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https://www.readbyqxmd.com/read/28533069/enrichment-and-characterization-of-hydrocarbon-degrading-bacteria-from-petroleum-refinery-waste-as-potent-bioaugmentation-agent-for-in-situ-bioremediation
#1
Poulomi Sarkar, Ajoy Roy, Siddhartha Pal, Balaram Mohapatra, Sufia K Kazy, Mrinal K Maiti, Pinaki Sar
Intrinsic biodegradation potential of bacteria from petroleum refinery waste was investigated through isolation of cultivable strains and their characterization. Pseudomonas and Bacillus spp. populated the normal cultivable taxa while prolonged enrichment with hydrocarbons and crude oil yielded hydrocarbonoclastic bacteria of genera Burkholderia, Enterobacter, Kocuria, Pandoraea, etc. Strains isolated through enrichment showed assemblages of superior metabolic properties: utilization of aliphatic (C6-C22) and polyaromatic compounds, anaerobic growth with multiple terminal electron acceptors and higher biosurfactant production...
May 4, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28528545/discovery-and-biosynthesis-of-gladiolin-a-burkholderia-gladioli-antibiotic-with-promising-activity-against-mycobacterium-tuberculosis
#2
Lijiang Song, Matthew Jenner, Joleen Masschelein, Cerith Jones, Matthew J Bull, Simon R Harris, Ruben C Hartkoorn, Anthony Vocat, Isolda Romero-Canelón, Paul Coupland, Gordon Webster, Matthew Dunn, Rebecca Weiser, Christopher Paisey, Stewart T Cole, Julian Parkhill, Eshwar Mahenthiralingam, Gregory L Challis
An antimicrobial activity screen of Burkholderia gladioli BCC0238, a clinical isolate from a cystic fibrosis patient, led to the discovery of gladiolin, a novel macrolide antibiotic with potent activity against Mycobacterium tuberculosis H37Rv. Gladiolin is structurally-related to etnangien, a highly unstable antibiotic from Sorangium cellulosum that is also active against Mycobacteria. Like etnangien, gladiolin was found to inhibit RNA polymerase, a validated drug target in M. tuberculosis. However, gladiolin lacks the highly labile hexaene moiety of etnangien and was thus found to possess significantly increased chemical stability...
May 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28528399/bacterial-microbiome-and-nematode-occurrence-in-different-potato-agricultural-soils
#3
Juan D Castillo, Jorge M Vivanco, Daniel K Manter
Pratylenchus neglectus and Meloidogyne chitwoodi are the main plant-parasitic nematodes in potato crops of the San Luis Valley, Colorado. Bacterial microbiome (16S rRNA copies per gram of soil) and nematode communities (nematodes per 200 g of soil) from five different potato farms were analyzed to determine negative and positive correlations between any bacterial genus and P. neglectus and M. chitwoodi. Farms showed differences in bacterial communities, percentage of bacterivorous and fungivorous nematodes, and numbers of P...
May 20, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28527763/aluminium-resistant-plant-growth-promoting-bacteria-induce-overexpression-of-aluminium-stress-related-genes-in-arabidopsis-thaliana-and-increase-the-ginseng-tolerance-against-aluminium-stress
#4
Mohamed El-Agamy Farh, Yeon-Ju Kim, Johan Sukweenadhi, Priyanka Singh, Deok-Chun Yang
Panax ginseng is an important cash crop in the Asian countries due to its pharmaceutical effects, however the plant is exposed to various abiotic stresses, lead to reduction of its quality. One of them is the Aluminum (Al) accumulation. Plant growth promoting bacteria which able to tolerate heavy metals has been considered as a new trend for supporting the growth of many crops in heavy metal occupied areas. In this study, twelve bacteria strains were isolated from rhizosphere of diseased Korean ginseng roots located in Gochang province, Republic of Korea and tested for their ability to grow in Al-embedded broth media...
July 2017: Microbiological Research
https://www.readbyqxmd.com/read/28522712/draft-genome-sequence-of-pseudomonas-sp-strain-ep-r1-isolated-from-echinacea-purpurea-roots-and-effective-in-the-growth-inhibition-of-human-opportunistic-pathogens-belonging-to-the-burkholderia-cepacia-complex
#5
Valentina Maggini, Luana Presta, Elisangela Miceli, Marco Fondi, Emanuele Bosi, Carolina Chiellini, Camilla Fagorzi, Patrizia Bogani, Vincenzo Di Pilato, Gian Maria Rossolini, Alessio Mengoni, Fabio Firenzuoli, Elena Perrin, Renato Fani
In this announcement, we detail the draft genome sequence of the Pseudomonas sp. strain Ep R1, isolated from the roots of the medicinal plant Echinacea purpurea The elucidation of this genome sequence may allow the identification of genes associated with the production of antimicrobial compounds.
May 18, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28520867/activity-of-ceftolozane-tazobactam-against-surveillance-and-problem-enterobacteriaceae-pseudomonas-aeruginosa-and-non-fermenters-from-the-british-isles
#6
David M Livermore, Shazad Mushtaq, Daniele Meunier, Katie L Hopkins, Robert Hill, Rachael Adkin, Aiysha Chaudhry, Rachel Pike, Peter Staves, Neil Woodford
Background: We assessed the activity of ceftolozane/tazobactam against consecutive isolates collected in the BSAC Bacteraemia Surveillance from 2011 to 2015 and against 'problem' isolates sent to the UK national reference laboratory from July 2015, when routine testing began. Methods: Susceptibility testing was by BSAC agar dilution with resistance mechanisms identified by PCR and interpretive reading. Results: Data were reviewed for 6080 BSAC surveillance isolates and 5473 referred organisms...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28511384/community-acquired-burkholderia-cepacia-bacteraemia-presenting-as-mods-in-an-immunocompetent-individual-an-unusual-case
#7
Ritesh Ranjan, Priti Chowdhary, Aman Kamra
Burkholderia cepacia has been recognized as a group of highly virulent organisms known as Burkholderia cepacia complex (Bcc). Bcc are ubiquitous in nature and most commonly found in moist environment, on plant roots and soil. Because of its high intrinsic antibiotic resistance, Bcc is a major cause of morbidity and mortality in hospitalized patients. It is reported most commonly in immunocompromised patients especially in patients with cystic fibrosis. Here, we report a rare case report of bacteraemia by Burkholderia cepacia in an immunocompetent male, who presented with fever and Multiple Organ Dysfunction Syndrome (MODS)...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510994/improved-detection-of-burkholderia-pseudomallei-from-non-blood-clinical-specimens-using-enrichment-culture-and-pcr-narrowing-diagnostic-gap-in-resource-constrained-settings
#8
Chaitanya Tellapragada, Tushar Shaw, Annet D'Souza, Vandana Kalwaje Eshwara, Chiranjay Mukhopadhyay
OBJECTIVES: To evaluate the diagnostic utility of enrichment culture and PCR for improved case detection rates of non-bacteremic form of melioidosis in limited resource settings. METHODS: Clinical specimens (n=525) obtained from patients presenting at a tertiary care hospital of south India with clinical symptoms suggestive of community-acquired pneumonia, lower respiratory tract infections, superficial or internal abscesses, chronic skin ulcers and bone or joint infections were tested for the presence of Burkholderia pseudomallei using conventional culture (CC), enrichment culture (EC) and PCR...
May 16, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28510362/burkholderia-thailandensis-genetic-manipulation
#9
Erin C Garcia
Burkholderia thailandensis is a Gram-negative bacterium endemic to Southeast Asian and northern Australian soils. It is non-pathogenic; therefore, it is commonly used as a model organism for the related human pathogens Burkholderia mallei and Burkholderia pseudomallei. B. thailandensis is relatively easily genetically manipulated and a variety of robust genetic tools can be used in this organism. This unit describes protocols for conjugation, natural transformation, mini-Tn7 insertion, and allelic exchange in B...
May 16, 2017: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/28510258/diversity-of-plant-growth-promoting-bacteria-associated-with-sugarcane
#10
J E L Antunes, M C C P Lyra, F J Ollero, A D S Freitas, L M S Oliveira, A S F Araújo, M V B Figueiredo
The sugarcane (Saccharum spp) presents economic importance, mainly for tropical regions, being an important Brazilian commodity. However, this crop is strongly dependent on fertilizers, mainly nitrogen (N). This study assessed the plant growth-promoting bacteria (PGPB) associated with sugarcane that could be used as a potential inoculant to the crop. We evaluated the genetic diversity of PGPB in the plant tissue of sugarcane varieties (RB 867515, RB 1011, and RB 92579). The primer BOX-A1R was used to differentiate the similar isolated and further sequencing 16S rRNA ribosomal gene...
May 10, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28509852/inhaled-antibiotic-therapy-in-chronic-respiratory-diseases
#11
REVIEW
Diego J Maselli, Holly Keyt, Marcos I Restrepo
The management of patients with chronic respiratory diseases affected by difficult to treat infections has become a challenge in clinical practice. Conditions such as cystic fibrosis (CF) and non-CF bronchiectasis require extensive treatment strategies to deal with multidrug resistant pathogens that include Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus, Burkholderia species and non-tuberculous Mycobacteria (NTM). These challenges prompted scientists to deliver antimicrobial agents through the pulmonary system by using inhaled, aerosolized or nebulized antibiotics...
May 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28507073/antibodies-against-in-vivo-expressed-antigens-are-sufficient-to-protect-against-lethal-aerosol-infection-with-burkholderia-mallei-and-burkholderia-pseudomallei
#12
Shawn M Zimmerman, Jeremy S Dyke, Tomislav P Jelesijevic, Frank Michel, Eric R Lafontaine, Robert J Hogan
Burkholderia mallei, a facultative intracellular bacterium and Tier 1 biothreat, causes the fatal zoonotic disease glanders. The organism possesses multiple genes encoding autotransporter proteins, which represent important virulence factors and targets for developing countermeasures in pathogenic Gram-negative bacteria. In the present study, we investigated one of these autotransporters, BatA, and demonstrate that it displays lipolytic activity, aids in intracellular survival, is expressed in vivo, elicits production of antibodies during infection, and contributes to pathogenicity in a mouse aerosol challenge model...
May 15, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28504473/dynamic-cooperative-glycan-assembly-blocks-the-binding-of-bacterial-lectins-to-epithelial-cells
#13
Takuya Machida, Alexandre Novoa, Émilie Gillon, Shuangshuang Zheng, Julie Claudinon, Thorsten Eierhoff, Anne Imberty, Winfried Römer, Nicolas Winssinger
Pathogens frequently rely on lectins for adhesion and cellular entry into the host. Since these interactions typically result from multimeric binding of lectins to cell-surface glycans, novel therapeutic strategies are being developed with the use of glycomimetics as competitors of such interactions. Herein we study the benefit of nucleic acid based oligomeric assemblies with PNA-fucose conjugates. We demonstrate that the interactions of a lectin with epithelial cells can be inhibited with conjugates that do not form stable assemblies in solution but benefit from cooperativity between ligand-protein interactions and PNA hybridization to achieve high affinity...
May 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28502643/are-brucellosis-q-fever-and-melioidosis-potential-causes-of-febrile-illness-in-madagascar
#14
Ides Boone, Klaus Henning, Angela Hilbert, Heinrich Neubauer, Vera von Kalckreuth, Denise Myriam Dekker, Norbert Georg Schwarz, Gi Deok Pak, Andreas Krüger, Ralf Matthias Hagen, Hagen Frickmann, Jean Noël Heriniaina, Raphael Rakotozandrindrainy, Jean Philibert Rakotondrainiarivelo, Tsiry Razafindrabe, Benedikt Hogan, Jürgen May, Florian Marks, Sven Poppert, Sascha Al Dahouk
Brucellosis, Q fever and melioidosis are zoonoses, which can lead to pyrexia. These diseases are often under-ascertained and underreported because of their unspecific clinical signs and symptoms, insufficient awareness by physicians and public health officers and limited diagnostic capabilities, especially in low-resource countries. Therefore, the presence of Brucella spp., Coxiella burnetii and Burkholderia pseudomallei was investigated in Malagasy patients exhibiting febrile illness. In addition, we analyzed zebu cattle and their ticks as potential reservoirs for Brucella and C...
May 11, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28493905/melioidosis-clinical-impact-and-public-health-threat-in-the-tropics
#15
REVIEW
Ramar Perumal Samy, Bradley G Stiles, Gautam Sethi, Lina H K Lim
This review briefly summarizes the geographical distribution and clinical impact of melioidosis, especially in the tropics. Burkholderia pseudomallei (a gram-negative bacterium) is the major causative agent for melioidosis, which is prevalent in Singapore, Malaysia, Thailand, Vietnam, and Northern Australia. Melioidosis patients are increasingly being recognized in other parts of the world. The bacteria are intrinsically resistant to many antimicrobial agents, but prolonged treatment, especially with combinations of antibiotics, may be effective...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28491333/burkholderia-cepacia-complex-and-limited-cutaneous-vasculitis-in-patients-with-cystic-fibrosis-a-case-series
#16
Muttardi Kayria, Orchard Chris, Devesh J Dhasmana, Morar Nilesh, Margaret E Hodson, Gyi Khin, Bilton Diana, Nicholas J Simmonds
There is a high association of reactive skin presentations, mainly limited cutaneous vasculitis in patients with cystic fibrosis and Burkholderia cepcia complex chronic infection. This may be due to raised levels of circulating inflammatory mediators.
April 2017: JRSM Open
https://www.readbyqxmd.com/read/28486529/ag-i-camphorimine-complexes-with-antimicrobial-activity-towards-clinically-important-bacteria-and-species-of-the-candida-genus
#17
João M S Cardoso, Soraia I Guerreiro, Andreia Lourenço, Marta M Alves, M Fátima Montemor, Nuno P Mira, Jorge H Leitão, M Fernanda N N Carvalho
The present work follows a previous report describing the antibacterial activity of silver camphorimine complexes of general formula [Ag(NO3)L]. The synthesis and demonstration of the antifungal and antibacterial activity of three novel [Ag(NO3)L] complexes (named 1, 2 and 3) is herein demonstrated. This work also shows for the first time that the previously studied complexes (named 4 to 8) also exert antifungal activity. The antibacterial activity of complexes was evaluated against Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia contaminans and Escherichia coli strains, while antifungal activity was tested against the Candida species C...
2017: PloS One
https://www.readbyqxmd.com/read/28483933/burkholderia-outbreak-proves-any-drug-product-can-be-risky
#18
Kate Traynor
No abstract text is available yet for this article.
May 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28475641/a-nonsense-mutation-in-tlr5-is-associated-with-survival-and-reduced-il-10-and-tnf-%C3%AE-levels-in-human-melioidosis
#19
Panjaporn Chaichana, Narisara Chantratita, Florian Brod, Sirikamon Koosakulnirand, Kemajittra Jenjaroen, Suchintana Chumseng, Manutsanun Sumonwiriya, Mary N Burtnick, Paul J Brett, Prapit Teparrukkul, Direk Limmathurotsakul, Nicholas P J Day, Susanna J Dunachie, T Eoin West
BACKGROUND: Melioidosis, caused by the flagellated bacterium Burkholderia pseudomallei, is a life-threatening and increasingly recognized emerging disease. Toll-like receptor (TLR) 5 is a germline-encoded pattern recognition receptor to bacterial flagellin. We evaluated the association of a nonsense TLR5 genetic variant that truncates the receptor with clinical outcomes and with immune responses in melioidosis. METHODOLOGY/PRINCIPLE FINDINGS: We genotyped TLR5 c...
May 5, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28473933/melioidosis-with-portal-vein-thrombosis
#20
Thanyaporn Direksunthorn
Melioidosis, caused by Burkholderia pseudomallei, is a common infectious disease in tropical regions. The author reports a case of melioidosis with a rare manifestation of portal vein thrombosis and cavernous transformation of the portal vein. Melioidosis should be considered a differential diagnosis in patients with underlying risk factors who present with multiple liver abscesses; moreover, portal vein thrombosis can be a potential complication. Computed tomography is the modality of choice to demonstrate venous thrombosis in various organs...
2017: Case Reports in Infectious Diseases
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