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Head and neck melanoma

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https://www.readbyqxmd.com/read/29661336/cutaneous-head-and-neck-malignancies-in-the-elderly
#1
REVIEW
Brian B Hughley, Cecelia E Schmalbach
Cutaneous malignancy of the head and neck affects a large proportion of elderly patients. The severity ranges from small, easily treatable lesions to large, invasive, potentially metastatic tumors. Surgical treatment is the primary treatment of most skin cancers; however, geriatric patients are more likely to have multiple comorbidities that increase the risk of surgery. Multiple treatment modalities exist, including surgical, radiation, and medical therapy. Recommendations and treatment options for basal cell carcinoma, squamous cell carcinoma, Merkel cell carcinoma, and melanoma are outlined and reviewed...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29644155/stereotactic-body-radiation-therapy-for-pulmonary-oligometastases-arising-from-non-lung-primaries-in-patients-without-extrapulmonary-disease
#2
Michael J Dohopolski, Zachary Horne, David Clump, Steven A Burton, Dwight E Heron
Purpose Stereotactic body radiation therapy (SBRT) is increasingly used in the management of patients with oligometastatic cancers and is under prospective evaluation by the Radiation Therapy Oncology Group (RTOG). Here we report outcomes from a high-volume institution of patients treated with SBRT for pulmonary oligometastases. Materials and methods We conducted a retrospective review of 105 patients who had one to five pulmonary oligometastases (185 lesions) without extrapulmonary disease treated with SBRT from 2002-2014...
February 7, 2018: Curēus
https://www.readbyqxmd.com/read/29626308/patterns-of-treatment-failure-in-patients-with-sinonasal-mucosal-melanoma
#3
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
BACKGROUND: Head and neck mucosal melanoma is a locally aggressive tumor with a high recurrence rate. The paranasal sinuses and nasal cavity are the most common primary tumor sites. OBJECTIVE: The purpose of this retrospective study was to identify independent predictors of outcome in sinonasal mucosal melanoma (SNMM) and characterize the patterns of treatment failure. METHODS: This study included 198 patients with SNMM who had been treated at The University of Texas MD Anderson Cancer Center from 1 January 1991 through 31 December 2016...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29594078/malignant-melanoma-of-the-external-auditory-canal-a-rare-entity
#4
Yookarin Khonglah, Nabanita Das, Vandana Raphael, Ankit-Kumar Jitani, N Brian Shunyu
Introduction: Although malignant melanomas (MM) are common in the head and neck region; primary malignant melanoma of the external auditory canal (EAC) is rare. Case Report: We present the case of a 50-year-old symptomatic man with a malignant melanoma of the external auditory canal, which clinically masqueraded as a haemangioma. The patient subsequently developed extensive loco-regional metastasis, requiring extensive surgery. We describe the clinical presentation, differential diagnosis, both clinical and pathological in terms of other pigmented lesions in the external auditory canal, detailed histopathology, and literature review...
March 2018: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29577784/updated-standard-operating-procedures-for-electrochemotherapy-of-cutaneous-tumours-and-skin-metastases
#5
Julie Gehl, Gregor Sersa, Louise Wichmann Matthiessen, Tobian Muir, Declan Soden, Antonio Occhini, Pietro Quaglino, Pietro Curatolo, Luca G Campana, Christian Kunte, A James P Clover, Giulia Bertino, Victor Farricha, Joy Odili, Karin Dahlstrom, Marco Benazzo, Lluis M Mir
Electrochemotherapy is now in routine clinical use to treat cutaneous metastases of any histology, and is listed in national and international guidelines for cutaneous metastases and primary skin cancer. Electrochemotherapy is used by dermatologists, surgeons, and oncologists, and for different degrees and manifestations of metastases to skin and primary skin tumours not amenable to surgery. This treatment utilises electric pulses to permeabilize cell membranes in tumours, thus allowing a dramatic increase of the cytotoxicity of anti-cancer agents...
March 25, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29575799/sentinel-lymph-node-biopsy-in-33-non-melanoma-skin-cancers-of-the-head-and-neck-a-twelve-year-experience-with-long-term-follow-up
#6
J P Foy, F Kolb, E Routier, A Cavalcanti, J Lumbroso, G Tomasic, C Mateus, S Temam, C Robert, A Moya-Plana
Non-melanoma skin cancer (NMSC), the most common malignancy worldwide, includes Merkel cell carcinoma (MCC) and cutaneous squamous cell carcinoma (CSCC). Although CSCC are often associated with favorable outcomes, one to ten percent of cases develop regional metastatic disease, lowering significantly the survival rate. In contrast, MCC is aggressive with high rate of loco-regional disease (around 50%), resulting in a poor prognosis. This article is protected by copyright. All rights reserved.
March 24, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29574334/immuno-oncology-in-head-and-neck-squamous-cell-cancers-news-from-clinical-trials-emerging-predictive-factors-and-unmet-needs
#7
REVIEW
Stefano Cavalieri, Licia Rivoltini, Cristiana Bergamini, Laura D Locati, Lisa Licitra, Paolo Bossi
According to the new determinants of cancer immunity, head and neck squamous cell cancer (HNSCC) has to be considered as an immunogenic tumor for the relatively high number of somatic mutations giving rise to neoantigens recognized by T cell. HNSCC develop at a significant rate despite the antitumoral immune response indicating the existence of effective escape mechanisms. The lack of antigen presentation or co-stimulatory molecules required and immunosuppressive phenomena established by the tumor or the host microenvironment impair immune-mediated recognition and cancer control...
March 20, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29573292/in-vivo-reflectance-confocal-microscopy-combined-with-the-spaghetti-technique-for-the-identification-of-surgical-margins-of-lentigo-maligna-experience-in-70-patients
#8
Emmanuelle Couty, Linda Tognetti, Bruno Labeille, Catherine Douchet, Cyril Habougit, Caroline Couzan, Anne Catherine Biron-Schneider, Frédéric Cambazard, Virginie Prade, Pietro Rubegni, Elisa Cinotti, J L Perrot
Lentigo maligna (LM) and lentigo maligna melanoma (LMM) account for 10% of all melanomas and are mainly located on head and neck areas.1-4 Complete surgical excision is the recommended treatment. However, this treatment is often challenging because of LM/LMM location in the face and the difficulty in the identification of its surgical margins1-5 . Local recurrence of LM/LMM still represents a major concern with recurrence rates after conventional surgical excision of 8 to 20% of cases, up to 47% in absence of Mohs micrographic surgery (MMS)...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29570169/telomerase-reverse-transcriptase-promoter-mutations-and-solar-elastosis-in-cutaneous-melanoma
#9
Johanne Lade-Keller, Sakineh Yuusufi, Rikke Riber-Hansen, Torben Steiniche, Magnus Stougaard
The aims of this study were to assess the prognostic potential of solar elastosis grading and telomerase reverse transcriptase (TERT) promoter mutations (TERTp) in melanoma and to evaluate whether an association between solar elastosis and TERTp exists. Solar elastosis in the dermis was evaluated in hematoxylin and eosin-stained whole slides from 486 malignant melanomas. Pyrosequencing was used to detect TERTp in 189 samples. There was no association between solar elastosis and TERTp (P=0.3). Severe elastosis was associated with older age (P<0...
March 21, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29569184/mucosal-melanoma-a-literature-review
#10
REVIEW
Simon Skovsted Yde, Pia Sjoegren, Martin Heje, Lars B Stolle
PURPOSE OF REVIEW: Mucosal melanoma is of great interest due to its aggressive behavior and less favorable prognosis. The literature is mainly case reports and case series. Here, we will collect the knowledge on mucosal melanoma from the last decade and review the literature. The main focus is being site-specific clinical features, treatment, and prognosis. RECENT FINDINGS: The use of immunotherapy gain ground as for others subsets of melanoma. Anti-CTLA-4 and anti-PD-1/ PD-L1 blockade in mucosal melanoma have been evaluated in recent studies...
March 23, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29567894/merkel-cell-carcinoma-with-seborrheic-keratosis-a-unique-association
#11
Murthy S Anand, Shantha Krishnamurthy, Suvarna Ravindranath, Jyothi Ranganathan
Merkel cell carcinoma (MCC) is a rare, clinically aggressive neuroendocrine carcinoma of the skin; MCC is 40 times less common as compared to melanoma. The most frequently reported sites have been the head and neck, extremities, and trunk. Potential mimics include malignant melanoma, lymphoma, or metastatic small cell (neuroendocrine) carcinomas. Histopathology of MCC resembles small cell carcinoma both morphologically and on IHC. The possible cell of origin was proposed as the Merkel cell, which functions as a mechanoreceptor...
January 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29566444/clinical-significance-of-tumor-mitotic-rate-and-lack-of-epidermal-attachment-in-melanoma-of-the-head-and-neck
#12
Eric E Babajanian, Akina Tamaki, Jeremy S Bordeaux, Kord Honda, Chad A Zender
BACKGROUND: The primary purpose of this study was to identify the prognostic role of primary dermal melanoma and tumor mitotic rate in melanomas of the head and neck. METHODS: A retrospective review of the histopathologic, clinical, and demographic data of 256 patients was performed to investigate the impact of primary dermal melanoma and tumor mitotic rate on sentinel lymph node positivity, recurrence, and 5-year overall and disease-free survival. RESULTS: Increased tumor mitotic rate, but not primary dermal melanoma, is a significant predictor of sentinel lymph node positivity and higher likelihood of recurrence...
March 22, 2018: Head & Neck
https://www.readbyqxmd.com/read/29558358/-gout-or-squamous-cell-cancer-of-the-ear-in-a-91-year-old-man-diagnostic-and-therapeutic-problems-a-case-report
#13
Andrzej N Majda, Aleksandra Majdan, Paweł Piłat, Paweł Cisek
Gout tophi around auricular area are common in old men. The differential diagnosis of papules or nodules on the ear includes tophaceous gout, rheumatoid nodules, basal or squamous cell cancer, melanoma, verruca vulgaris or actinic keratosis. The presence of the skin cancer, most commonly located on the head and neck, is often related to the long exposure of the skin to sunlight. Elderly patients are the predominant group of patients with skin malignancies. The aim of this study is to emphasize the importance of early cancer detection in elderly people and use of appropriate therapeutic options that take into account the special requirements of geriatric patients...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29556384/mage-a9-in-head-and-neck-cancer-prognostic-value-and-preclinical-findings-in-the-context-of-irradiation
#14
Till J Meyer, Stefan Hartmann, Gisela Wohlleben, Muna Brisam, Axel Seher, Alexander C Kübler, Bülent Polat, Urs D A Müller-Richter
Radiotherapy alone, or as an addition to surgery is important for the treatment of head and neck squamous cell carcinoma (HNSCC). In addition to their expression in germ cells, melanoma associated antigens-A (MAGE-A) are only expressed in malignant tissue. Notably, there is a known correlation between MAGE-A9 expression and poor prognosis in HNSCC patients. However, current knowledge regarding the function of MAGE-A9 expression, particularly in the context of irradiation, is limited. MAGE-A9 expression in 37 oral squamous cell carcinoma patents was immunohistochemically determined and analyzed for overall survival by the Kaplan-Meier log-rank test...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29552728/sentinel-lymph-node-biopsy-in-cutaneous-head-and-neck-melanoma
#15
D Evrard, E Routier, C Mateus, G Tomasic, J Lombroso, F Kolb, C Robert, A Moya-Plana
PURPOSE: Sentinel lymph node biopsy (SLNB) is now a standard of care for cutaneous melanoma, but it is still controversial for cutaneous head and neck melanoma (CHNM). This study aims to confirm the feasibility, accuracy and low morbidity of SLNB in CHNM and evaluate its prognostic value. METHODS: A monocentric and retrospective study on patients with CHNM treated in our tertiary care center (Gustave Roussy) between January 2008 and December 2012 was performed. The feasibility, morbidity and prognostic value of this technique were analysed...
March 19, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29549903/metastases-to-the-parotid-gland-a-review-of-the-clinicopathological-evolution-molecular-mechanisms-and-management
#16
REVIEW
James Badlani, Ruta Gupta, Joel Smith, Bruce Ashford, Sydney Ch'ng, Michael Veness, Jonathan Clark
Metastases to the parotid gland are the commonest cause of parotid malignancies in many regions of the world including Australia. The most common etiology of these metastases is head and neck cutaneous squamous cell carcinoma (HNcSCC) followed by melanoma of the head and neck. This article focuses on the management of the aforementioned pathologies including Merkel cell carcinoma (MCC).
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29543619/treatment-for-lentigo-maligna-of-the-head-and-neck-survey-of-practices-in-ontario-canada
#17
Annie Liu, Alexis Botkin, Christian Murray, David Goldstein, Stefan O P Hofer, Nowell Solish, Jessica Kitchen, An-Wen Chan
BACKGROUND: Lentigo maligna is an in situ form of cutaneous melanoma that commonly arises on the head and neck. Various surgical and nonsurgical treatment options are available but no randomized trials exist to guide practice. OBJECTIVE: To determine the current treatment practices for lentigo maligna of the head and neck in Ontario, Canada. MATERIALS AND METHODS: Cross-sectional survey of dermatologists, plastic surgeons, and head and neck surgeons...
March 13, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29535425/second-malignancies-in-patients-with-myeloproliferative-neoplasms-a-population-based-cohort-study-of-9379-patients
#18
Anna Ravn Landtblom, Hannah Bower, Therese M-L Andersson, Paul W Dickman, Jan Samuelsson, Magnus Björkholm, Sigurdur Yngvi Kristinsson, Malin Hultcrantz
To determine the risk of a wide range of second malignancies in patients with myeloproliferative neoplasms (MPNs), we conducted a large population-based study and compared the results to matched controls. From national Swedish registers, 9379 patients with MPNs diagnosed between 1973 and 2009, and 35,682 matched controls were identified as well as information on second malignancies, with follow-up until 2010. Hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated using Cox regression and a flexible parametric model...
January 30, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/29528717/malignant-mesothelioma-in-individuals-with-nonmesothelial-neoplasms
#19
Kelly J Butnor, Elizabeth N Pavlisko, Thomas A Sporn, Victor L Roggli
CONTEXT: - Malignant mesothelioma (MM) is a component of the BAP1 tumor predisposition syndrome. Other than in BAP1 familial studies, nonmesothelial neoplasms in individuals with MM has not been comprehensively assessed. OBJECTIVE: - To assess the spectrum and prevalence of nonmesothelial neoplasms in individuals with MM. DESIGN: - Individuals with MM and second neoplasms were identified from a database of 3900 MM cases. The expected prevalence of each type of neoplasm was calculated and compared with the actual prevalence in the study population using available Surveillance, Epidemiology, and End Results data and other published data...
March 12, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29524319/efficacy-of-hypofractionated-radiotherapy-in-patients-with-non-melanoma-skin-cancer-results-of-a-systematic-review
#20
REVIEW
Dakshika A Gunaratne, Michael J Veness
Radiation oncologists are increasingly tasked with the management of elderly patients with non-melanoma skin cancer, unsuitable for surgical intervention due to inoperable lesions and/or poor performance status. In this cohort, hypofractionated radiotherapy, delivered either daily, alternative daily or once weekly is highly effective. A systematic literature search was conducted of PUBMED, MEDLINE and EMBASE databases using the algorithm ('radiotherapy' OR 'radiation therapy' OR 'brachytherapy') AND ('hypofraction' OR 'hypofractionated' OR 'hypofractionation') AND ('skin neoplasms' OR 'carcinoma' OR 'malignancy') AND ('skin' OR 'epidermis' OR 'epidermal' OR 'cutaneous')...
March 9, 2018: Journal of Medical Imaging and Radiation Oncology
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