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https://www.readbyqxmd.com/read/29457432/-micro-ct-evaluating-inhibitory-effect-of-zoledronic-acid-on-polyethylene-particle-induced-periprosthetic-osteolysis-model
#1
Lian-Guo Wu, Feng-Qing Wu, Hua Chen
OBJECTIVE: To observe inhibitory effect of zoledronic acid on polyethylene particle-induced periprosthetic osteolysis model. METHODS: Thirty male adult specific-pathogen-free SD rats (weighted 250 to 300 g) were randomly divided into sham group, model group, and zoledronic acid group, 10 in each group. Modeling were building by titanium screws and polyethylene particles implanted into right femur of rats, sham group and model group were performed hypodermic injection by 0...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29454808/a-new-multifunctionalized-material-against-multi-drug-resistant-bacteria-and-abnormal-osteoclast-activity
#2
Elisa Boanini, Paola Torricelli, Francesca Bonvicini, Maria Cristina Cassani, Milena Fini, Giovanna Angela Gentilomi, Adriana Bigi
The development of new biomaterials able to favor bone formation and to inhibit bone abnormal resorption is mandatory to face the increasing number of age-related musculo-skeletal disorders. Moreover, the increasing antibiotic resistance of clinically important bacteria, which is among the main causes of implant failure, requires new antimicrobial systems. In this study, we prepared multifunctional materials consisting of hydroxyapatite-zoledronate composite crystals decorated with Ag Nanoparticles (AgNPs)...
February 15, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29454616/zoledronate-modulates-intracellular-vesicle-trafficking-in-mast-cells-via-disturbing-the-interaction-of-myosinva-rab3a-and-sytaxin4-vamp7
#3
Shuang Liu, Muhammad N A Sahid, Erika Takemasa, Kazutaka Maeyama, Masaki Mogi
Nitrogen-containing bisphosphonates (NBPs) have been widely used as bone anti-resorptive drugs for the treatment of osteoclast-dependent bone disorders. Zoledronate is currently the most potent NBP, and has potential as an inhibitor of farnesyl pyrophosphate synthase. The present study was undertaken to elucidate the possible effects of zoledronate on FcεRI-dependent mast cell activity in vitro, which is essential for in maintaining homeostasis of the gastrointestinal mucosa. Treatment with zoledronate significantly diminished exocytosis of mast cells, which was reflected by a decrease of FcεRI-dependent histamine release compared to that in vehicle-treated mast cells...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29454604/cytotoxic-and-inflammatory-effects-of-alendronate-and-zolendronate-on-human-osteoblasts-gingival-fibroblasts-and-osteosarcoma-cells
#4
Yahya Açil, Mia Leena Arndt, Aydin Gülses, Henning Wieker, Hendrik Naujokat, Mustafa Ayna, Jörg Wiltfang
OBJECTIVE: The aim of this paper was to assess the effects of zoledronate (ZOL) and alendronate (FOS) on apoptotic behavior and gene expression of pro- and inflammatory cytokines of three cell types (human osteoblasts, human gingival fibroblasts and human osteogenic sarcoma cell lines) during a period of 4 weeks. MATERIAL AND METHODS: Cell viability and proliferation was assessed via cell proliferation test (MTT), fluorescence diacetate analysis (FDA). Expression of inflammatory cytokines was investigated by using polymerase chain reaction...
January 10, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29453497/bone-mineralization-and-vascularization-in-bisphosphonate-related-osteonecrosis-of-the-jaw-an-experimental-study-in-the-rat
#5
Jean-Daniel Kün-Darbois, Hélène Libouban, Guillaume Mabilleau, Florence Pascaretti-Grizon, Daniel Chappard
OBJECTIVES: Pathogenesis of bisphosphonate-related osteonecrosis of the jaws (BRONJ) is not fully explained. An antiangiogenic effect of bisphosphonates (BPs) or an altered bone quality have been advocated. The aims of the present study were to analyze alveolar mandibular vascularization and bone quality in rats with BRONJ. MATERIALS AND METHODS: Thirty-eight Sprague-Dawley rats were randomized into two groups: zoledronic acid (ZA), n = 27, and control (CTRL) n = 11...
February 16, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29445836/bone-loss-after-romosozumab-denosumab-effects-of-bisphosphonates
#6
Anne M Horne, Borislav Mihov, Ian R Reid
Romosozumab and denosumab are monoclonal antibodies for the treatment of osteoporosis. Both have a rapid offset of effect resulting in loss of bone density (BMD) gained on-treatment and, in some cases, multiple vertebral fractures following treatment cessation. We recently reported disappointing results from transitioning patients from denosumab to intravenous zoledronate at the time the next denosumab injection is due. The present report re-assesses the role of bisphosphonates following the use of denosumab...
February 14, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29429912/denosumab-versus-zoledronic-acid-in-bone-disease-treatment-of-newly-diagnosed-multiple-myeloma-an-international-double-blind-double-dummy-randomised-controlled-phase-3-study
#7
Noopur Raje, Evangelos Terpos, Wolfgang Willenbacher, Kazuyuki Shimizu, Ramón García-Sanz, Brian Durie, Wojciech Legieć, Marta Krejčí, Kamel Laribi, Li Zhu, Paul Cheng, Douglas Warner, G David Roodman
BACKGROUND: Multiple myeloma is characterised by monoclonal paraprotein production and osteolytic lesions, commonly leading to skeletal-related events (spinal cord compression, pathological fracture, or surgery or radiotherapy to affected bone). Denosumab, a monoclonal antibody targeting RANKL, reduces skeletal-related events associated with bone lesions or metastases in patients with advanced solid tumours. This study aimed to assess the efficacy and safety of denosumab compared with zoledronic acid for the prevention of skeletal-related events in patients with newly diagnosed multiple myeloma...
February 8, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29425304/associations-between-serum-bone-biomarkers-in-early-breast-cancer-and-development-of-bone-metastasis-results-from-the-azure-big01-04-trial
#8
Janet Brown, Emma Rathbone, Samantha Hinsley, Walter Gregory, Fatma Gossiel, Helen Marshall, Roger Burkinshaw, Helen Shulver, Hasina Thandar, Gianfilippo Bertelli, Keane Maccon, Angela Bowman, Andrew Hanby, Richard Bell, David Cameron, Robert Coleman
Background: Adjuvant therapies can prevent/delay bone metastasis development in breast cancer. We investigated whether serum bone turnover markers in early disease have clinical utility in identifying patients with a high risk of developing bone metastasis. Methods: Markers of bone formation (N-terminal propeptide of type-1 collagen [P1NP]) and bone resorption (C-telopeptide of type-1 collagen [CTX], pyridinoline cross-linked carboxy-terminal telopeptide of type-1 collagen [1-CTP]) were measured in baseline (pretreatment blood samples from 872 patients from a large randomized trial of adjuvant zoledronic acid (AZURE-ISRCTN79831382) in early breast cancer...
February 7, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29423715/modeling-and-simulation-of-bone-mineral-density-in-japanese-osteoporosis-patients-treated-with-zoledronic-acid-using-tartrate-resistant-acid-phosphatase-5b-a-bone-resorption-marker
#9
Y Mori, H Kasai, A Ose, M Serada, M Ishiguro, M Shiraki, Y Tanigawara
Annual intravenous administration of zoledronic acid is used in the treatment of osteoporosis. A mathematical model was developed to predict bone mineral density up to 2 years after two annual doses of zoledronic acid from the early values of a bone resorption marker in osteoporosis patients. INTRODUCTION: The measurement of bone mineral density (BMD) has been used as a surrogate marker instead of the observation of incident fractures to detect the efficacy of treatment. However, this method requires a long time to obtain significant changes...
February 8, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29416816/comprehensive-immunotherapy-combined-with-intratumoral-injection-of-zoledronate-pulsed-dendritic-cells-intravenous-adoptive-activated-t-lymphocyte-and-gemcitabine-in-unresectable-locally-advanced-pancreatic-carcinoma-a-phase-i-ii-trial
#10
Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Takashi Kamigaki, Shigenori Goto, Masashi Takahara, Hidemi Goto
Dendritic cell (DC)-based vaccines prepared using various antigen loading methods have been studied for cancer immunotherapy. The in vivo provocation of immunity by the direct injection of DCs without using tumor-specific antigens into tumors after apoptosis-inducing chemotherapy is more applicable. We previously reported that zoledronate-pulsed DCs (Zol-DCs) may induce tumor-antigen-specific CD8+ T cells by activating Vγ9γδT cells. In this report, we studied the feasibility, safety, and efficacy of a comprehensive immunotherapy involving the combined intratumoral injection of Zol-DC, gemcitabine (GEM) and αβT cells in locally advanced pancreatic carcinoma...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416169/effect-of-intravenous-zoledronic-acid-on-histopathology-and-recurrence-after-extended-curettage-in-giant-cell-tumors-of-bone-a-comparative-prospective-study
#11
Zile Singh Kundu, Rajeev Sen, Ankur Dhiman, Pankaj Sharma, Ramchander Siwach, Parveen Rana
Background: Giant cell tumor (GCT) of the bone is known for its locally aggressive behavior and tendency to recur. It is an admixture of rounded or spindle-shaped mononuclear neoplastic stromal cells and multinucleated osteoclast-like giant cells with their proportionate dispersion among the former. Zoledronic acid (a bisphosphonate) is being used in various cancers such as myelomas and metastasis, for osteoporosis with an aim to reduce the resorption of bone, and as an adjuvant treatment for the management of GCT of bone for reduction of local recurrence...
January 2018: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29412504/preventive-dental-management-of-osteonecrosis-of-the-jaws-related-to-zoledronic-acid-treatment
#12
J A Coello-Suanzes, V Rollon-Ugalde, A Castaño-Seiquer, E Lledo-Villar, J Herce-Lopez, P Infante-Cossio, A Rollon-Mayordomo
OBJECTIVE: To evaluate the effect of preventive dental management on reducing the incidence and delaying the onset of bisphosphonate-related osteonecrosis of the jaw (BRONJ) in patients treated with intravenous zoledronic acid (ZA). MATERIAL AND METHODS: This single-center clinical study included 255 cancer patients monitored over a 6-year period. Patients received dental treatment prior (Group A) or after (Group B) the initiation of ZA therapy. Dental treatments performed, incidence proportion (IP) and incidence rate (IR) in both groups were analyzed using significance tests...
February 7, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29411304/efficacy-of-anti-osteoporotic-medications-in-patients-with-type-1-and-2-diabetes-mellitus-a-systematic-review
#13
REVIEW
Panagiotis Anagnostis, Stavroula A Paschou, Nifon N Gkekas, Aikaterini-Maria Artzouchaltzi, Konstantinos Christou, Dimitrios Stogiannou, Andromachi Vryonidou, Michael Potoupnis, Dimitrios G Goulis
PURPOSE: Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with bone fragility and increased fracture risk. However, little is known regarding the effect of anti-osteoporotic treatment on bone mineral density (BMD) and/or fracture risk in these patients. We aimed to systematically investigate the efficacy of anti-osteoporotic medications in patients with diabetes in comparison with non-diabetic subjects. METHODS: MEDLINE and Scopus databases were searched (up to 31st October 2017)...
February 6, 2018: Endocrine
https://www.readbyqxmd.com/read/29410755/influence-of-the-teaching-program-on-the-learning-in-knowledge-and-practice-of-osteonecrosis-of-the-jaws-produced-by-antireasorptives-in-dental-students-of-the-principality-of-asturias-spain
#14
Matias-Ferrán Escobedo, Luis García-Consuegra, Silvia Gay, Lorena Álvarez, Sonsoles Olay, Giuliano Ascani, Luis Junquera
Background: This study aims to evaluate the influence of changes in the teaching contents on medication-related osteonecrosis of the jaw may have on the knowledge and the capacity for practical case resolution about this pathology. Material and Methods: A cross-sectional descriptive study was conducted through a survey divided into four sections: degree of means of knowledge acquisition, habitual practice and ability to solve clinical cases. The total number of respondents (n = 225) was divided into two groups: Group A (Year 2015-2016) and Group B (Year 2016-2017)...
December 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29408511/removal-of-matrix-bound-zoledronate-prevents-post-extraction-osteonecrosis-of-the-jaw-by-rescuing-osteoclast-function
#15
Ranya Elsayed, Pheba Abraham, Mohamed E Awad, Zoya Kurago, Balasudha Baladhandayutham, Gary M Whitford, David H Pashley, Charles E McKenna, Mohammed E Elsalanty
Unlike other antiresorptive medications, bisphosphonate molecules accumulate in the bone matrix. Previous studies of side-effects of anti-resorptive treatment focused mainly on systemic effects. We hypothesize that matrix-bound bisphosphonate molecules contribute to the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). In this study, we examined the effect of matrix-bound bisphosphonates on osteoclast differentiation in vitro using TRAP staining and resorption assay, with and without pretreatment with EDTA...
February 8, 2018: Bone
https://www.readbyqxmd.com/read/29399411/monocytes-macrophages-promote-vascular-cxcr4-expression-via-the-erk-pathway-in-hepatocellular-carcinoma
#16
Ya-Ming Meng, Jing Liang, Chong Wu, Jing Xu, Dan-Ni Zeng, Xing-Juan Yu, Huiheng Ning, Li Xu, Limin Zheng
We recently identified CXCR4 as a novel vascular marker for vessel sprouting in hepatocellular carcinoma (HCC) tissues. Thus, CXCR4+ endothelial cells (ECs) could serve as a potential predictor for patients who may benefit from sorafenib treatment; however, the mechanism that regulates vascular CXCR4 expression in HCC remains largely unknown. Here, we revealed a large number of monocytes/macrophages (Mo/Mϕ) to be selectively enriched in the perivascular areas of CXCR4+ vessels in HCC samples. The depletion of Mo/Mϕ with gadolinium chloride (GdCl3) or zoledronic acid (ZA) treatment significantly reduced vascular CXCR4 expression in HCC tumors...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29395991/effect-of-different-doses-and-durations-of-teriparatide-therapy-on%C3%A2-resolution-of-medication-related-osteonecrosis-of-the-jaw-a%C3%A2-randomized-controlled-preclinical-study-in-rats
#17
Mohammad Zandi, Arash Dehghan, Najmeh Zandipoor, Payam Amini, Shideh Doulati
OBJECTIVE: To evaluate the effects of different doses and durations of teriparatide therapy on MRONJ resolution in rats. SUBJECTS AND METHODS: A total of 120 rats that had been affected with MRONJ (after six weekly zoledronate injections and tooth extraction) were randomly divided into eight subgroups: 2, 10, and 20 μg/kg/day teriparatide were administered to L4, M4, and H4 for 4 weeks, and to L8, M8, and H8 for 8 weeks, respectively. C4 and C8 received saline for 4 and 8 weeks, respectively...
December 30, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29395290/an-observational-study-of-concomitant-use-of-emerging-therapies-and-denosumab-or-zoledronic-acid-in-prostate-cancer
#18
Alexander Liede, Sally Wade, Jan Lethen, Rohini K Hernandez, Douglas Warner, Amy P Abernethy, Antonio Finelli
PURPOSE: This observational study of oncologic clinical practices was designed to describe real-world patterns of use of emerging therapies (abiraterone acetate, cabazitaxel, enzalutamide, radium-223, sipuleucel-T) in patients with castration-resistant prostate cancer and to characterize their concomitant use with denosumab or zoledronic acid. METHODS: A retrospective cohort study was conducted using a database of electronic health records from oncology practices across the United States...
January 24, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29394705/-a-case-of-metastases-to-the-bone-skin-and-ovary-from-gastric-cancer-occurring-more-than-eight-years-after-distal-gastrectomy
#19
Yukari Woo, Shigeru Fujisaki, Motoi Takashina, Ryouichi Tomita, Kenichi Sakurai, Tadatoshi Takayama
We report a 72-year-old woman with rare metastases of gastric cancer to the bone, skin, and ovary occurring more than 8 years after distal gastrectomy, which were subsequently effectively controlled. Histopathological diagnosis revealed signetring cell carcinoma, and the comprehensive findings were pT4a, pN3, ly2, v0, and Stage III c. The adjuvant chemotherapy of S- 1 plus cisplatin(CDDP)was switched to S-1monotherapy for 4 years and then to tegafur/uracil(UFT)for an additional year. Eight years after the operation, I-CTP and alkaline phosphatase(ALP)levels were elevated, and bone scintigraphy revealed bone metastasis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394628/-a-case-of-skull-base-metastasis-of-breast-cancer-with-dysphasia-odynophagia-and-dysarthria
#20
Hirotoshi Takahashi, Maya Uno, Kazuya Miyoshi
While skull base metastases from breast cancer are not uncommon, there are relatively few reported cases in the literature. We report a case of skull base metastasis of breast cancer that resulted in dysphasia, odynophagia, and dysarthria. The case involved a woman in her 50 s who was diagnosed with cancer of the right breast(cT4N1M0, cStage III B)at another medical institution 9 years previously and who underwent a partial mastectomy and an axillary lymph node dissection following neoadjuvant chemotherapy...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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