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https://www.readbyqxmd.com/read/28931434/long-term-outcome-of-autistic-spectrum-disorder-a-retrospective-case-study-in-a-southern-italian-region
#1
Francesca Felicia Operto, Federica Martino, Annalisa Rinaldi, Angelo Cerracchio, Giovanni Salvati, Mariano Orza, Claudia Lembo, Gianvito Panzarino, Claudia Di Paolantonio, Alberto Verrotti, Giovanni Farello, Giangennaro Coppola
BACKGROUND: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder, characterized by impaired social communication and restricted and repetitive behaviours, as well as associated features including intellectual disability and impaired sensorimotor function. Despite a growing interest in this devastating disorder for families and young parents, there are no certainties as regards its aetiology, although a significant genetic background is considered to be important. Since there is little information about the social adaptation and quality of life of patients with Autism Spectrum Disorder, we decided to study and evaluate the long-term outcome and quality of life in a sample of children, adolescent and young adults...
September 20, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28927730/decreased-structural-connectivity-and-resting-state-brain-activity-in-the-lateral-occipital-cortex-is-associated-with-social-communication-deficits-in-boys-with-autism-spectrum-disorder
#2
REVIEW
Minyoung Jung, Yiheng Tu, Courtney Amanda Lang, Ana Ortiz, Joel Park, Kristen Jorgenson, Xue-Jun Kong, Jian Kong
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder characterized by atypical social communication and repetitive behaviors. In this study, we applied a multimodal approach to investigate brain structural connectivity, resting state activity, and surface area and their associations with the core symptoms of ASD. Data from forty boys with ASD (mean age, 11.5 years; age range, 5.5-19.5) and forty boys with typical development (TD) (mean age, 12.3; age range, 5.8-19.7) were extracted from the Autism Brain Imaging Data Exchange II (ABIDE II) for data analysis...
September 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28922953/high-technology-augmentative-and-alternative-communication-for-individuals-with-intellectual-and-developmental-disabilities-and-complex-communication-needs-a-meta-analysis
#3
Jennifer B Ganz, Kristi L Morin, Margaret J Foster, Kimberly J Vannest, Derya Genç Tosun, Emily V Gregori, Stephanie L Gerow
The use of mobile technology is ubiquitous in modern society and is rapidly increasing in novel use. The use of mobile devices and software applications ("apps") as augmentative and alternative communication (AAC) is rapidly expanding in the community, and this is also reflected in the research literature. This article reports the social-communication outcome results of a meta-analysis of single-case experimental research on the use of high-tech AAC, including mobile devices, by individuals with intellectual and developmental disabilities, including autism spectrum disorder...
September 19, 2017: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/28922239/cleft-lip-and-palate-an-experience-of-a-developing-center-in-egypt
#4
Tarek A Abulezz
BACKGROUND: Cleft lip and palate is the most common congenital anomaly in the head and neck region. These clefts are not just a distortion of the normal appearance, but they may impose a major influence on the whole patient's life, both functionally and psychologically. Clefts affect feeding, teething, hearing, speech, and social communication. The incidence of cleft lip and palate is variable in different countries and different communities. The surgical correction of cleft lip and palate went through many evolutions, but still there is no single universal protocol of repair; however, many European countries have adopted national protocols and have established cleft centers for the management and follow up of affected population...
September 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28914085/development-of-a-patient-centered-conceptual-model-of-the-impact-of-living-with-autism-spectrum-disorder
#5
Fiona McDougall, Thomas Willgoss, Steve Hwang, Federico Bolognani, Lorraine Murtagh, Evdokia Anagnostou, Diana Rofail
The aim of this study was to generate a patient-centered conceptual model of the impact of living with autism spectrum disorder, which can be used to support the selection of outcome measures for clinical trials. Following an initial literature review to identify preliminary concepts and inform an interview guide, in-depth face-to-face interviews were conducted with adolescents and adults with autism spectrum disorder (IQ ⩾ 70) (n = 10), as well as parents of children, adolescents, and adults with autism spectrum disorder (IQ ⩾ 70) (n = 26)...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28913834/which-children-and-young-people-are-excluded-from-school-findings-from-a-large-british-birth-cohort-study-the-avon-longitudinal-study-of-parents-and-children-alspac
#6
A Paget, C Parker, J Heron, S Logan, W Henley, A Emond, T Ford
BACKGROUND: Exclusion from school is increasingly recognized as pertinent to child health. National educational data reveal that boys, children who are looked-after, living in poverty, have special educational needs, or from certain ethnic minorities, are disproportionately excluded from school. As population-based data on the wider characteristics of excluded children are scarce, we aimed to describe predictors of school exclusion in the Avon Longitudinal Study of Parents and Children...
September 14, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28901162/imagining-autism-feasibility-of-a-drama-based-intervention-on-the-social-communicative-and-imaginative-behaviour-of-children-with-autism
#7
Julie Beadle-Brown, David Wilkinson, Lisa Richardson, Nicola Shaughnessy, Melissa Trimingham, Jennifer Leigh, Beckie Whelton, Julian Himmerich
We report the feasibility of a novel, school-based intervention, coined 'Imagining Autism', in which children with autism engage with drama practitioners though participatory play and improvisation in a themed multi-sensory 'pod' resembling a portable, tent-like structure. A total of 22 children, aged 7-12 years, from three UK schools engaged in the 10-week programme. Measures of social interaction, communication and emotion recognition, along with parent and teacher ratings, were collected before and up to 12 months after the intervention...
September 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28895033/three-category-classification-of-magnetic-resonance-hearing-loss-images-based-on-deep-autoencoder
#8
Wenjuan Jia, Ming Yang, Shui-Hua Wang
Hearing loss, a partial or total inability to hear, is known as hearing impairment. Untreated hearing loss can have a bad effect on normal social communication, and it can cause psychological problems in patients. Therefore, we design a three-category classification system to detect the specific category of hearing loss, which is beneficial to be treated in time for patients. Before the training and test stages, we use the technology of data augmentation to produce a balanced dataset. Then we use deep autoencoder neural network to classify the magnetic resonance brain images...
September 11, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28888501/the-effectiveness-of-assertiveness-training-for-school-aged-children-on-bullying-and-assertiveness-level
#9
Fatma Avşar, Sultan Ayaz Alkaya
PURPOSE: The aim of this study was to determine the effectiveness of an assertive training for school-aged children on peer bullying and assertiveness. DESIGN AND METHODS: A quasi-experimental design using pre- and post-testing was conducted. Data were collected using a demographic questionnaire, an assertiveness scale, and the peer victimization scale. The training program was comprised of eight sessions which were implemented to intervention group. RESULTS: Descriptive characteristics were not statistically different between the groups (p>0...
September 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28878717/understanding-the-self-in-individuals-with-autism-spectrum-disorders-asd-a-review-of-literature
#10
REVIEW
Ann X Huang, Tammy L Hughes, Lawrence R Sutton, Marissa Lawrence, Xiaohan Chen, Zhe Ji, Waganesh Zeleke
When the system of self is explored in individuals with Autism Spectrum Disorders (ASDs), it is important to measure it via both their own perceptions of the self and their understanding of others' perceptions on themselves at a multidimensional level. This paper reviews existing research in this area using a three-dimension approach. Researchers have found that impairments in the self-system are usually correlated with these individuals' social and cognitive functioning levels: high functioning individuals with ASD who have higher IQ are found to have better awareness of their limitations in social and communication domains than those with lower IQ...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28867767/arid1b-haploinsufficiency-causes-abnormal-brain-gene-expression-and-autism-related-behaviors-in-mice
#11
Mihiro Shibutani, Takuro Horii, Hirotaka Shoji, Sumiyo Morita, Mika Kimura, Naomi Terawaki, Tsuyoshi Miyakawa, Izuho Hatada
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with core symptoms that include poor social communication, restricted interests, and repetitive behaviors. Several ASD mouse models exhibit impaired social interaction, anxiety-like behavior, and elevated perseveration. Large-scale whole exome sequencing studies identified many genes putatively associated with ASD. Like chromodomain helicase DNA binding protein 8 (CHD8), the most frequently mutated gene in individuals with ASD, the candidate gene AT-rich interaction domain 1B (ARID1B) encodes a chromatin remodeling factor...
August 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28864977/oxytocin-and-animal-models-for-autism-spectrum-disorder
#12
Shlomo Wagner, Hala Harony-Nicolas
Autism spectrum disorder (ASD) is a group of complex neurodevelopmental conditions characterized by deficits in social communication and by repetitive and stereotypic patterns of behaviors, with no pharmacological treatments available to treat these core symptoms. Oxytocin is a neuropeptide that powerfully regulates mammalian social behavior and has been shown to exert pro-social effects when administered intranasally to healthy human subjects. In the last decade, there has been a significant interest in using oxytocin to treat social behavior deficits in ASD...
September 2, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28856480/screening-for-autism-with-the-srs-and-scq-variations-across-demographic-developmental-and-behavioral-factors-in-preschool-children
#13
Eric J Moody, Nuri Reyes, Caroline Ledbetter, Lisa Wiggins, Carolyn DiGuiseppi, Amira Alexander, Shardel Jackson, Li-Ching Lee, Susan E Levy, Steven A Rosenberg
The Social Communication Questionnaire (SCQ) and the Social Responsiveness Scales (SRS) are commonly used screeners for autism spectrum disorder (ASD). Data from the Study to Explore Early Development were used to examine variations in the performance of these instruments by child characteristics and family demographics. For both instruments, specificity decreased as maternal education and family income decreased. Specificity was decreased with lower developmental functioning and higher behavior problems. This suggests that the false positive rates of the SRS and the SCQ are associated with child characteristics and family demographic factors...
August 30, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28855879/how-social-communications-influence-advertising-perception-and-response-in-online-communities
#14
Fue Zeng, Ran Tao, Yanwu Yang, Tingting Xie
This research aims to explore how social communications of online communities affect users' perception and responses toward social media advertising. We developed a conceptual model based on the SBT, encapsulating 9 constructs and 10 hypothesis extracted from the extant social media advertising literature. Our research outcome proves that social communications can effectively boost users' behaviors to be in accordance with an online social community, thus facilitate their acceptance and responses toward social media advertising, with users' group intention as an intervening factor...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28844789/protocadherin-10-alters-%C3%AE-oscillations-amino-acid-levels-and-their-coupling-baclofen-partially-restores-these-oscillatory-deficits
#15
Russell G Port, Christopher Gajewski, Elizabeth Krizman, Holly C Dow, Shinji Hirano, Edward S Brodkin, Gregory C Carlson, Michael B Robinson, Timothy P L Roberts, Steven J Siegel
Approximately one in 45 children have been diagnosed with Autism Spectrum Disorder (ASD), which is characterized by social/communication impairments. Recent studies have linked a subset of familial ASD to mutations in the Protocadherin 10 (Pcdh10) gene. Additionally, Pcdh10's expression pattern, as well as its known role within protein networks, implicates the gene in ASD. Subsequently, the neurobiology of mice heterozygous for Pcdh10 (Pcdh10(+/-)) has been investigated as a proxy for ASD. Male Pcdh10(+/-) mice have demonstrated sex-specific deficits in social behavior, recapitulating the gender bias observed in ASD...
August 24, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28842344/allosteric-modulation-of-nicotinic-and-gabaa-receptor-subtypes-differentially-modify-autism-like-behaviors-in-the-btbr-mouse-model
#16
Ryan F Yoshimura, Minhtam B Tran, Derk J Hogenkamp, Narielle L Ayala, Timothy Johnstone, Andrew J Dunnigan, Timothy K Gee, Kelvin W Gee
Autism spectrum disorder (ASD) is associated with two core symptoms (social communication deficits and stereotyped repetitive behaviors) in addition to a number of comorbidities. There are no FDA-approved drugs for the core symptoms and the changes that underlie these behaviors are not fully understood. One hypothesis is an imbalance of the excitation (E)/inhibition (I) ratio with excessive E and diminished I occurring in specific neuronal circuits. Data suggests that both gamma-aminobutyric acidA (GABAA) and α7 nicotinic acetylcholine receptors (nAChRs) significantly impact E/I...
August 24, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28839245/hypermasculinised-facial-morphology-in-boys-and-girls-with-autism-spectrum-disorder-and-its-association-with-symptomatology
#17
Diana Weiting Tan, Syed Zulqarnain Gilani, Murray T Maybery, Ajmal Mian, Anna Hunt, Mark Walters, Andrew J O Whitehouse
Elevated prenatal testosterone exposure has been associated with Autism Spectrum Disorder (ASD) and facial masculinity. By employing three-dimensional (3D) photogrammetry, the current study investigated whether prepubescent boys and girls with ASD present increased facial masculinity compared to typically-developing controls. There were two phases to this research. 3D facial images were obtained from a normative sample of 48 boys and 53 girls (3.01-12.44 years old) to determine typical facial masculinity/femininity...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28835209/altered-sensitivity-to-social-gaze-in-the-fmr1-premutation-and-pragmatic-language-competence
#18
Jessica Klusek, Joseph Schmidt, Amanda J Fairchild, Anna Porter, Jane E Roberts
BACKGROUND: The FMR1 premutation affects 1:291 women and is associated with a range of cognitive, affective, and physical health complications, including deficits in pragmatic language (i.e., social language). This study investigated attention to eye gaze as a fundamental social-cognitive skill that may be impaired in the FMR1 premutation and could underlie pragmatic deficits. Given the high prevalence of the FMR1 premutation, efforts to define its phenotype and mechanistic underpinnings have significant public health implications...
August 24, 2017: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/28833100/language-impairment-and-comorbid-vulnerabilities-among-young-people-in-custody
#19
Nathan Hughes, Prathiba Chitsabesan, Karen Bryan, Rohan Borschmann, Nathaniel Swain, Charlotte Lennox, Jennifer Shaw
BACKGROUND: While the prevalence of language and communication difficulties among young people in custody is well established, holistic understanding of the complexity and co-occurrence of additional vulnerabilities among this population are rare. METHODS: Ninety-three young people in a young offenders institution in England were assessed using the Comprehensive Health Assessment Tool, the Test of Word Knowledge, and a range of additional assessments of communication, cognition, and neurodevelopmental difficulties...
August 22, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28828866/facilitating-pragmatic-skills-through-role-play-in-learners-with-language-learning-disability
#20
Fareeaa Abdoola, Penelope S Flack, Saira B Karrim
BACKGROUND: Role-based learning involves the process whereby learners acquire skills, knowledge and understanding through the assumption of roles within real-life settings. Role-play holds potential as an effective learning strategy for children; however, there is limited research on the use of role-play as a therapy method within the field of speech-language pathology. Children with language learning disability (LLD) typically present with difficulties in social communication, which can negatively affect their social and academic achievement...
July 26, 2017: South African Journal of Communication Disorders. die Suid-Afrikaanse Tydskrif Vir Kommunikasieafwykings
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