D Rendina, A Falchetti, D Diacinti, F Bertoldo, D Merlotti, S Giannini, L Cianferotti, G Girasole, M Di Monaco, S Gonnelli, N Malavolta, S Minisola, F Vescini, M Rossini, B Frediani, I Chiodini, F Asciutti, L Gennari
INTRODUCTION: Paget's disease of bone is a focal skeletal disorder causing bone deformities and impairing bone quality. Despite the prevalence of asymptomatic cases is increasing, the progression of the disease can lead to invalidating complications that compromise the quality of life. Doubts on clinical and therapeutic management aspects exist, although beneficial effects of antiresorptive drugs, particularly bisphosphonates are known. However, limited information is available from randomized controlled trials on the prevention of disease complications so that somewhat contrasting positions about treatment indications between expert panels from the main scientific societies of metabolic bone diseases exist...
March 15, 2024: Journal of Endocrinological Investigation