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https://www.readbyqxmd.com/read/28208989/central-telangiectatic-osteosarcoma-of-the-mandible-in-a-paediatric-patient-a-rarity
#1
Divya Tomar, Manu Dhillon, Muhamad Nishad Thayath, Iram Zaidi, Shikha Singh
Osteosarcoma (OS) involving the head and neck region is rare and is a diagnostic challenge due to its aggressive nature and varied presentations. Although OS constitute 40% to 60% of all bone tumours, only 10% of these occur in the head and neck region, most commonly in the maxilla and mandible. OS of the jaw bone has a different pattern and behaviour when compared to OS at other anatomic location. It occurs in a more elderly population, less aggressive and usually spreads locally rather than distant metastases...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28205286/association-of-mmp-9-gene-polymorphisms-with-nephrolithiasis-patients
#2
Atheer Awad Mehde, Wesen Adel Mehdi, Faridah Yusof, Raha Ahmed Raus, Zaima Azira Zainal Abidin, Hamid Ghazali, Azlina Abd Rahman
BACKGROUND: Nephrolithiasis is one of the causes which lead to chronic kidney disease (CKD). Matrix metalloproteinases (MMPs) are endopeptidases degrading extracellular matrix which correlate with the pathogenesis of atherosclerosis. The current study was designed to analyze the association of (R279Q, C1562T) polymorphism of MMP-9 with nephrolithiasis patients. METHODS: Genotyping of MMP-9/R279Q and of MMP-9/C1562T polymorphism were carried out by PCR-based restriction digestion method...
February 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28203075/co-delivery-of-paclitaxel-and-tos-cisplatin-via-tat-targeted-solid-lipid-nanoparticles-with-synergistic-antitumor-activity-against-cervical-cancer
#3
Bo Liu, Li Han, Junyan Liu, Shumei Han, Zhen Chen, Lixi Jiang
BACKGROUND: Cervical cancer is a major world health problem for women. Currently, cancer research focuses on improving therapy for cervical cancer using various treatment options such as co-delivery of chemotherapeutic agents by nanocarriers. PURPOSE: The aim of this study was to develop trans-activating transcriptional activator (TAT)-modified solid lipid nanoparticles (SLNs) for co-delivery of paclitaxel (PTX) and α-tocopherol succinate-cisplatin prodrug (TOS-CDDP) (TAT PTX/TOS-CDDP SLNs) in order to achieve synergistic antitumor activity against cervical cancer...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28202649/antioxidants-and-embryo-phenotype-is-there-experimental-evidence-for-strong-integration-of-the-antioxidant-system
#4
Cristina Daniela Possenti, Filiz Karadas, Graziano Colombo, Manuela Caprioli, Diego Rubolini, Aldo Milzani, Isabella Dalle Donne, Nicola Saino, Marco Parolini
Organisms have evolved complex defense systems against oxidative stress. Bird eggs contain maternally derived antioxidants that protect embryos from oxidative damage. The antioxidant system components are thought to be integrated, but few studies have analyzed the covariation between antioxidant concentrations, embryo 'oxidative status' and morphology. In addition, no study has tested the effects of experimental change in yolk antioxidant concentration on other antioxidants, on their reciprocal relationships and on their relationships with embryo oxidative status or growth, which are expected if antioxidants defenses are integrated...
February 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28202378/neonatology-oxidative-status-in-preterm-infants-with-premature-preterm-rupture-of-membranes-and-fetal-inflammatuar-response-syndrome
#5
Elif Özalkaya, Güner Karatekin, Sevilay Topçuoğlu, Hande Özgün Karatepe, Taner Hafızoğlu, Pervin Baran, Fahri Ovalı
BACKGROUND: The aim of this study, to determine an index of oxidative stress index in preterm infants less than 34 weeks gestational age with premature preterm rupture of membrane (PPROM) and fetal inflammatory response syndrome (FIRS). METHODS: This study was designed as a prospective study. Fifty-one premature infants less than 35 weeks of gestational age were included in the study. The umbilical cord blood concentrations of IL-6, TAC (total antioxidant capacity) and PON-1 (paraoxonase-1) levels and TOS (total oxidative stress) were studied...
January 17, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28202006/differences-in-serum-oxidative-status-between-glaucomatous-and-nonglaucomatous-cataract-patients
#6
Wojciech Rokicki, Jolanta Zalejska-Fiolka, Dorota Pojda-Wilczek, Alicja Hampel, Wojciech Majewski, Serap Ogultekin, Ewa Mrukwa-Kominek
BACKGROUND: Oxidative stress contributes to both intraocular pressure regulation and glaucomatous neuropathy. The systemic redox status (solitary determination) was examined in primary open-angle glaucoma (POAG) patients with cataract and nonglaucomatous cataract patients. Cataract-matched group comparisons appear more precise in the context of oxidative stress evaluation. The aim of this study was to establish if systemic oxidative status in POAG patients was elevated compared with the cataract only subjects...
February 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28199314/whole-genome-landscape-of-pancreatic-neuroendocrine-tumours
#7
Aldo Scarpa, David K Chang, Katia Nones, Vincenzo Corbo, Ann-Marie Patch, Peter Bailey, Rita T Lawlor, Amber L Johns, David K Miller, Andrea Mafficini, Borislav Rusev, Maria Scardoni, Davide Antonello, Stefano Barbi, Katarzyna O Sikora, Sara Cingarlini, Caterina Vicentini, Skye McKay, Michael C J Quinn, Timothy J C Bruxner, Angelika N Christ, Ivon Harliwong, Senel Idrisoglu, Suzanne McLean, Craig Nourse, Ehsan Nourbakhsh, Peter J Wilson, Matthew J Anderson, J Lynn Fink, Felicity Newell, Nick Waddell, Oliver Holmes, Stephen H Kazakoff, Conrad Leonard, Scott Wood, Qinying Xu, Shivashankar Hiriyur Nagaraj, Eliana Amato, Irene Dalai, Samantha Bersani, Ivana Cataldo, Angelo P Dei Tos, Paola Capelli, Maria Vittoria Davì, Luca Landoni, Anna Malpaga, Marco Miotto, Vicki L J Whitehall, Barbara A Leggett, Janelle L Harris, Jonathan Harris, Marc D Jones, Jeremy Humphris, Lorraine A Chantrill, Venessa Chin, Adnan M Nagrial, Marina Pajic, Christopher J Scarlett, Andreia Pinho, Ilse Rooman, Christopher Toon, Jianmin Wu, Mark Pinese, Mark Cowley, Andrew Barbour, Amanda Mawson, Emily S Humphrey, Emily K Colvin, Angela Chou, Jessica A Lovell, Nigel B Jamieson, Fraser Duthie, Marie-Claude Gingras, William E Fisher, Rebecca A Dagg, Loretta M S Lau, Michael Lee, Hilda A Pickett, Roger R Reddel, Jaswinder S Samra, James G Kench, Neil D Merrett, Krishna Epari, Nam Q Nguyen, Nikolajs Zeps, Massimo Falconi, Michele Simbolo, Giovanni Butturini, George Van Buren, Stefano Partelli, Matteo Fassan, Kum Kum Khanna, Anthony J Gill, David A Wheeler, Richard A Gibbs, Elizabeth A Musgrove, Claudio Bassi, Giampaolo Tortora, Paolo Pederzoli, John V Pearson, Nicola Waddell, Andrew V Biankin, Sean M Grimmond
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to more sensitive detection methods, and this increase is creating challenges for clinical management. We performed whole-genome sequencing of 102 primary PanNETs and defined the genomic events that characterize their pathogenesis. Here we describe the mutational signatures they harbour, including a deficiency in G:C > T:A base excision repair due to inactivation of MUTYH, which encodes a DNA glycosylase. Clinically sporadic PanNETs contain a larger-than-expected proportion of germline mutations, including previously unreported mutations in the DNA repair genes MUTYH, CHEK2 and BRCA2...
February 15, 2017: Nature
https://www.readbyqxmd.com/read/28195259/telangiectatic-osteosarcoma-of-the-rib-a-rare-entity-and-a-potential-diagnostic-pitfall
#8
I Saguem, L Ayadi, R Kallel, S Charfi, I Bahri, N Gouiaa, T Sellami-Boudawara
Osteosarcoma (OS) is a common primary malignant tumor of bones that produces osteoid matrix. Telangiectatic osteosarcoma (TOS) is a rare variant of OS. It affects the long bones especially the lower end of femur and the upper ends of tibia and humerus, a distribution similar to the conventional osteosarcoma. The rib involvement is very infrequent. We present a case of TOS of the rib that posed a diagnostic difficulty owing to its unusual location and to its resemblance to giant cell tumor and aneurysmal bone cyst...
December 2016: Pathologica
https://www.readbyqxmd.com/read/28188255/efficiacy-of-safranal-to-cisplatin-induced-nephrotoxicity
#9
Yasemin Karafakıoglu, Mehmet Fatih Bozkurt, Ömer Hazman, Fatih Fidan
The aim of this study was to investigate the effects of safranal on cisplatin-induced nephrotoxicity and oxidative stress in rats. Adult male Sprague-Dawley rats were randomly divided into five groups. The control group received physiological saline; animals in group 2 received only safranal and in group 3 received only cisplatin; 5 days of safranal treatment was performed following administration of cisplatin for the animals in group 4;5 days of safranal pre-treatment was applied to the animals in group 5 before administration of cisplatin...
February 10, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28187024/residual-symptom-analysis-after-the-subtotal-anterior-and-middle-scalenectomy-for-disputed-thoracic-outlet-syndrome-comparison-between-surgical-and-untreated-patients
#10
Xu Gong, Zhen Min Jiang, Lai Jin Lu
OBJECTIVE: There are significant differences in the results on disputed thoracic outlet syndrome (TOS) surgery, which reflect that not all patients with disputed TOS are amenable to surgery. It is necessary to find out appropriate indicators for screening of patients who are suitable for surgery. Pain and paresthesia are 2 prominent symptoms of disputed TOS. The purpose of this study was to identify which symptoms could be removed by surgery. METHODS: Data for all patients with disputed TOS who were admitted and prepared for surgical treatment between July 2008 and April 2012 were collected...
February 10, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28180101/evaluation-of-complications-after-surgical-treatment-of-thoracic-outlet-syndrome
#11
Mohammad Ali Hosseinian, Ali Gharibi Loron, Yalda Soleimanifard
BACKGROUND: Surgical treatment of thoracic outlet syndrome (TOS) is necessary when non-surgical treatments fail. Complications of surgical procedures vary from short-term post-surgical pain to permanent disability. The outcome of TOS surgery is affected by the visibility during the operation. In this study, we have compared the complications arising during the supraclavicular and the transaxillary approaches to determine the appropriate approach for TOS surgery. METHODS: In this study, 448 patients with symptoms of TOS were assessed...
February 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28177660/carvacrol-attenuates-cyclophosphamide-induced-oxidative-stress-in-rat-kidney
#12
Sibel Gunes, Adnan Ayhanci, Varol Sahinturk, Diler Us Altay, Ruhi Uyar
Cyclophosphamide (CP) is an antineoplastic drug inducing kidney damage via producing oxidative stress. Carvacrol (CAR) has antioxidative effect and we postulated that it can be protective against CP-induced nephrotoxicity. Six groups (n=7) of rats (control, 100 mg/kg CP, CP+5 and CP+10 mg/kg CAR and 5 and 10 mg/kg CAR) were injected intraperitoneally. Serum malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), creatinine (CRE), total antioxidant capacity (TAC) and total oxidant state (TOS) were measured, and oxidative stress indexes (OSI) were calculated...
February 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28177329/fibular-osteofasciocutaneous-flap-in-computer-assisted-mandibular-reconstruction-technical-aspects-in-oral-malignancies
#13
M Berrone, E Crosetti, P L Tos, M Pentenero, G Succo
Virtual surgical planning technology in head and neck surgery is witnessing strong growth. In the literature, the validity of the method from the point of view of accuracy and clinical utility has been widely documented, especially for bone modelling. To date, however, with its increased use in head and neck oncology, and consequently the increased need for bone and soft tissue reconstruction, is important to carry out the virtual programme considering not only bone reconstruction but also all aspects related to the reconstruction of soft tissue using composite flaps...
December 2016: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28168638/the-relationship-between-the-latency-period-infection-markers-and-oxidant-and-antioxidant-states-in-women-with-preterm-premature-rupture-of-membranes
#14
N Ilhan, B K Aygun, H Gungor
BACKGROUND: A major cause of perinatal morbidity and mortality has been reported to be preterm premature rupture of membranes (PPROM). Our objective was to evaluate oxidant-antioxidant balance, infection parameters, time interval between rupture of membranes and delivery (latency period), and the relationship among all these parameters. METHODS: Seventy-five cases with PPROM between 24 and 34 gestational weeks were included in the study. A control group of 41 women who gave birth at term were considered as the control group...
February 6, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28168159/synthesis-of-metal-nanoparticles-and-metal-fluoride-nanoparticles-from-metal-amidinate-precursors-in-1-butyl-3-methylimidazolium-ionic-liquids-and-propylene-carbonate
#15
Kai Schütte, Juri Barthel, Manuel Endres, Marvin Siebels, Bernd M Smarsly, Junpei Yue, Christoph Janiak
Decomposition of transition-metal amidinates [M{MeC(NiPr)2} n ] [M(AMD) n ; M=Mn(II), Fe(II), Co(II), Ni(II), n=2; Cu(I), n=1) induced by microwave heating in the ionic liquids (ILs) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIm][BF4]), 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIm][PF6]), 1-butyl-3-methylimidazolium trifluoromethanesulfonate (triflate) ([BMIm][TfO]), and 1-butyl-3-methylimidazolium tosylate ([BMIm][Tos]) or in propylene carbonate (PC) gives transition-metal nanoparticles (M-NPs) in non-fluorous media (e...
February 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28167469/relationship-of-oxidative-stress-with-elevated-level-of-dna-damage-and-homocysteine-in-cardiovascular-disease-patients
#16
Muhammad Qasim, Shazia Anwer Bukhari, Madiha Javeed Ghani, Muhammad Shareef Masoud, Tayyabah Huma, Muhammad Arshad, Asma Haque, Zubair Ibrahim, Sadia Javed, Muhammad Ibrahim Rajoka
Amounts of DNA damage and homocysteine (Hcy) in heart patients blood may have strong function in the causation of cardiovascular disease (CVD). The main objective of this work was to know experimentally the role of total oxidants (produced by Reactive Oxygen species (ROS), clinical biochemical indices, their oxidized products and total antioxidant status (TAS) among such patients to find the association of homocysteine, total oxidation status (TOS) and oxidative DNA damage with other clinical parameters in sixty positive CVD patients compared with those of 60 normal subjects...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28165200/selective-production-of-2-methylfuran-by-gas-phase-hydrogenation-of-furfural-on-copper-incorporated-by-complexing-to-mesoporous-silica-catalysts
#17
Carmen Pilar Jiménez-Gómez, Juan A Cecilia, Ramón Moreno-Tost, Pedro Maireles-Torres
Copper species have been incorporated to a mesoporous silica by complexing with amino group of dodecylamine molecules, used as structure-directing agent in the synthesis. A series of Cu/SiO2 catalysts, with copper loadings from 2.5 to 20 wt%, has been synthesized and evaluated in the gas phase hydrogenation of furfural. The most suitable catalytic performance, in terms of 2-methylfuran yield, has been found for intermediate copper content (10 wt%). In this sense, the 10Cu-MS catalyst, at a reaction temperature of 210ºC, after 5 h of time-on-stream, exhibits a 2-methylfuran yield higher than 95 mol%, with a H2:FUR molar ratio of 11...
February 6, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28164639/oxidative-status-and-dna-damage-following-analgesic-treatment-in-patients-with-acute-pancreatitis
#18
B Gulen, A Kocyigit, C Eken, M Serinken, O Karcioglu, A Dur, E Kilic
BACKGROUND: This study is designed to investigate the effect of three different analgesics, used to treat pain in AP, on oxidative stress, DNA damage in mononuclear leukocytes, and on oxidative status. METHODS: This parallel design randomized controlled trial is composed of three treatment arms, intravenous paracetamol, intravenous dexketoprofen, and intravenous tramadol. RESULTS: A total of 107 patients were diagnosed with acute pancreatitis within the study period in the ED...
July 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162924/fed-batch-operation-for-the-synthesis-of-lactulose-with-%C3%AE-galactosidase-of-aspergillus-oryzae
#19
Cecilia Guerrero, Carlos Vera, Andrés Illanes
Fed-batch synthesis of lactulose from lactose and fructose with Aspergillus oryzae β-galactosidase was evaluated, obtaining a concentration of 40.4g·L(-1), which is 20% higher than obtained in batch, while the concentration of transgalactosylated oligosaccharides (TOS) was reduced by 98%. Therefore, selectivity of lactulose synthesis can be significantly higher by operating in fed-batch mode. The enzyme-limiting substrate mass ratio (E/S) is a critical variable in fed-batch operation. Higher values favor lactose hydrolysis over transgalactosylation, being 400IU/g the limit for proper lactulose synthesis in fed-batch operation...
January 26, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28145432/succinate-ester-derivative-of-%C3%AE-tocopherol-enhances-the-protective-effects-against-60-co-%C3%AE-ray-induced-hematopoietic-injury-through-granulocyte-colony-stimulating-factor-induction-in-mice
#20
Zhong-Tang Li, Li-Mei Wang, Li-Rong Yi, Chao Jia, Fan Bai, Ren-Jun Peng, Zu-Yin Yu, Guo-Lin Xiong, Shuang Xing, Ya-Jun Shan, Ri-Fang Yang, Jun-Xing Dong, Yu-Wen Cong
α-tocopherol succinate (α-TOS), γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have drawn large attention due to their efficacy as radioprotective agents. α-TOS has been shown to act superior to α-tocopherol (α-TOH) in mice by reducing lethality following total body irradiation (TBI). Because α-TOS has been shown to act superior to α-tocopherol (α-TOH) in mice by reducing lethality following total body irradiation (TBI), we hypothesized succinate may be contribute to the radioprotection of α-TOS. To study the contributions of succinate and to identify stronger radioprotective agents, we synthesized α-, γ- and δ-TOS...
February 1, 2017: Scientific Reports
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