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https://www.readbyqxmd.com/read/28911689/effect-of-oleuropein-against-chemotherapy-drug-induced-histological-changes-oxidative-stress-and-dna-damages-in-rat-kidney-injury
#1
Fatime Geyikoglu, Murat Emir, Suat Colak, Kubra Koc, Hasan Turkez, Murat Bakir, Mirkhalil Hosseinigouzdagani, Salim Cerig, Osman Nuri Keles, Nihal Simsek Ozek
Cisplatin-based chemotherapy is responsible for a large number of renal failures, and it is still associated with high rates of mortality today. Oleuropein (OLE) presents a plethora of pharmacological beneficial properties. In this study we investigated whether OLE could provide sufficient protection against cisplatin-induced nephrotoxicity. With this aim, Sprague-Dawley rats were divided into eight groups: control; 7 mg/kg/d cisplatin, 50 mg/kg, 100 mg/kg, and 200 mg/kg OLE; and treatment with OLE for 3 days starting at 24 hours following cisplatin injection...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28910746/transport-of-imidazolium-based-ionic-liquids-with-different-anion-cation-species-in-sand-soil-columns
#2
Zhiqiang Dong, Li Wei, Suwei Xu, Jingwei Sun, Xinyi Shi, Yuping Qiu
Ionic liquids (ILs) have been widely used as environmentally friendly solvents to replace volatile organic solvents in the chemistry industries. They have a high water solubility and potential risk to organisms in the soil-water environment. At present, most studies focused on the batch sorption of ILs in soil and neglected the investigation of IL transports in soil, which results in a lack of understanding of the structure-dependent mobility of ILs in the environment. Laboratory-scale sand/soil column experiments were performed to study the transport of imidazolium-based ILs, such as [C4mim][OTF], [C4mim][TOS], [C4mim][MeSO3], [C4mim][BF4], [C2mim][BF4], and [C6mim][BF4] including different counteranions and alkyl chain lengths of IL cations...
September 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28910125/threat-of-shock-and-aversive-inhibition-induced-anxiety-modulates-pavlovian-instrumental-interactions
#3
Anahit Mkrtchian, Jonathan P Roiser, Oliver J Robinson
Anxiety can be an adaptive response to potentially threatening situations. However, if experienced in inappropriate contexts, it can also lead to pathological and maladaptive anxiety disorders. Experimentally, anxiety can be induced in healthy individuals using the threat of shock (ToS) paradigm. Accumulating work with this paradigm suggests that anxiety promotes harm-avoidant mechanisms through enhanced inhibitory control. However, the specific cognitive mechanisms underlying anxiety-linked inhibitory control are unclear...
September 14, 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28910121/the-impact-of-uncertain-threat-on-affective-bias-individual-differences-in-response-to-ambiguity
#4
Maital Neta, Julie Cantelon, Zachary Haga, Caroline R Mahoney, Holly A Taylor, F Caroline Davis
Individuals who operate under highly stressful conditions (e.g., military personnel and first responders) are often faced with the challenge of quickly interpreting ambiguous information in uncertain and threatening environments. When faced with ambiguity, it is likely adaptive to view potentially dangerous stimuli as threatening until contextual information proves otherwise. One laboratory-based paradigm that can be used to simulate uncertain threat is known as threat of shock (TOS), in which participants are told that they might receive mild but unpredictable electric shocks while performing an unrelated task...
September 14, 2017: Emotion
https://www.readbyqxmd.com/read/28899740/histone-3-3-mutations-in-giant-cell-tumor-and-giant-cell-rich-sarcomas-of-bone
#5
Alberto Righi, Irene Mancini, Marco Gambarotti, Piero Picci, Gabriella Gamberi, Cristina Marraccini, Angelo Paolo Dei Tos, Lisa Simi, Pamela Pinzani, Alessandro Franchi
Mutually exclusive histone 3.3 gene mutations have been recognized in chondroblastoma and giant cell tumor of bone (GCTB), which may be useful for differential diagnostic purposes in morphologically ambiguous cases. While over 90% of GCTB presents histone 3.3 variants exclusively in the H3F3A gene, chondroblastoma is mutated mainly in H3F3B. In this study we examined a series of giant cell rich primary bone tumors, aiming to evaluate the possible diagnostic role of histone 3.3 mutations in the differential diagnosis between GCTB and giant cell rich sarcomas...
September 9, 2017: Human Pathology
https://www.readbyqxmd.com/read/28892787/hepatoprotective-effects-of-crocin-on-biochemical-and-histopathological-alterations-following-acrylamide-induced-liver-injury-in-wistar-rats
#6
Sema Gedik, Mehmet Erman Erdemli, Mehmet Gul, Birgul Yigitcan, Harika Gozukara Bag, Zeynep Aksungur, Eyup Altinoz
The objective of the present study is the treatment of oxidative damage caused by acrylamide induced oxidative stress in rats with the administration of a strong antioxidant, namely crocin. High acrylamide (AA) levels have genotoxic, carcinogenic and neurotoxic effects on living organisms. In the present study, 40 Wistar rats were randomly divided into four equal groups. These groups were control, acrylamide (25mg/kg), crocin (50mg/kg), acrylamide+crocin (25mg/kg acrylamide and 50mg/kg crocin) groups. At the end of the application, biochemical and histological variations were examined in liver and blood samples...
September 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28891476/effect-of-conventional-and-led-phototherapy-on-the-antioxidant-oxidant-status-in-preterm-neonates-with-jaundice
#7
Anusha Allam, S R Ravikiran, B Shantaram Baliga, Kamalakshi Bhat, Nitin Joseph
OBJECTIVE: To compare oxidative stress due to conventional and LED phototherapy among jaundiced preterm neonates. METHODS: Cross-sectional study conducted in NICU on 82 neonates (equal numbers received conventional and LED phototherapy). Total antioxidant capacity (TAC), total oxidant status (TOS) and Oxidative stress index (OSI) were assessed. RESULTS: Post-phototherapy, mean (SD) OSI increased significantly compared to baseline in both conventional [0...
August 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28883228/paget-schroetter-syndrome-resulting-from-thoracic-outlet-syndrome-and-kaatsu-training
#8
Tatsunori Noto, Go Hashimoto, Takahito Takagi, Toru Awaya, Tadashi Araki, Masanori Shiba, Raisuke Iijima, Hidehiko Hara, Masao Moroi, Masato Nakamura, Kaoru Sugi
A 29-year-old woman who worked as a KAATSU (a type of body exercise that involves blood flow restriction) instructor visited our emergency room with a chief complaint of swelling and left upper limb pain. Chest computed tomography (CT) showed non-uniform contrast images corresponding to the site from the left axillary vein to the left subclavian vein; vascular ultrasonography of the upper limb revealed a thrombotic obstruction at the same site, leading to a diagnosis of Paget-Schroetter syndrome (PSS). We herein report our experience with a case of PSS derived from thoracic outlet syndrome (TOS), in a patient who was a KAATSU instructor...
September 6, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28875239/spatial-variance-of-pops-and-heavy-metals-in-transformer-oil-contaminated-soil-around-tamil-nadu
#9
Karuvelan Murugan, Namasivayam Vasudevan
The persistent organic pollutants in the environment are one of the global issues to their unregulated disposal and informal recycling. This study investigates the contamination of soil with polychlorinated biphenyls (PCBs), polyaromatic hydrocarbons (PAHs), phenolic compounds and heavy metals via spillage of transformer oil (TO). Fresh TO (FTO), used TO (UTO) and soil samples were analysed using GC-MS to confirm the presence of 8 PCB congeners, 16 PAHs and 24 types of phenolic compounds and using inductively coupled plasma optical emission spectrometry to confirm the presence of 7 heavy metals...
September 5, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28868943/evaluation-of-pro-oxidant-antioxidant-balance-pab-and-its-association-with-inflammatory-cytokines-in-polycystic-ovary-syndrome-pcos
#10
T Artimani, J Karimi, M Mehdizadeh, M Yavangi, E Khanlarzadeh, M Ghorbani, S Asadi, N Kheiripour
Chronic low-grade inflammation has been suggested as a key contributor of the pathogenesis and development of polycystic ovary syndrome (PCOS). To investigate the association between oxidative stress status and inflammatory cytokines in follicular fluid of 21 PCOS women compared to 21 women with normal ovarian function who underwent intra-cytoplasmic sperm injection. Concentration of IL-6, IL-8, IL-10, and TNF-α was measured using sandwich ELISA. Oxidative stress was examined by measuring total oxidant status (TOS), malondialdehyde (MDA), total antioxidant capacity (TAC), and thiol groups...
September 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28867357/serum-prolidase-enzyme-activity-in-obese-subjects-and-its-relationship-with-oxidative-stress-markers
#11
Mehmet Aslan, Ufuk Duzenli, Ramazan Esen, Yasemin Usul Soyoral
BACKGROUND: The relationship between increased serum enzyme activity of prolidase and increased rate of collagen turnover in the arterial wall has been asserted in previous studies. Collagen reflects much of the strength to the connective tissue involved in the arterial wall. Atherosclerosis is very common vessel disease and oxidative stress plays a pivotal role in the etiopathogenesis. Our objective was to examine the serum enzyme activity of prolidase and its possible relationships with oxidative stress parameters in obese subjects...
October 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28865963/can-shoulder-range-of-movement-be-measured-accurately-using-the-microsoft-kinect-sensor%C3%A2-plus-medical-interactive-recovery-assistant-software
#12
James D Wilson, Jennifer Khan-Perez, Dominic Marley, Susan Buttress, Michael Walton, Baihua Li, Bibhas Roy
BACKGROUND: This study compared the accuracy of measuring shoulder range of movement (ROM) with a simple laptop-sensor combination vs. trained observers (shoulder physiotherapists and shoulder surgeons) using motion capture (MoCap) laboratory equipment as the gold standard. METHODS: The Microsoft Kinect sensor (Microsoft Corp., Redmond, WA, USA) tracks 3-dimensional human motion. Ordinarily used with an Xbox (Microsoft Corp.) video game console, Medical Interactive Recovery Assistant (MIRA) software (MIRA Rehab Ltd...
August 30, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28862263/neurofibromin-c-terminus-specific-antibody-clone-nfc-is-a-valuable-tool-for-the-identification-of-nf1-inactivated-gists
#13
Sabrina Rossi, Daniela Gasparotto, Matilde Cacciatore, Marta Sbaraglia, Alessia Mondello, Maurizio Polano, Alessandra Mandolesi, Alessandro Gronchi, David E Reuss, Andreas von Deimling, Roberta Maestro, Angelo Paolo Dei Tos
An increasing body of evidence supports the involvement of NF1 mutations, constitutional or somatic, in the pathogenesis of gastrointestinal stromal tumors (GISTs). Due to the large size of the NF1 locus, the existence of multiple pseudogenes and the wide spectrum of mechanisms of gene inactivation, the analysis of NF1 gene status is still challenging for most laboratories. Here we sought to assess the efficacy of a recently developed neurofibromin-specific antibody (NFC) in detecting NF1-inactivated GISTs...
September 1, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28861765/multifunctional-decoration-of-alpha-tocopheryl-succinate-based-np-for-cancer-treatment-effect-of-tpp-and-ltvspwy-peptide
#14
Raquel Palao-Suay, María Rosa Aguilar, Francisco J Parra-Ruiz, Sergio Martín-Saldaña, Nathan A Rohner, Susan N Thomas, Julio San Román
Active targeting not only of a specific cell but also a specific organelle maximizes the therapeutic activity minimizing adverse side effects in healthy tissues. The present work describes the synthesis, characterization, and in vitro biological activity of active targeting nanoparticles (NP) for cancer therapy based on α-tocopheryl succinate (α-TOS), a well-known mitocan, that selectively induces apoptosis of cancer cells and proliferalting endothelial cells. Human epidermal growth factor receptor 2 (HER2) targeting peptide LTVSPWY (PEP) and triphenylphosphonium lipophilic cation (TPP) were conjugated to a previously optimized RAFT block copolymer that formed self-assembled NP of appropriate size for this application and low polydispersity by self-organized precipitation method...
August 31, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28859554/effects-of-ecballium-elaterium-on-brain-in-a-rat-model-of-sepsis-associated-encephalopathy
#15
Demet Arslan, Aysun Ekinci, Akgul Arici, Eda Bozdemir, Esref Akil, Hasan Huseyin Ozdemir
Despite recent advances in antibiotic therapy, sepsis remains a major clinical challenge in intensive care units. Here we examined the anti-inflammatory and antioxidant effects of Ecballium elaterium (EE) on brain, and explored its therapeutic potential in an animal model of sepsis-associated encephalopathy (SAE) [induced by cecal ligation and puncture (CLP)]. Thirty rats were divided into three groups of 10 each: control, sepsis, and treatment. Rats were subjected to CLP except for the control group, which underwent laparatomy only...
December 2017: Libyan Journal of Medicine
https://www.readbyqxmd.com/read/28855545/influence-of-oxalate-ligand-functionalization-on-co-zsm-5-activity-in-fischer-tropsch-synthesis-and-hydrodeoxygenation-of-oleic-acid-into-hydrocarbon-fuels
#16
Olumide Bolarinwa Ayodele
Achieving high degree of active metal dispersions at the highest possible metal loading and high reducibility of the metal remains a challenge in Fischer Tropsch synthesis (FTS) as well as in hydrogeoxygenation (HDO).This study therefore reports the influence of oxalic acid (OxA) functionalization on the metal dispersion, reducibility and activity of Co supported ZSM-5 catalyst in FTS and HDO of oleic acid into paraffin biofuel. The Brunauer-Emmett-Teller (BET) results showed that cobalt oxalate supported ZSM-5 catalyst (CoOx/ZSM-5) synthesized from the incorporation of freshly prepared cobalt oxalate complex into ZSM-5 displayed increase in surface area, pore volume and average pore size while the nonfunctionalized cobalt supported on ZSM-5 (Co/ZSM-5) catalyst showed reduction in those properties...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28852467/activity-of-anthracycline-and-ifosfamide-based-chemotherapy-in-a-series-of-patients-affected-by-advanced-myxofibrosarcoma
#17
Vittoria Colia, Marco Fiore, Salvatore Provenzano, Elena Fumagalli, Rossella Bertulli, Carlo Morosi, Angelo P Dei Tos, Marta Barisella, Alessandro Gronchi, Paolo G Casali, Roberta Sanfilippo
BACKGROUND: We report on the activity of anthracycline-based and high-dose prolonged-infusion ifosfamide chemotherapy in a retrospective series of patients affected by advanced myxofibrosarcoma treated at Istituto Nazionale Tumori in Milan, Italy, and within the Italian Rare Cancer Network (RTR). METHODS: Advanced myxofibrosarcoma patients treated with anthracycline + ifosfamide and high-dose prolonged-infusion ifosfamide as a single agent from November 2001 to December 2016 were retrospectively reviewed...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28845317/arterial-thoracic-outlet-syndrome-treated-successfully-with-totally-endoscopic-first-rib-resection
#18
Sofoklis Mitsos, Davide Patrini, Sara Velo, Achilleas Antonopoulos, Martin Hayward, Robert S George, David Lawrence, Nikolaos Panagiotopoulos
Thoracic outlet syndrome (TOS) is a constellation of signs and symptoms caused by compression of the neurovascular structures in the thoracic outlet. TOS may be classified as either neurogenic TOS (NTOS) or vascular TOS: venous TOS (VTOS) or arterial TOS (ATOS), depending on the specific structure being affected. The basis for the surgical treatment of TOS is resection of the first rib, and it may be combined with scalenectomy or cervical rib resection. Herein, we describe a case of arterial thoracic outlet syndrome which was successfully treated with totally endoscopic video-assisted thoracoscopic surgery (VATS) first rib resection...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/28840002/video-assisted-thoracoscopic-surgery-for-intrathoracic-first-rib-resection-in-thoracic-outlet-syndrome
#19
Jinwook Hwang, Byung-Ju Min, Won-Min Jo, Jae Seung Shin
BACKGROUND: First rib resection is a surgical treatment for decompressing the neurovascular structures in thoracic outlet syndrome (TOS). Historically, extrathoracic approaches have used a posterior, supraclavicular, or transaxillary incision to remove the first rib. In this report, we demonstrate video-assisted thoracoscopic surgery for intrathoracic first rib resection (VATS-IFRR). METHODS: Between 2009 and 2014, eight patients underwent VATS-IFRR for TOS. Surgery was performed through two 5-mm ports and one 10-mm port...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28834825/intraocular-pressure-fluctuations-and-24-hour-continuous-monitoring-for-glaucoma-risk-in-wind-instrument-players
#20
Ronald M P C de Crom, Carroll A B Webers, Marina A W van Kooten-Noordzij, Agnes C Michiels, Jan S A G Schouten, Tos T J M Berendschot, Henny J M Beckers
PURPOSE: The purpose of this study is to investigate the influence of playing a wind instrument on intraocular pressure (IOP) and to monitor 24-hour (IOP) fluctuations in wind musicians of symphony and wind orchestras to compare IOP levels during normal daily activities with IOP levels during playing. METHODS: Professional and amateur musicians of symphony and wind orchestras were invited to participate. A total of 42 participants, 9 with glaucoma, underwent a routine ophthalmologic examination...
August 30, 2017: Journal of Glaucoma
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