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https://www.readbyqxmd.com/read/27922539/effect-of-tomographic-operator-inaccuracies-and-respiratory-motion-on-pet-ct-lung-nodule-images-smearing
#1
Joël Daouk, Pascal Bailly, Roger Bouzerar, Marc-Étienne Meyer
BACKGROUND: In thoracic PET/computed tomography (CT) imaging, uptake foci usually appear smeared because of postreconstruction smoothing and respiratory motion. OBJECTIVE: The aim of the present study was to assess the respective contributions of the reconstruction process and respiratory motion on PET/CT images. MATERIALS AND METHODS: Thirty-one pulmonary lesions were studied. Free-breathing PET/CT acquisitions were followed by a 10-min respiratory-gated PET/CT acquisition...
December 2, 2016: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/27909983/4-4-%C3%A3-resolution-cryo-em-structure-of-human-mtor-complex-1
#2
Huirong Yang, Jia Wang, Mengjie Liu, Xizi Chen, Min Huang, Dan Tan, Meng-Qiu Dong, Catherine C L Wong, Jiawei Wang, Yanhui Xu, Hong-Wei Wang
Mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates signals from growth factors, cellular energy levels, stress and amino acids to control cell growth and proliferation through regulating translation, autophagy and metabolism. Here we determined the cryo-electron microscopy structure of human mTORC1 at 4.4 Å resolution. The mTORC1 comprises a dimer of heterotrimer (mTOR-Raptor-mLST8) mediated by the mTOR protein. The complex adopts a hollow rhomboid shape with 2-fold symmetry. Notably, mTORC1 shows intrinsic conformational dynamics...
December 1, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27905214/the-association-of-plasma-oxidative-status-and-inflammation-with-the-development-of-atrial-fibrillation-in-patients-presenting-with-st-elevation-myocardial-infarction
#3
Hasan Aydin Bas, Fatih Aksoy, Atilla Icli, Ercan Varol, Abdullah Dogan, Dogan Erdogan, Ibrahim Ersoy, Akif Arslan, Hatem Ari, Nihal Bas, Recep Sutcu, Mehmet Ozaydin
Atrial fibrillation (AF) is the most common supraventricular arrhythmia following ST elevation myocardial infarction (STEMI). Oxidative stress and inflammation may cause structural and electrical remodeling in the atria making these critical processes in the pathology of AF. In this study, we aimed to evaluate the association between total oxidative status (TOS), total antioxidative capacity (TAC) and high-sensitivity C-reactive protein (hs-CRP) in the development of AF in patients presenting with STEMI. This prospective cohort study consisted of 346 patients with STEMI...
December 1, 2016: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/27901469/obestatin-improves-hepatic-injury-induced-by-ischemia-reperfusion-in-rats-role-of-nitric-oxide
#4
Ola A El-Gohary
Hepatic ischemia/reperfusion (I/R) injury is a common clinical problem. The present study was conducted to evaluate the protective effect of obestatin against I/R-induced liver injury. Rats were divided into three groups (n = 10): control sham-operated group, I/R group and obestatin treatment group. Rats of I/R group and obestatin treatment group underwent partial hepatic ischemia for 60 min followed by 90 min reperfusion. At the beginning of the 90-min reperfusion period, rats of obestatin treatment group were injected with obestatin (100 μg/kg) intravenously...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27900241/changes-in-the-salivary-oxidative-status-in-individuals-with-temporomandibular-disorders-and-pain
#5
Claudyane de Almeida, José Miguel Amenábar
Temporomandibular joint disorders are quite common among the general public. Free radicals may play a role in the pathogenesis of joint diseases, and the oxidative stress is an important aspect in the mechanism of TMDs. The use of new biotechnologies has enabled the use of saliva as a diagnostic method. This is the first paper that aims to investigate changes in the oxidative status, through saliva analysis, in individuals who suffer from temporomandibular disorder and pain. Sixty individuals, 54 women and 06 men, aged between 10 and 60, participated in this research...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27899171/the-effects-of-melatonin-and-colchicine-on-ischemia-reperfusion-injury-in-experimental-rat-testicular-torsion-model
#6
Tamer Sekmenli, Metin Gunduz, Bahadır Öztürk, Pınar Karabağlı, Ilhan Ciftci, Gülsüm Tekin, Mustafa Yılmaz
PURPOSE: The aim of the present study is to investigate the efficiency of colchicine and melatonın in an experimental rat testicular torsion model in the light of histological and biochemical data. METHODS: A total of 34 Wistar albino male rats were randomly divided into 5 groups as: Group C (control, n=6), Group S (sham; underwent only left scrotal exploration, n=7), Group TD (torsion and detorsion; 6h of ischemia and 7days of reperfusion, n=7), Group TD/M (TD+Melatonin; 6h of ischemia and 7days of reperfusion and 7days of 17mg/kg intraperitoneal melatonin per day, n=7), group TD/Col (TD+Colchicine; 6h of ischemia and 7days of reperfusion and 7days of 1mg/kg oral colchicine per day, n=7)...
November 18, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27892790/line-1-methylation-status-in-prostate-cancer-and-non-neoplastic-tissue-adjacent-to-tumor-in-association-with-mortality
#7
Valentina Fiano, Daniela Zugna, Chiara Grasso, Morena Trevisan, Luisa Delsedime, Luca Molinaro, Anna Gillio-Tos, Franco Merletti, Lorenzo Richiardi
Aberrant DNA methylation seems to be associated with prostate cancer behavior. We investigated LINE-1 methylation in prostate cancer and non-neoplastic tissue adjacent to tumor (NTAT) in association with mortality from prostate cancer. We selected 157 prostate cancer patients with available NTAT from two cohorts of patients diagnosed between 1982-1988 and 1993-1996, followed up until 2010. An association between LINE-1 hypomethylation and prostate cancer mortality in tumor was suggested [hazard ratio per 5% decrease in LINE-1 methylation levels: 1...
November 28, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27889788/inhibition-of-angiotensin-ii-production-increases-susceptibility-to-acute-ischemia-reperfusion-arrhythmia
#8
Eylem Taskin, Kadir Ali Tuncer, Celal Guven, Salih Tunc Kaya, Nurcan Dursun
BACKGROUND Myocardial ischemia and reperfusion lead to impairment of electrolyte balance and, eventually, lethal arrhythmias. The aim of this study was to investigate the effects of pharmacological inhibition of angiotensin-II (Ang-II) production on heart tissue with ischemia-reperfusion damage, arrhythmia, and oxidative stress. MATERIAL AND METHODS Rats were divided into 4 groups: only ischemia/reperfusion (MI/R), captopril (CAP), aliskiren (AL), and CAP+AL. The drugs were given by gavage 30 min before anesthesia...
November 27, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27876213/the-impact-of-methotrexate-on-lung-inflammatory-and-apoptotic-pathway-biomarkers-the-role-of-gallic-acid
#9
Mustafa Saygin, Onder Ozturk, Ozlem Ozmen, Ilter Ilhan, Taner Gonca, Nurhan Gumral, Hikmet Orhan, Rahime Aslankoc
BACKGROUNDS: The aim of this study was to investigate the effects of methotrexate (MTX) on the lung via inflammatory and apoptotic pathway biomarkers and the role of gallic acid (GA). METHODS: In this study, twenty four male Wistar-Albino rats weighing 300-350g were divided into 3 groups as follows; Control group (0.1ml/oral saline, for 7 days+2nd day i.p.). MTX group (20mg/kg, single dose, on 2nd day). MTX+GA group (15mg/kg, orally, for 7 days). Comet analysis, oxidant-antioxidant status, IMA were conducted...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27865264/changes-in-serum-biomarkers-of-oxidative-stress-after-treatment-for-canine-leishmaniosis-in-sick-dogs
#10
Camila Peres Rubio, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Josefa Hernández-Ruiz, Luis Pardo-Marin, Sergi Segarra, José Joaquín Ceron
Canine leishmaniosis (CanL) is a zoonotic disease being endemic in several parts of the world. In this study we investigated the behavior of a panel of biomarkers of oxidative stress in 12 sick dogs naturally infected by CanL before and at days 30 and 180 of a successful therapy with a standard treatment. The assays total oxidant status (TOS), trolox equivalent antioxidant capacity (TEAC), ferric reducing ability of plasma (FRAP), cupric reducing antioxidant capacity (CUPRAC), serum thiol and paraoxonase 1 (PON1) were included in the panel...
December 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/27862718/peritoneal-catheter-fixation-combined-with-straight-upward-tunnel-and-low-implant-position-to-prevent-catheter-malfunction
#11
Qingyan Zhang, Chunming Jiang, Wei Zhu, Cheng Sun, Yangyang Xia, Tianfeng Tang, Cheng Wan, Qiuyuan Shao, Jing Liu, Bo Jin, Miao Zhang
AIM: Catheter malfunction is the main reason for early peritoneal dialysis (PD) technique failure. This study aimed to evaluate the effect of a new surgery technique with catheter fixation to the lower abdominal wall combined with straight upward tunnel and low implant position in reducing catheter malfunction. METHODS: Patients with end stage renal disease who received PD in our center from January 2013 to December 2015 were involved in this study. They were randomly divided into 3 groups according to surgical technique: traditional open surgery group, modified open surgery group and modified open surgery with catheter fixation group...
November 16, 2016: Nephrology
https://www.readbyqxmd.com/read/27862614/transorbital-sonography-and-visual-outcome-for-the-diagnosis-and-monitoring-of-optic-neuritis
#12
Piergiorgio Lochner, Maurizio A Leone, Klaus Fassbender, Roberto Cantello, Lorenzo Coppo, Raffaele Nardone, Gianni Zorzi, Martin Lesmeister, Cristoforo Comi, Francesco Brigo
BACKGROUND AND PURPOSE: Transorbital sonography (TOS) is a promising tool to support the clinical diagnosis of optic neuritis (ON) by showing thickening of optic nerve. In this study, we aimed to define its specific role in follow-up of ON patients. METHODS: We measured ultrasonography parameters and visual acuity (VA) at presentation and after 1 year in 45 patients with newly diagnosed ON. Two vascular sonographers used B-mode TOS to evaluate mean optic nerve diameter (OND) and optic nerve sheath diameter (ONSD)...
November 13, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/27831632/disulfiram-as-a-candidate-nf-%C3%AE%C2%BAb-and-proteasome-inhibitor-prevents-endometriotic-implant-growing-in-a-rat-model-of-endometriosis
#13
O Celik, A Ersahin, M Acet, N Celik, Y Baykus, R Deniz, E Ozerol, I Ozerol
OBJECTIVE: Disulfiram (DSF) exerts its therapeutic effects through oxidative, proteasome, and nuclear factor kappa beta (NF-κB) pathways. The study was planned to test the impact of DSF on growing of endometriotic implants in rats with experimentally induced endometriosis. PATIENTS AND METHODS: Thirty rats were labeled as the control (n = 8), sham (n = 6), GnRH-agonist (n = 8) and the DSF (n = 8) groups. The rats in the group 3 exposed to single dose leuprolide acetate...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27830671/prolidase-activity-and-oxidative-stress-in-patients-with-breast-carcinoma-a-prospective-randomized-case-controlled-study
#14
Zulfu Bayhan, Sezgin Zeren, Cengiz Kocak, Fatma Emel Kocak, Sukru Aydin Duzgun, Mustafa Cem Algin, Burcu Yapar Taskoylu, Faik Yaylak
INTRODUCTION: Oxidative stress plays an important role in the pathogenesis of malign diseases. Prolidase is a member of the matrix metalloproteinase family, plays a major role in collagen metabolism, cell growth, and matrix remodeling. Elevated serum prolidase activity have beendemonstrated in several types of carcinoma. The aim of this study is to investigate the serum prolidase activity, total oxidant status (TOS), total antioxidant status (TAS) and to evaluate their relationship with tumor stage, lymph node metastasis, and tumor size in patients with breast carcinoma...
September 19, 2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27826979/the-anti-inflammatory-and-antioxidant-effects-of-thymoquinone-on-ceruleine-induced-acute-pancreatitis-in-rats
#15
A Dur, H Kose, A Kocyigit, O Kocaman, M Ismayilova, F C Sonmez
INTRODUCTION: The aim of this study is to investigate the potential antioxidant and anti-inflammatory effects of thymoquinone (TQ) on ceruleine induced acute pancreatitis. MATERIAL AND METHODS: A total of 14 male Wistar albino rats were divided into 2 groups as follows: (1) normal saline-treated group and (2) thymoquinone- treated groups. For achieving acute pancreatitis, intraperitoneal (IP) cerulein, a stable cholecystokinin (CCK) analogue, was applied in a 50 mcg/kg dose 2 times in one-hour interval in total...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27813035/-thoracic-outlet-syndrome-a-case-of-scalene-muscle-hypertrophy-in-long-term-follow-up-of-diagnosis-of-cervical-discopathy
#16
Damla Yürük, Güngör Enver Özgencil, Ahmet Yılmaz, Merve Hayriye Kocaoğlu, Sırrı Sinan Bilgin, İbrahim Aşık
Described in this article is diagnosis and treatment of mixed type of thoracic outlet syndrome (TOS) resulting from scalene muscle hypertrophy. Many diseases should be considered in the differential diagnosis to definitively diagnose this syndrome, and it is necessary to ask about activities of daily life, in addition to adding provocative tests to physical examination and examining electrophysiological and imaging results. Once diagnosed, even if complaints decrease with conservative treatment, surgery may be required...
July 2016: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/27810806/evaluation-of-the-transverse-oscillation-technique-for-cardiac-phased-array-imaging-a-theoretical-study
#17
Brecht Heyde, Nick Bottenus, Jan D'hooge, Gregg E Trahey
The transverse oscillation (TO) technique can improve the estimation of tissue motion perpendicular to the ultrasound beam direction. TOs can be introduced using plane wave (PW) insonification and bi-lobed Gaussian apodisation (BA) on receive (abbreviated as PWTO). Furthermore, the TO frequency can be doubled after a heterodyning demodulation process is performed (abbreviated as PWTO*). This study is concerned with identifying the limitations of the PWTO technique in the specific context of myocardial deformation imaging with phased arrays and investigating the conditions in which it remains advantageous over traditional focused (FOC) beamforming...
October 28, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/27772753/antioxidant-and-inflammatory-biomarkers-for-the-identification-of-prodromal-parkinson-s-disease
#18
Jonica Campolo, Renata De Maria, Lorena Cozzi, Marina Parolini, Stefano Bernardi, Paola Proserpio, Lino Nobili, Giorgio Gelosa, Immacolata Piccolo, Elio C Agostoni, Maria G Trivella, Paolo Marraccini
OBJECTIVES: We explored the role of oxidative stress and inflammatory molecules as potential Parkinson (PD) biomarkers and correlated biological with non-motor abnormalities (olfactory impairment and dysautonomia), in patients with idiopathic REM behavior disorder (iRBD) (prodromal PD) and established PD. METHODS: We recruited 11 iRBD and 15 patients with idiopathic PD (Hohen&Yahr 1-3, on L-DOPA and dopamine agonists combination therapy) and 12 age- and sex-matched controls (CTRL)...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27771984/the-effects-of-adding-ischemic-preconditioning-during-desflurane-inhalation-anesthesia-or-propofol-total-intravenous-anesthesia-on-pneumoperitoneum-induced-oxidative-stress
#19
Safinaz Karabayirli, Onder Surgit, Hulya Kasikara, Cemile Koca Bicer, Merve Ergin, Ruveyda Irem Demircioglu, Bunyamin Muslu
BACKGROUND: The aim of the study was to explore the differences in oxidative stress during anesthesia with desflurane/N2O or propofol/remifentanil in patients undergoing laparoscopic cholecystectomy and additionally to evaluate the differential effects of desflurane and propofol on ischemic preconditioning (IP). MATERIALS AND METHODS: One hundred patients were randomly allocated to four groups. For anesthesia maintenance, the inhalation group (Group I) and the inhalation plus IP group (Group IIP) received desflurane at an end-tidal concentration of 4-6 vol% in oxygen/N2O, and the TIVA group (Group T) and TIVA plus IP group (Group TIP) received infusions of propofol and remifentanil...
October 24, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27761284/evaluation-of-serum-s100a8-s100a9-levels-in-patients-with-autoimmune-thyroid-diseases
#20
Hakan Korkmaz, Suzan Tabur, Esen Savaş, Mesut Özkaya, Şefika Nur Aksoy, Nurten Aksoy, Ersin Akarsu
BACKGROUND: The correlation of S100A8/S100A9 with various inflammatory conditions, including autoimmune diseases have been reported. There is no study investigating the levels of S100A8/S100A9 in autoimmune thyroid diseases (AITD). AIMS: We aimed to evaluate the level of serum S100A8/S100A9 in AITD. STUDY DESIGN: Case control study. METHODS: Fifty patients with AITD (25 Hashimoto's thyroiditis (HT) and 25 Graves' disease (GD)) were included in the study...
September 2016: Balkan Medical Journal
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