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inonotus obliquus

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https://www.readbyqxmd.com/read/27869186/regulation-of-anticancer-styrylpyrone-biosynthesis-in-the-medicinal-mushroom-inonotus-obliquus-requires-thioredoxin-mediated-transnitrosylation-of-s-nitrosoglutathione-reductase
#1
Yanxia Zhao, Meihong He, Jianing Ding, Qi Xi, Gary J Loake, Weifa Zheng
The medicinal macrofungus Inonotus obliquus widely utilized as folk medicine in Russia and Baltic countries is a source of phenylpropanoid-derived styrylpyrone polyphenols that can inhibit tumor proliferation. Insights into the regulatory machinery that controls I. obliquus styrylpyrone polyphenol biosynthesis will enable strategies to increase the production of these molecules. Here we show that Thioredoxin (Trx) mediated transnitrosylation of S-nitrosoglutathione reductase (GSNOR) underpins the regulation of styrylpyrone production, driven by nitric oxide (NO) synthesis triggered by P...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865960/identification-of-inonotus-obliquus-polysaccharide-with-broad-spectrum-antiviral-activity-against-multi-feline-viruses
#2
Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting...
November 16, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27807684/inhibition-of-murine-norovirus-and-feline-calicivirus-by-edible-herbal-extracts
#3
Dong Joo Seo, Changsun Choi
Human noroviruses (HuNoVs) cause foodborne and waterborne viral gastroenteritis worldwide. Because HuNoV culture systems have not been developed thus far, no available medicines or vaccines preventing infection with HuNoVs exist. Some herbal extracts were considered as phytomedicines because of their bioactive components. In this study, the inhibitory effects of 29 edible herbal extracts against the norovirus surrogates murine norovirus (MNV) and feline calicivirus (FCV) were examined. FCV was significantly inhibited to 86...
November 2, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27667194/effects-of-polysaccharides-isolated-from-inonotus%C3%A2-obliquus-against-hydrogen-peroxide-induced-oxidative-damage-in-rinm5f-pancreatic-%C3%AE-cells
#4
Ye Chan Sim, Jong Seok Lee, Sarah Lee, Youn Kyoung Son, Jung-Eun Park, Jeong Eun Song, Suk-Jin Ha, Eock Kee Hong
The purpose of the present study was to elucidate the cytoprotective effects of polysaccharides isolated from Inonotus obliquus. The polysaccharides were extracted from the fruiting body of I. obliquus (PFIO) and the liquid culture broth of I. obliquus (PLIO). The effects of PFIO and PLIO on hydrogen peroxide (H2O2)‑induced oxidative damage of RINm5F pancreatic β‑cells were comparatively investigated using an MTT assay, immunofluorescent staining, flow cytometry, and western blot analyses in vitro...
September 22, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27666322/polysaccharide-isolated-from-the-liquid-culture-broth-of-inonotus%C3%A2-obliquus-suppresses-invasion-of-b16-f10-melanoma-cells-via-akt-nf-%C3%AE%C2%BAb-signaling-pathway
#5
Ki Rim Lee, Jong Seok Lee, Sarah Lee, Youn Kyoung Son, Ga Ryun Kim, Ye Chan Sim, Jeong Eun Song, Suk-Jin Ha, Eock Kee Hong
A number of polysaccharides exhibit pharmacological activities. Polysaccharides derived from Inonotus obliquus (PLIO) appear to have various potential pharmacological properties, including anti‑tumor activity. However, the molecular mechanisms underlying these properties remain to be elucidated. The present study investigated the anti‑metastatic potential of PLIO and the underlying signaling pathways in B16‑F10 murine melanoma cells using the MTT colorimetric assay, in vitro migration and invasion assays, and flow cytometric and western blot analyses...
September 23, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27649606/cloning-and-characterization-of-a-squalene-synthase-gene-from-the-chaga-medicinal-mushroom-inonotus-obliquus-agaricomycetes
#6
Panpan Zhang, Xiaoying Cao, Changgen Li, Zhujun Zheng, Sun Yong, Ji-Hong Jiang
Squalene synthase catalyzes the condensation of 2 molecules of farnesyl diphosphate to produce squalene, the first committed precursor for sterol, brassinosteroid, and triterpene biosynthesis. A squalene synthase gene, designated IoSQS, was isolated from Inonotus obliquus, a medicinal mushroom that produces a plethora of bioactive triterpenes. IoSQS complementary DNA was found to contain an open reading frame of 1476 bp, encoding a protein of 491 amino acids with a calculated molecular mass of 55.85 kDa. The IoSQS genomic DNA sequence consisted of 1813 bp and contained 4 exons and 3 introns...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27649140/renal-protective-effects-of-low-molecular-weight-of-inonotus-obliquus-polysaccharide-liop-on-hfd-stz-induced-nephropathy-in-mice
#7
Yen-Jung Chou, Wei-Chih Kan, Chieh-Min Chang, Yi-Jen Peng, Hsien-Yi Wang, Wen-Chun Yu, Yu-Hsuan Cheng, Yu-Rou Jhang, Hsia-Wei Liu, Jiunn-Jye Chuu
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease in diabetes mellitus. Oxidative stress, insulin resistance and pro-inflammatory cytokines have been shown to play an important role in pathogeneses of renal damage on type 2 diabetes mellitus (DM). Inonotus obliquus (IO) is a white rot fungus that belongs to the family Hymenochaetaceae; it has been used as an edible mushroom and exhibits many biological activities including anti-tumor, anti-oxidant, anti-inflammatory and anti-hyperglycemic properties...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27562990/-composition-and-biological-activity-of-triterpenes-and-steroids-from-inonotus-obliquus-chaga
#8
REVIEW
S A Nikitina, V R Khabibrakhmanova, M A Sysoeva
Data on the chemical composition of triterpenic and steroid compounds, isolated from the chaga mushroom grown in natural environment or in a synthetic culture have been summarized. Special attention has been paid to the biological activity of chaga mushroom extracts and these particular compounds against various cancer cell lines in vitro and in vivo. This analysis has demonstrated some common features in inhibition of growth of various cell lines by chaga mushroom components. In this context, the most active are triterpene compounds containing OH group at C-22 and a side chain unsaturated bond...
May 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/27441282/continuous-intake-of-the-chaga-mushroom-inonotus-obliquus-aqueous-extract-suppresses-cancer-progression-and-maintains-body-temperature-in-mice
#9
Satoru Arata, Jun Watanabe, Masako Maeda, Masato Yamamoto, Hideto Matsuhashi, Mamiko Mochizuki, Nobuyuki Kagami, Kazuho Honda, Masahiro Inagaki
AIMS: Cancer is a leading cause of morbidity and mortality worldwide; therefore, effective measures for cancer prevention and treatment are in constant demand. The extracts of Inonotus obliquus (Chaga mushroom) demonstrate potent anti-tumor activities and have been used to treat cancer in several countries; however, the actual effect and underlying mechanisms are still unclear. In the present study, we aimed to investigate the effects of continuous intake of aqueous extract from I. obliquus on tumor suppression...
May 2016: Heliyon
https://www.readbyqxmd.com/read/27180084/chemical-constituents-from-inonotus-obliquus-and-their-antitumor-activities
#10
Fenqin Zhao, Guiyang Xia, Lixia Chen, Junli Zhao, Zhanfang Xie, Feng Qiu, Guang Han
Four new lanostane-type triterpenes (inonotusanes D-G, 1-4), including a 24,25,26,27-tetranorlanostane, together with 11 known compounds (5-15), including 7 lanostane derivatives, 2 steroids and 2 aromatic compounds, were isolated from the sclerotia of Inonotus obliquus. Their structures were elucidated by 1D and 2D NMR spectroscopy and HRMS. To our knowledge, 1 is the first 24,25,26,27-tetranorlanostane-type triterpenoid from fungus, and this is the first time that 31-member lanostane-type triterpenes, 5 and 6, have been isolated from the sclerotia of I...
October 2016: Journal of Natural Medicines
https://www.readbyqxmd.com/read/27000840/reversible-s-nitrosylation-limits-over-synthesis-of-fungal-styrylpyrone-upon-nitric-oxide-burst
#11
Yanxia Zhao, Meihong He, Qi Xi, Jianing Ding, Baixia Hao, Nancy P Keller, Weifa Zheng
Nitric oxide (NO) is known to be involved in modulating production of styrylpyrone polyphenols in the basidiomycete Inonotus obliquus. However, it remains unknown how NO orchestrates fungal styrylpyrone biosynthesis. Here, we show that a transient NO burst correlated with an enhanced expression of phenylalanine ammonia lyase (PAL), 4-coumarate CoA ligase (4CL), and styrylpyrone synthase (SPS), the key enzymes involved in styrylpyrone biosynthesis, and subsequently an increased production of styrylpyrone polyphenols...
May 2016: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/26955745/antioxidant-activity-of-inonotus-obliquus-polysaccharide-and-its-amelioration-for-chronic-pancreatitis-in-mice
#12
Yang Hu, Yi Sheng, Min Yu, Koukou Li, Guangming Ren, Xiuhong Xu, Juanjuan Qu
Inonotus obliquus polysaccharide (IOP) was extracted by water with a yield of 9.83% and purified by an anion-exchange DEAE cellulose column and Sephadex G-200 gel with a polysaccharide content of 98.6%. The scavenging activities for 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and hydroxyl radicals of IOP were 82.3% and 81.3% respectively at a concentration of 5 mg/mL. IOP was composed of Man, Rha, Glu, Gal, Xyl and Ara in a molar ratio of 9.81:3.6:29.1:20.5:21.6:5.4 respectively. The gel permeation chromatography indicated that IOP was a homogeneous polysaccharide with molecular weight of 32...
June 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26853962/hepatoprotective-activity-of-water-extracts-from-chaga-medicinal-mushroom-inonotus-obliquus-higher-basidiomycetes-against-tert-butyl-hydroperoxide-induced-oxidative-liver-injury-in-primary-cultured-rat-hepatocytes
#13
Ki Bae Hong, Dong Ouk Noh, Yooheon Park, Hyung Joo Suh
We examined the hepatoprotective activity of Inonotus obliquus water extract (IO-W) against tert-butyl hydroperoxide (t-BHP)-induced oxidative liver injury in the primary cultured rat hepatocyte. The 50% radical scavenging concentrations (SC50s) of IO-W for radical-scavenging activity against 2,2'-azino-bis-(3-ethylbenzothi- azoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picryl-hydrazyl (DPPH) were 5.19 mg/mL and 0.39 mg/mL, respectively. IO-W pretreatment to the primary cultured hepatocytes significantly (p<0...
2015: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/26845476/investigation-of-three-lignin-complexes-with-antioxidant-and-immunological-capacities-from-inonotus-obliquus
#14
Hong Niu, Dan Song, Haibo Mu, Wuxia Zhang, Feifei Sun, Jinyou Duan
Mushroom Inonotus obliquus (I. obliquus), a folk medicine, has been widely used to treat several human malicious tumors since 16th century. In this study, three homogenous biomolecules (designated IOA1, IOA2 and IOA3) were prepared from the alkali extract of I. obliquus. Their molecular weights were measured to be 6.1 × 10(4), 2.9 × 10(4) and 3.5 × 10(4) g/mol respectively and all of them were characterized as lignin-carbohydrate complexes mainly comprised lignin as well as -25% carbohydrates. Antioxidant assays indicated that all of them exhibited pronounced reductive power and strong scavenging activities on DPPH and hydroxyl radicals in vitro...
May 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/26672329/-comparative-analysis-of-different-inonotus-obliquus
#15
COMPARATIVE STUDY
Xiao-fan Guo, Zhong-yun Piao, Shou-ming Wang
OBJECTIVE: To screen optimal Inonotus obliquus strains that is suitable to cultivation, extracting effective components on industrialized production, genetics and breeding. METHODS: Inonotus obliquus mycelia from different countries were used. High quality strain was screened by comparing the antagonism between Inonotus obliquus and penicillium. The contents of crude fat, crude ash, crude protein and crude fiber were analyzed. RESULTS: It was showed that antagonism ability of Finnish birch was the strongest, its mycelia diameter was up to 53...
April 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/26427119/effect-of-inonotus-obliquus-polysaccharides-on-physical-fatigue-in-mice
#16
Zhong Yue, Zhong Xiuhong, Yang Shuyan, Zheng Zhonghua
OBJECTIVE: To evaluate the potential beneficial effects of Inonotus obliquuspolysaccharides (IOP) on the alleviation of physical fatigue in mice. METHODS: Sixty-four male mice were randomly divided into four groups (n = 16 per group). Mice were orally administered IOP for a period of 14 days at 0, 100, 200 and 300 mg/kg/d, and were assigned to the control, IOP-100, IOP-200, and IOP-300 groups, respectively by the random number table method. Mice in the control group received an oral administration of sterile distilled water...
August 2015: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/26243028/ameliorating-effects-of-inonotus-obliquus-on-high-fat-diet-induced-obese-rats
#17
Tao Wu, Qingyu Shu, Kai Yang, Xiaoxian Xie, Xia Wang, Yangling Wang, Anqi Guo, Nate Yuan, Binggong Zhao, Binbin Chi, Qiaobei Wu, Zhengwei Fu
No abstract text is available yet for this article.
September 2015: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/26219502/phenolic-compounds-from-the-fungus-inonotus-obliquus-and-their-antioxidant-properties
#18
Byung Soon Hwang, In-Kyoung Lee, Bong-Sik Yun
No abstract text is available yet for this article.
February 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/26210065/ergosterol-peroxide-from-chaga-mushroom-inonotus-obliquus-exhibits-anti-cancer-activity-by-down-regulation-of-the-%C3%AE-catenin-pathway-in-colorectal-cancer
#19
Ju-Hee Kang, Jeong-Eun Jang, Siddhartha Kumar Mishra, Hee-Ju Lee, Chu Won Nho, Dongyun Shin, Mirim Jin, Mi Kyung Kim, Changsun Choi, Seung Hyun Oh
AIM OF THE STUDY: In this study, we examined the effect of different fractions and components of Chaga mushroom (Inonotus Obliquus) on viability and apoptosis of colon cancer cells. Among them, one component showed the most effective growth inhibition and was identified as ergosterol peroxide by NMR analysis. We investigated the anti-proliferative and apoptosis mechanisms of ergosterol peroxide associated with its anti-cancer activities in human colorectal cancer (CRC) cell lines and tested its anti-tumor effect on colitis-induced CRC developed by Azoxymethane (AOM)/Dextran sulfate sodium (DSS) in a mouse model...
September 15, 2015: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26182655/-antiviral-activity-of-aqueous-extracts-of-the-birch-fungus-inonotus-obliquus-on-the-human-immunodeficiency-virus
#20
V A Shibnev, T M Garaev, M P Finogenova, L B Kalnina, D N Nosik
Fractions of aqueous and water-alcohol extracts of the birch fungus Inonotus obliquus have antiviral effect against the human immunodeficiency virus type 1 (HIV-1). Antiviral properties of low toxic extracts were manifested in the concentration of 5.0 μg/ml upon simultaneous application with the virus in the lymphoblastoid cells culture MT-4. The extract of the birch fungus can be used for development of new antiviral drugs, inhibitors of HIV-replication when used both in the form of individual drugs and as a part of complex therapy...
2015: Voprosy Virusologii
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