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inonotus obliquus

Jiwon Baek, Hyun-Soo Roh, Kwan-Hyuck Baek, Seulah Lee, Seul Lee, Seong-Soo Song, Ki Hyun Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus, also known as Chaga mushroom, is one of the most widely appreciated wild edible mushrooms in Russia and northern European countries and is renowned for its use in cancer treatment. Indeed, recently published in vitro and in vivo studies have demonstrated its anticancer activity in various types of cancer and support its potential application for therapeutic intervention in cancer. However, its activity against lung cancer, the most commonly diagnosed cancer and the leading cause of cancer death worldwide, and the underlying molecular basis of its action remain to be fully elucidated...
May 22, 2018: Journal of Ethnopharmacology
Cong Wang, Xudong Gao, Ramesh Kumar Santhanam, Zhongqin Chen, Yue Chen, Leilei Xu, Chunli Wang, Nicola Ferri, Haixia Chen
In the present study, the antioxidant activity, anti-glycation activity, α-amylase, α-glucosidase inhibitory activity of polysaccharides from Inonotus obliquus (UIOPS) and its chromium (III) complex (UIOPC) were investigated. Their protective effects against H2 O2 -induced oxidative damages in hepatic L02 cells were also assessed. Results demonstrated that UIOPC and UIOPS exhibited remarkable DPPH scavenging activity, ferric reducing power and hemolysis inhibitory activity. UIOPC also showed significant inhibitory capacity on α-amylase and α-glucosidase than UIOPS (P < 0...
April 21, 2018: Food and Chemical Toxicology
Alla V Shnyreva, Anastasia A Shnyreva, Cesar Espinoza, José M Padrón, Ángel Trigos
We analyzed the antiproliferative activity of 6 medicinal wood-destroying mushrooms (Fomes fomentarius, Fomitopsis pinicola, Trametes versicolor, Trichaptum biforme, Inonotus obliquus, and Coniophora puteana) that are common in deciduous and mixed coniferous forests in Central Russia. Morphological identification of strains collected from the wild was confirmed based on ribosomal DNA internal transcribed spacer phylogenetic analysis. We observed cytotoxic and cell growth-inhibitory effects of hot water extracts from mycelial biomass of 5 species-T...
2018: International Journal of Medicinal Mushrooms
Antoine Géry, Christelle Dubreule, Véronique André, Jean-Philippe Rioult, Valérie Bouchart, Natacha Heutte, Philippe Eldin de Pécoulas, Tetyana Krivomaz, David Garon
BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems. In this study, we aimed to quantify the 3 metabolites frequently cited in literature, that is, betulin, betulinic acid, and inotodiol in the Chaga recently discovered in forests located in Normandy (France), and to compare their concentrations with Ukrainian and Canadian Chaga. This study also explores the cytotoxicity of the French Chaga against cancer-derived cells and transformed cells...
February 1, 2018: Integrative Cancer Therapies
Christian Winther Wold, Christian Kjeldsen, Alexandre Corthay, Frode Rise, Bjørn E Christensen, Jens Øllgaard Duus, Kari Tvete Inngjerdingen
The aim of this paper was to perform a comprehensive characterization of polysaccharides isolated from the interior (IOI) and exterior (IOE) parts of the fungus Inonotus obliquus. Pre-extraction with DCM and MeOH, followed by water and alkali extraction and ethanol precipitation gave two water extracts and two alkali extracts. Neutral and acidic polysaccharide fractions were obtained after anion-exchange chromatography of the water extracts. The neutral polysaccharides (60-73 kDa) were heterogeneous and branched and consisted of a (1 → 3)-linked β-Glc backbone with (1 → 6)-linked kinks in the chain at approximately every fifth residue, with branches of (1 → 6)-linked β-Glc in addition to substantial amounts of (1 → 6)-linked α-Gal with 3-O-methylation at about every third Gal residue...
April 1, 2018: Carbohydrate Polymers
Cong Wang, Weiwei Li, Zhongqin Chen, Xudong Gao, Guoqi Yuan, Yuxiang Pan, Haixia Chen
This study was aimed to investigate the impacts of gastrointestinal digestion in vitro on the physicochemical properties and the biological activities of polysaccharides from Inonotus obliquus (UIOPS-1). Results showed that the monosaccharides composition, structure and conformation of polysaccharides were remarkably altered, and the molecular weight (Mw) of UIOPS-1 was steadily decreased from 105.02kDa to 88.97kDa and 36.74kDa after simulated digestion. The reducing ends were increased and the free monosaccharides including d-glucose, d-galactose and d-xylose were released suggested that the degradation of UIOPS-1 was caused by disrupting the aggregates and glycosidic bonds...
January 2018: Food Research International
Xia Zhang, Cuiyu Bao, Jingping Zhang
Breast cancer is amongst the most common cancers causing death of women worldwide. Breast cancer occurrence is more prominent in people with diabetes. A recent trend is management of diabetes and cancer has evolved to be natural remedy including single molecule therapy or combination. In this study, we investigated the effect of inotodiol on breast cancer growth in diabetic conditions. Inotodiol is a lanostane triterpenoid found in natural resources like edible mushroom Inonotus obliquus. We established a rat model of diabetic-breast cancer by treating female Sprague-Dawley rats with streptazotocin (STZ) at 35 mg/kg followed by induction of breast cancer by administration of 7,12-dimethylbenz(a)anthracene (DMBA) at 10 mg/kg...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Aaron Smith, Sumreen Javed, Ankush Barad, Vicky Myhre, Wai Ming Li, Kerry Reimer, Hugues B Massicotte, Linda E Tackaberry, Geoffrey W Payne, Keith N Egger, Chow H Lee
Wild mushrooms, especially from North America, have not been systematically explored for their medicinal properties. Here we report screening for the growth-inhibitory and immunomodulatory activities of 12 species collected from multiple locations in north-central British Columbia, Canada. Mushrooms were characterized using morphology and DNA sequencing, followed by chemical extraction into 4 fractions using 80% ethanol, 50% methanol, water, and 5% sodium hydroxide. Growth-inhibitory, immunostimulatory, and anti-inflammatory activities of 5 mushrooms (Leucocybe connata, Trichaptum abietinum, Hydnellum sp...
2017: International Journal of Medicinal Mushrooms
Thi Minh Nguyen Nguyet, Maria Lomunova, Ba Vinh Le, Ji Sun Lee, Seol Kyu Park, Jong Seong Kang, Young Ho Kim, Inkyu Hwang
While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known. We examined the effect of 70% ethanol extract of Chaga mushroom (EE) and its dichloromethane (DF) and aqueous (AF) fractions using a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and found that only EE and DF ameliorated allergy symptoms to a significant extent. The in vivo mast cell-stabilizing activity was also found only in EE and DF whereas the activities to suppress Th2 and Th17 immune responses and cOVA-specific IgE production in the small intestine were observed in all three treatment regimens, implying that inhibition of the mast cell function by lipophilic compounds was vital for the therapeutic effect...
January 2018: International Immunopharmacology
Cheng-Chih Tsai, Yu-Sheng Li, Pei-Pei Lin
Because of irregular dietary habits and lifestyle in Taiwan, the incidence and mortality rate of colorectal cancer have been increasing rapidly these years. This study investigated the inhibitory activity against the proliferation of human colorectal cancer HCT-116 cells by Inonotus obliquus extracts obtained from submerged fermentation. Cell viability was measured by the reduction of MTT and cell membrane integrity was determined by lactic dehydrogenase (LDH) release. The mRNA expression of proapoptosis and antiapoptosis mediators was assayed by real-time PCR, and the levels of p53 and NF-κB p65 were assessed using Western blot analysis...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Jia Wang, Cong Wang, Shuqin Li, Weiwei Li, Guoqi Yuan, Yuxiang Pan, Haixia Chen
Polysaccharides are the main components of mushroom Inonotus obliquus (I. obliquus) with antihyperglycemic activities. This study was aimed to investigate the anti-diabetic effects and the potential mechanism of I. obliquus polysaccharides (IOPS) in high fat diet and STZ-induced type 2 diabetic mice. Results showed that oral administration of IOPS (900mg/kg) could significantly restore the body and fat mass weight, reduce fasting blood glucose levels, improve glucose tolerance ability, increase hepatic glycogen level and ameliorate insulin resistance compared to those of the control diabetic mice (P<0...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xiangqun Xu, Mengmeng Lin, Qiang Zang, Song Shi
White rot fungi have been usually considered for lignin degradation and ligninolytic enzyme production. To understand whether the white rot fungus Inonotus obliquus was able to produce highly efficient cellulase system, the production of cellulolytic enzyme cocktails was optimized under solid state fermentation. The activities of CMCase, FPase, and β-glucosidase reached their maximum of 27.15IU/g, 3.16IU/g and 2.53IU/g using wheat bran at 40% (v/w) inoculum level, initial pH of 6.0 and substrate-moisture ratio of 1:2...
September 1, 2017: Bioresource Technology
Juan Wang, Wenji Hu, Lanzhou Li, Xinping Huang, Yange Liu, Di Wang, Lirong Teng
This study evaluated the effects of Inonotus obliquus polysaccharides (IOs) on diabetes and other underlying mechanisms related to inflammatory factors and oxidative stress in a mouse model of streptozotocin (STZ)-induced diabetes. Four weeks administration of metformin (120 mg/kg) and IO1-4 (50%-80% alcohol precipitation), or IO5 (total 80% alcohol precipitation) at doses of 50 mg/kg reverses the abnormal changes of bodyweights and fasting blood glucose levels of diabetic mice. IOs significantly increased the insulin and pyruvate kinase levels in serum, and improved the synthesis of glycogen, especially for IO5...
2017: PloS One
Xiangqun Xu, Zhiqi Xu, Song Shi, Mengmeng Lin
This study examined the white rot fungus I. obliquus on the degradation of three types of straw biomass and the production of extracellular lignocellulolytic enzymes under submerged fermentation. The fungus process resulted in a highest lignin loss of 72%, 39%, and 47% in wheat straw, rice straw, and corn stover within 12days, respectively. In merely two days, the fungus selectively degraded wheat straw lignin by 37%, with only limited cellulose degradation (13%). Fourier transform infrared spectroscopy revealed that the fungus most effectively degraded the wheat straw lignin and rice straw crystalline cellulose...
October 2017: Bioresource Technology
Yang Hee Hong
BACKGROUND: This study was designed to investigate the effect of a herbal mixture extract (DTS20) on the attenuation of oxidative stress and hangover after alcohol consumption in healthy volunteers. METHODS: DTS20 consists of Viscum album L. (40%), Lycium chinense L. (30%), Inonotus obliquus (20%), and Acanthopanax senticosus H. (10%). We recruited healthy, nonsmoking, adult men volunteers aged between 21 years and 30 years to participate in a crossover trial. Twenty participants received either one package of placebo with 200 mL water or DTS20 with 200 mL water...
December 2016: Integrative Medicine Research
Yang Hu, Chunying Teng, Sumei Yu, Xin Wang, Jinsong Liang, Xin Bai, Liying Dong, Tao Song, Min Yu, Juanjuan Qu
Polysaccharide is efficient in attenuation of metabolic ailments and modulation of gut microbiota as prebiotics. The therapeutic effect of Inonotus obliquus polysaccharide (IOP) on chronic pancreatitis (CP) in mice has been validated in our previous study. However, it is not clear whether IOP is conducive to maintaining the homeostasis between gut microbiota and host. The aim of this study is to testify the potential effects of IOP on gut microbiota composition and diversity in mice with CP. The changes in glutathione peroxidase (GSH-PX), total antioxidant capacity (TAOC), tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), lipase and trypsin levels were measured by commercial assay kits, meanwhile the gut microbiota composition and diversity were analyzed by high throughput sequencing...
December 2017: AMB Express
Cong Wang, Zhongqin Chen, Yuxiang Pan, Xudong Gao, Haixia Chen
Polysaccharides are important bioactive ingredients from Inonotus obliquus. This study aimed to synthesize and characterize a novel I. obliquus polysaccharides-chromium (III) complex (UIOPC) and investigate the anti-diabetic effects in streptozotocin (STZ) induced type 2 diabetes mellitus (T2DM) mice and sub-acute toxicity in normal mice. The molecular weight of UIOPC was about 11.5 × 10 4  Da with the chromium content was 13.01% and the chromium was linked with polysaccharides through coordination bond...
October 2017: Food and Chemical Toxicology
Yanxia Zhao, Meihong He, Jianing Ding, Qi Xi, Gary J Loake, Weifa Zheng
The medicinal macrofungus Inonotus obliquus widely utilized as folk medicine in Russia and Baltic countries is a source of phenylpropanoid-derived styrylpyrone polyphenols that can inhibit tumor proliferation. Insights into the regulatory machinery that controls I. obliquus styrylpyrone polyphenol biosynthesis will enable strategies to increase the production of these molecules. Here we show that Thioredoxin (Trx) mediated transnitrosylation of S-nitrosoglutathione reductase (GSNOR) underpins the regulation of styrylpyrone production, driven by nitric oxide (NO) synthesis triggered by P...
November 21, 2016: Scientific Reports
Jin Tian, Xiaoliang Hu, Dafei Liu, Hongxia Wu, Liandong Qu
Inonotus obliquus polysaccharides (IOPs) are a potential drug for the prevention and treatment of cancer, cardiopathy, diabetes, AIDs, pancreatitis and other diseases. In this study, we found that IOP can act as a broad-spectrum antiviral drug against feline viruses in the in vitro experiment. Using cell models of feline calicivirus (FCV), we demonstrated that IOP treatment was capable of exhibiting anti-FCV strain F9 activity in cell-based assays and also showed low cytotoxicity. Investigation of the mechanism of action of the compound revealed that IOP treatment induces its inhibitory actions directly on virus particles through blocking viral binding/absorpting...
February 2017: International Journal of Biological Macromolecules
Dong Joo Seo, Changsun Choi
Human noroviruses (HuNoVs) cause foodborne and waterborne viral gastroenteritis worldwide. Because HuNoV culture systems have not been developed thus far, no available medicines or vaccines preventing infection with HuNoVs exist. Some herbal extracts were considered as phytomedicines because of their bioactive components. In this study, the inhibitory effects of 29 edible herbal extracts against the norovirus surrogates murine norovirus (MNV) and feline calicivirus (FCV) were examined. FCV was significantly inhibited to 86...
March 2017: Food and Environmental Virology
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