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https://www.readbyqxmd.com/read/28325685/a-positive-feedback-strategy-for-enhanced-chemotherapy-based-on-ros-triggered-self-accelerating-drug-release-nanosystem
#1
Jing-Jing Hu, Qi Lei, Meng-Yun Peng, Di-Wei Zheng, Yi-Xuan Chen, Xian-Zheng Zhang
Here, a positive feedback strategy was utilized to amplify the concentration of intracellular reactive oxygen species (ROS) and a ROS-triggered self-accelerating drug release nanosystem (defined as T/D@RSMSNs) was demonstrated for enhanced tumor chemotherapy. The mesoporous silica nanoparticles (MSNs) based nanocarriers were gated by β-cyclodextrin (β-CD) through the ROS-cleavable thioketal (TK) linker to encapsulate the anticancer drug doxorubicin hydrochloride (DOX) and ROS producing agent α-tocopheryl succinate (α-TOS), whose surface was further anchored with adamantane conjugated poly(ethylene glycol) chain (AD-PEG) via host-guest interaction...
March 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28320109/protective-effect-of-dexpanthenol-against-nephrotoxic-effect-of-amikacin-an-experimental-study
#2
Elif Ece Doğan, Reha Erkoç, İskender Ekinci, Jamshid Hamdard, Barış Döner, Mehmet Ali Çıkrıkçıoğlu, Cumali Karatoprak, Ganime Çoban, Ömer Faruk Özer, Rümeyza Kazancıoğlu
BACKGROUND: Amikacin has the largest spectrum among aminoglycosides, its nephrotoxic effect limits its utilization. Our purpose in this study is to review the protective effect of dexpanthenol against the nephrotoxic effect of amikacin, accompanied with histopathological and biochemical parameters. METHODS: 32 rats were randomly separated into four groups with eight in each (amikacin (1.2mg/kg/day), amikacin (1.2mg/kg/day)+dexpanthenol (500mg/kg/day), dexpanthenol (500mg/kg/day) and control)...
March 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28319407/investigation-of-procalcitonin-il-6-oxidative-stress-index-osi-plasma-and-tissue-levels-in-experimental-mild-and-severe-pancreatitis-in-rats
#3
M Soyalp, M Yalcin, V Oter, A Ozgonul
AIM: This study was planned to evaluate blood and tissue levels of procalcitonin, IL-6 and Oxidative Stress Index (OSI), which have a role in the pathophysiology of inflammation, in rats with experimental mild and severe pancreatitis. MATERIAL AND METHODS: Thirty male Wistar Albino rats were included in the study and the rats were equally divided into the three groups. After 1, 5 and 24 hours, blood was obtained from the tail of all rats and samples were taken from pancreas tissue after 24 hours...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28303559/-thoracic-outlet-syndrome
#4
Sven Seifert, Pavel Sebesta, Marian Klenske, Mirko Esche
Introduction Thoracic outlet syndrome (TOS) is one of the most extensively discussed diagnoses. There is neither a clear and homogenous clinical presentation nor an accepted definition. The term describes a complex of symptoms and complaints caused by the compression of nerves and vascular structures at one of the three defined constrictions of the upper thoracic aperture. Methods Based on a comprehensive literature review, this article presents the etiology, epidemiology and clinical diagnostics as well as the possibilities and outcomes of surgical treatment...
February 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28298173/effects-of-two-different-lipid-emulsions-on-morbidities-and-oxidant-stress-statuses-in-preterm-infants-an-observational-study
#5
Sezin Unal, Nihal Demirel, Sara Erol, Dilek Ulubas Isik, Ferit Kulali, Fatma Iyigun, Ahmet Yagmur Bas
OBJECTIVE: We examined the morbidities and oxidative stress statuses in preterms receiving either SMOFlipid or ClinOleic. STUDY DESIGN: This observational study was performed in Etlik Zubeyde Hanim Hospital, Turkey. Infants received SMOFlipid (5 months) or ClinOleic (7 months). Two hundred and twenty seven infants (SMOFlipid: 93, ClinOleic: 134) very low birth weighted infants were included. The oxidative stress status was evaluated in infants at low risk of oxidative stress by total antioxidant capacity (TAC) and total oxidant status (TOS) and oxidative stress index (OSI; TAC/TOS/100) at baseline, first week and third week...
March 15, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28293182/visual-field-map-clusters-in-high-order-visual-processing-organization-of-v3a-v3b-and-a-new-cloverleaf-cluster-in-the-posterior-superior-temporal-sulcus
#6
Brian Barton, Alyssa A Brewer
The cortical hierarchy of the human visual system has been shown to be organized around retinal spatial coordinates throughout much of low- and mid-level visual processing. These regions contain visual field maps (VFMs) that each follows the organization of the retina, with neighboring aspects of the visual field processed in neighboring cortical locations. On a larger, macrostructural scale, groups of such sensory cortical field maps (CFMs) in both the visual and auditory systems are organized into roughly circular cloverleaf clusters...
2017: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/28285138/molecular-details-of-the-raptor-binding-motif-on-arabidopsis-s6-kinase
#7
Ora Son, Sunghan Kim, Yoon-Sun Hur, Choong-Ill Cheon
A putative raptor-binding fragment was identified from Arabidopsis S6 kinase 1 (AtS6K1) N-terminal domain in our previous study. Here, we report a further characterization of this fragment, which identified a 12-amino acid core element absolutely required for the interaction. Although the amino acid sequence of the element per se had no significant homology with the canonical consensus of the TOS (TOR-signaling) motif found in the mammalian TOR (target of rapamycin) kinase substrates, its overall sequence composition is similar to that of the TOS motif in that the acidic and non-polar amino acids residues are arranged in alternating fashion and having one or two of the bulky hydrophobic amino acid (F) buried in the interior...
April 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28284173/patient-derived-solitary-fibrous-tumour-xenografts-predict-high-sensitivity-to-doxorubicin-dacarbazine-combination-confirmed-in-the-clinic-and-highlight-the-potential-effectiveness-of-trabectedin-or-eribulin-against-this-tumour
#8
S Stacchiotti, M Saponara, R Frapolli, M Tortoreto, D Cominetti, S Provenzano, T Negri, G P Dagrada, A Gronchi, C Colombo, B Vincenzi, G Badalamenti, V Zuco, S L Renne, P Collini, C Morosi, A P Dei Tos, E Bello, S Pilotti, P G Casali, M D'Incalci, N Zaffaroni
BACKGROUND: Preclinical models that mimic pathological and molecular features of solitary fibrous tumour (SFT) represent an important tool to select effective regimes and novel compounds to be tested in the clinic. This study was aimed at developing two preclinical models of SFT, assessing their predictive value in the clinic and selecting potential novel effective treatments. MATERIAL AND METHODS: Two dedifferentiated-SFT (D-SFT) models obtained from patients' biopsies were grown in immunodeficient mice...
March 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28277125/role-of-serum-levels-of-irisin-and-oxidative-stress-markers-in-pregnant-women-with-and-without-gestational-diabetes
#9
Betül Usluoğullari, Celil Alper Usluogullari, Fevzi Balkan, Mustafa Orkmez
Irisin regulates glucose levels, lipid levels, insulin sensitivity, and low-grade inflammation. Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy, and is associated with increased rates of perinatal problems. Oxidative stress biomarkers have a role in the pathogenesis of patients with GDM. In total, 94 patients were included in our study including 46 control patients and 48 patients with GDM. Fasting blood glucose, HOMA-IR, total oxidative stress (TOS), irisin, and oxidative stress index (OSI) levels of the patients were measured...
February 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28263739/development-of-a-paper-based-microfluidic-analytical-device-by-a-more-facile-hydrophobic-substrate-generation-strategy
#10
Yuan-Yuan Xue, Wen-Tao Zhang, Meng-Yue Zhang, Li-Zhi Liu, Wen-Xin Zhu, Ling-Zhi Yan, Jing Wang, Yan-Ru Wang, Jian-Long Wang, Dao-Hong Zhang
Microfluidic paper-based analytical devices (μPADs) have a significant potential in developing portable and disposable point-of-care testing (POCT). Herein, a facile, rapid, cost-effective and environment friendly strategy for μPADs fabrication is proposed. Specifically, the substrate paper was hydrophobized by coating with trimethoxysilane (TOS), and then the selected area was hydrophilized by treating with surfactant. The whole fabrication process was implemented within 7 min, with no need for complex pre-treatment, high-temperature and special equipment...
March 3, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28262130/oxidative-status-and-prolidase-activities-in-generalized-anxiety-disorder
#11
A Cenk Ercan, Bulent Bahceci, Selim Polat, Ozgur Cagla Cenker, Ilkay Bahceci, Ayse Koroglu, Kazim Sahin, Cicek Hocaoglu
OBJECTIVE: Prolidase (Pro), an intracellular enzyme necessary for collagen turnover, matrix remodelling and cell growth has been shown to be related to Oxidative Stress (OS). To our knowledge, serum Pro activity in generalized anxiety disorder (GAD) has not been documented yet. In this study, we aimed to evaluate OS and its relation with Pro activity in patients diagnosed with GAD. METHOD: Thirty untreated GAD patients and 30 healthy controls were included in the study...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28261890/ozone-prevents-cochlear-damage-from-ischemia-reperfusion-injury-in-guinea-pigs
#12
Merih Onal, Cagdas Elsurer, Nebil Selimoglu, Mustafa Yilmaz, Ender Erdogan, Jale Bengi Celik, Oznur Kal, Ozkan Onal
The cochlea is an end organ, which is metabolically dependent on a nutrient and oxygen supply to maintain its normal physiological function. Cochlear ischemia and reperfusion (IR) injury is considered one of the most important causes of human idiopathic sudden sensorineural hearing loss. The aim of the present study was to study the efficacy of ozone therapy against cochlear damage caused by IR injury and to investigate the potential clinical use of this treatment for sudden deafness. Twenty-eight guinea pigs were randomized into four groups...
March 5, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28261836/oxidative-stress-and-motility-impairment-in-the-semen-of-fertile-males
#13
M Dobrakowski, S Kasperczyk, S Horak, D Chyra-Jach, E Birkner, A Kasperczyk
The aim of the study was to determine the total oxidant status (TOS) and evaluate the influence of oxidative stress on sperm quality in fertile males. The study population consisted of 55 fertile males. Based on the seminal plasma TOS value, the study subjects were divided into the two subgroups: a group with a low (TOS-L) and a high (TOS-H) value. Comparing the TOS-H group with the TOS-L group, we found poorer sperm motility in the TOS-H group. We found lower total antioxidant capacity values and lower activity levels in the majority of the determined superoxide dismutase, glutathione peroxidase, glutathione-S-transferase and glucose-6-phosphate dehydrogenase...
March 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28260803/reversal-of-paclitaxel-resistance-in-human-ovarian-cancer-cells-with-redox-responsive-micelles-consisting-of-%C3%AE-tocopheryl-succinate-based-polyphosphoester-copolymers
#14
Feng-Qian Chen, Jin-Ming Zhang, Xie-Fan Fang, Hua Yu, Yu-Ling Liu, Hui Li, Yi-Tao Wang, Mei-Wan Chen
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a major obstacle in achieving the therapeutic benefits of paclitaxel (PTX) in the treatment of human ovarian carcinoma. This study is aimed to develop an efficient PTX drug delivery approach to overcome MDR. Redox-responsive micelles consisting of amphiphilic polymers containing disulfide linkages, ie, poly (phosphate ester)-SS-D-α-tocopheryl succinate (POPEA-SS-TOS, PSST) were prepared. PTX-loaded PSST micelles (PTX/PSST-M) designed to display synergistic functions, including reversible inhibition of P-gp, intracellular redox-sensitive release and potent anticancer activities...
March 6, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28259825/soft-tissue-neoplasms-causing-apparent-venous-thoracic-outlet-syndrome
#15
Aleem K Mirza, Ian J Barrett, Animesh Rathore, Bassem T Elhassan, Peter S Rose, Thomas Shives, Thomas C Bower
Venous thoracic outlet syndrome (vTOS) usually results from compression of the subclavian vein classically as a result of narrowing of the costoclavicular space. We report two rare cases of soft tissue neoplasms resulting in apparent vTOS. The first case is a 46-year old female with a two-year history intermittent unilateral shoulder pain, who was initially diagnosed with intervertebral disk herniation. Cervical fusion was performed, however her symptoms progressed and she additionally developed paresthesias and venous congestion...
March 1, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28252318/oxidative-injury-associated-with-stenting-of-asymptomatic-carotid-artery-stenosis
#16
Erhan Saraçoğlu, Ertan Vuruşkan, Yusuf Çekici, Salih Kiliç, Halil Ay, Uğur Ergün
BACKGROUND: After carotid artery stenting (CAS), neurological complications that cannot be explained with imaging methods may develop. In our study we aimed to show, using oxidative stress markers, isolated oxidative damage and resulting neurological findings following CAS in patients with asymptomatic carotid artery stenosis. PATIENTS AND METHODS: We included 131 neurologically asymptomatic patients requiring CAS. The neurological findings were evaluated using the modified Rankin Scale (mRS) prior to the procedure, one hour post-procedure, and two days after...
March 2, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28250657/short-term-effects-of-date-palm-extract-phoenix-dactylifera-on-ischemia-reperfusion-injury-induced-by-testicular-torsion-detorsion-in-rats
#17
Alireza Raayat Jahromi, Rokhsana Rasooli, Younes Kamali, Nasrollah Ahmadi, Ehsan Sattari
BACKGROUND: Antioxidants are potent scavengers of free radicals and have beneficial effects on human health. OBJECTIVE: The aim of this study was to investigate the potential protective antioxidant activity of the edible portion of date fruit extract in an experimental testicular torsion/detorsion (T/D) model in rats. MATERIALS AND METHODS: To investigate the potential protective effects of date palm (DP), 30 male Spraque-Dawley rats were divided into three groups: sham-operated, T/D, and T/D + DP-treated (500 mg/kg, PO) groups...
January 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28242484/orthodontic-treatment-modifies-the-oxidant-antioxidant-balance-in-saliva-of-clinically-healthy-subjects
#18
Piotr Buczko, Małgorzata Knaś, Monika Grycz, Izabela Szarmach, Anna Zalewska
PURPOSE: The aim of our study was to analyse salivary markers of oxidative stress and an antioxidant response in clinically healthy subjects with fixed orthodontic appliances. MATERIAL/METHODS: 37 volunteers were included in the study. Unstimulated (UWS) and stimulated (SWS) whole saliva were analysed for oxidative and antioxidant status and nickel levels immediately before the insertion of the appliances, an one week after and twenty four weeks after the insertion of fixed appliances...
February 24, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28239886/fibrocartilaginous-mesenchymoma-of-bone-a-single-institution-experience-with-molecular-investigations-and-a-review-of-the-literature
#19
M Gambarotti, A Righi, D Vanel, S Cocchi, S Benini, F M Elli, G Mantovani, P Ruggieri, S Boriani, D Donati, M Sbaraglia, A P Dei Tos, P Picci
AIMS: Fibrocartilaginous mesenchymoma is a rare intraosseous lesion with a total of 25 cases described in the literature. This study describes the clinical, radiological, and histological features of eight new cases of fibrocartilaginous mesenchymoma collected at a single institution between 1982 and 2016. The presence of GNAS and IDH1/2 mutations and MDM2 amplification was explored to evaluate possible links between fibrocartilaginous mesenchymoma, fibrous dysplasia, dedifferentiated chondrosarcoma, and low-grade osteosarcoma...
February 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28237749/redox-sensitive-self-assembled-nanoparticles-based-on-alpha-tocopherol-succinate-modified-heparin-for-intracellular-delivery-of-paclitaxel
#20
Xiaoye Yang, Xiaoqing Cai, Aihua Yu, Yanwei Xi, Guangxi Zhai
To remedy the problems riddled in cancer chemotherapy, such as poor solubility, low selectivity, and insufficient intra-cellular release of drugs, novel heparin-based redox-sensitive polymeric nanoparticles were developed. The amphiphilic polymer, heparin-alpha-tocopherol succinate (Hep-cys-TOS) was synthesized by grafting hydrophobic TOS to heparin using cystamine as the redox-sensitive linker, which could self-assemble into nanoparticles in phosphate buffer saline (PBS) with low critical aggregation concentration (CAC) values ranging from 0...
February 16, 2017: Journal of Colloid and Interface Science
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