicity tests were considered unnecessary by the Panel...
February 2024: EFSA journal
https://read.qxmd.com/read/38403251/oleuropein-has-modulatory-effects-on-systemic-lipopolysaccharide-induced-neuroinflammation-in-male-rats
#38
JOURNAL ARTICLE
Sevim Şahin, Elif Şahin, Gülnur Esenülkü, Gülin Renda, Seren Gülşen Gürgen, Ahmet Alver, İsmail Abidin, Ali Cansu
BACKGROUND: Neuroinflammation induced by systemic inflammation is a risk factor for developing chronic neurological disorders. Oleuropein (OLE) has antioxidant and anti-inflammatory properties; however, its effect on systemic inflammation-related neuroinflammation is unknown. OBJECTIVE: This study aims to determine whether OLE protects against systemic lipopolysaccharide (LPS)-induced neuroinflammation in rats. METHODS: Six-week-old Wistar rats were randomly assigned to one of five groups: (1) control, (2) OLE-only, (3) LPS+vehicle, (4) OLE+LPS (O-LPS), and (5) a single dose OLE+LPS (SO-LPS group)...
February 23, 2024: Journal of Nutrition
https://read.qxmd.com/read/38399492/a-pilot-prospective-study-evaluating-the-effect-of-curcuma-based-herbal-food-supplement-on-the-outcome-of-in-vitro-fertilization-in-patients-testing-positive-for-four-immunological-biomarkers
#39
JOURNAL ARTICLE
Renato Colognato, Incoronata Laurenza, Gabriele Ersettigh, Giada Antonia Aiello, Marta Carnovali, Massimo Mariotti, Nicoletta Maxia
Background and Objectives: Inflammation and oxidative stress have been described to reduce the chance for pregnancy instauration and maintenance. NOFLAMOX, a recently developed herbal preparation with recognized antioxidant and anti-inflammatory properties, can represent an interesting treatment to increase the chance of pregnancy, both physiological or after in vitro fertilization (IVF). The aim of this study was to assess NOFLAMOX's effect; a population with unexplained infertility was screened for the recently described IMMUNOX panel based on four immunological biomarkers with a prospective study approach...
January 25, 2024: Medicina
https://read.qxmd.com/read/38398826/the-protective-impact-of-aronia-melanocarpa-l-berries-extract-against-prooxidative-cadmium-action-in-the-brain-a-study-in-an-in-vivo-model-of-current-environmental-human-exposure-to-this-harmful-element
#40
JOURNAL ARTICLE
Agnieszka Ruczaj, Małgorzata M Brzóska, Joanna Rogalska
Cadmium (Cd) is a prooxidant that adversely affects human health, including the nervous system. As exposure of the general population to this heavy metal is inevitable, it is crucial to look for agents that can prevent the effects of its toxic action. An experimental model on female rats of current lifetime human exposure to cadmium (3-24-months' treatment with 1 or 5 mg Cd/kg diet) was used to test whether low-level and moderate intoxication can exert a prooxidative impact in the brain and whether supplementation with a 0...
February 9, 2024: Nutrients
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