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carotid intimal thickening

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https://www.readbyqxmd.com/read/28765521/contrast-enhanced-ultrasound-imaging-quantification-of-adventitial-vasa-vasorum-in-a-rabbit-model-of-varying-degrees-of-atherosclerosis
#1
Xiaoying Li, Ruyou Zhang, Zongmin Li, Chunping Ning, Zhenzhen Wang, Meizheng Dang, Yanqing Peng, Xuesong Han, Litao Sun, Jiawei Tian
This study used an atherosclerotic rabbit model to investigate the feasibility of quantifying adventitial vasa vasorum (VV) via contrast-enhanced ultrasound (CEUS) imaging to identify early atherosclerosis. Recent evidence has linked adventitial VV with atherosclerotic plaque progression and vulnerability. A growth in VV density has been detected preceding intimal thickening and even endothelial dysfunction. In our study, carotid atherosclerosis rabbit models were used, and animals underwent CEUS imaging at the end of the atherosclerotic induction period...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28712642/a-rare-case-of-febrile-abdominal-pain-revealing-horton-s-disease
#2
Arnaud Chaudet, Jean-Michel Goujon, Aiham Daniel Ghazali
BACKGROUND: Horton's disease is a systemic inflammatory vasculitis, usually found in persons over 50years old. It affects medium and large-sized arteries stemming from the external carotid, especially the superficial temporal arteries. It can affect extracranial large vessels but only rarely the aorta. Diagnosis of aortitis is difficult and its incidence is probably underestimated. CASE PRESENTATION: A 68-year-old Caucasian woman consulted in an emergency department for febrile abdominal pain with inflammatory syndrome...
July 8, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28702876/cardiovascular-histopathology-of-a-11-year-old-with-mucopolysaccharidosis-vii-demonstrates-fibrosis-macrophage-infiltration-and-arterial-luminal-stenosis
#3
Valerie Lew, Louis Pena, Robert Edwards, Raymond Y Wang
Mucopolysaccharidosis type VII (MPS VII) is caused by β-glucuronidase deficiency, resulting in lysosomal accumulation of glycosaminoglycans (GAGs) and multisystemic disease. We present cardiovascular gross and histopathology findings from a 11-year-old MPS VII male, who expired after developing ventricular fibrillation following anesthesia induction. Gross anatomic observations were made at autopsy; postmortem formalin-fixed paraffin-embedded samples of the carotid artery, aorta, myocardium, and valves were sectioned and stained with hematoxylin-eosin, Verhoeff-Van Gieson, CD68, and trichrome stains...
July 13, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28654057/murine-aortic-crush-injury-an-efficient-in-vivo-model-of-smooth-muscle-cell-proliferation-and-endothelial-function
#4
Dan Yu, George Makkar, Rajabrata Sarkar, Dudley K Strickland, Thomas S Monahan
Arterial reconstruction, whether angioplasty or bypass surgery, involves iatrogenic trauma causing endothelial disruption and vascular smooth muscle cell (VSMC) proliferation. Common murine models study small vessels such as the carotid and femoral arteries. Herein we describe an in vivo system in which both VSMC proliferation and endothelial barrier function can be simultaneously assessed in a large vessel. We studied the infrarenal aortic response to injury in C57BL/6 mice. The aorta was injured from the left renal vein to the aortic bifurcation by 30 transmural crushes of 5-seconds duration with a cotton-tipped applicator...
June 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28540322/targeting-wnt-%C3%AE-catenin-activated-cells-with-dominant-negative-n-cadherin-to-reduce-neointima-formation
#5
Sarah Hulin-Curtis, Helen Williams, Kerry S Wadey, Graciela B Sala-Newby, Sarah J George
Approximately 50% of coronary artery bypass grafts using the autologous saphenous vein fail within 10 years due to intimal thickening. This study examined whether a gene therapy approach that selectively kills Wnt/β-catenin/T cell factor (TCF) activated vascular smooth muscle cells (VSMCs) using dominant-negative N-cadherin (dn-N-cadherin) reduced intimal thickening. Cultured human VSMCs infected with an adenovirus (Ad) encoding dn-N-cadherin via the TCF promoter (Ad-TOP-dn-N-cadherin) specifically expressed dn-N-cadherin in response to activation of the Wnt/β-catenin/TCF pathway...
June 16, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28397443/an-evaluation-of-dual-source-computed-tomography-used-with-the-de-weert-classification-to-detect-vulnerable-plaque-using-ivus-virtual-histology-as-a-standard-of-reference
#6
Bartosz Dołęga-Kozierowski, Piotr Klimeczek, Michał Lis, Róża Krycińska, Anna Chrapusta, Urszula Zaleska-Dorobisz, Jerzy Garcarek, Wojciech Witkiewicz
BACKGROUND: One of the main risk factors for cerebral ischemic events is atherosclerotic disease of the internal carotid artery (ICA). Nowadays, increasing attention is being paid to the relationship between the morphological features of atherosclerotic plaque and the occurrence of stroke. Several studies have demonstrated that the presence of specific vulnerable plaque types, with a large lipid core and thin fibrous cap, can be used as an independent risk predictor of cerebral ischemic events...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28360226/dual-function-for-mature-vascular-smooth-muscle-cells-during-arteriovenous-fistula-remodeling
#7
Jinjing Zhao, Frances L Jourd'heuil, Min Xue, David Conti, Reynold I Lopez-Soler, Roman Ginnan, Arif Asif, Harold A Singer, David Jourd'heuil, Xiaochun Long
BACKGROUND: The arteriovenous fistula (AVF) is the preferred form of hemodialysis access for patients with chronic kidney disease. However, AVFs are associated with significant problems including high incidence of both early and late failures, usually attributed to inadequate venous arterialization and neointimal hyperplasia, respectively. Understanding the cellular basis of venous remodeling in the setting of AVF could provide targets for improving AVF patency rates. METHODS AND RESULTS: A novel vascular smooth muscle cell (VSMC) lineage tracing reporter mouse, Myh11-Cre/ERT2-mTmG, was used to track mature VSMCs in a clinically relevant AVF mouse model created by a jugular vein branch end to carotid artery side anastomosis...
March 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28338883/the-effects-of-oleanolic-acid-on-atherosclerosis-in-different-animal-models
#8
Hanqiong Luo, Jine Liu, Qiong Ouyang, Chunxiao Xuan, Lanlan Wang, Tingting Li, Jun Liu
In the present study, three animal models, including C57BL/6J mice, low-density lipoprotein receptor knockout (LDLR-/-) mice, and rabbit that mimicked atherosclerosis, were established to investigate the inhibitory effect of oleanolic acid (OA) on atherosclerosis. In rabbit model, serum total cholesterol (TC), triglyceride, low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were measured. Carotid artery lesions were isolated for histological analysis. The red oil O and hematoxylin-eosin staining in liver were examined...
March 4, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28285092/visceral-to-subcutaneous-fat-ratio-is-independently-related-to-small-and-large-cerebrovascular-lesions-even-in-healthy-subjects
#9
Satoshi Higuchi, Yusuke Kabeya, Kiyoe Kato
BACKGROUND AND AIMS: The severity of obesity is evaluated by visceral-to-subcutaneous fat ratio (VS ratio), which may be useful for predicting atherosclerosis. However, it is unclear how VS ratio affects different types of cerebrovascular lesions. This study was conducted to evaluate the clinical impact of visceral fat accumulation on the cerebrovascular lesions. METHODS: This cross-sectional study included 980 apparently healthy Japanese adults who underwent a health check-up program focused toward atherosclerosis, between 2011 and 2014...
April 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28199358/association-between-carotid-atherosclerosis-and-different-subtypes-of-hypertension-in-adult-populations-a-multiethnic-study-in-xinjiang-china
#10
Yun Wu, Fen Liu, Dilare Adi, Yi-Ning Yang, Xiang Xie, Xiao-Mei Li, Xiang Ma, Zhen-Yan Fu, Ying Huang, Bang-Dang Chen, Chun-Fang Shan, Yi-Tong Ma
BACKGROUND: Ethnic differences in non-invasive measurements of carotid atherosclerosis are being increasingly reported, but the association between carotid atherosclerosis and different subtypes of hypertension in adult populations is not fully understood in different ethnicities. We aimed to investigate the association of carotid atherosclerosis with different subtypes of hypertension in different ethnicities in Xinjiang, a northwestern province in China. METHODS: A total of 14,618 participants (5,757 Hans, 4,767 Uygurs, and 4,094 Kazakhs) from 26 villages of seven cities in Xinjiang were randomly selected from the Cardiovascular Risk Survey conducted during 2007 and 2010...
2017: PloS One
https://www.readbyqxmd.com/read/28180006/effects-of-amniotic-epithelial-cell-transplantation-in-endothelial-injury
#11
REVIEW
Gabriella Vácz, Attila Cselenyák, Zsuzsanna Cserép, Rita Benkő, Endre Kovács, Eszter Pankotai, Andrea Lindenmair, Susanne Wolbank, Charlotte M Schwarz, Dénes B Horváthy, Levente Kiss, István Hornyák, Zsombor Lacza
PURPOSE: Human amniotic epithelial cells (hAECs) are promising tools for endothelial repair in vascular regenerative medicine. We hypothesized that these epithelial cells are capable of repairing the damaged endothelial layer following balloon injury of the carotid artery in adult male rats. RESULTS: Two days after injury, the transplanted hAECs were observed at the luminal side of the arterial wall. Then, 4 weeks after the injury, significant intimal thickening was observed in both untreated and cell implanted vessels...
December 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28173642/a-novel-urotensin-ii-receptor-antagonist-kr-36996-inhibits-smooth-muscle-proliferation-through-erk-ros-pathway
#12
Tae-Ho Kim, Dong Gil Lee, Young-Ae Kim, Byung Ho Lee, Kyu Yang Yi, Yi-Sook Jung
Urotensin II (UII) is a mitogenic and hypertrophic agent that can induce the proliferation of vascular cells. UII inhibition has been considered as beneficial strategy for atherosclerosis and restenosis. However, currently there is no therapeutics clinically available for atherosclerosis or restenosis. In this study, we evaluated the effects of a newly synthesized UII receptor (UT) antagonist, KR- 36996, on the proliferation of SMCs in vitro and neointima formation in vivo in comparison with GSK-1440115, a known potent UT antagonist...
May 1, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28042220/internal-carotid-artery-fibromuscular-dysplasia-in-a-child-incidental-postmortem-finding-after-head-injury
#13
Arulselvi Subramanian, Garima Aggarwal, Deepak Agarwal, Sanjeev Lalwani
Fibromuscular dysplasia (FMD) is a rare, segmental, nonatheromatous, and noninflammatory arterial disease of unknown etiology. It predominantly involves renal artery (60-75%) followed by extracranial part of the internal carotid artery and vertebral arteries (25-30%). The disease typically affects middle-aged women and involves intermediate-sized arteries throughout the body. There are rare case reports of extracranial FMD compounding a trauma case. A patient was brought to trauma center emergency with a history of fall from height...
January 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/27815507/suppression-of-neointima-formation-by-targeting-%C3%AE-catenin-tcf-pathway
#14
Helen Williams, Sadie Slater, Sarah Jane George
Coronary artery disease is treated by vein grafting and stent implantation. Late vein graft failure and restenosis of stented arteries reduce the success rates of these approaches and are caused by neointima formation. We have previously shown that Wnt proteins are up-regulated during intimal thickening, and have speculated that these lead to activation of downstream genes with β-catenin/T-cell factor (TCF)-responsive promoters. In the present study, we aimed to provide evidence that β-catenin/TCF signalling promotes neointima formation and assess whether targeting this pathway has potential for reducing neointima formation...
December 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27763268/use-of-brilliant-blue-fcf-during-vein-graft-preparation-inhibits-intimal-hyperplasia
#15
Michael J Osgood, Kevin Sexton, Igor Voskresensky, Kyle Hocking, Jun Song, Padmini Komalavilas, Colleen Brophy, Joyce Cheung-Flynn
BACKGROUND: Intimal hyperplasia remains the primary cause of vein graft failure for the 1 million yearly bypass procedures performed using human saphenous vein (HSV) grafts. This response to injury is caused in part by the harvest and preparation of the conduit. The use of Brilliant Blue FCF (FCF) restores injury-induced loss of function in vascular tissues possibly via inhibition of purinergic receptor signaling. This study investigated whether pretreatment of the vein graft with FCF prevents intimal hyperplasia...
August 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27582556/blockade-of-urotensin-ii-receptor-prevents-vascular-dysfunction
#16
Young-Ae Kim, Dong Gil Lee, Kyu Yang Yi, Byung Ho Lee, Yi-Sook Jung
Urotensin II (UII) is a potent vasoactive peptide and mitogenic agent to induce proliferation of various cells including vascular smooth muscle cells (VSMCs). In this study, we examined the effects of a novel UII receptor (UT) antagonist, KR-36676, on vasoconstriction of aorta and proliferation of aortic SMCs. In rat aorta, UII-induced vasoconstriction was significantly inhibited by KR-36676 in a concentration-dependent manner. In primary human aortic SMCs (hAoSMCs), UII-induced cell proliferation was significantly inhibited by KR-36676 in a concentration-dependent manner...
September 1, 2016: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/27477859/a-new-clinically-relevant-model-for-intracranial-atherosclerosis-in-rats
#17
Jiamei Shen, James Stevenson, Xiaokun Geng, Jianjie Yang, Changbin Yin, Fengwu Li, Sainan Wang, Huishan Du, Xunming Ji, Yuchuan Ding
INTRODUCTION: Intracranial atherosclerotic stenosis (ICAS) is one of the most common causes of stroke worldwide and, in particular, has been implicated as a leading cause of recurrent ischemic stroke. We developed a new rat model to study intracranial atherosclerosis. METHODS: Twelve-week-old male Sprague-Dawley rats were divided into a control (on a maintain diet) and a high-cholesterol group (on a daily 1% cholesterol diet) for up to 6 weeks. During the first two weeks, NG-nitro-L-arginine methylester (L-NAME, 3 mg/mL) was added to the drinking water in the high-cholesterol group to induce intimal changes making the rats susceptible to atherosclerosis...
September 2016: Neurological Research
https://www.readbyqxmd.com/read/27477186/pcsk9-knock-out-mice-are-protected-from-neointimal-formation-in-response-to-perivascular-carotid-collar-placement
#18
Nicola Ferri, Silvia Marchianò, Gianpaolo Tibolla, Roberta Baetta, Ashish Dhyani, Massimiliano Ruscica, Patrizia Uboldi, Alberico L Catapano, Alberto Corsini
BACKGROUND AND AIMS: Proprotein convertase subtilisin kexin type 9 (PCSK9) induces degradation of the low-density lipoprotein-receptor (LDLR). Smooth muscle cells (SMCs) in human atherosclerotic plaques and cultured SMCs express PCSK9. The present study aimed at defining the role of PCSK9 on vascular response to injury. METHODS: Carotid neointimal lesions were induced by positioning a non-occlusive collar in PCSK9 knock-out (PCSK9(-/-)) and wild type littermate (PCSK9(+/+)) mice...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27379921/inhibition-of-intimal-thickening-after-vascular-injury-with-a-cocktail-of-vascular-endothelial-growth-factor-and-cyclic-arg-gly-asp-peptide
#19
Yue Li, Lucinda S McRobb, Levon M Khachigian
BACKGROUND: Percutaneous coronary intervention is widely used for the treatment of coronary artery disease; however, significant challenges such as restenosis remain. Key to solving these problems is to inhibit smooth muscle cell activation while enhancing re-endothelialization. Early growth response-1 (Egr-1) is a transcription factor that regulates vascular smooth muscle cell (SMC) proliferation and migration through its control of an array of downstream genes. METHODS: A "cocktail" of vascular endothelial growth factor (VEGF)-A, VEGF-D and cyclic RGD was tested for its ability to inhibit neointima formation and accelerate re-endothelialization following balloon injury to carotid arteries of rats...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27336336/takayasu-s-arteritis-followed-the-effects-of-therapeutic-pharmacology-by-carotid-ultrasonography
#20
Gabriel E Pérez Baztarrica, Andrea Iglesias, Tereza Zuñiga Infanta, Ricardo Levin, Rafael Porcile
INTRODUCTION: The carotid ultrasonography could be used to assess the effects of therapeutic pharmacology in the Takayasu's arteritis (TA). CASE PRESENTATION: 21-year-old female with a pulsatile headache and high blood pressure. There were difference in the blood pressure between arms and a bruit over the carotid and subclavian region. The CT angiography demonstrated arterial wall thickening of nearly the whole aorta and its branches. We diagnosed the patient as having AT...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
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